Comparative clinical study of conventional dental implant and mini dental implant‐retained mandibular overdenture: A 5‐ to 8‐Year prospective clinical outcomes in a previous randomized clinical trial

alexandrossfakianakis shared this article with you from Inoreader Comparative clinical study of conventional dental implant and mini dental implant‐retained mandibular overdenture: A 5‐ to 8‐Year prospective clinical outcomes in a previous randomized clinical trial via Clinical Implant Dentistry and Related Research Abstract Aim To compare the long-term prospective clinical outcomes in a previous randomized controlled clinical trial (RCT) of 2 Mini Dental Implant (2MDI), 4 Mini Dental Implant (4MDI), and 2 Conventional Dental Implant (2CDI)-retained mandibular overdenture with follow-up between 5 to 8 years. Materials and Methods Thirty-seven patients formerly participated in the Comparative Clinical Study of CDI and MDI for Mandibular Overdenture were requested for examination of clinical outcomes. A total of 104 implants were placed with mean follow-up periods 6.64 ± 0.60 years. In Group 1 (2MDI) and Group 2 (4MDI), implants were placed and immediately loaded with Equator® attachments to retained mandibular overdenture. In Group 3 (2CDI), implants were placed and delayed 3 months for denture loading with ball attachment. The success rate, survival rate, clinical implant performance scale (CIP scale), peri-implant tissue status, prosthetic complication, implant stability quotient (ISQ), marginal bone level change (MBLC), and patient satisfactions were analyzed. Results After 5 to 8 years follow-up, the success rate in Groups 1, 2, and 3 were 90.91%, 93.33%, and 54.55%, respectively. The success rate in Group 3 was significantly lesser than Group 1 (p = 0.016) and Group 2 (p < 0.001). The survival rate in Groups 1, 2, and 3 was 100%, 96.67%, and 90.91%, respectively, and showed no significant differences. Mean ISQ reported no significant differences between groups. Mean MBLC were 0.57 ± 1.19 mm, 0.68 ± 0.90 mm, and 1.55 ± 1.60 mm in Groups 1, 2, and 3, respectively. Group 3 reported significantly greater mean MBLC than Group 1 (p = 0.016) and Group 2 (p = 0.011), but Groups 1 and 2 were not significantly differences. The overall patient satisfactions were reported as not significant differences between groups. Conclude Two MDI-retained mandibular overdentures with immediate loaded protocol performed had favorable clinical outcomes, cost effectiveness, and overall patient satisfactions after 5 to 8 years follow-up. View on Web

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Data Analytics for Diagnosis and Prediction of Central Line–Associated Bloodstream Infections in Critical Care Units

alexandrossfakianakis shared this article with you from Inoreader Data Analytics for Diagnosis and Prediction of Central Line–Associated Bloodstream Infections in Critical Care Units via Computers Informatics Nursing - Current Issue Central line–associated bloodstream infections are among the leading causes of in-hospital deaths in the United States and are a significant factor for increased morbidity, mortality, and healthcare costs. This study integrates several hospital data systems into a case-controlled database to use data analytics for the identification of significant central line–associated bloodstream infection risk factors and develop time-varying patient risk scores for central line–associated bloodstream infections. A case-control study was performed utilizing patient data collected from various sources then gathered and organi zed into a case-controlled dataset for analysis examining various patient-specific attributes for central line–associated bloodstream infections. Training and testing sets were created, and multivariate logistic regressions were used to identify risk factors for central line–associated bloodstream infection. Furthermore, the Cox proportional hazards model was used to infer the hazard rate and risk score for central line–associated bloodstream infections for each individual patient during hospitalization. Significant attributes for central line–associated bloodstream infection cases were the ICU location (P = .008), time from insertion (P ≤ .001), number of surgeries (P = .003), and number of central line manipulations (P = .003). Real-time data analytics and point of care at the bedside can facilitate precision care for patients with an elevated central line–associated bloodstream infection risk, subsequently changing the way healthcare prevents hospital-acquired infecti ons. View on Web

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In Vitro Analysis of Shear Stress: CAD Milled vs Printed Denture Base Resins with Bonded Denture Tooth

alexandrossfakianakis shared this article with you from Inoreader In Vitro Analysis of Shear Stress: CAD Milled vs Printed Denture Base Resins with Bonded Denture Tooth via Journal of Prosthodontics Abstract Purpose : As the fabrication of computer-aided design (CAD) milled and 3D printed denture base resins with bonded denture teeth increase in popularity, there is a need for research comparing the shear bond stress of milled and printed denture base resins with bonded denture teeth to that of a conventional heat processed denture base. Materials and methods : Denture base resin specimens (n = 9) were fabricated according to manufacturers' instructions using a novel test design. Two milled (Ivobase CAD PMMA, Ivoclar Vivadent and Polident PMMA, Polident Dental) and two 3D printed (Denture Base LP Resin, Formlabs and Lucitone Digital Print, Dentsply Sirona) materials were used. Conventional heat processed polymethylmethacrylate was used as the control (Lucitone 199, Dentsply Sirona, USA). Denture teeth (VITA Vitapan XL T44, #8, VITA Zahnfabrik) were bonded to their respective bases using denture tooth bonding agent (Ivobase CAD bonding system, Ivoclar). Specimens were aged in water for 600 hours at 37˚C and loaded until failure in a Universal testing machine. Shear bond stress was calculated. All specimens were evaluated for mode of failure and select specimens under scanning electron microscope and vertical scanning interferometry. Data were analyzed with one-way ANOVA followed by Tukey test (IBM SPSS) and fracture analysis performe d. Results : Shear stress was highest for the heat processed control (mean = 180 N ±26.76) and Polident test groups (mean = 180 N ±34.90). Milled specimens were not significantly different from the control (p = 0.076 for IvoBase CAD and 1.00 for Polident), while the printed groups were significantly different from the control (p = 0.012 for Formlabs Denture Base Resin and p = 000 for Carbon Lucitone Digital Print). Milled denture base resins perform similarly to heat processed denture base resin and better than 3D printed denture bases. Conclusion : For complete denture wearers, all resin materials used in this study may be clinically acceptable, as the sheer stress for all groups was higher than the reported maximum biting force of complete denture patients. However, for implant retained prostheses, the incorporation of additional retentive features should be considered when bonding denture teeth to printed bases. More research is needed to evaluate methods to increase the bond strength of denture teeth to printed denture base resins. This article is protected by copyright. All rights reserved View on Web

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Investigational PET tracers in neuro-oncology—What’s on the horizon? A report of the PET/RANO group

alexandrossfakianakis shared this article with you from Inoreader Investigational PET tracers in neuro-oncology—What's on the horizon? A report of the PET/RANO group via Neuro-Oncology Advance Access Abstract Many studies in patients with brain tumors evaluating innovative PET tracers have been published in recent years, and the initial results are promising. Here, the Response Assessment in Neuro-Oncology (RANO) PET working group provides an overview of the literature on novel investigational PET tracers for brain tumor patients. Furthermore, newer indications of more established PET tracers for the evaluation of glucose metabolism, amino acid transport, hypoxia, cell proliferation, and others are also discussed. Based on the preliminary findings, these novel investigational PET tracers should be further evaluated considering their promising potential. In particular, novel PET probes for imaging of translocator protein and somatostatin receptor overexpression as well as for immune system reactions appear to be of additional clinical value for tumor delineation and therapy monitoring. Progress in developing these radiotracers may contribute to improvi ng brain tumor diagnostics and advancing clinical translational research. View on Web

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SARS‐CoV‐2and Mutation RT‐qPCR Test Positivity Correlation with ABO and Rh Blood Types

alexandrossfakianakis shared this article with you from Inoreader SARS‐CoV‐2and Mutation RT‐qPCR Test Positivity Correlation with ABO and Rh Blood Types via Journal of Medical Virology ABSTRACT Introduction Studies show that there may be a relationship between ABO blood type and SARS-CoV-2transmission. It was aimed to determine by investigating the blood type of patients whose one-step reverse transcription and real-time polymerase chain reaction (RT-qPCR) test was positive for Sars-CoV-2. Materials and Methods ABO and Rh blood type of individuals whose RT-qPCR test was positive for SARS-CoV-2were examined and an evaluation was made to identify whether there was a relationship between them or not. Results The blood type data of 44.928 SARS-CoV-2positive RT-qPCR test results has been obtained. 17.656 (39.29%) were delta, 8048 (17.91%) were alpha, 800 (1.78%) were beta and 3000 (6.67%) were omicrons while 15.424 (34.33%) SARS-CoV-2positive mutation was found to be negative. Discussion Our study suggests that O and Rh (-) blood types may provide protection against delta, AB and Rh (+) blood types may hinder omicron infection while A and Rh (+) blood types may be more vulnerable to alpha and delta while B and Rh (+) are more sensitive to beta mutation. Conclusion Molecular mechanism underlying the relationship between blood types and SARS-CoV-2infection needs further molecular studies and multi-centered studies. This article is protected by copyright. All rights reserved. View on Web

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T cell epitopes are largely conserved in the SARS‐CoV‐2 Omicron subvariant (BA.1, BA.2, BA.3 and GKA)

alexandrossfakianakis shared this article with you from Inoreader T cell epitopes are largely conserved in the SARS‐CoV‐2 Omicron subvariant (BA.1, BA.2, BA.3 and GKA) via Journal of Medical Virology Abstract The SARS-CoV-2 variant Omicron (B.1.1.529) was first reported in South Africa by the World Health Organization (WHO) in November 2021 and the Omicron variant is now the predominant globally prevalent variant and account for almost all sequences recently reported to GISAID1. This article is protected by copyright. All rights reserved. View on Web

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