Morphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial Dysplasia Using Verhoeff–Van Gieson StainJanardhanam Dineshshankar, Nalliappan Ganapathy, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Jeyaraman Swathiraman, Thangadurai Maheswaran, and Vadivel IlayarajaTrends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015)Konstantinos Z. Vardakas, Katerina N. Apiranthiti, Spiridoula E. Almpani, Dominiki Heliou, Dimitra...
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Genetic EpidemiologyInvited AbstractGenetic Epidemiology22hBivariate logistic Bayesian LASSO for detecting rare haplotype association with two correlated phenotypesAbstract In genetic association studies, joint modeling of related traits/phenotypes can utilize the correlation between them and thereby provide more power and uncover additional information about genetic etiology. Moreover, detecting rare genetic variants are of current scientific interest as a key to missing heritability. Logistic...
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Emergency Medicine Journal current issuePoint-of-care ultrasound compared with conventional radiographic evaluation in children with suspected distal forearm fractures in the Netherlands: a diagnostic accuracy studyBackgroundDistal forearm fractures are common in children. The reference standard to diagnose these fractures is by conventional radiography, which exposes these patients to harmful radiation. Ultrasound (US) seems to be a good alternative. However, emergency physicians (EPs) in the Netherlands...
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Emergency Medicine Journal current issue02 'Have you had the surgery?: A survey of transgender and non-binary patients experiences of interacting with the ambulance serviceBackgroundPre-hospital research around the experience of transgender and non-binary (TNB) patients is scarce, with existing articles lacking input from TNB patients. This research aimed to collate TNB patients' experiences of interacting with the ambulance service. A secondary aim was to gather TNB patients' opinions regarding...
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British Journal of DermatologyTrends in epidemiology of melanoma in situ in Greece: Data from a melanoma reference center during the period 2000‐2018Abstract The incidence of melanoma in situ (MIS) is increasing more rapidly than this of invasive,1. According to SEER database it represents one of the most fast‐growing malignancies2. Reported data from South Europe mostly include information from Italy and Spain3. We tried to study the epidemiological trends of MIS in Greece.British Journal of Dermatology21hAcquired...
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pubmed: melanomaParaneoplastic opsoclonus-myoclonus syndrome secondary to melanoma metastasis form occult primary cancer.Related ArticlesParaneoplastic opsoclonus-myoclonus syndrome secondary to melanoma metastasis form occult primary cancer. Case Rep Neurol. 2019 Jan-Apr;11(1):66-79 Authors: Mondragón JD, Jiménez-Zarazúa O, Vélez-Ramírez LN, Martínez-Rivera MA, Enríquez-Maciel S, González-Guzmán J, Alvarez-Delgado MM, González-Carrillo PL Abstract Introduction: Opsoclonus-myoclonus syndrome (OMS)...
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Antibiotics, Vol. 8, Pages 165: Stability of Biological Activity of Frozen β-lactams over Time as Assessed by Time-Lapsed Broth MicrodilutionsAntibiotics, Vol. 8, Pages 165: Stability of Biological Activity of Frozen β-lactams over Time as Assessed by Time-Lapsed Broth Microdilutions Antibiotics doi: 10.3390/antibiotics8040165 Authors: Gleice Leite Alexander Lawandi Matthew P. Cheng Todd Lee To evaluate the antimicrobial agent's stability stored at −80 °C, six β-lactams (meropenem, ertapenem, imipenem,...
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pubmed: frontiers in neurosc... Immune Mediated Degeneration and Possible Protection in Glaucoma....
pubmed: frontiers in neurosc...Immune Mediated Degeneration and Possible Protection in Glaucoma.Related ArticlesImmune Mediated Degeneration and Possible Protection in Glaucoma. Front Neurosci. 2019;13:931 Authors: Tsai T, Reinehr S, Maliha AM, Joachim SC Abstract The underlying pathomechanisms for glaucoma, one of the most common causes of blindness worldwide, are still not identified. In addition to increased intraocular pressure (IOP), oxidative stress, excitotoxicity, and immunological processes...
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Future(s) Studies,The Future of APAC, 2030: mapping megatrendsHi, folks. A while ago, my team was pegged by the UNDP Regional Innovation Center to perform a work of futurism - roughly in Naisbitt's vein - for the Asia Pacific, 2030. Population stresses, geopolitics, the works. Instead of just newspapers, though, we've been analyzing projections from economists and futurists, digging through policies from governments in the region, cross-checking with experts on the ground to try and paint a grounded...
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cortical auditoryAuditory Late Latency Response in Individuals with Type 2 Diabetes Mellitus.Related ArticlesAuditory Late Latency Response in Individuals with Type 2 Diabetes Mellitus. J Int Adv Otol. 2018 Dec;14(3):408-411 Authors: Kumar K, Bhat J, Varghese A Abstract OBJECTIVES: The study was done to compare Auditory late latency response (ALLR) in normal-hearing individuals without diabetes mellitus and normal-hearing individuals with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: A...
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AllergyModification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activationAbstract Background Abacavir is associated with hypersensitivity reactions in individuals positive for the HLA‐B*57:01 allele. The drug binds within the peptide‐binding groove of HLA‐B*57:01 altering peptides displayed on the cell surface. Presentation of these HLA‐abacavir‐peptide complexes to T‐cells is hypothesised to trigger a CD8+...
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Remove ads American Society for Stereotactic and Functional NeurosurgeryBook ReviewStereotact Funct NeurosurgAmerican Society for Stereotactic and Functional Neurosurgery19hMark above section as read BMJ Case Reports Last 6 IssuesAcute mesenteric ischaemia secondary to portal, splenic and superior mesenteric vein thrombosisMesenteric ischaemia represents an uncommon complication of splanchnic vein thrombosis which requires a high level of suspicion to diagnose in a timely manner. This report discusses...
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cochlear implantsElectrode Designs for Protection of the Delicate Cochlear Structures.Related ArticlesElectrode Designs for Protection of the Delicate Cochlear Structures. J Int Adv Otol. 2018 Dec;14(3):401-403 Authors: Downing M Abstract The most recent electrode introductions from Advanced Bionics, the HiFocus™ Mid-Scala and the HiFocus SlimJ arrays, have common design goals intended to provide sufficient access to the necessary frequency range while avoiding intracochlear trauma. The electrode...
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RSC - Photochem. Photobiol. Sci. latest articlesEnergy Transfer Mediated White Light Emission from Nile Red Doped 9,10-diphenylanthracene Nanoaggregate upon Excitation with Near UV-LightPhotochem. Photobiol. Sci., 2019, Accepted ManuscriptDOI: 10.1039/C9PP00272C, PaperBiswajit Manna, Amitabha Nandi, Rajib GhoshLow cost, ease of preparation, colour tunability and wide application range garnered huge research interest on organic light emitting diode materials (OLED). Development of white light emitting...
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European Journal of NeuroscienceAblation of striatal somatostatin interneurons affects MSNs morphology, electrophysiological properties and increases cocaine‐induced hyperlocomotion in miceAbstract The striatum is mainly composed by medium spiny neurons (95 %) (MSNs). Although outnumbered, in other brain regions such as the hippocampus and the cortex, somatostatin interneurons (SSTi) are known to control and fine‐tune the activity of principal cells. This information is still fragmented for the...
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Free Radical Biology and MedicineInhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinasePublication date: Available online 24 September 2019Source: Free Radical Biology and MedicineAuthor(s): Keum Jin Yang, Jeong Ho Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah HongAbstractReactive oxygen species (ROS) play a pivotal role in the development of contrast-induced nephropathy (CIN). The...
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Pediatric Surgery InternationalConcurrent Hirschsprung's disease and anorectal malformation: a systematic reviewAbstract Background/purpose Hirschsprung's disease (HSCR) and anorectal malformation (ARM) are often associated with other congenital malformations, but the association of each other is rare. Some studies have reported the incidence of HSCR associated with ARM ranging from 2.0 to 3.4%. The purpose of this study was to update the current epidemiological and therapeutic features of this rare...
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CardiologyTCT-790 Forearm Radial Artery Occlusion Following Distal Radial Artery ApproachPublication date: 1 October 2019Source: Journal of the American College of Cardiology, Volume 74, Issue 13, SupplementAuthor(s): Kazuki Tobita, Shigeru Saito, Koki ShishidoJournal of the American College of Cardiology16hTCT-789 Comparison of Radial With Femoral Access Coronary Angiography in Patients With Previous Coronary Artery Bypass SurgeryPublication date: 1 October 2019Source: Journal of the American College...
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TCT-830 Efficacy of PCSK-9 Inhibitors on Coronary Lipid Rich Plaque Assessed by Serial Near-Infrared SpectroscopyPublication date: 1 October 2019Source: Journal of the American College of Cardiology, Volume 74, Issue 13, SupplementAuthor(s): Hiroyuki Omori, Hideaki Ota, Masahiko Hara, Yoshiaki Kawase, Toru Tanigaki, Tetsuo Hirata, Yoshihiro Sobue, Munenori Okubo, Hitoshi MatsuoScienceDirect Publication: Journ...16hTCT-829 Intensity of Lipid Lowering Therapy Among Patients With Prior or New Revascularization:...
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Critical Care Medicine - Published Ahead-of-PrintValidation of Early Warning Scores at Two Long-Term Acute Care HospitalsObjectives: Early warning scores were developed to identify high-risk patients on the hospital wards. Research on early warning scores has focused on patients in short-term acute care hospitals, but there are other settings, such as long-term acute care hospitals, where these tools could be useful. However, the accuracy of early warning scores in long-term acute care hospitals...
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Pediatric Gastroenterology and Nutrition - Published Ahead-of-PrintNovel Use of Impedance Technology Shows that Esophageal Air Events Can Be Temporally Associated with GERD-Like SymptomsA few studies have shown that esophageal air events (EAEs) such as air-swallows may be associated with symptoms that have historically been associated with gastroesophageal reflux disease (GERD). To objectively test a hypothesis that all EAE types (air swallows, supra-gastric belches and gastric belches) can be associated...
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Cancer Biotherapy & Radiopharmaceuticals - Table of ContentsUpregulation of SCNN1A Promotes Cell Proliferation, Migration, and Predicts Poor Prognosis in Ovarian Cancer Through Regulating Epithelial–Mesenchymal TransformationCancer Biotherapy and Radiopharmaceuticals, Ahead of Print.Cancer Biotherapy & Radiopharmaceuticals - Table of Contents15hMark above section as read AntibioticsAntibiotics, Vol. 8, Pages 164: Gut Bacteria of Water Monitor Lizard (Varanus salvator) Are a Potential Source...
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Clinical Microbiology and Antimicrobials - Latest ArticlesDetection and molecular characterization of urinary tract HIV-1 populationsIdentification of all possible HIV reservoirs is an important aspect in HIV eradication efforts. The urinary tract has however not been well studied as a potential HIV reservoir. In this pilot study we molecul...Annals of Clinical Microbiology and Antimicrobials - Latest Articles14hHealth care providers' perceptions regarding antimicrobial stewardship programs (AMS)...
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Clinical Microbiology and AntimicrobialsDetection and molecular characterization of urinary tract HIV-1 populationsAbstract Background Identification of all possible HIV reservoirs is an important aspect in HIV eradication efforts. The urinary tract has however not been well studied as a potential HIV reservoir. In this pilot study we molecularly characterized HIV-1 viruses in urine and plasma samples to investigate HIV-1 replication, compartmentalization and persistence in the urinary tract. ...Latest...
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Proceedings of the National Academy of Sciences current issueDigital-resolution detection of microRNA with single-base selectivity by photonic resonator absorption microscopy [Medical Sciences]Circulating exosomal microRNA (miR) represents a new class of blood-based biomarkers for cancer liquid biopsy. The detection of miR at a very low concentration and with single-base discrimination without the need for sophisticated equipment, large volumes, or elaborate sample processing is a challenge. To...
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Proceedings of the National Academy of Sciences current issueRevealing the metabolic capacity of Streblomastix strix and its bacterial symbionts using single-cell metagenomics [Microbiology]Lower termites harbor in their hindgut complex microbial communities that are involved in the digestion of cellulose. Among these are protists, which are usually associated with specific bacterial symbionts found on their surface or inside their cells. While these form the foundations of a classic system in symbiosis...
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Proceedings of the National Academy of Sciences BiochemistryChemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon [Biochemistry]Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have functional photochemistry....
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NeuroReport - Current IssueDrosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damageAlkB family proteins are enzymes that repair alkylated DNA and RNA by oxidative demethylation. Nine homologs have been identified and characterized in mammals. ALKBH1 is conserved among metazoans including Drosophila. Although the ALKBH1 mouse homolog, Alkbh1 functions in neurogenesis, it currently remains unclear whether ALKBH1 plays a role...
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Common brain disorders are associated with heritable patterns of apparent aging of the brainNature Neuroscience, Published online: 24 September 2019; doi:10.1038/s41593-019-0471-7Using structural MRI data from 45,615 individuals aged 3–96 years, Kaufmann and colleagues reveal that common brain disorders are associated with heritable patterns of apparent aging of the brain.Nature Neuroscience - Issue - nature.com science feeds11hNeuromodulation in circuits of aversive emotional learningNature Neuroscience,...
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Hindawi Publishing CorporationEvaluation of CMIP5 Global Climate Models for Simulating Climatological Temperature and Precipitation for Southeast AsiaThis study evaluates the performances of all forty different global climate models (GCMs) that participate in the Coupled Model Intercomparison Project Phase 5 (CMIP5) for simulating climatological temperature and precipitation for Southeast Asia. Historical simulations of climatological temperature and precipitation of the 40 GCMs for the 40-year...
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Reporting guidelines for clinical trials evaluating artificial intelligence interventions are neededNature Medicine, Published online: 24 September 2019; doi:10.1038/s41591-019-0603-3As artificial intelligence moves into the realm of clinical trials, consideration is needed on whether the current CONSORT and SPIRIT reporting statements are sufficient to ensure transparency.Nature Medicine - Issue - nature.com science feeds10hReporting guidelines for clinical trials evaluating artificial intelligence...
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PLOS ONE Alerts: New ArticlesHow do seabirds modify their search behaviour when encountering fishing boats?by Alexandre Corbeau, Julien Collet, Melissa Fontenille, Henri Weimerskirch Seabirds are well known to be attracted by fishing boats to forage on offal and baits. We used recently developed loggers that record accurate GPS position and detect the presence of boats through their radar emissions to examine how albatrosses use Area Restricted Search (ARS) and if so, have specific ARS behaviours,...
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Clinical NeuroscienceDiffuse leptomeningeal enhancement in a patient with rapidly progressive dementia: AnswerIntraoperative inspection revealed abnormal arachnoid with a pale tan complexion. Histopathologic analysis demonstrated leptomeningeal infiltration by nodular masses of epithelioid cells with melanin pigmentation. These showed strong nuclear reactivity for Sry-related HMg-Box gene 10 (SOX10). Sequencing did not reveal any clinically relevant hotspot mutations in BRAF, NRAS or KIT genes. These...
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Plastic, Reconstructive & Aesthetic SurgeryQuantifying normal head form and craniofacial asymmetry of elementary school students in TaiwanDefining three-dimensional (3D) normal craniofacial morphology in healthy children could provide craniofacial surgeons a reference point to assess disease, plan surgical reconstruction and evaluate treatment outcome. The purposes of this study were to report normal craniofacial form and quantify craniofacial asymmetry of healthy children in Taiwan by implementing...
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Multidisciplinary selection of pulmonary nodules for surgical resection: diagnostic results and long-term outcomesPulmonary nodules found incidentally or by lung cancer screening differ in prevalence, risk profile and diagnostic intervention. The results of surgical intervention for incidental versus screening lung nodules during multidisciplinary Pulmonary Nodule and Lung Cancer Screening Clinic (PNLCSC) follow-up have not been reported.The Journal of Thoracic and Cardiovascular Surgery7hDel Nido...
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Cutaneous and Aesthetic Surgery : 2010 - 3(2)Who should carry out skin cancer excisions? A systematic reviewEnas Shuber, Dalia Abdulhussein, Pierre Sinclair, Murtaza KadhumJournal of Cutaneous and Aesthetic Surgery 2019 12(3):153-157Background: The incidence of melanoma and nonmelanoma skin cancers is increasing in the United Kingdom. Surgical excision carries the highest cure rates for all skin cancers and is the first-line treatment for melanomas and high-risk nonmelanoma cancers. This is most...
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BioMed Research InternationalOccupational Health and Safety and Turnover Intention in the Ghanaian Power Industry: The Mediating Effect of Organizational CommitmentThis study aimed at investigating the effect of occupational health and safety (OHS) on employee's turnover intention (TI) with the mediating effect of organizational commitment (OC) in the Ghanaian power industry. Methods. With stratified sampling technique, 350 participants were selected to participate in the study with standardized...
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CancerSystemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapyCancer7hCorrection: Desperately seeking…Models to find the right partner and the best use for checkpoint inhibitorsBritish Journal of Cancer, Published online: 24 September 2019; doi:10.1038/s41416-019-0591-6Correction: Desperately seeking…Models to find the right partner and the best use for checkpoint inhibitorsCancer17hCorrection: Long-term outcomes of the GPOH NB97 trial for children with high-risk...
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Stroke and Cerebrovascular DiseasesCerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST StudySystemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter...
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NeurologyEuropean muscle MRI study in limb girdle muscular dystrophy type R1/2A (LGMDR1/LGMD2A)Abstract Background Limb girdle muscular dystrophy type R1/2A (LGMDR1/LGMD2A) is a progressive myopathy caused by deficiency of calpain 3, a calcium-dependent cysteine protease of skeletal muscle, and it represents the most frequent type of LGMD worldwide. In the last few years, muscle magnetic resonance imaging (MRI) has been proposed as a tool for identifying patterns of muscular involvement in genetic...
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Drugs.com - FDA MedWatch AlertsSandoz Inc. Issues Voluntary Recall of Ranitidine Hydrochloride Capsules 150mg and 300mg Due to an Elevated Amount of Unexpected Impurity, N-Nitrosodimethylamine (NDMA) in the ProductAudience: Consumer, Health Professional, Pharmacy September 23, 2019 -- Sandoz Inc. is voluntarily recalling all quantities and lots within expiry of Ranitidine Hydrochloride Capsules in the US to the consumer level because of confirmed...Drugs.com - FDA MedWatch Alerts1hSandoz Inc. Issues...
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Annals of the New York Academy of SciencesMusical anhedonia and rewards of music listening: current advances and a proposed modelHere, we review the recent cognitive neuroscience evidence for musical engagement of the reward system, as well as an extreme end of the spectrum of individual differences in sensitivity to music reward in specific musical anhedonia. Based on our review of the literature, we propose a model that accounts for the nature of the auditory access to the human reward system,...
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OncologyMYC-Rearrangement Affects Prognosis 2 Years Post-DLBCL DiagnosisMYC-rearrangement within 2 years after diagnosis may affect the prognosis of patients with diffuse large B-cell lymphoma. (Source: CancerNetwork)MedWorm: Cancer & Oncology4hTibolone & #039;s Role in GlioblastomaInvestigators assessed effects of TIB on cell number, migration, invasion, estrogen, and progesterone receptor activity and content. (Source: CancerNetwork)MedWorm: Cancer & Oncology4hFDA Approves CRC Screening...
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Consciousness StudiesEditorial Introduction: Debates on the Meta-Problem of ConsciousnessLatest Issue of Journal of Consciousness Studies7mBayesing Qualia: Consciousness as Inference, Not Raw DatumLatest Issue of Journal of Consciousness Studies7mUndermining Belief in ConsciousnessLatest Issue of Journal of Consciousness Studies7mWelcome to Strong IllusionismLatest Issue of Journal of Consciousness Studies7mMeta-Hard or Hardly Meta?: Some Possible Confusions Leading to the Hard Problem of ConsciousnessLatest...
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