Beverages Beverages, Vol. 5, Pages 51: Brewing and Craft BeerBeverages, Vol. 5, Pages 51: Brewing and Craft Beer Beverages doi: 10.3390/beverages5030051 Authors: Luis F. Guido Beer is a beverage with more than 8000 years of history, and the process of brewing has not changed much over the centuries [...]Beverages03:00Mark above section as read BiomoleculesBiomolecules, Vol. 9, Pages 374: Proteomic Insights into Phycobilisome Degradation, A Selective and Tightly Controlled Process in The Fast-Growing...
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OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemiaPublication date: Available online 13 August 2019Source: Journal of Genetics and GenomicsAuthor(s): Jun Yao, Huasha Zeng, Min Zhang, Qinjun Wei, Ying Wang, Haiyuan Yang, Yajie Lu, Rongfeng Li, Qiang Xiong, Lining Zhang, Zhibin Chen, Guangqian Xing, Xin Cao, Yifan DaiAbstractOxysterol binding protein like 2 (OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a...
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MicrosurgeryEarly ViewOnline Version of Record before inclusion in an issueCLINICAL ARTICLESSPECT/CT and fusion ultrasound to target the efferent groin lymph node for lymphatic surgeryStefano Gentileschi MD, PhD, Roberta Albanese MD, Valentina Pino MD, Gianluigi Stefanizzi MD, Simona Fragomeni MD, Luca Zagaria MD, Francesco P. Ieria MD, Marzia Salgarello MD, Giovanni Scambia MD, Giorgia Garganese MDVersion of Record online: 10 August 2019CLINICAL ARTICLESLower medial thigh perforator (LMTP) propeller...
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Clinical Otolaryngology Volume 44, Issue 5Pages: i-iii, 715-885 September 2019 ISSUE INFORMATION ...
Clinical OtolaryngologyVolume 44, Issue 5Pages: i-iii, 715-885September 2019ISSUE INFORMATIONIssue InformationPages: i-iii | First Published: 13 August 2019ORIGINAL ARTICLESValidation of the olfactory disorders questionnaire for English‐speaking patients with olfactory disordersLorna Langstaff, Nisha Pradhan, Allan Clark, Duncan Boak, Mahmoud Salam, Thomas Hummel, Carl M. PhilpottPages: 715-728 | First Published: 30 April 2019Clinical utility and effectiveness of a training programme in the application...
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Head & NeckVolume 41, Issue 9Pages: C1-C2, 2843-3482, E146-C4September 2019COVER IMAGEFront CoverPages: C1 | First Published: 13 August 2019 The cover image is based on the Original Article Parotidectomy by an endoscopic‐assisted postauricular‐groove approach, by Tiancheng Li et al., https://doi.org/10.1002/hed.25720.Inside Front CoverPages: C2 | First Published: 13 August 2019 The cover image is based on the Original Article Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma...
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Identification of plasmid encoded osmoregulatory genes from halophilic bacteria isolated from the rhizosphere of halophytesPublication date: November 2019Source: Microbiological Research, Volume 228Author(s): Salma Mukhtar, Samia Ahmad, Aftab Bashir, Samina Mehnaz, Muhammad Sajjad Mirza, Kauser Abdulla MalikAbstractBacterial plasmids carry genes that code for additional traits such as osmoregulation, CO2 fixation, antibiotic and heavy metal resistance, root nodulation and nitrogen fixation. The main...
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ORIGINAL ARTICLES,Fusarium onychomycoses in Switzerland—A mycological and histopathological studyAnna Rammlmair, Konrad Mühlethaler, Eckart HanekeVersion of Record online: 08 August 2019ORIGINAL ARTICLESScopulariopsis/Microascus isolation in lung transplant recipients: A report of three cases and a review of the literatureLinna Huang, Wenhui Chen, Lijuan Guo, Li Zhao, Bin Cao, Yingmei Liu, Binghuai Lu, Binbin Li, Jingyu Chen, Chen WangVersion of Record online: 07 August 2019ORIGINAL ARTICLESCut it...
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Orphan drugs The role of small molecule development and links made with common disease as a means...
Orphan drugsThe role of small molecule development and links made with common disease as a means to maintain the sustainability of drug budgetsStemming from the fact that despite an acceleration of the development of novel therapies for rare diseases, high price threatens their sustainability, a paper analyses possibilities to solve this issue. The authors base their analysis on the case of lysosomal storage disorders. They emphasise the opportunities of making connections between common and rare...
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Are you doing enough to protect personnel exchanging oxygen cylinders?Is your department short-staffed due to back strains, slipped discs, and other avoidable injuries? Increase department safety by installing a QUIC-LIFT Oxygen Tank System from Zico—they raise, and lower oxygen cylinders so your personnel don't have to. Available for new builds and in-service apparatus.Learn More CompX introduces NARC Box with NARC iDThe NARC iD Inventory Control System uses RFID tags and provides complete chain...
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MGUS to Myeloma: Study Suggests Risk of Progression Can Change08/13/2019A person's risk of progressing from a benign condition called monoclonal gammopathy of undetermined significance (MGUS) to the blood cancer multiple myeloma can change over time, according to a new study.National Cancer Institute theNCI14 AugRT @NCIDataSci: August 22 is the last day to submit a proposal to build the @theNCI #CancerData Aggregator that will allow users to query a…Details | RetweetNational Cancer Institute theNCI14...
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Myriad Genetics Stock Plummets on Lower-Than-Expected Q4 Revenues, FDA Interactions on GeneSightPublished on Aug 13, 2019 Syapse to Provide Real-World Evidence to FDA Oncology Center of ExcellencePublished on Aug 14, 2019 Adaptive Biotechnologies' Q2 Revenues Rise 91 PercentPublished on Aug 13, 2019 Personalis Q2 Revenues Up 80 PercentPublished on Aug 13, 2019 Quanterix Closes $69M Stock OfferingPublished on Aug 13, 2019 Expedeon Posts 18 Percent Q2 Revenue IncreasePublished on Aug 14, 2019Featured...
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American Journal of Neuroradiology August 2019; Vol. 40, No. 8PerspectivesBejoy ThomasAJNR Am J Neuroradiol 2019; 40:1251 doi:10.3174/ajnr.P0057http://www.ajnr.org/content/40/8/1251Practice PerspectivesRisk Factors for Perceptual-versus-Interpretative Errors in Diagnostic NeuroradiologyS.H. Patel, C.L. Stanton, S.G. Miller, J.T. Patrie, J.N. Itri and T.M. ShepherdAJNR Am J Neuroradiol 2019; 40:1252-1256 doi:10.3174/ajnr.A6125http://www.ajnr.org/content/40/8/1252.abstractGeneral ContentsIntrathecal...
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Human Gene Therapy,Expert Panel Discussion on Home-Cage Monitoring and its Effects on Research Capability and OutcomesIn this engaging new roundtable discussion, experts discuss the current state of high-throughput home-cage monitoring, inherently enabled by digital ventilated cage technology and its effects on research capabilities now and in the future.READ NOWModerator:Kevin Davies, PhD, Executive Editor of The CRISPR JournalPanelists:Dr. Amanda J. Kiliaan, Radboud University Nijmegen Medical...
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The Journal of Neuroscience Online Table of Contents Alert14 August 2019; Vol. 39, No. 33This Week in The JournalThis Week in The JournalThe Journal of Neuroscience, 14 August 2019, 39(33):6395; doi:10.1523/JNEUROSCI.twij.39.33.2019http://www.jneurosci.org/content/39/33/6395Journal ClubStroke Primes New Hippocampal Neurons for HyperexcitabilityMichael R. WilliamsonThe Journal of Neuroscience, 14 August 2019, 39(33):6396-6398; doi:10.1523/JNEUROSCI.0644-19.2019http://www.jneurosci.org/content/39/33/6396Research...
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More and More Genes Linked to Autism RiskPublished on Aug 14, 2019Researchers in California link additional genes to autism risk, HealthDay News reports. Read more >Adding in DiversityPublished on Aug 14, 2019Through the NeuroGAP-Psychosis program, researchers hope to include more individuals of African ancestry in genetic research, as they write at WBUR. Read more >Prostate Cancer PredispositionPublished on Aug 14, 2019Australian researchers are studying the prevalence of genetic alterations...
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Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor‐intact or heterozygous skinRobert‐Marlo Felicilda Bautista, Katharine Marie Carter, Stuart Gordon Jarrett, Dana Napier, Kazumasa Wakamatsu, Shosuke Ito, John August D'OrazioFirst Published: 09 August 2019Manuscript Category: Signaling & Cell biology (SCB)Original ArticlesA ROCK inhibitor promotes keratinocyte survival and paracrine secretion, enhancing...
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Diffuse, mottled hyperpigmentation and mutations in LMNA gene in a 5‐year‐old boy, his mother, and his grandmother: Atypical progeroid syndromeBrittney Schultz MD, Daniel D. Miller MD, Sheilagh Maguiness MDVersion of Record online: 04 August 2019
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Home range of the Columbian mammoths (Mammuthus columbi) and grazing herbivores from the Waco Mammoth National Monument, (Texas, USA) based on strontium isotope ratios from tooth enamel bioapatitePublication date: 15 November 2019Source: Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 534Author(s): D. Esker, S.L. Forman, C. Widga, J.D. Walker, J.E. AndrewAbstractWaco Mammoth National Monument (WMNM) is a central Texas, Late Pleistocene fossil site dating to ~67 ka. At least 23 Columbian...
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Fast and Efficient Method to Obtain Tagitinin F by Photocyclization of Tagitinin C ,Victor Hugo Catricala Fernandes, Natalie de Barros Viera, Luiza Beatriz Lima Zanini, Aline de Fátima Silva, Paula Pio de Oliveira Salem, Marisi Gomes Soares, Karen de Jesus Nicácio, Ana Claudia Chagas de Paula, Luciano Sindra Virtuoso, Tiago Branquinho Oliveira, Eliane de Oliveira Silva, Danielle Ferreira Dias, Daniela Aparecida Chagas‐PaulaFirst Published: 10 August 2019
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MiLaboratories, MIODx Collaborate on Immune Cell Receptor Repertoire ProfilingPublished on Aug 14, 2019 Microbial Genes Characterized in Human Gut, Oral MicrobiomesPublished on Aug 14, 2019 Adaptive Biotechnologies Plans New Product Launches, Expanded FDA Label for ClonoSeqPublished on Aug 14, 2019 Complex Genetic Testing Errors Emerge Amid Increasing Panel Use, Consumer Access, Case Series FindsPublished on Aug 13, 2019 'Click Chip' CTC Purification Method Enables Identification of Cancer-Linked...
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Feel the heat: Managing exertional heat strokeBy Mark Liao, NAEMSPNAEMSP and NATA recommend a cool first, transport second approach to exertional heat stroke treatment with cold water immersion therapyTraining Day: Train citizens to use an AEDBy Tim NowakCitizens are the force multipliers of public safety, and have the potential to save lives before EMS arrivesOTHER HIGHLIGHTS10 reasons we are on the cusp of Peak EMSBy Greg Friese, Editor-in-ChiefA bold prediction that EMS patient transport to the...
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Employing a User-Centered Design to Engage Mothers in the Development of a mHealth Breastfeeding ApplicationBreastfeeding has numerous health benefits; however, many mothers do not continue breastfeeding to the recommended 6 months of age. Breastfeeding support after discharge from the hospital is often lacking in the communities with the greatest need. Therefore, the Mother's Milk Connection mHealth application was designed to improve breastfeeding duration and access to support. This article describes...
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Enteral Nutrition Can Be Given to Patients on VasopressorsNo abstract availableNurse Practitioners and Physician Assistants in Acute and Critical Care: A Concise Review of the Literature and Data 2008–2018Objectives: To provide a concise review of the literature and data pertaining to the use of nurse practitioners and physician assistants, collectively called advanced practice providers, in ICU and acute care settings. Data Sources: Detailed search strategy using the databases PubMed, Ovid MEDLINE,...
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24-Hour Movement Behaviors and Impulsivity Michelle D. Guerrero, Joel D. Barnes, Jeremy J. Walsh,...
24-Hour Movement Behaviors and Impulsivity Michelle D. Guerrero, Joel D. Barnes, Jeremy J. Walsh, Jean-Philippe Chaput, Mark S. Tremblay and Gary S. GoldfieldCase ReportScurvy Due to Selective Diet in a Seemingly Healthy 4-Year-Old BoyAndrew Nastro, Natalie Rosenwasser, Steven P. Daniels, Jessie Magnani, Yoshimi Endo, Elisa Hampton, Nancy Pan and Arzu Kovanlikaya
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American Journal of Neuroradiology Publication Preview articles for 14 August 2019ADULT BRAINDefining Ischemic Core in Acute Ischemic Stroke Using CT Perfusion: A Multiparametric Bayesian-Based ModelK. Nael, E. Tadayon, D. Wheelwright, A. Metry, J.T. Fifi, S. Tuhrim, R.A. De Leacy, A.H. Doshi, H.L. Chang and J. MoccoAJNR Am J Neuroradiol first published on 14 August 2019 doi:10.3174/ajnr.A6170 OPEN ACCESS ARTICLEhttp://www.ajnr.org/content/early/2019/08/14/ajnr.A6170.abstractMolecular Subtype Classification...
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Teaching Topic A Pregnant Woman with Abdominal Pain CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITALCase 25-2019: A 41-Year-Old Pregnant Woman with Abdominal PainN.N. Saillant and Others The differential diagnosis and evaluation of abdominal pain during pregnancy can be complicated because maternal adaptations lead to an insidious presentation of intraabdominal disorders.Clinical Pearls In what ways can pregnancy complicate the evaluation of abdominal pain?In pregnant patients, the typical findings...
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Teaching Topic Warm Autoimmune Hemolytic Anemia CLINICAL PRACTICEWarm Autoimmune Hemolytic AnemiaR.A. Brodsky Warm autoimmune hemolytic anemia (WAHA) is often considered benign; however, mortality from vascular events (pulmonary emboli, myocardial infarction, and stroke) or from infection or sepsis may approach 5%.Clinical Pearls What are some of the risk factors for WAHA?Approximately 50% of cases of WAHA are primary and idiopathic; the rest are secondary to other disorders. Acquired lymphoproliferative...
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Case Studies in Social Medicine: Reproductive (In)justice — Two Patients with Avoidable Poor Reproductive OutcomesK.R. Knight and OthersN Engl J Med 2019;381:593-596Time to Reevaluate U.S. Mifepristone RestrictionsJ.E. Henney and H.D. GayleN Engl J Med 2019;381:597-598 | Published Online June 26, 2019A Most Reckless Proposal — A Plan to Continue Asbestos Use in the United StatesP.J. Landrigan and R.A. LemenN Engl J Med 2019;381:598-600 | Published Online July 10, 2019Mike's LabelsO. WarrenN Engl...
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With Neuroimaging, Large NIH Study Could Shine a Light on the Adolescent BrainJennifer AbbasiAudio: With Neuroimaging, Large NIH Study Could Shine a Light on the Adolescent BrainHealth Agencies Update: NIH Releases Data from Large Adolescent Brain Study; Rita Rubin, MAJAMA Pediatrics Viewpoint: Ensuring the Best Use of Data: The Adolescent Brain Cognitive Development Study ; Wilson M. Compton, MD, MPE; Gayathri J. Dowling, PhD; Hugh Garavan, PhDQuick UptakesVacationing More Often May Reduce Metabolic...
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"The Scalpel is Passed," a Conversation With Dr Vincent J.M. DiMaioEditor's Note This is the first article in a new series of interviews with mentors in forensic pathology. These interviews will also be recorded, and the audio files will be available online through the journal's Web site, http://links.lww.com/FMP/A31.Understanding Gunshot Residue Evidence and Its Role in Forensic ScienceGunshot residue, or GSR, can be a valuable tool in forensic science, but its importance depends greatly on how...
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Physiological Evaluation for Endurance Exercise Prescription in Sickle Cell DiseasePurpose Although strenuous exercise may expose sickle cell disease (SCD) patients to risks of vaso-occlusive crisis, evidence suggests that regular endurance exercise may be beneficial. This study aimed to test (i) the safety and usefulness of a submaximal incremental exercise in evaluating physical ability of SCD patients and identify a marker for the management of endurance exercise and (ii) the feasibility of endurance...
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"Guanhai Resort of HaiYan, JiaXing, Zhejiang Province, China"No abstract availableThe Role of Type I Diabetes in Intervertebral Disc DegenerationStudy Design. An experimental laboratory study. Objective. To investigate the pathogenesis of intervertebral disc degeneration (IDD) in a murine model of type 1 diabetes mellitus (DM), namely nonobese diabetic (NOD) mouse. Summary of Background Data. IDD is a leading contributor of low back pain, which represents one of the most disabling symptoms within...
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Self-Reported Extragenital Chlamydia and Gonorrhea Testing in the Past 12 Months Among Men Who Have Sex with Men in the United States—American Men's Internet Survey, 2017Background Current guidelines recommend that sexually active men who have sex with men (MSM) be screened at least annually for bacterial sexually transmitted infections (STIs) at sites of sexual contact regardless of condom use. Extragenital (rectal and pharyngeal) STI are common in MSM and associated with an increased risk of human...
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Solutions for management of angiotensin-converting enzyme–induced angioedema in a high risk population: a single center retrospective observational studyBackground: There is an increasing rate of angiotensin-converting enzyme (ACE) inhibitor-induced angioedema in the United States which has not plateaued since this side effect was first described in 1980. There are no studies reporting a plateau, decrease in the incidence or decrease in the rate of rise in high risk populations. High risk populations...
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Mobile health at critical moments: how bold is global health?No abstract availableBreast massage: can it keep mothers breastfeeding longer?No abstract availableExperiences of adults participating in infertility support groups: a qualitative systematic review protocolObjective: The objective of this review is to identify and synthesize the best available evidence on the experiences of adults participating in infertility support groups to understand the value of support groups for this population....
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Augmentative Antirotational Plating May Be Superior to Exchanging Reamed Nailing in Femoral Shaft Aseptic Atrophic NonunionNo abstract availableEffects of Infliximab Withdrawal and Reintroduction in Ankylosing Spondylitis Patients in Persistent Clinical RemissionNo abstract availableReview Examines Spinal Manipulation for Chronic Low Back PainNo abstract availableResearchers Search for Better Tendinosis TreatmentNo abstract availableObtaining Vitamin D Levels in Children With Fractures Improves Compliance...
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Functional anatomy of the nerve and optimal placement of the needle for successful (and) safe nerve blocksPurpose of review Summarize the current thinking concerning the clinically relevant aspects of nerve anatomy and best injection sites for nerve blocks. Recent findings The widespread use of ultrasound in regional anesthesia has changed the practice of regional anesthesia and created new possibilities. Among them is the ability to identify fascial planes, and this has become the basis for a new...
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Web-based decision aid tool for disclosure of a mental health condition in the workplace: a randomised controlled trialMaking decisions about disclosing a mental illness in the workplace is complicated. Decision aid tools are designed to help an individual make a specific choice. We developed a web-based decision aid to help inform decisions about disclosure for employees. This study aimed to examine the efficacy of this tool. [...]By Elizabeth Stratton, Isabella Choi, Rafael calvo et al.CommentaryVerbal...
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Symptoms in individuals with adult-onset ADHD are masked during childhoodThe limitations associated with measuring cannabis dependence, a response to Budney and colleaguesCorticosteroid-induced psychiatric disorders: genetic studies are neededAttention as neurocognitive endophenotype of ADHD across the life span: a family studyAbstractEndophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes...
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Effect of bifunctional acid on the porosity improvement of biomass-derived activated carbon for methylene blue adsorptionAbstractActivated carbon (AC) with high specific surface area was prepared by using bifunctional H3PO4 agent, which led to dehydrating and activation effects through hydrothermal pretreatment and subsequent pyrolysis process. N2 adsorption and desorption isotherms of AC showed a high BET surface area of 2434 m2 g−1 and a total volume of pores (VT) of 2.0447 m3 g−1 for AC. The morphology...
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Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy VolunteersAbstractIntroductionTafenoquine has been recently registered for the prevention of relapse in Plasmodium vivax malaria.ObjectiveThis study assessed the pharmacodynamic effects of 300-mg single-dose tafenoquine on the retina.MethodsThis phase I, prospective, multicenter, randomized, single-masked, placebo-controlled, parallel-group study was conducted between 2 February 2016 and 14...
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How Do Patients with Mental Health Diagnoses Use Online Patient Portals? An Observational Analysis from the Veterans Health AdministrationAbstractOnline patient portals may be effective for engaging patients with mental health conditions in their own health care. This retrospective database analysis reports patient portal use among Veterans with mental health diagnoses. Unadjusted and adjusted odds of portal feature use was calculated using logistic regressions. Having experienced military sexual...
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Neurotoxicology: an update on epidemiology, mechanisms, and pathologyEndogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy modelsAbstractMultiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial...
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Incidence and Risks for Non Alcoholic Fatty Liver Disease and Steatohepatitis Post Liver Transplant: Systematic Review and Meta-analysisBackground: The true incidence and unique risk factors for recurrent and de novo nonalcoholic fatty liver (NAFLD) and nonalcoholic steatohepatitis (NASH) post liver transplant (LT) remain poorly characterized. We aimed to identify the incidence and risk factors for recurrent and de novo NAFLD/NASH post-LT. Methods: MEDLINE via PubMed, Embase, Scopus and CINAHL were...
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Natural Breast Symmetry in Preoperative Breast Cancer PatientsBackground: Plastic surgeons aim to achieve breast symmetry during cosmetic and reconstructive breast surgery. They rely on measures of breast size, position, and projection to determine and achieve breast symmetry, but normative data on symmetry in preoperative breast reconstruction patients are scarce. Methods: A statistical evaluation was performed to examine the relationship of breast symmetry to demographic and clinical factors such...
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Time and Change: The Importance of Innovation and Leadership to the Future of SurgeryNo abstract availableSurvival Outcomes Associated With Clinical and Pathological Response Following Neoadjuvant FOLFIRINOX or Gemcitabine/Nab-Paclitaxel Chemotherapy in Resected Pancreatic CancerObjective: To compare the survival outcomes associated with clinical and pathological response in pancreatic ductal adenocarcinoma (PDAC) patients receiving neoadjuvant chemotherapy (NAC) with FOLFIRINOX (FLX) or gemcitabine/nab-paclitaxel...
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Serum Anti-PGL-1 IgG, IgM, and IgA in a 3-Year Follow-up Study of 4–15-Year-old Leprosy ContactsBackground: In 2015, the detection rate of leprosy in Santana do Ipanema municipality, Alagoas state, Brazil, was 39.3 cases per 100,000 inhabitants, and among young people below 15 years of age, it was 32.8 cases per 100,000 inhabitants. Material and methods: A prospective study was carried out from 2015 to 2017, in Santana do Ipanema city, with 69 leprosy contacts in the age group of 4–15 years. Measurement...
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Common Polymorphisms in Genes Related to Vitamin D Metabolism Affect the Response of Cognitive Abilities to Vitamin D SupplementationAbstractIt is possible that vitamin D acts as a neurosteroid and that vitamin D deficiency may have an adverse impact on brain function and cognitive function. There are a few reports that have demonstrated an association between polymorphisms of genes involved in vitamin D metabolism and neurodegenerative disease. We aimed to evaluate the relationship between common,...
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Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT, and DNA-Binding Studies of ( E )-2-(3-Hydroxy-4-Methoxybenzylidene)HydrazinecarbothioamideAbstract(E)-2-(3-Hydroxy-4-methoxybenzylidene)hydrazinecarbothioamide 3 was synthesized by reacting thiosemicarbazide with 2-hydorxy-3-methoxybenzaldehyde in dry ethanol. The structure was elucidated by spectroscopic (FT-IR, 1H NMR, and 13C NMR) and single crystal X-ray diffraction techniques. A detailed analysis of the intermolecular interactions...
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Increased bioavailability of plasma polyphenols via the intestinal fermentation of soybean fibers: a role for gut microbiome?Increased bioavailability of plasma polyphenols via the intestinal fermentation of soybean fibers: a role for gut microbiome?Chronic refined low-fat diet consumption reduces cholecystokinin satiation in ratsAbstractPurposeReduced ability of cholecystokinin (CCK) to induce satiation contributes to hyperphagia and weight gain in high-fat/high-sucrose (HF/HS) diet-induced obesity,...
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r -th order nonlinearity, correlation measure and least significant bit of the discrete logarithmAbstractEach finite binary sequence (sh) is associated with a Boolean function B. The correlation measure of order k and the r-th order nonlinearity are figures of merit for the unpredictability of (sh) and B, respectively. We estimate the r-th order nonlinearity of B in terms of the correlation measure of order 2r of (sh). We apply our result to Boolean functions associated with the Legendre sequence,...
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3D Photogrammetry of Bat Skulls: Perspectives for Macro-evolutionary AnalysesAbstractPhotogrammetry (PH) is relatively cheap, easy to use, flexible and portable but its power and limitations have not been fully explored for studies of small animals. Here we assessed the accuracy of PH for the reconstruction of 3D digital models of bat skulls by evaluating its potential for evolutionary morphology studies at interspecific (19 species) level. Its reliability was assessed against the performance of...
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American Journal of Roentgenology Gastrointestinal ImagingSmall-Bowel Crohn Disease Treated With Anti–Tumor Necrosis Factor-α Therapy: MR Enterography Score Changes After 1 Year Predict Long-Term OutcomesJose C. Gallego, et al. | American Journal of Roentgenology | Aug 15, 2019Ahead of PrintCT in Differentiating Complicated From Uncomplicated Appendicitis: Presence of Any of 10 CT Features Versus Radiologists' Gestalt AssessmentHae Young Kim, et al. | American Journal of Roentgenology | Aug 15, 2019Ahead...
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Controlled mechanical vibration and impacts on skin biology Elisa Caberlotto, Miguel Bernal, Zane Miller, Aaron Poole, Laetitia Ruiz, Mickaël Tanter, Jean‐Luc Gennisson, Bernard QuerleuxVersion of Record online: 09 August 2019
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YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathwayPublication date: 28 October 2019Source: Cancer Letters, Volume 463Author(s): Qun Chen, Jing-Jing Zhang, Wan-Li Ge, Lei Chen, Hao Yuan, Ling-Dong Meng, Xu-Min Huang, Peng Shen, Yi Miao, Kui-Rong JiangAbstractPancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate. The transcription factor YY1 acts as an inhibitor of many types of tumors....
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Proceedings of the Royal Society BVol. 286, No. 1908, (August 2019) The above issue is now available online at:https://royalsocietypublishing.org/toc/rspb/2019/286/1908?ai=aqlf&ui=cbwb&af=HClick the links below to view the abstract for each article, or click the link above to view all Just Released articles for this journal.Review articlesReview articles: Neurocognitive free willThomas T. HillsProceedings of the Royal Society B: Biological Sciences, Vol. 286, No. 1908, August 2019Abstract | Full...
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Ultra-low-cost fabrication of polymer-based microfluidic devices with diode laser ablationAbstractIn this work, a diode laser ablation approach was used for the fabrication of PMMA-based microfluidic devices. Compared with the conventional CO2 or femtosecond laser fabrication method, the proposed laser ablation method based on diode laser significantly lowered the cost in the fabrication of polymer-based microfluidic devices with comparable resolution and surface quality. PMMA substrate was used...
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Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivoPublication date: 1 November 2019Source: Nitric Oxide, Volume 92Author(s): Miguel Diaz, Vijay Parikh, Saira Ismail, Raja Maxamed, Emily Tye, Clare Austin, Tristan Dew, Brigitte A. Graf, Luc Vanhees, Hans Degens, May AzzawiAbstractResveratrol is a plant-derived phytoalexin with antioxidant, anti-inflammatory and cardio-protective properties and may be a promising therapeutic intervention strategy in cardiovascular...
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Human macrophage response to microbial supernatants from diabetic foot ulcersCarly B. Deusenbery BS, Lindsay Kalan PhD, Jacquelyn S. Meisel PhD, Sue E. Gardner RN PhD, Elizabeth A. Grice PhD, Kara L. Spiller PhDVersion of Record online: 10 August 2019Original Research–Clinical ScienceThe beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu‐ekki‐to (Bu‐Zhong‐Yi‐Qi‐Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trialShinsuke...
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EHA 2019: Expertendialog multiples Myelom - Lebensqualität ist ein wichtiger Parameter in der TherapieDie Lebensqualität gerät in den Studien zum multiplen Myelom zunehmend in den Fokus. Und: Der Einzug der monoklonalen Antikörper in die Primärtherapie beim multiplen Myelom bringt einen enormen Fortschritt. Unsere Experten diskutieren die neuen Erkenntnisse vom EHA 2019.>> WeiterlesenFotonachweis: © dkg-web.gmbhAnzeigeUnternehmerin oder Kämpferin?Wissen und Tipps zu beruflichen Soft Skills,...
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Perioperative Medicine Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of LaryngoscopyMaud A. S. Weerink, M.D.; Clemens R. M. Barends, M.D.; Ernesto R. R. Muskiet, M.D.; Koen M. E. M. Reyntjens, M.D.; Froukje H. Knotnerus, R.N.; Martine Oostra, R.N.; Jan F. P. van Bocxlaer, Pharm.D., Ph.D.; Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.; Pieter J. Colin, Pharm.D., Ph.D.Anesthesiology Published online August 14, 2019. doi:10.1097/ALN.0000000000002882Images...
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Reviews Chromosomal Instability in Tumor Initiation and DevelopmentDuc-Hiep Bach et al.Microenvironmental Metabolism Regulates Antitumor ImmunityVerra M. Ngwa et al.Cancer Research HighlightsPrecision Therapy for Aggressive Endometrial Cancer by Reactivation of Protein Phosphatase 2AKaitlin Haines et al.Controversy and ConsensusConnecting Students with Patients and Survivors to Enhance Cancer Research TrainingRobert N. Riter et al.Molecular Cell BiologyMYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to...
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The effect of vitamin D levels on gastrointestinal bleeding in patients with warfarin therapyUpper tract gastrointestinal system (GIS) bleeding is considered as an important cause of morbidity and mortality despite modern and advanced endoscopic interventions. In patients with thrombotic state and vitamin D deficiency, vitamin D analogs and vitamin D receptor activators have been determined as adjunctive anticoagulant treatment in previous studies. However, these studies did not evaluate or reveal...
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Plasmalemma Function is Rapidly Restored in Mdx Muscle after Eccentric ContractionsPurpose Muscle that lacks dystrophin, as in the mdx mouse, has a heightened sensitivity to eccentric (ECC) contraction-induced strength loss, but an enhanced rate of recovery. However, the timeline and mechanisms underlying why mdx muscle recovers quicker has yet to be determined. We used an electromyographic (EMG) approach to analyze plasmalemma electrophysiological function during and following ECC contraction-induced...
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Cardiotonic steroids induce vascular fibrosis via pressure-independent mechanism in NaCl-loaded diabetic ratsEndogenous cardiotonic steroid, marinobufagenin (MBG), induces Fli1-dependent tissue fibrosis. We hypothesized that an increase in MBG initiates the development of aortic fibrosis in salt-loaded rats with type 2 diabetes mellitus (DM2) via pressure-independent mechanism. DM2 was induced by a single intraperitoneal administration of 65 mg/kg streptozotocin to neonatal (4-5 days) male Wistar...
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Evaluation of the effect of three constituent metals of monazita on the radiosensibility of human osteoblastsPublication date: November 2019Source: Journal of Environmental Radioactivity, Volumes 208–209Author(s): Lucas K. da F. Iwahara, Monica S. de Oliveira, Marcus A.V. de AlencarAbstractThorium has gained notoriety in recent years, as a potential source of nuclear energy, substituting uranium in power plants. Monazite is an important source of thorium, as well of uranium and rare earths elements....
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Jalview Sequence Alignment, Visualization Software Gets New FundingPublished on Aug 15, 2019 Personalis CEO Claims Strong Interest From Early Customers of Comprehensive Tumor Profiling PanelPublished on Aug 14, 2019 Adaptive Biotechnologies Plans New Product Launches, Expanded FDA Label for ClonoSeqPublished on Aug 14, 2019 Complex Genetic Testing Errors Emerge Amid Increasing Panel Use, Consumer Access, Case Series FindsPublished on Aug 13, 2019Planning Your 2019 Marketing Strategy? GenomeWeb can...
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Improving Cochlear Implant Performance in the Wind Through Spectral Masking Release: A Multi-microphone and Multichannel StrategyObjectives: Adopting the omnidirectional microphone (OMNI) mode and reducing low-frequency gain are the two most commonly used wind noise reduction strategies in hearing devices. The objective of this study was to compare the effectiveness of these two strategies on cochlear implant users' speech-understanding abilities and perceived sound quality in wind noise. We also...
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Optimizing value in head and neck cancer free flap surgeryPurpose of review Value has become an increasingly important topic in healthcare delivery as our systems attempt to deliver increased value to patients at lower costs. This review highlights research performed regarding value for head and neck cancer reconstruction in three evolving areas: care pathway development, virtual surgical planning (VSP), and free flap versus locoregional flap reconstruction. Recent findings Improvements in quality-driven...
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This arresting image of surgeons about to transplant a human face removed from its deceased donor was shortlisted for the 2019 Wellcome Photography Prize in January. "There was complete silence in the room as the surgical team absorbed the gravity of their mission," says the prize's description of the image. The face was given to 21-year-old Katie Stubblefield, who became the youngest person ever to receive a successful full face transplant. (Lynn Johnson/Wellcome Photography Prize 2019)
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In April, the Event Horizon Telescope network announced that it had obtained the first image of a black hole — at the centre of the galaxy M87. (EHT Collaboration)In April, the first-ever image of a black holeThis golden doughnut is the first image ever of the event horizon that surrounds a black hole — in this case, the supermassive black hole at the centre of a nearby galaxy called M87. The image offered a spectacular confirmation of the existence of black holes, first deduced from Albert Einstein's...
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The distance between the glottis and cuff of a tracheal tube placed through three supraglottic airway devices in children: A randomised controlled trialBACKGROUND After tracheal tube insertion via various types of supraglottic airway devices, the distance from the tube cuff to the vocal cords has not been evaluated in children. OBJECTIVES The aim of this study was to evaluate the position of a tracheal tube cuff relative to the glottis in children when one of three supraglottic airway devices (I-gel,...
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Two Out After Data Manipulation Published on Aug 15, 2019Novartis replaced two top executives from its AveXis unit following data manipulation during early testing of its new gene therapy, Reuters reports. Read more >Access to Moonshot WorkPublished on Aug 15, 2019ScienceInsider reports that researchers funded through the Cancer Moonshot program will have to make their papers immediately accessible to the public. Read more >Nature Describes a Circular Consensus Sequencing Method, CRISPR Platform,...
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What Motivates Us to Excel? A Personalized Look at Employee EngagementBy Chuck Gipson MA, NRP / CCPWhat's the best way to motivate and encourage first responders?READ NOW » Dealing with Psychotic PatientsBy A.J. Heightman, MPA, EMT PIf you are involved in the delivery of emergency medical services, you will be confronted with these patients on the streets.READ MORE » EMS AIRWAYVideo: Waveform CapnographyBy Mike McEvoy, PhD, NRP, RN, CCRNA primer on basic waveform capnography, using a device to...
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Clinical characteristics, antihypertensive medication use and blood pressure control among patients with treatment-resistant hypertension: the Survey of PatIents with treatment ResIstant hyperTension studyObjective: We evaluated the characteristics of patients with treatment-resistant hypertension (TRH) and the prevalence of TRH in a large multicountry sample of specialist tertiary centres. Methods: The Survey of PatIents with treatment ResIstant hyperTension (SPIRIT) study was a retrospective review...
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Review, Vascular Imaging, Bioprosthetic Heart Valve Degeneration and Dysfunction: Focus on Mechanisms and Multidisciplinary Imaging Considerations Valve dysfunction and degeneration remain fundamental problems of bioprosthetic heart valves; key processes involved in dysfunction and degeneration and associated imaging findings are reviewed. Stephanie L. Sellers, Philipp Blanke, Jonathon A. Leipsic
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CLINICIAN'S TRAUMA UPDATE OnlineIssue 13(4), AUGUST 2019For COMPLETE summaries, see this month's CTU-Online.TreatmentJury still out on Imagery Rehearsal Therapy for nightmares in PTSDEvidence-based psychotherapies for PTSD have limited effects on sleep problems (see the August 2018 CTU-Online and February 2019 CTU-Online), suggesting the need for additional treatment approaches. In two recent studies, investigators tested imagery rehearsal therapy (IRT), a cognitive-behavioral therapy for recurrent...
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Effects of Healthcare-Associated Infections on Length of PICU Stay and MortalityObjectives: To identify the effects of healthcare-associated infections on length of PICU stay and mortality. Design: Retrospective, single-center, observational study. Setting: PICU of a tertiary children's hospital. Patients: Consecutive patients who stayed greater than 48 hours in the PICU between January 2013 and December 2017. Interventions: None. Measurements and Main Results: Data were retrospectively collected...
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Author Interview: Communication Strategies for Sharing Prognostic Information With Patients: Beyond Survival StatisticsCommunication Strategies for Sharing Prognostic Information With Patients: Beyond Survival StatisticsJoanna Paladino, MD; Joshua R. Lakin, MD; Justin J. Sanders, MD, MScAudio Interview: Communication Strategies for Sharing Prognostic Information With Patients: Beyond Survival StatisticsWill Increasing Primary Care Spending Alone Save Money?Zirui Song, MD, PhD; Suhas Gondi, BAAUDIOAudio...
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The Decline in Community Preceptor Teaching Activity: Exploring the Perspectives of Pediatricians Who No Longer Teach Medical StudentsPurpose: Difficulty in recruiting and retaining community preceptors for medical student education has been described in the literature. Yet little if any information is known about community outpatient preceptors who have stopped or decreased teaching time with students. This study aimed to examine these preceptors' perspectives about this phenomenon. Method: Using...
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Persistent Neuroinflammation and Brain Specific Immune Priming in A Novel Survival Model of Murine PneumosepsisPneumonia is the leading cause of sepsis and septic shock. Patients who survive pneumonia are vulnerable to long-term complications including increased risk of neurocognitive dysfunction. This study investigated the immune response and long-term complications of a non-surgical mouse model of Klebsiella pneumoniae pneumosepsis with antibiotic treatment. Pneumosepsis resulted in acutely enhanced...
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Prednisolone Versus Dexamethasone for Croup: a Randomized Controlled TrialColin M. Parker and Matthew N. CooperQuality ReportA Discharge Vital Sign Documentation Improvement Initiative in the Pediatric Emergency DepartmentAdam A. Vukovic, Corrie Berry and David P. Johnson
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Effects of Hatha Yoga and Resistance Exercise on Affect and State Anxiety in WomenPurpose This study aimed to compare the effects of single bouts of moderate-intensity resistance exercise (RE) and Hatha Yoga (HY) on postexercise affect and anxiety. Methods Active, college-aged women (N = 25) completed RE, HY, and no-exercise control sessions. Affect (energy, tiredness, tension, calmness) and state anxiety were assessed before exercise and 0, 15, 30, 45, and 60 min after exercise. Results RE promoted...
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Religion in the Context of Clinical CareNo abstract availableTraditional Chinese Medicine and Intestinal Microbiota: A Complementary and Integrative Health Approach to Ameliorate Obesity-Related DiseasesThe incidence of obesity and obesity-related diseases, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease, is increasing worldwide, which threatens quality of life and human health. "The toxins in the stool enter the body and blood and then cause a variety of diseases"; this quote...
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Prediction of Nonelective Central Venous Catheter Removal in Medically Complex NeonatesIntroduction: Central venous catheters (CVCs) are essential to neonatal care but associated with significant morbidity. Nonelective CVC removal (NER) is an inadequately studied outcome associated with increased morbidity, infant and family stress, and cost. This study describes prevalence and predictors of NER in infants admitted to a level IV neonatal intensive care unit and NER variation between peripherally...
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Split-Face Study of the Efficacy and Persistence of Reconstituted and Refrigerated PrabotulinumtoxinATemporary Greater Auricular Nerve Paresthesia After Radiofrequency Microneedling TreatmentObservations Regarding Infection Risk in Lower-Extremity Wound Healing by Second IntentionReducing Anxiety With Art Activities During the Mohs Micrographic Surgery Waiting PeriodBotulinum Toxin A Improves Supramuscular Fat Graft Retention by Enhancing Angiogenesis and AdipogenesisBACKGROUND Autologous fat grafting...
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Reaping What We Sow—Reflections on the Otolaryngologist's Role in Opioid StewardshipMichael J. Brenner, MDORIGINAL INVESTIGATIONAssociation of Sinonasal Factors With Chronic Laryngitis in Korean AdultsKijeong Lee, MD; Cha Young Kang, MD; Hoyoung Lee, MD; et al.Association of a Lean Surgical Plan of the Day With Reduced Operating Room Time for Head and Neck Free Flap ReconstructionAhmed Ibrahim, MD; Kavindu Ndeti, BA; Andres Bur, MD; et al.CLINICAL CHALLENGERadiologyProgressive Bilateral Nasal Obstruction...
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The role of ferroptosis in digestive system cancer (Review)Yan Song, Hu Yang, Rui Lin, Kui Jiang, Bang‑Mao WangView Abstract ❯The true colors of autophagy in doxorubicin‑induced cardiotoxicity (Review)Bin Xiao, Lang Hong, Xinyong Cai, Songbo Mei, Ping Zhang, Liang ShaoView Abstract ❯Role of cancer-associated fibroblasts in tumor structure, composition and the microenvironment in ovarian cancer (Review)Wei Sun, Shilong FuView Abstract ❯Soft tissue sarcomas of the upper extremities: Maximizing treatment...
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Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumorsLucile Delespaul, Candice Merle, Tom Lesluyes, Pauline Lagarde, Sophie Le Guellec et al. Oncogene 2019 38 :6083 - 6094; July 03, 2019; 10.1038/s41388-019-0859-6Abstract | Full TextIdentifying and targeting angiogenesis-related microRNAs in ovarian cancerXiuhui Chen, Lingegowda S. Mangala, Linda Mooberry, Emine Bayraktar, Santosh K. Dasari et al. Oncogene 2019 38 :6095 - 6108; July 09, 2019; 10.1038/s41388-019-0862-yAbstract | Full...
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Statistical power in genome-wide association studies and quantitative trait locus mappingMeiyue Wang & Shizhong Xu Heredity 2019 123 :287 - 306; March 11, 2019; 10.1038/s41437-019-0205-3Abstract | Full TextGenomic selection strategies for breeding adaptation and production in dairy cattle under climate changeIsmo Strandén, Juha Kantanen, Isa-Rita M. Russo, Pablo Orozco-terWengel & Michael W. Bruford Heredity 2019 123 :307 - 317; March 18, 2019; 10.1038/s41437-019-0207-1Abstract | Full TextHeterotic...
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Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης Occupational and Environmental Medicine current issue Dermatitis among workers in Ontario:... Occupational and Environmental Medicine current issue Dermatitis among workers in Ontario: results from the Occupational Disease Surveillance SystemObjectivesDermatitis is the most common occupational skin disease, and further evidence is needed regarding preventable risk factors. The Occupational Disease Surveillance System (ODSS) derived...
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Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης Occupational and Environmental Medicine current issue Dermatitis among workers in Ontario:... Occupational and Environmental Medicine current issue Dermatitis among workers in Ontario: results from the Occupational Disease Surveillance SystemObjectivesDermatitis is the most common occupational skin disease, and further evidence is needed regarding preventable risk factors. The Occupational Disease Surveillance System (ODSS) derived...
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Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης Occupational and Environmental Medicine current issue Dermatitis among workers in Ontario:... Occupational and Environmental Medicine current issue Dermatitis among workers in Ontario: results from the Occupational Disease Surveillance SystemObjectivesDermatitis is the most common occupational skin disease, and further evidence is needed regarding preventable risk factors. The Occupational Disease Surveillance System (ODSS) derived...
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