IJMS, Vol. 21, Pages 3747: High Homology-Directed Repair Using Mitosis Phase and Nucleus Localizing Signal International Journal of Molecular Sciences doi: 10.3390/ijms21113747 Authors: Jeong Pil Han Yoo Jin Chang Dong Woo Song Beom Seok Choi Ok Jae Koo Seung Youn Yi Tae Sub Park Su Cheong Yeom In homology-directed repair, mediated knock-in single-stranded oligodeoxynucleotides (ssODNs) can be used as a homologous template and present high efficiency, but there is...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3746: Differential Secretome Profiling of Human Osteoarthritic Synoviocytes Treated with Biotechnological Unsulfated and Marine Sulfated Chondroitins International Journal of Molecular Sciences doi: 10.3390/ijms21113746 Authors: Russo Vassallo Stellavato Valletta Cimini Pedone Schiraldi Chambery Symptomatic slow-acting drugs (SYSADOA) are increasingly used as effective therapies for osteoarthritis, representing an attractive alternative...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3745: Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres International Journal of Molecular Sciences doi: 10.3390/ijms21113745 Authors: Michiyo Honda Yusuke Kawanobe Kohei Nagata Ken Ishii Morio Matsumoto Mamoru Aizawa Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3748: DI-5-Cuffs: Lumbar Intervertebral Disc Proteoglycan and Water Content Changes in Humans after Five Days of Dry Immersion to Simulate Microgravity International Journal of Molecular Sciences doi: 10.3390/ijms21113748 Authors: Treffel Loïc Navasiolava Nastassia Karen Mkhitaryan Jouan Emmanuelle Zuj Kathryn Gauquelin-Koch Guillemette Custaud Marc-Antoine Gharib Claude Most astronauts experience back pain after spaceflight, primarily located...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3743: Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21113743 Authors: Graille Wild Sauvain Hemmendinger Guseva Canu Hopf Oxidative stress reflects a disturbance in the balance between the production and accumulation of reactive oxygen species (ROS). ROS are scavenged by the antioxidant system, but when in excess concentration, they...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3744: Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts International Journal of Molecular Sciences doi: 10.3390/ijms21113744 Authors: Márton R. Szabó Renáta Gáspár Márton Pipicz Nóra Zsindely Petra Diószegi Márta Sárközy László Bodai Tamás Csont Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3741: From Graphite to Laccase Biofunctionalized Few-Layer Graphene: A “One Pot” Approach Using a Chimeric Enzyme International Journal of Molecular Sciences doi: 10.3390/ijms21113741 Authors: Sorrentino Stanzione Nedellec Piscitelli Giardina Le Goff A chimeric enzyme based on the genetic fusion of a laccase with a hydrophobin domain was employed to functionalize few-layer graphene, previously exfoliated from graphite in the presence of the hydrophobin....
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3742: Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21113742 Authors: Crous Abrahamse Cancer stem cells (CSCs) are a leading contributor to lung cancer mortality rates. CSCs are responsible for tumor growth and recurrence through inhibition of drug-induced cell death, decreasing the effect of traditional cancer therapy and photodynamic...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3740: Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21113740 Authors: Espinosa-Garcia Atif Yousuf Sayeed Neigh Stein NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation and improve outcome in rodent models of cerebral ischemia. However,...
Tue May 26, 2020 03:00
IJMS, Vol. 21, Pages 3739: The Potential of CD16 on Plasma-Derived Exosomes as a Liquid Biomarker in Head and Neck Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113739 Authors: Hofmann Ludwig Schuler Hoffmann Brunner Theodoraki Head and neck squamous cell carcinomas (HNSCC) are highly immune suppressive and aggressive malignancies. As part of the tumor microenvironment, exosomes contribute to this immune suppression. The Fc receptor CD16 is...
Tue May 26, 2020 03:00
IJNS, Vol. 6, Pages 41: Genomic Analysis of Historical Cases with Positive Newborn Screens for Short-Chain Acyl-CoA Dehydrogenase Deficiency Shows That a Validated Second-Tier Biochemical Test Can Replace Future Sequencing International Journal of Neonatal Screening doi: 10.3390/ijns6020041 Authors: Aashish N. Adhikari Robert J. Currier Hao Tang Coleman T. Turgeon Robert L. Nussbaum Rajgopal Srinivasan Uma Sunderam Pui-Yan Kwok Steven E. Brenner Dimitar Gavrilov...
Tue May 26, 2020 03:00
IJNS, Vol. 6, Pages 40: Constructing a Bioethical Framework to Evaluate and Optimise Newborn Bloodspot Screening for Cystic Fibrosis International Journal of Neonatal Screening doi: 10.3390/ijns6020040 Authors: Armstrong Frith Ulph Southern Newborn bloodspot screening for cystic fibrosis is a valid public health strategy for populations with a high incidence of this inherited condition. There are a wide variety of approaches to screening and in this paper, we propose that...
Tue May 26, 2020 03:00
JCDD, Vol. 7, Pages 21: Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7020021 Authors: Stevens Wallace Refaey Roberts Koenig Mohler Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural and electrical cardiac abnormalities, including myocardial fibro-fatty replacement. Its pathological ventricular substrate predisposes subjects...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1617: Discrepancy between Lung Function Measurements at Home and in the Hospital in Children with Asthma and CF Journal of Clinical Medicine doi: 10.3390/jcm9061617 Authors: Frederick L.G.R. Gerzon Quirijn Jöbsis Michiel A.G.E. Bannier Bjorn Winkens Edward Dompeling The Coronavirus pandemic stresses the importance of eHealth techniques to monitor patients at home. Home monitoring of lung function in asthma and cystic fibrosis (CF) may help to detect deterioration...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1615: Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and Diagnostics Journal of Clinical Medicine doi: 10.3390/jcm9061615 Authors: Rene Kaden The phylogenetic clustering of 95 SARS-CoV-2 sequences from the first 3 months of the pandemic reveals insights into the early evolution of the virus and gives first indications of how the variants are globally distributed. Variants might become a challenge...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1616: Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound Journal of Clinical Medicine doi: 10.3390/jcm9061616 Authors: Lukas Prantl Andreas Eigenberger Sebastian Gehmert Silke Haerteis Thiha Aung Reinhard Rachel Ernst Michael Jung Oliver Felthaus Vitamin C is an essential nutrient for humans and is involved in a plethora of health-related functions. Several studies have shown a connection between vitamin C intake and an improved...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1613: Hyperspectral Ophthalmoscope Images for the Diagnosis of Diabetic Retinopathy Stage Journal of Clinical Medicine doi: 10.3390/jcm9061613 Authors: Yao Tseng Nguyen Kuo Wang A methodology that applies hyperspectral imaging (HSI) on ophthalmoscope images to identify diabetic retinopathy (DR) stage is demonstrated. First, an algorithm for HSI image analysis is applied to the average reflectance spectra of simulated arteries and veins in ophthalmoscope...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1612: Effect of Body Mass Index on Postoperative Nausea and Vomiting: Propensity Analysis Journal of Clinical Medicine doi: 10.3390/jcm9061612 Authors: Jong Ho Kim Mingi Hong Young Joon Kim Ho Seok Lee Young Suk Kwon Jae Jun Lee The impact of body mass index (BMI) on postoperative nausea and vomiting (PONV) is controversial, and few studies have focused on their relationship. We investigated the effects of BMI on PONV, taking into account other PONV...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1611: Gender, Albuminuria and Chronic Kidney Disease Progression in Treated Diabetic Kidney Disease Journal of Clinical Medicine doi: 10.3390/jcm9061611 Authors: Beatriz Fernandez-Fernandez Ignacio Mahillo Jinny Sanchez-Rodriguez Sol Carriazo Ana B. Sanz Maria Dolores Sanchez-Niño Alberto Ortiz Background: Women are reported to have a lower incidence of renal replacement therapy, despite a higher prevalence of chronic kidney disease (CKD). Aim: To...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1614: Analysis of Usage Data from a Self-Guided App-Based Virtual Reality Cognitive Behavior Therapy for Acrophobia: A Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9061614 Authors: Tara Donker Chris van Klaveren Ilja Cornelisz Robin N. Kok Jean-Louis van van Gelder This study examined user engagement with ZeroPhobia, a self-guided app-based virtual reality (VR) Cognitive Behavior Therapy for acrophobia symptoms using cardboard...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1609: Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals Journal of Clinical Medicine doi: 10.3390/jcm9061609 Authors: Carlotta Cocchetti Jiska Ristori Alessia Romani Mario Maggi Alessandra Daphne Fisher Introduction: To date no standardized hormonal treatment protocols for non-binary transgender individuals have been described in the literature and there is a lack of data regarding their efficacy and safety. Objectives: To suggest...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1610: Robot-Assisted versus Laparoscopic Donor Nephrectomy: A Comparison of 250 Cases Journal of Clinical Medicine doi: 10.3390/jcm9061610 Authors: Philip Zeuschner Linda Hennig Robert Peters Matthias Saar Johannes Linxweiler Stefan Siemer Ahmed Magheli Jürgen Kramer Lutz Liefeldt Klemens Budde Thorsten Schlomm Michael Stöckle Frank Friedersdorff Living kidney donation is the best treatment for end-stage renal disease, however, the...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1608: Post-Infectious Myocardial Infarction: Does Percutaneous Coronary Intervention Improve Outcomes? A Propensity Score-Matched Analysis Journal of Clinical Medicine doi: 10.3390/jcm9061608 Authors: Alain Putot Frédéric Chagué Patrick Manckoundia Philippe Brunel Jean-Claude Beer Yves Cottin Marianne Zeller Acute infection is a frequent trigger of myocardial infarction (MI). However, whether percutaneous coronary intervention (PCI) improves post-infectious...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1607: Epidemiological Trend of Sepsis in Patients with Hospital Admissions Related to Hepatitis C in Spain (2000–2015): A Nationwide Study Journal of Clinical Medicine doi: 10.3390/jcm9061607 Authors: Alejandro Alvaro-Meca Irene Maté-Cano Pablo Ryan Verónica Briz Salvador Resino Background: Hepatitis C virus (HCV) infection predisposes patients to other infectious diseases, such as sepsis. We aimed to analyze epidemiological trends of sepsis-related admissions,...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1606: The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9061606 Authors: Belén Atienza-Mateo Sara Remuzgo-Martínez Víctor Mora Cuesta David Iturbe-Fernández Sonia Fernández-Rozas Diana Prieto-Peña Mónica Calderón-Goercke Alfonso Corrales Gerardo Blanco Rodríguez...
Tue May 26, 2020 03:00
JCM, Vol. 9, Pages 1605: Effects of Anesthesia Techniques on Outcomes after Hip Fracture Surgery in Elderly Patients: A Prospective, Randomized, Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9061605 Authors: Seokyung Shin Seung Hyun Kim Kwan Kyu Park Seon Ju Kim Jae Chan Bae Yong Seon Choi The superiority of distinct anesthesia methods for geriatric hip fracture surgery remains unclear. We evaluated high mobility group box-1 (HMGB1) and interleukin-6 (IL-6)...
Tue May 26, 2020 03:00
JFMK, Vol. 5, Pages 33: Effectiveness of Workplace Yoga Interventions to Reduce Perceived Stress in Employees: A Systematic Review and Meta-Analysis Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5020033 Authors: Elisabetta Della Valle Stefano Palermi Irene Aloe Roberto Marcantonio Rocco Spera Stefania Montagnani Felice Sirico Work-related stress represents a relevant public health issue and solution strategies are mandatory. Yoga is a common approach...
Tue May 26, 2020 03:00
Life, Vol. 10, Pages 78: Comparative Study of SPA Mud from “Bacino Idrominerario Omogeneo dei Colli Euganei (B.I.O.C.E.)–Italy” and Industrially Optimized Mud for Skin Applications Life doi: 10.3390/life10060078 Authors: Beatrice Bergamaschi Laura Marzola Matteo Radice Stefano Manfredini Erika Baldini Chiara Beatrice Vicentini Elena Marrocchino Sonia Molesini Paola Ziosi Carmela Vaccaro Silvia Vertuani The term “Salus per aquam (SPA) therapies”...
Tue May 26, 2020 03:00
Life, Vol. 10, Pages 77: The Hypopiezotolerant Bacterium, Serratia liquefaciens, Failed to Grow in Mars Analog Soils under Simulated Martian Conditions at 7 hPa Life doi: 10.3390/life10060077 Authors: Andrew C. Schuerger Rebecca L. Mickol Petra Schwendner The search for life on Mars is predicated on the idea that Earth and Mars life (if present) should be both carbon- and water-based with similar forms of evolution. However, the astrobiology community can currently only investigate...
Tue May 26, 2020 03:00
Medicina, Vol. 56, Pages 256: Submuscular and Pre-Pectoral ADM Assisted Immediate Breast Reconstruction: A Literature Review Medicina doi: 10.3390/medicina56060256 Authors: Roberto Cuomo Background and objectives: Breast cancer treatment has deeply changed in the last fifty years. Acellular dermal matrices (ADMs) were introduced for breast reconstruction, with encouraging results, but with conflicting reports too. The present paper aims to summarize the current data on breast reconstruction...
Tue May 26, 2020 03:00
Medicina, Vol. 56, Pages 257: Stress in the Volunteer Caregiver: Human-Centric Technology Can Support Both Caregivers and People with Dementia Medicina doi: 10.3390/medicina56060257 Authors: Barbara Huelat Sharon T. Pochron Background and Objectives: Currently, one in eight people over the age of 65 have dementia, and approximately 75% of caregiving is provided by volunteer family members with little or no training. This study aimed to quantify points of stress for home-based caregivers...
Tue May 26, 2020 03:00
Medicina, Vol. 56, Pages 255: Autoimmune Thyroid Disease is Associated with a Lower Prevalence of Diabetic Retinopathy in Patients with Type 1 Diabetic Mellitus Medicina doi: 10.3390/medicina56060255 Authors: Magdalena Maria Stefanowicz-Rutkowska Wojciech Matuszewski Elżbieta Maria Bandurska-Stankiewicz Background and objectives: The aim of the study was to assess the correlation of autoimmune thyroid diseases (AITD) in patients with diabetes mellitus type 1 (DM1) with the occurrence...
Tue May 26, 2020 03:00
Metabolites, Vol. 10, Pages 218: Age-Dependent Metabolic Profiles Unravel the Metabolic Relationships Within and Between Flax Leaves (Linum usitatissimum) Metabolites doi: 10.3390/metabo10060218 Authors: Nicole Pontarin Roland Molinié David Mathiron Job Tchoumtchoua Solène Bassard David Gagneul Benjamin Thiombiano Hervé Demailly Jean-Xavier Fontaine Xavier Guillot Vivien Sarazin Anthony Quéro François Mesnard Flax for oil seed is a crop of increasing...
Tue May 26, 2020 03:00
Metabolites, Vol. 10, Pages 217: Lipidomic Phenotyping Reveals Extensive Lipid Remodeling during Adipogenesis in Human Adipocytes Metabolites doi: 10.3390/metabo10060217 Authors: Florian Miehle Gabriele Möller Alexander Cecil Jutta Lintelmann Martin Wabitsch Janina Tokarz Jerzy Adamski Mark Haid Differentiation of preadipocytes into mature adipocytes is a highly complex cellular process. At lipidome level, the adipogenesis remains poorly characterized. To investigate...
Tue May 26, 2020 03:00
MPs, Vol. 3, Pages 42: Production and Purification of Artificial Circular RNA Sponges for Application in Molecular Biology and Medicine Methods and Protocols doi: 10.3390/mps3020042 Authors: Breuer Rossbach Characterized by their covalently closed structure and thus an elevated stability compared to linear RNA molecules, circular RNAs (circRNAs) form a novel class of mainly non-coding RNAs. Although the biological functions of naturally occurring circRNAs are largely unknown, they...
Tue May 26, 2020 03:00
Microorganisms, Vol. 8, Pages 804: Anti-Inflammatory Effects of Vitamin E in Response to Candida albicans Microorganisms doi: 10.3390/microorganisms8060804 Authors: Barros Ribeiro Offenbacher Loewy Oral mucositis, inflammation, and ulceration that occur in the oral cavity can manifest in significant pain. A formulation was designed to investigate the potential of vitamin E to ameliorate inflammation resulting from Candida albicans in cell-based systems. Human gingival fibroblasts...
Tue May 26, 2020 03:00
Microorganisms, Vol. 8, Pages 796: Bacillus cytotoxicus Isolated from a Pristine Natural Geothermal Area Reveals High Keratinolytic Activity Microorganisms doi: 10.3390/microorganisms8060796 Authors: Cavello Urbieta Cavalitto Donati Geothermal areas are the niches of a rich microbial diversity that is not only part of the intangible patrimony of a country but also the source of many microbial species with potential biotechnological applications. Particularly, microbial species...
Tue May 26, 2020 03:00
Microorganisms, Vol. 8, Pages 802: Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis Microorganisms doi: 10.3390/microorganisms8060802 Authors: Markus M. Heimesaat Soraya Mousavi Sigri Kløve Claudia Genger Dennis Weschka Eliezer Giladi Stefan Bereswill Illana Gozes Human infections with the food-borne zoonotic pathogen Campylobacter jejuni are progressively rising and constitute serious global...
Tue May 26, 2020 03:00
Microorganisms, Vol. 8, Pages 798: Comparing the Influence of Assembly Processes Governing Bacterial Community Succession Based on DNA and RNA Data Microorganisms doi: 10.3390/microorganisms8060798 Authors: Jia Dini-Andreote Falcão Salles Quantifying which assembly processes structure microbiomes can assist prediction, manipulation, and engineering of community outcomes. However, the relative importance of these processes might depend on whether DNA or RNA are used, as they...
Tue May 26, 2020 03:00
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,