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Τετάρτη 11 Νοεμβρίου 2020

Biosensors, Vol. 10, Pages 173: Electromagnetic Piezoelectric Acoustic Sensor Detection of Extracellular Vesicles through Interaction with Detached Vesicle Proteins

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Μέσω Biosensors

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Biosensors, Vol. 10, Pages 173: Electromagnetic Piezoelectric Acoustic Sensor Detection of Extracellular Vesicles through Interaction with Detached Vesicle Proteins

Biosensors doi: 10.3390/bios10110173

Authors: Románszki Varga Mihály Keresztes Thompson

An electromagnetic piezoelectric acoustic sensor (EMPAS) was used to study the non-specific adsorption of human red blood cell-derived extracellular vesicle preparations. Vesicle storage history (temperature and duration) highly affected the obtained results: The signal change, namely the frequency decrease of the crystal measured at 20 °C, was negligibly small (<1 s−2) when the vesicle solutions had previously been stored at 4 °C, and was in the order of 10 s−2 when the vesicle solutions had been stored at −30 °C. Moreover, the rate of frequency decrease increased exponentially with the storage time at −30 °C. Upon a 4 °C storage period following the −30 °C storage period of the same sample, the measured frequency decrease dropped, suggesting a partial relaxation of the system. The results are explained by the disintegration of the vesicles triggered by the freeze–t haw cycle, likely due to the detachment of proteins from the vesicle surface as was proved by size-exclusion chromatography. Surface modification of the sensor crystal provided the possibility of signal enhancement, as the maximum rate of the frequency change for the same vesicle concentrations was higher on hydrophobic, octadecyl trichlorosilane–modified quartz than on hydrophilic, bare quartz. The EMPAS signal has been associated with the amount of detached proteins, which in turn is proportional to the originating vesicle concentration.

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Factors Influencing Total Serum IgE in Adults: The Role of Obesity and Related Metabolic Disorders

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Background and Aim: Few reports have investigated the association between metabolic abnormalities (obesity and related metabolic syndrome) and total serum IgE concentrations. Methods: This cross-sectional study included a random sample of 1,516 adult individuals (44.7% men, aged 18–91 years, median 52 years) from a single municipality in Spain. Serum IgE was measured in the ADVIA Centaur system. Atopy was defined by the presence of positive skin prick tests to a panel of common aeroallergens in the area. Body mass index and data related to the definition of metabolic syndrome were obtained from all participants. Alcohol consumption, smoking, and regular physical exercise were assessed by a questionnaire. Results: Atopy (present in 21.9% of 1,514 evaluable individuals) was the strongest factor determining serum IgE concentrations. Male sex and heavy alcohol drinking were independently associated with higher IgE concentrations, particularly in the non-atopic individuals. Body mass index was positively associated with IgE concentrations, independent of potential confounders, although the effect was only evident among non-atopic individuals. In that group, median IgE concentrations in normal-weight and obese individuals were 15 and 24 kU/L, respectively (p #x3c; 0.001); likewise, obesity was asso ciated with high (#x3e;100 kU/L) IgE concentrations after adjusting for potential confounders (odds ratio: 1.79, 95% confidence interval: 1.26–2.56, p = 0.001). The presence of metabolic syndrome and its components, particularly abdominal obesity and hyperglycaemia, was also positively and independently associated with higher IgE concentrations in non-atopic individuals. Conclusions: Obesity and metabolic syndrome components are associated with high total serum IgE concentrations, particularly in non-atopic individuals.
Int Arch Allergy Immunol
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Intralymphatic Administration of Metagonimus yokogawai-Extracted Protein Attenuates Experimental Murine Allergic Rhinitis Model

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Objectives: This study aimed to evaluate potential therapeutic effect of Metagonimus yokogawai on the OVA-induced allergic rhinitis model. Methods: OVA-sensitized mice were used to assess potential therapeutic effect of the extract protein of M. yokogawai (My-TP). My-TP was administrated via the intralymphatic route to cervical lymph nodes. The frequencies of sneezing or nasal rubbing were recorded. Histopathologic evaluation was performed for eosinophil infiltrations in the tissues of the nasal mucosa and skin. The mRNA relative expressions of the cytokine profiles including Th1, Th2, Th17, and Treg subsets in the nasal mucosa, cervical lymph nodes, and spleen were analyzed by quantitative real-time reverse-transcriptase polymerase chain reaction. The potential underlying mechanism was investigated by examining cytokine profiles including IL-4 and Treg subsets from lymphocytes of the spleen by flow cytometry. Results: Int ralymphatic injection of My-TP reduced allergic symptoms and eosinophil infiltration in the nasal mucosa. My-TP-treated group showed markedly decreased levels of OVA-specific IgE and WBC counts in nasal lavage. My-TP-treated group showed the decreased expression levels of IL-4, while those of IL-10 were increased in both the nasal mucosa. The levels of IFN-γ and IL-17 were also decreased in the nasal mucosa and cervical lymph nodes. The immunological mechanism may involve the downregulation of Th2 response and upregulation of Tregs in the nasal mucosa and cervical lymph nodes. Conclusions: Our results provide the first evidence of potential therapeutic effect of M. yokogawai in OVA-sensitized allergic rhinitis mice, suggesting that a Treg/Th2 reorganization may play a role in clinical course of allergic rhinitis.
Int Arch Allergy Immunol
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J. Intell., Vol. 8, Pages 38: A Reappraisal of the Threshold Hypothesis of Creativity and Intelligence

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J. Intell., Vol. 8, Pages 38: A Reappraisal of the Threshold Hypothesis of Creativity and Intelligence

Journal of Intelligence doi: 10.3390/jintelligence8040038

Authors: Selina Weiss Diana Steger Ulrich Schroeders Oliver Wilhelm

Intelligence has been declared as a necessary but not sufficient condition for creativity, which was subsequently (erroneously) translated into the so-called threshold hypothesis. This hypothesis predicts a change in the correlation between creativity and intelligence at around 1.33 standard deviations above the population mean. A closer inspection of previous inconclusive results suggests that the heterogeneity is mostly due to the use of suboptimal data analytical procedures. Herein, we applied and compared three methods that allowed us to handle intelligence as a continuous variable. In more detail, we examined the threshold of the creativity-intelligence relation with (a) scatterplots and heteroscedasticity analysis, (b) segmented regression analysis, and (c) local structural equation models in two multivariate studies (N1 = 456; N2 = 438). We found no evidence for the threshold hypothesis of creativity across different analytical procedures in both studies. Given the problem atic history of the threshold hypothesis and its unequivocal rejection with appropriate multivariate methods, we recommend the total abandonment of the threshold.

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Coronary anatomy and comorbidities impact on elective PCI outcomes in left main and multivessel coronary artery disease

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Abstract

Introduction

The effects of coronary anatomy, lesion complexity, and comorbidities on outcomes of elective percutaneous coronary intervention (PCI) in high‐risk patients with left main (LM) and/or multivessel coronary artery disease (CAD) are not well studied, as these patients are typically underrepresented in the clinical trials.

Methods

This cohort study involved 33,568 consecutive elective PCI cases, excluding patients with prior coronary artery bypass graft, acute coronary syndrome within 24 hr of index PCI, or shock. All data were obtained from the New York State's PCI Reporting System from the calendar year 2015. In‐hospital mortality was the primary outcome of study. Logistic regression models were built to calculate odds ratios (OR) with 95% confidence intervals (CI) for in‐hospital mortality after adjustment for coronary anatomy and significant clinical comorbidities.

Results

In this cohort of elective PCI cases all cause in‐hospital mortality was low (0.3%), with a clear mortality gradient according to the extent of CAD: 0.1% in 1 vessel disease, 0.4% in 2 vessel, 0.5% in 3 vessel disease, and 3.2% in patients with LM CAD (p < .001). Mortality was also significantly increased in patients with multiple comorbidities: 0.1% in patients with 1 comorbidity, 0.7% with 2, 2.5% with 3, and 7.4% with 4 or more studied comorbidities (p < .0001). When adjusted for coronary anatomy and lesion complexity, having any 4 or more comorbidities was associated with significantly increased odds of dying after elective PCI (OR 25.9, 95% CI 8.152–82.063, p < .0001). Furthermore, when compared to patients with 3‐vessel CAD, and accounted for comorbidities, the patients with LM disease still had significantly increased (OR 5.254, 95% CI 3.104–8.891, p < .0001) odds of dying after elective PCI.

Conclusions

In patients undergoing elective PCI, multivessel CAD and particularly LM disease are associated with significantly increased all‐cause mortality. Furthermore, when adjusted for the extent of CAD and lesion complexity, comorbidity burden remains an important predictor of mortality.

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Transcatheter mitral valve thrombosis: A case report and literature review

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Abstract

Transcatheter mitral valve replacement (TMVR) is an exciting alternative therapy for complex patients with mitral valve disease. Experience with TMVR is new and there is a lot yet to discover about their durability, long‐term outcomes, and complications including mitral transcatheter heart valve (THV) thrombosis. Many factors have been speculated to increased risk of THV thrombosis. Here, we report a case of a 72‐year‐old woman who developed mitral THV thrombosis after undergoing TMVR for severe mitral regurgitation with mitral annular calcification. We reviewed 42 TMVR papers with 1,484 patients, including 60 with mitral THV thrombosis. We discussed the most common strategies used for mitral THV thromboprophylaxis and treatment.

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VersaCross transseptal system for transcatheter mitral valve repair

Alexandros G.Sfakianakis shared this article with you from Inoreader

Abstract

Objectives

The aim of this study is to describe the initial experience with versacross transseptal (TS) system for transseptal puncture for the transcatheter mitral valve repair using the MitraClip device.

Background

Transeptal puncture is a key step in transcatheter mitral valve repair (MVR) and the use of the VersaCross system comprised of a sheath, a dilator and a radiofrequency wire has not been previously described.

Methods

Prospective single center study of consecutive patients undergoing transcatheter mitral valve repair with the MitraClip device were included. Targeted TS puncture was performed under transesophageal echocardiographic (TEE) guidance. Baseline demographics, procedural characteristics, and major adverse procedural events were collected.

Results

Twenty‐five consecutive patients underwent transseptal puncture using the VersaCross TS system. Transseptal puncture was successful in 100% of patients. The mean time for TS puncture was 3 3 ± 1.6 min with no major adverse procedural events. The mean time from insertion of the VersaCross system to insertion of the MitraClip guide catheter was 3.8 ± 3.0 minutes.

Conclusion

The VersaCross TS system was successful in all patients for MitraClip procedure with no adverse procedural events and may be associated with increased procedural efficiency.

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' ... sciens quia melior est misericordia tua super vitas.' La théologie de la miséricorde de Gertrude von Helfta dans le contexte de la mystique médiévale féminine

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Gertrude the Great
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Saint Gertrude
Santa Giustina (Padua) - Ecstasy of St. Gertrude by Pietro Liberi.jpg
Saint Gertrude of Helfta
Virgin
Born January 6, 1256
Eisleben, Thuringia, Holy Roman Empire
Died c. 1302
Helfta, Saxony, Holy Roman Empire
Venerated in Catholic Church
Canonized 1677 (equipollent) by Clement XII
Feast November 7
Attributes crown, lily, taper
Patronage West Indies
Gertrude the Great (or Saint Gertrude of Helfta; Italian: Santa Gertrude; January 6, 1256 – c. 1302) was a German Benedictine nun, mystic, and theologian. She is recognized as a saint by the Catholic Church, and is inscribed in the General Roman Calendar for optional celebration throughout the Roman Rite, as a memorial on November 16.


Contents
1 Life
2 Works
3 Devotion to the Sacred Heart
4 Later reputation and influence
5 Veneration
6 Patronage
7 Legacy
8 See also
9 Notes
10 References
11 Further reading
12 External links
Life
Little is known of the early life of Gertrude who was born on the Feast of the Epiphany, January 6, 1256, in Eisleben, Thuringia (within the Holy Roman Empire). At the age of four,[1] she entered the monastery school at St. Mary at Helfta (with much debate having occurred as to whether this monastery is best described as Benedictine or Cistercian),[2] under the direction of its abbess, Gertrude of Hackeborn. It is speculated that she was offered as a child oblate to the church by devout parents. Given that Gertrude implies in the Herald that her parents were long dead at the time of writing,[3] however, it is also possible that she entered the monastery school as an orphan.

Gertrude was confided to the care of Mechtilde, younger sister of the Abbess Gertrude, and joined the monastic community in 1266.[4] It is clear from her own writings that she received a thorough education in a range of subjects. She, and the nun who authored Books 1 and 3-5 of the Herald, are thoroughly familiar with scripture, the Church Fathers such as Augustine and Gregory the Great, and also more contemporary spiritual writers such as Richard and Hugh of St Victor, William of St Thierry, and Bernard of Clairvaux. Moreover, Gertrude's writing demonstrates that she was well-versed in rhetoric, and her Latin is very fluent.[5]

In 1281, at the age of 25, she experienced the first of a series of visions[6] that continued throughout her life, and which changed the course of her life. Her priorities shifted away from secular knowledge and toward the study of scripture and theology. Gertrude devoted herself strongly to personal prayer and meditation, and began writing spiritual treatises for the benefit of her monastic sisters.[7] Gertrude became one of the great mystics of the 13th century. Together with her friend and teacher Mechtilde, she practiced a spirituality called "nuptial mysticism," that is, she came to see herself as the bride of Christ.[8]

Gertrude died at Helfta, near Eisleben, Saxony, around 1302. Her feast day is celebrated on November 16, but the exact date of her death is unknown; the November date stems from a confusion with Abbess Gertrude of Hackeborn.

Works

Gertrud von Helfta, Merazhofen Pfarrkirche Chorgestühl
Gertrude produced numerous writings, though only some survive today. The longest survival is the Legatus Memorialis Abundantiae Divinae Pietatis (known in English today as The Herald of Divine Love or The Herald of God's Loving-Kindness, and sometimes previously known as Life and Revelations), partly written by other nuns. There also remains her collection of Spiritual Exercises. A work known as Preces Gertrudianae (Gertrudian Prayers) is a later compilation, made up partly of extracts from the writings of Gertrude and partly of prayers composed in her style.[9] It is also very possible that Gertrude was the author of a part of the revelations of Mechthild of Hackeborn, the Book of Special Grace.[9]

The Herald is composed of five books. Book 2 forms the core of the work, and was written by Gertrude herself; she states that she began the work on Maundy Thursday 1289. Books 3, 4, and 5 were written by another nun, or possibly more than one, during Gertrude's lifetime and probably at least in part at her dictation. Book 1 was written shortly before or after Gertrude's death as an introduction to the whole collection; it is possible it was written by Gertrude's confessor, but far more likely that the author was another Helfta nun.[10]

The importance of the Spiritual Exercises extends to the present day because they are grounded in the themes and rites of Catholic liturgy for occasions of baptism, conversion, commitment, discipleship, union with God, praise of God, and preparation for death. Gertrude's Spiritual Exercises can still be used by anyone who seeks to deepen spirituality through prayer and meditation.[11]

Devotion to the Sacred Heart
One of the most esteemed woman saints of the Christian West, she was a notable early devotee of the Sacred Heart of Jesus.[7] Book 2 of the Herald of Divine Love is notable within the history of Christian devotion because its vivid descriptions of Gertrude's visions show a considerable elaboration on the long-standing but ill-defined veneration of Christ's heart. This veneration was present in the belief that Christ's heart poured forth a redemptive fountain through the wound in his side, an image culminating in its most famous articulation by Bernard of Clairvaux in his commentary on the Song of Songs. The women of Helfta—Gertrude foremost, who surely knew Bernard's commentary, and to a somewhat lesser extent the two Mechthilds, Mechthild of Magdeburg and Mechthild of Hackeborn—made this devotion central to their mystical visions.[12] Gertrude reported a vision on the Feast of John the Evangelist. She was resting her head near the wound in the Christ's side and hearing the beati ng of his heart. She asked John if on the night of the Last Supper he had felt these pulsations, why he had never spoken of the fact. John replied that this revelation had been reserved for subsequent ages when the world, having grown cold, would have need of it to rekindle its love.[13]

Later reputation and influence
After her death, Gertrude's works seem to have vanished almost without trace. Only five manuscripts of the Herald have survived, the earliest one being written in 1412, and only two of these manuscripts are complete. With the invention of printing, Gertrude became far more prominent, with Latin, Italian and German editions being published in the sixteenth century. She was popular in seventeenth-century France, where her trust in and burning love for God were potent antidotes to Jansenism.

Philip Neri and Francis de Sales both used her prayers and recommended them to others.

In Spain, Bishop Diego of Tarragona, the confessor to Philip II, read the revelations of Gertrude aloud to the king as he lay dying in the Escorial.

Her works were also popular with the Discalced Carmelites in the sixteenth century. Francisco Ribera, the confessor to Teresa of Ávila, recommended that she take Gertrude as spiritual mistress and guide.

More recently, Dom Prosper Guéranger, the restorer of Benedictine monasticism in France, was influenced by Gertrude. His Congregation of Solesmes was responsible for most of the work done on Gertrude in the nineteenth century.[14]

Veneration

Saint Gertrude by Miguel Cabrera, 1763
Gertrude was never formally canonized, but a liturgical office of prayer, readings, and hymns in her honor was approved by Rome in 1606. The Feast of Saint Gertrude was extended to the Catholic Church by Clement XII and today is celebrated on November 16, the date of her death. Some religious communities, including the Benedictines, celebrate her feast on November 17. Pope Benedict XIV gave her the title "the Great" to distinguish her from Abbess Gertrude of Hackeborn and to recognize the depth of her spiritual and theological insight.[11]

Gertrude showed "tender sympathy towards the souls in purgatory" and urged prayers for them.[15] She is therefore invoked for suffering souls in purgatory. The following prayer is attributed to St. Gertrude, and is often depicted on her prayer card:

Eternal Father, I offer Thee the Most Precious Blood of Thy Divine Son, Jesus, in union with the Masses said throughout the world today, for all the Holy Souls in Purgatory, for sinners everywhere, for sinners in the universal Church, for those in my own home and in my family. Amen.

Perhaps for that reason, her name has been attached to a prayer that, according to a legend of uncertain origin and date (neither are found in the Revelations of Saint Gertrude the Great), Christ promised to release a thousand souls from purgatory each time it was said; despite the fact that practices relative to alleged promises to free one or more souls from purgatory by the recitation of some prayer were prohibited by Pope Leo XIII.[16] Nonetheless, the material that is found in her Revelations, such as the celebration of Gregorian Masses for the departed, is well in line with the devotions approved by the Catholic Church.

Patronage
In compliance with a petition from King Philip IV of Spain she was declared Patroness of the West Indies; in Peru her feast is celebrated with great pomp, and in New Mexico the town Santa Gertrudis de lo de Mora was built in her honor and bears her name.[4]

Legacy
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In subsequent centuries, Gertrude the Great was often confused with the abbess of St Mary at Helfta, Gertrude of Hackeborn; as a result, she is often incorrectly depicted in art holding a crosier.
The Monastery of St. Gertrude in Cottonwood, Idaho, is home to a community of about 50 professed Benedictine nuns.[11]
Parishes are dedicated to Saint Gertrude in Washington, Missouri;[17] Cincinnati, Ohio;[18] Kingsville, Texas;[19] Woodstock, New Brunswick, Canada; Franklin Park, Illinois; and Chicago, Illinois.
Saint Gertrude High School is a Catholic college preparatory day school for young women in grades 9-12 in Richmond, Virginia.[20]
Saint Gertrude Church in Firies, Killarney, County Kerry, Ireland.
Saint Gertrude the Great Catholic School (TK-8th Grade) and Parish in Bell Gardens, California.[21]
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Notes
Her biographer states "in her fifth year", leading some to misinterpret this as being when she was five years old. See Alexandra Barrett, 'Introduction', in Gertrud the Great of Helfta, The Herald of God's Loving-Kindness: Books One and Two, (Kalamazoo, 1991), p10
This has been a point of some contention in twentieth-century studies of Gertrude. The best answer is that, technically, Helfta was a Benedictine monastery, but one which was strongly influenced by the Cistercian reform; this reflects the lack of clear-cut distinctions between the Orders at this time. Helfta, like many other monasteries of nuns following the Rule of St Benedict, was very much influenced by the Cistercian customs (and was in fact founded in 1258 by a group of nuns from Halberstadt who had adopted Cistercian customs). However, it was not, and could not, have been officially Cistercian, because in 1228 the General Chapter of Citeaux had forbidden the acceptance of any more monasteries of nuns into their Order, since the monks were already overburdened by the number of nuns under their care. Helfta, therefore, could not have been officially Cistercian. It is clear, though, that Helfta's customs seem to have been those of Citeaux, and certainly the works of Bernard of Cl airvaux were extremely influential at Helfta. It is unclear whether the nuns wore a black 'Benedictine' or white 'Cistercian' habit, but interesting to note that both Gertrude and Mechtilde are almost universally represented in black. The spiritual directors of the monastery were neither Benedictines nor Cistercians, but Dominicans. See Sr Maximilian Marnau, 'Introduction', in Gertrude of Helfta, The Herald of Divine Love, (New York: Paulist Press, 1993), p10; Caroline Bynum Walker, Jesus as Mother, (Berkeley and Los Angeles, 1982), pp174-5.
Herald, Book 2, chapter 16
"CATHOLIC ENCYCLOPEDIA: St. Gertrude the Great". www.newadvent.org. Retrieved 18 August 2017.
Sr Maximilian Marnau, 'Introduction', in Gertrude of Helfta, The Herald of Divine Love, (New York: Paulist Press, 1993), p6
This is described in Herald 1.1 and 2.1
"ST. GERTRUDE THE GREAT :: Catholic News Agency (CNA)". Retrieved 18 August 2017.
Foley O.F.M., Leonard. Saint of the Day, Lives, Lessons, and Feast, (revised by Pat McCloskey O.F.M.), Franciscan Media ISBN 978-0-86716-887-7
Marnau, p.11.
Sr Maximilian Marnau, 'Introduction', in Gertrude of Helfta, The Herald of Divine Love, (New York: Paulist Press, 1993), p12. Marnau suggests that Book 1 was written after Gertrude's death. Alezandra Barrett suggests that the absence of mention of Gertrude's death in Book 1 implies it was possibly written before her death. See Alexandra Barrett, 'Introduction', in Gertrud the Great of Helfta, The Herald of God's Loving-Kindness: Books One and Two, (Kalamazoo, 1991), p17
"Bossert, Sr. Evangela. "St. Gertrude of Helfta", Monastery of St. Gertrude, Cottonwood, Idaho". Archived from the original on 16 May 2013. Retrieved 18 August 2017.
"Illiniois Medieval Association - EMS". ima.wildapricot.org. Retrieved 2020-08-23.
, Mark W. Lynn Phd, Mark W., "History of the Feast of the Sacred Heart of Jesus", Knights of Columbus-Florida State Council Archived 2014-02-01 at the Wayback Machine
Marnau, p.43.
Knight, Kevin (January 9, 2009). "St. Gertrude the Great". New Advent.
O'Sullivan, Paul (March 4, 1936). "Prayer of St. Gertrude the Great (from "Read Me or Rue It")". Our Lady of the Rosary Library.
"St. Gertrude Parish, Washington, Missouri". Archived from the original on 6 January 2017. Retrieved 18 August 2017.
"Saint Gertrude the Great - St. Gertrude Parish". www.stgertrude.org. Archived from the original on 6 January 2017. Retrieved 18 August 2017.
"Welcome!". Retrieved 18 August 2017.
"St. Gertrude High School, Richmond, Virginia". Archived from the original on 2 June 2013. Retrieved 18 August 2017.
"Our Parish - St. Gertrude the Great Catholic School". Retrieved 18 August 2017.
References
Gertrude of Helfta, The Herald of Divine Love, translated and edited by Margaret Winkworth, introduced by Sister Maximilian Marnau, preface by Louis Bouyer. Classics of Western Spirituality. (New York: Paulist Press, 1993) [This contains a full translation of Books 1 and 2, and a partial translation of Book 3.]
Further reading
Gertrude the Great of Helfta, Spiritual Exercises, Translated, with an Introduction, by Gertrud Jaron Lewis and Jack Lewis. Cistercian Fathers series no. 49, (Kalamazoo: Cistercian Publications, 1989)
Gertrud the Great of Helfta, The Herald of God's Loving-Kindness, books 1 and 2, translated, with an Introduction, by Alexandra Barratt. Cistercian Fathers series no. 35, (Kalamazoo, MI: Cistercian Publications, 1991)
Gertrud the Great of Helfta, The Herald of God's Loving-Kindness, book 3, translated, with an Introduction, by Alexandra Barratt. Cistercian Fathers series no. 63, (Kalamazoo, MI: Cistercian Publications, 1999)
External links
Benedict XVI, "On St. Gertrude", General audience, October 6, 2010
The Life and Revelations of Saint Gertrude the Great - the full text online.
Dolan, Gilbert. St. Gertrude the Great, Sands & Co., London, 1913
St. Gertrude of Helfta at the Christian Iconography web site.
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La mystique Gertrude d'Helfta (1256-1302) développe dans ses écrits une théologie convaincue de la miséricorde. La misericordia y est considérée comme la forme essentielle de rencontre avec la présence de Dieu. Dans son ouvrage des Exercices ( exercitia spiritualia) , précisément, Gertrude d'Helfta envisage fondamentalement la miséricorde divine comme le principe de toute vie. L'homme peut y répondre uniquement par un amour inconditionnel. Les voies catégorielles de connaissance que sont l'intellect, l'émotion ou la sagesse ne permettent d'appréhender ni l'amour, ni la miséricorde. Cette ébauche fait donc de la miséricorde un existential mystique. La mystique féminine des treizième et quatorzième siècles comprend, dans son ensemble, de nombreuses références à la miséricorde divine. Mathilde de Magdebourg (1207-1282 environ) mentionne très souvent la vertu humaine de la miséricorde, entravée principalement par l'« indolence du cœur ». A c ertains égards, la position de Mathilde importe pour le vaste champ de la mystique médiévale féminine. La miséricorde a certes valeur de « principe originel » de l'aide divine. Néanmoins, dans ce contexte, cette miséricorde essentielle passe au second plan, confrontée à la grâce de médiation et aux dons divins concrets. Leurs implications éthiques et les préceptes moraux correspondants dominent le chemin théologique.
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The emerging landscape of nanotheranostic-based diagnosis and therapy for osteoarthritis

Alexandros G.Sfakianakis shared this article with you from Inoreader

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Publication date: 10 December 2020

Source: Journal of Controlled Release, Volume 328

Author(s): Shuyi Xiao, Liang Chen

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