Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174: 06/12/17

Δευτέρα 12 Ιουνίου 2017

Direct cost comparison of minimally invasive punch technique versus traditional approaches for percutaneous bone anchored hearing devices

Minimally Invasive Ponto Surgery (MIPS) was recently described as a new technique to facilitate the placement of percutaneous bone anchored hearing devices.

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The AYA Director: A Synthesizing Concept to Understand Psychosocial Experiences of Adolescents and Young Adults With Cancer

Background: Adolescents and young adults with cancer face distinct psychosocial challenges because of the multiple developmental tasks associated with their age. Research on psychosocial care, directed to the unique needs and demands of this population, is limited. Objective: The aim of this study was to describe the psychosocial experiences of adolescents and young adults with cancer to further the understanding of the meanings they attribute to their experiences. Intervention/Methods: This study used a qualitative design in which individual semistructured interviews were conducted with 23 participants aged 15 to 25 years. Results: Physical consequences of the disease and its treatment, loss of independence, and being alone were significant challenges. Major coping strategies of the participants were to avoid the possible threats to life and maintain a positive attitude and normal life. Participants were "directors" who took control in order to manage their illness, maintain a sense of control, and master their lives to the fullest extent possible. Conclusions: The concept of the "AYA (adolescent and young adult) director" provides insight for healthcare professionals to understand how adolescents and young adults experience cancer. Implications for Practice: Throughout the cancer experience, participants wanted to be treated as individuals with specific needs and preferences. They preferred circumstances they are accustomed to; some found it difficult to accept restrictions imposed by the hospital. Adolescents and young adults with cancer want to be involved in the way healthcare professionals communicate with them and the information they are provided.

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A Bayesian Model to Estimate Individual Skull Conductivity for EEG Source Imaging

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Corrigendum to: 'Preoperative Volumetric Assessment Matched with High-Field Intraoperative Magnetic Resonance Imaging-Guided Stereotactic Evacuation of Brain Abscesses' [World Neurosurg. 91 (2016) 238-244].

Corrigendum to: 'Preoperative Volumetric Assessment Matched with High-Field Intraoperative Magnetic Resonance Imaging-Guided Stereotactic Evacuation of Brain Abscesses' [World Neurosurg. 91 (2016) 238-244].

World Neurosurg. 2017 Jun 07;:

Authors: Pesce A, D'Andrea G, Frati A, Wierzbicki V, Caruso R, Raco A

PMID: 28601402 [PubMed - as supplied by publisher]

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A Model for C-F Activation by Electrophilic Phosphonium Cations

Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C7CC04057A, Communication

Ian Mallov, Tim Johnstone, Darcy Burns, Douglas W Stephan
The synthesis of the electrophilic phosphonium cation (EPC) salt [C10H6(CF3)PF(C6F5)2][B(C6F5)4] 4 was achieved via oxidation of phosphine [C10H6(CF3)P(C6F5)2] 2 with XeF2 to form phosphorane [C10H6(CF3)PF2(C6F5)2] 3 and subsequent fluoride ion...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Dynamics of fully nonlinear capillary–gravity solitary waves under normal electric fields

Abstract

Two-dimensional capillary–gravity waves travelling under the effect of a vertical electric field are considered. The fluid is assumed to be a dielectric of infinite depth. It is bounded above by another fluid which is hydrodynamically passive and perfectly conducting. The problem is solved numerically by time-dependent conformal mapping methods. Fully nonlinear waves are presented, and their stability and dynamics are studied.

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Clinical and genetic analysis of Indian patients with NDP-related retinopathies.

Clinical and genetic analysis of Indian patients with NDP-related retinopathies.

Int Ophthalmol. 2017 Jun 10;:

Authors: Sudha D, Ganapathy A, Mohan P, Mannan AU, Krishna S, Neriyanuri S, Swaminathan M, Rishi P, Chidambaram S, Arunachalam JP

Abstract
PURPOSE: NDP-related retinopathies are a group of X-linked disorders characterized by degenerative and proliferative changes of the neuroretina, occasionally accompanied with varying degrees of mental retardation and sensorineural hearing loss. NDP is the predominant gene associated with NDP-related retinopathies. The purpose of this study was to report the clinical and genetic findings in three unrelated patients diagnosed with NDP-related retinopathies.
METHODS: The patients underwent complete ophthalmic examination followed by genetic analyses. NDP gene was screened by direct sequencing approach. Targeted resequencing of several other ocular genes was carried out in patient samples that either indicated NDP gene deletion or tested negative for NDP mutation. Gene quantitation analysis was performed using real-time PCR.
RESULTS: The whole NDP gene was deleted in patient I, while a missense NDP mutation, c.205T>C, was identified in patient II, and both had classical Norrie disease ocular phenotype (with no other systemic defects). Patient III who was diagnosed with familial exudative vitreoretinopathy did not show any mutation in the known candidate genes as well as in other ocular genes tested.
CONCLUSIONS: The patient with whole NDP gene deletion did not exhibit any apparent extraocular defects (like mental retardation or sensorineural hearing loss) during his first decade of life, and this is considered to be a notable finding. Our study also provides evidence emphasizing the need for genetic testing which could eliminate ambiguities in clinical diagnosis and detect carrier status, thereby aiding the patient and family members during genetic counseling.

PMID: 28602015 [PubMed - as supplied by publisher]

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Circadian variation in post void residual in nursing home residents with moderate impairment in activities of daily living

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AUNA2: A Novel Type of Non-Syndromic Slowly Progressive Auditory Synaptopathy/Auditory Neuropathy with Autosomal-Dominant Inheritance.

AUNA2: A Novel Type of Non-Syndromic Slowly Progressive Auditory Synaptopathy/Auditory Neuropathy with Autosomal-Dominant Inheritance.

Audiol Neurootol. 2017 Jun 10;22(1):30-40

Authors: Lang-Roth R, Fischer-Krall E, Kornblum C, Nürnberg G, Meschede D, Goebel I, Nürnberg P, Beutner D, Kubisch C, Walger M, Volk AE

Abstract
BACKGROUND: Auditory synaptopathy/neuropathy (AS/AN) is a heterogeneous disorder, which may be caused by environmental factors like postnatal hyperbilirubinemia or by genetic factors. The genetic forms are subdivided into syndromic and non-syndromic types, and show different inheritance patterns with a strong preponderance of autosomal-recessive forms. To date, only a single locus for non-syndromic autosomal-dominant AS/AN (AUNA1) has been reported in a single family, in which a non-coding DIAPH3 mutation was subsequently described as causative.
MATERIALS AND METHODS: Here, we report detailed clinical data on a large German AS/AN family with slowly progressive postlingual hearing loss. Affected family members developed their first symptoms in their second decade. Moderate hearing loss in the fourth decade then progressed to profound hearing impairment in older family members. Comprehensive audiological and neurological tests were performed in the affected family members. Genetic testing comprised linkage analyses with polymorphic markers and a genome-wide linkage analysis using the Affymetrix GeneChip® Human Mapping 250K.
RESULTS AND CONCLUSION: We identified a large family with autosomal-dominant AS/AN. By means of linkage analyses, the AUNA1 locus was excluded, and putatively linked regions on chromosomal bands 12q24 and 13q34 were identified as likely carrying the second locus for autosomal-dominant AS/AN (AUNA2). AUNA2 is associated with a slowly progressive postlingual hearing loss without any evidence for additional symptoms in other organ systems.

PMID: 28601886 [PubMed - as supplied by publisher]

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Osteoarthritis and spontaneous fusion of facet joints after percutaneous instrumentation in thoracolumbar fractures

Abstract

Purpose

This retrospective study determined the rate of osteoarthritis and spontaneous facet joint fusion and analyzed risk factors related to patient characteristics, fracture type or surgical technique on pre- and postoperative CT after percutaneous instrumentation in thoracolumbar fractures.

Methods

1050 facet joints adjacent to screws in 148 patients (15–85 years) with thoracolumbar fractures were analyzed with an average time between CTs of 12.3 months. Screw diameters, lengths and cement augmentation were recorded. Facet joint violation by screw trajectory and by insertion depth was classified in three grades. Pre- and postoperative osteoarthritis was graded as absent, minor or severe and postoperative facet joint fusion as absent, partial or complete.

Results

The facet violation rate was moderate in 15.4% and severe in 0.6% according to screw trajectory, and 11.0 and 0.6%, respectively, according to insertion depth. Osteoarthritis was preoperatively rated moderate in 9.6% and severe in 1.2%. A progression was evidenced in 79 facet joints (7.5%). Screw cement augmentation was the main predictive factor (p < 0.0001). Partial fusion was evidenced in 2.6% and complete fusion in 1% of facet joints. Risk factors were: BMI (p = 0.0002), age (p = 0.0013), preoperative osteoarthritis (p = 0.0005), time between 2 CTs (p = 0.0001), B-type fractures (p = 0.0005), concomitant anterior fusion (p = 0.0034).

Conclusions

Occurrence or worsening of osteoarthritis was mainly observed in elderly patients with cement-augmented screws and spontaneous facet fusion in elderly patients with high BMI and preoperative osteoarthritis, or in anteriorly fused B-type injuries. Thus, percutaneous instrumentation can safely be removed after fracture consolidation in younger patients while preserving facet joints.

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A Bayesian Model to Estimate Individual Skull Conductivity for EEG Source Imaging

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Development and psychometric validation of PUKAT 2.0, a knowledge assessment tool for pressure ulcer prevention.

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Trasjanka und Suržyk - gemischte weißrussisch-russische und ukrainisch-russische Rede, eds. G. Hentschel, O. Taranenko, S. Zaprusdski

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Musical Instruments, body movement, space, and motion data : music as an emergent multimodal choreography

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The AYA Director: A Synthesizing Concept to Understand Psychosocial Experiences of Adolescents and Young Adults With Cancer

Background: Adolescents and young adults with cancer face distinct psychosocial challenges because of the multiple developmental tasks associated with their age. Research on psychosocial care, directed to the unique needs and demands of this population, is limited. Objective: The aim of this study was to describe the psychosocial experiences of adolescents and young adults with cancer to further the understanding of the meanings they attribute to their experiences. Intervention/Methods: This study used a qualitative design in which individual semistructured interviews were conducted with 23 participants aged 15 to 25 years. Results: Physical consequences of the disease and its treatment, loss of independence, and being alone were significant challenges. Major coping strategies of the participants were to avoid the possible threats to life and maintain a positive attitude and normal life. Participants were "directors" who took control in order to manage their illness, maintain a sense of control, and master their lives to the fullest extent possible. Conclusions: The concept of the "AYA (adolescent and young adult) director" provides insight for healthcare professionals to understand how adolescents and young adults experience cancer. Implications for Practice: Throughout the cancer experience, participants wanted to be treated as individuals with specific needs and preferences. They preferred circumstances they are accustomed to; some found it difficult to accept restrictions imposed by the hospital. Adolescents and young adults with cancer want to be involved in the way healthcare professionals communicate with them and the information they are provided.

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Finite element analysis of fretting wear under variable coefficient of friction and different contact regimes

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Fast mixing with quantum walks vs. classical processes

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Commentary on "Does intramuscular gluteal augmentation using implants affect sensitivity in the buttocks?"

Commentary on "Does intramuscular gluteal augmentation using implants affect sensitivity in the buttocks?"

J Plast Reconstr Aesthet Surg. 2017 May 20;:

Authors: Oranges CM, Tremp M, di Summa PG, Schaefer DJ, Kalbermatten DF

PMID: 28601601 [PubMed - as supplied by publisher]

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Prognostic relevance of Src activation in stage II-III colon cancer.

Prognostic relevance of Src activation in stage II-III colon cancer.

Hum Pathol. 2017 Jun 07;:

Authors: Perez JM, Lopez-Calderero I, Saez C, Benavent M, Limon ML, Gonzalez-Exposito R, Soldevilla B, Riesco-Martinez MC, Salamanca J, Carnero A, Garcia-Carbonero R

Abstract
Src belongs to a family of cytoplasmic tyrosine kinases that play a key role in tumor initiation and progression. Src activation has been associated with a more aggressive neoplastic phenotype and induces resistance to platinum agents in preclinical models. The aim of our study was to assess the prognostic and/or predictive value of Src activation in stage II-III colon cancer patients. pSrc expression was assessed in paraffin-embedded tumor samples by immunohistochemistry (phospho Y418, ab4816, Abcam). Cases were classified by staining intensity in four categories: no staining (0), weak (1+), moderate (2+) and intense (3+) staining. A total of 487 patients were evaluated (240 stage II, 247 stage III), of whom 298 (61%) had received adjuvant chemotherapy. Staining was absent in 78 (16%), weak in 262 (54%), moderate in 103 (21%) and intense in 44 (9%). High pSrc expression was significantly associated with decreased 5-year disease-free survival (39% vs 63% for patients with high vs low pSrc expression, HR=0.56, P=.005) and overall survival (58% vs 74%, HR=0.55, P=.02). Multivariate analysis confirmed pSrc expression as a significant prognostic factor both for DFS and OS, independent of age, gender, tumor stage, bowel obstruction/perforation or adjuvant chemotherapy. These findings illustrate the relevance of Src activation in colon cancer biology, conferring a poor prognosis to early stage colon cancer patients regardless of adjuvant chemotherapy. Our findings may help improve prognostic stratification of patients for clinical decissions, and open new avenues for potential pharmacological manipulation that may eventually improve patients' outcomes.

PMID: 28601656 [PubMed - as supplied by publisher]

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A systematic review of patient values, preferences and expectations for the treatment of recurrent ovarian cancer.

A systematic review of patient values, preferences and expectations for the treatment of recurrent ovarian cancer.

Gynecol Oncol. 2017 Jun 07;:

Authors: PEBC's Ovarian Oncology Guidelines Group

Abstract
BACKGROUND AND OBJECTIVES: It is our belief that patient preference should play a significant role in disease management of recurrent ovarian cancer. Since cure is seldom an endpoint in this circumstance, patients' attitudes toward the risks and benefits of chemotherapy versus palliation are relevant.
METHODS: Medline, Embase, CINAHL and PsycINFO from were searched from January 1, 2000 to December 13, 2016 for studies of values, preferences or expectations of women with platinum-sensitive recurrent or refractory ovarian cancer.
RESULTS: Ten studies representing five countries met inclusion criteria. Although there was regional variation in preference for palliation over treatment, certain themes emerged. 1) Patients, even in the context of counselling overestimated the curative capability of chemotherapy. In one study 92% of patients had high expectations of healing after completing an expectation of treatment checklist. Another study observed that patients are often overwhelmed by information provided at diagnosis and there can be a discrepancy between what patients report to have heard and what the clinicians said. 2) Patients who had previously tolerated chemotherapy well were more likely to be accepting of the side-effects of chemotherapy. 3) Patients were more willing to accept chemotherapy and the related side effects when treatment was of curative intent or when overall survival was increased. 4) Patients valued both overall and progression free survival. 5) A significant minority (24%) consistently chose treatment over palliation. 6) Patients were more willing to accept the side effects of chemotherapy than were their health care providers.
CONCLUSIONS: These findings, in aggregate, highlight the importance of communication with patients regarding prognosis, adverse effects and symptom management to help negotiate the decision making process. Chemotherapy in the recurrent setting should be managed on a case by case basis, combining both medical constraints and consideration to patient preferences.

PMID: 28601379 [PubMed - as supplied by publisher]

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Innervated dorsoradial perforator free flap: A reliable supermicrosurgery fingertip reconstruction technique.

Innervated dorsoradial perforator free flap: A reliable supermicrosurgery fingertip reconstruction technique.

J Plast Reconstr Aesthet Surg. 2017 May 27;:

Authors: Song D, Pafitanis G, Yang P, Narushima M, Li Z, Liu L, Wang Z

Abstract
INTRODUCTION: This study demonstrates the use of a modified free innervated DRAP flap utilizing the supermicrosurgery technique for fingertip reconstruction.
MATERIALS AND METHODS: From January 2010 to February 2014, 20 cases of fingertip reconstruction were performed using a short pedicle mini innervated transverse DRAP flap. The patients demographics, the mechanism of injury, the defect size and anatomical location, the source of pedicle vessels, the recipient vessels, the nerve branch used for innervation, the follow-up and sensation outcomes are reported. Three cases are presented demonstrating different anatomical fingertip injury reconstructions.
RESULTS: 20 consecutive traumatic fingertip injuries (M:F-14:6) were reconstructed with a free DRAP flap from the same hand. 6 index, 6 middle, 5 ring and 3 little finger defects were included in this study. All procedures were performed under regional anaesthesia and sedation. There were no intra- or post-operative complications. The average operative time was 105 (85-120) minutes. Each flap size was matching the size of the defects. All donor sites achieved primary closure and good cosmesis. The average follow-up was 12.8 (6-28) months. Follow-up demonstrated a static two-point discrimination of the flaps with an average distance of 5.5 (4-7) mm.
CONCLUSION: The innervated DRAP flap has proven to be an easy, reliable and effective sensate fingertip reconstruction option, utilizing the supermicrosurgery technique.
LEVEL OF EVIDENCE: Level IV, retrospective series.

PMID: 28601599 [PubMed - as supplied by publisher]

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Preventing the complications of tissue expansion using fat grafting under expanded skin.

Preventing the complications of tissue expansion using fat grafting under expanded skin.

J Plast Reconstr Aesthet Surg. 2017 May 20;:

Authors: Jiang T, Zhao P, Cheng C, Liu K, Xie Y, Li Q

PMID: 28601600 [PubMed - as supplied by publisher]

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A Randomized, Placebo-Controlled, Phase 1b/2 Study of Rilotumumab or Ganitumab in Combination With Platinum-Based Chemotherapy as First-Line Treatment for Extensive-Stage Small-Cell Lung Cancer.

A Randomized, Placebo-Controlled, Phase 1b/2 Study of Rilotumumab or Ganitumab in Combination With Platinum-Based Chemotherapy as First-Line Treatment for Extensive-Stage Small-Cell Lung Cancer.

Clin Lung Cancer. 2017 May 10;:

Authors: Glisson B, Besse B, Dols MC, Dubey S, Schupp M, Jain R, Jiang Y, Menon H, Nackaerts K, Orlov S, Paz-Ares L, Ramlau R, Tang R, Zhang Y, Zhu M

Abstract
INTRODUCTION/BACKGROUND: In this randomized, double-blind, placebo-controlled phase 1b/2 study we assessed the efficacy/safety of rilotumumab or ganitumab combined with etoposide and carboplatin or cisplatin as first-line treatment in patients with extensive stage small-cell lung cancer (ES-SCLC).
PATIENTS AND METHODS: In the phase 1b study, patients received rilotumumab 15 mg/kg or ganitumab 18 mg/kg with etoposide and carboplatin or cisplatin. In the phase 2 study, patients were randomly assigned 1:1:1 to receive placebo, rilotumumab, or ganitumab with etoposide and carboplatin or cisplatin. Chemotherapy was administered for ≤ 6 cycles; rilotumumab, ganitumab, or placebo was then continued as maintenance therapy. The primary end points were incidence of dose-limiting toxicities (DLTs; phase 1b) and overall survival (OS; phase 2). Secondary end points included progression-free survival (PFS) and safety.
RESULTS: In the phase 1b study (n = 28), 1 patient treated with ganitumab experienced a DLT (Grade 4 neutropenia/thrombocytopenia lasting ≥ 7 days). In the phase 2 study, 185 patients were enrolled (placebo, n = 61; rilotumumab, n = 62; ganitumab, n = 62). Median OS was 10.8, 12.2 (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.56-1.25; P = .384), and 10.7 (HR, 0.95; 95% CI, 0.63-1.41; P = .787) months, in placebo, rilotumumab, or ganitumumab arms, respectively. Median PFS was 5.4, 5.4 (HR, 1.05; 95% CI, 0.71-1.54; P = .797), and 5.5 (HR, 1.05; 95% CI, 0.72-1.55; P = .780) months, respectively. Adverse events resulting in treatment discontinuation occurred in 11 (19%), 10 (16%), and 7 (12%) patients, respectively. Serum biomarker analysis showed improved survival for patients with baseline hepatocyte growth factor levels below the median in the rilotumumab arm.
CONCLUSION: Although the combination of rilotumumab or ganitumab with chemotherapy was tolerable, overall outcomes were not improved in patients with ES-SCLC.

PMID: 28601388 [PubMed - as supplied by publisher]

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quality of care; +18 new citations

18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

quality of care

These pubmed results were generated on 2017/06/12

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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RT @WorkWithCancer : NEW #WorkWithCancer blog post. 4 thinking traps around cancer at work. Some things to avoid. #HR #Cancer https://t.co/8…

RT @WorkWithCancer : NEW #WorkWithCancer blog post. 4 thinking traps around cancer at work. Some things to avoid. #HR #Cancer https://t.co/8…

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Potential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Placebo-Controlled Trial

Abstract

Background

Contrast-induced nephropathy (CIN) is a major drawback in percutaneous coronary intervention (PCI). Significant uricosuria has been reported following contrast exposure. Allopurinol—a xanthine oxidase inhibitor—has been suggested to prevent the formation of oxygen-free radicals, which may contribute to CIN. The aim of the present study was to evaluate the possible efficacy of allopurinol in preventing CIN.

Methods

In this double-blind placebo-controlled trial, patients with an estimated glomerular filtration rate ≥60 mL/min who were admitted for elective PCI, were randomized to receive either allopurinol 600 mg or a placebo administered 24 h before the procedure, and again immediately before the procedure. Blood samples were drawn at 24 h before and 24 h after contrast exposure to measure serum creatinine (SCr), uric acid, and serum cystatin-c.

Results

The baseline characteristics were almost similar between the placebo and allopurinol groups. The overall change in SCr and the rate of CIN, which is defined as ≥25% increase in serum cystatin-c relative to baseline, failed to show a significant difference between the two groups. When adjusted on the baseline cystatin-c, SCr, sex, and positive family history, the difference in the overall increase in serum cystatin-c was statistically significantly lower in the allopurinol group.

Conclusions

Allopurinol administration in patients undergoing PCI failed to show efficacy in preventing CIN. Nevertheless, this effect should be further evaluated in the patient population with chronic kidney disease.

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New results on radioguided localisation of non-palpable lesions of the breast from Costa Rica… https://t.co/slRo1Gw7z6

New results on radioguided localisation of non-palpable lesions of the breast from Costa Rica… https://t.co/slRo1Gw7z6

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Genes, Vol. 8, Pages 160: Haplotypes of the Ovine Adiponectin Gene and Their Association with Growth and Carcass Traits in New Zealand Romney Lambs

Adiponectin plays an important role in energy homeostasis and metabolism in mammalian adipose tissue. In this study, the relationship between adiponectin gene (ADIPOQ) haplotypes and variation in growth and carcass traits in New Zealand (NZ) Romney lambs was investigated using General Linear Models (GLMs). Eight haplotypes were found in these lambs and they were composed of the four previously reported promoter fragment sequences (A1–D1) and three previously reported intron 2–exon 3 sequences (A3–C3). The frequencies of the haplotypes ranged from 0.07% to 45.91%. The presence of A1–A3 was associated with a decreased pre-weaning growth rate (p = 0.037), and decreased leg lean-meat yield (p = 0.001), loin lean-meat yield (p = 0.018) and total lean-meat yield (p = 0.004). The presence of A1–C3 was associated with increased carcass fat depth over the 12th rib (V-GR; p = 0.001) and a decreased proportion of loin lean-meat yield (p = 0.045). The presence of B1–A3 was associated with an increased proportion of leg lean-meat yield (p = 0.016) and proportion of shoulder lean-meat yield (p = 0.030). No associations were found with birth weight, tailing weight and weaning weight. These results suggest that ovine ADIPOQ may have value as a genetic marker for NZ Romney sheep breeding.

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Personalized medicine in Parkinson's disease: Time to be precise

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Response to DC Whiteman, CM Olsen and AC Green: In-Deed Wise To Get Some Sensible Sun Exposure

Abstract

Whiteman, Olsen and Green noted the Felton study (1) was short term and limited by the number of biopsies. What this study demonstrated was that even for only 6 weeks of repeated exposures to sensible suberythemal doses of simulated solar ultraviolet radiation (UVR), there was a marked increase in the skin's defense mechanisms to overcome the damaging effects caused by the DNA absorbing the UVR. Whiteman et al. acknowledge that within 24 hours after the final exposure the levels of photo damage were significantly lower.

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Mild cognitive impairment as a risk factor for Parkinson's disease dementia

ABSTRACT

Background

The International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated.

Objectives

The aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia.

Methods

Individual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia. Survival analysis evaluated the predictive value of level II criteria for cognitive decline toward dementia as expressed by the relative hazard of dementia.

Results

A total of 467 patients were included. The analyses showed a clear contribution of impairment according to level II mild cognitive impairment criteria, age, and severity of PD motor symptoms to the hazard of dementia. There was a trend of increasing hazard of dementia with declining neuropsychological performance.

Conclusions

This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence. © 2017 International Parkinson and Movement Disorder Society

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The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway.

The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway.

Iran J Allergy Asthma Immunol. 2017 Apr;16(2):147-158

Authors: Li AL, Sun YQ, Du P, Meng XC, Guo L, Li S, Zhang C

Abstract
Our previous study reported that Lactobacillus acidophilus(L.acidophilus) key laboratory of dairy science (KLDS) 1.0738 had an effective impact on inhibiting β-lactoglobulin (β-lg) allergy. This study further investigated the anti-allergic activity of peptidoglycan (PGN) isolated from KLDS 1.0738. This study aimed to assess whether toll-like receptor 2 (TLR2)/NF-kappaB (NF-κB) signaling activated by PGN was responsible for reducing allergic inflammation. Our data showed that administration of L. acidophilus PGN inhibited IgE production and improved the Treg/Th17 balance toward a Treg response in a mouse model of β-lg allergy. In addition, treating different doses L. acidophilus PGN to sensitized mice significantly increased TLR2 levels, along with enhancing NF-κB expression, especially in medium and high concentration (p<0.05). Further analysis revealed that the mRNA expression of TLR2 and NF-κB were positively correlated with the Foxp3 mRNA expression (p<0.05), but were negatively correlated with the RORγt mRNA expression in L. acidophilus PGN-treated group compared to allergy group (p<0.05). This study suggests PGN was similar to probiotics in preventing β-lg allergy through regulating Treg/Th17 imbalance, and activation of TLR2/NF-κB signaling may be involved in this process.

PMID: 28601055 [PubMed - in process]

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Tofacitinib ameliorates atherosclerosis and reduces foam cell formation in apoE deficient mice.

Tofacitinib ameliorates atherosclerosis and reduces foam cell formation in apoE deficient mice.

Biochem Biophys Res Commun. 2017 Jun 07;:

Authors: Wang Z, Wang S, Wang Z, Yun T, Wang C, Wang H

Abstract
Atherosclerosis is a chronic inflammatory cardiovascular disease with high mortality worldwide. Tofacitinib (CP-690,550), an oral small-molecule Janus kinase inhibitor, has been shown to be effective in the treatment of rheumatoid arthritis, autoimmune encephalomyelitis and ulcerative colitis. However, its protective effect against atherosclerosis remains poorly understood. The aim of the present study was to evaluate the effects of Tofacitinib on atherogenic diet (ATD)-induced atherosclerosis using apolipoprotein E deficient (apoE-/-) mice. Atherosclerosis-prone apoE-/- mice were fed with ATD and treated with or without Tofacitinib through intragastrical administration (10 mg kg(-1) day(-1)) for 8 weeks. Our results showed that Tofacitinib did not change plasma lipids, while significantly reduced the levels of plasma pro-inflammatory cytokines IL-6 and TNF-α. It also significantly attenuated atherosclerotic plaque lesion in the aortic root and macrophages contained in plaque as shown with Mac2 immuno-staining. Peritoneal macrophages (PMC) were separated from apoE-/- mice fed with 8-week ATD, and then subjected to inflammation tests. Flow cytometry analysis of F4/80 and CD206 and mRNA levels of M1 and M2 macrophages markers showed that M1 macrophages decreased while M2 macrophages increased in Tofacitinib treated group. Expressions of other inflammatory genes also indicated an anti-inflammatory status in mice treated with Tofacitinib. Ox-LDL was used to induce foam cell formation from PMC in wild type mice, and the results displayed a reduced formation of foam cells and decreased inflammation in mice with Tofacitinib administration (1 μM). The mRNA and protein levels of ATP binding cassette subfamily A member 1 (ABCA1), a key gene involved in cholesterol efflux, remarkably increased, while it was absence of alterations in scavenger receptors expression. Therefore, we demonstrated that Tofacitinib could attenuate atherosclerosis and foam cells formation by inhibiting inflammation and upregulating ABCA1 expression.

PMID: 28601639 [PubMed - as supplied by publisher]

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The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

Surg Radiol Anat. 2017 Jun 10;:

Authors: Natsis K, Konstantinidis GA, Symeonidis PD, Totlis T, Anastasopoulos N, Stavrou P

Abstract
PURPOSE: The accessory tendon (AT) of the extensor hallucis longus (EHL) is a common anatomic variation, whose clinical significance remains debatable. The purpose of this study was to investigate the incidence and morphology of accessory EHL tendons in cadavers and to examine any possible correlation to the occurrence and severity of hallux valgus (HV) deformity.
METHODS: We examined any possible correlation between the AT presence and the cadavers' age and the HV deformity in 98 female adult cadaveric feet. The HV and intermetatarsal (IMA) angles were measured and compared with the relative angle between the primary EHL tendon and AT as well as the length of the AT.
RESULTS: AT was present in 26.5% and HV deformity existed in 36.7% of all feet. There was a high prevalence (65.4%) of HV deformity in feet with AT, but the HV angle and IMA were similar in feet with AT and without AT. No significant correlations were found between AT morphological characteristics and the cadavers' age or the HV angle and IMA.
CONCLUSIONS: In conclusion, there is a high incidence of HV deformity in cadaveric feet with AT of EHL (almost 2/3), but there is no correlation between the severity of the HV deformity and the presence or characteristics of the AT.

PMID: 28601923 [PubMed - as supplied by publisher]

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BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

J Voice. 2017 Jun 07;:

Authors: Lou Z, Yu X, Li Y, Duan H, Zhang P, Lin Z

Abstract
OBJECTIVE: This study aimed to investigate the risk factors for postoperative arytenoid dislocation caused by endotracheal intubation.
METHODS: From September 2014 to September 2016, the records of 28 patients with a history of postoperative arytenoid dislocation were reviewed. Patients matched in type of anesthesia and surgery were chosen as the control (n = 56). Recorded data for all patients were demographics, smoking status, alcoholic status, operation time, and anesthesia procedures. For arytenoid dislocation cases, we further analyzed the incidences of the left and right arytenoid dislocations. Categorical variables were presented as frequencies and percentages, and were compared using the chi-square test. Continuous variables were expressed as means ± standard deviation and compared using the Student unpaired t test. To determine the predictors of arytenoid dislocation, a logistic regression model was used for multivariate analysis. Statistical significance was indicated by P < 0.05.
RESULTS: Twenty-eight patients demonstrating postoperative arytenoid dislocation (10 women and 18 men) were included, with a mean age of 55 ± 12 years. Sixteen patients (57.14%) had left arytenoid dislocation and 12 (42.86%) had right arytenoid dislocation. Univariate analysis indicated that body mass index (BMI) was associated with arytenoid dislocation (P < 0.01), and logistic regression analysis showed that BMI (P = 0.025) was an independent risk factor for postoperative arytenoid dislocation.
CONCLUSIONS: BMI might be the independent risk factor for postoperative arytenoid dislocation.

PMID: 28601417 [PubMed - as supplied by publisher]

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A novel systemic immune-inflammation index predicts survival and quality of life of patients after curative resection for esophageal squamous cell carcinoma.

A novel systemic immune-inflammation index predicts survival and quality of life of patients after curative resection for esophageal squamous cell carcinoma.

J Cancer Res Clin Oncol. 2017 Jun 10;:

Authors: Wang L, Wang C, Wang J, Huang X, Cheng Y

Abstract
PURPOSE: A novel systemic immune-inflammation index (SII) based on platelet (P), neutrophil (N), and lymphocyte (L) counts has been reported to be associated with clinical outcomes in several solid tumors. We aimed to investigate its prognostic value in esophageal squamous cell carcinoma (ESCC) and the potential relationship with quality of life (QOL).
METHODS: A total of 280 ESCC patients who underwent esophagectomy were enrolled. SII (SII = P × N/L) was calculated on the basis of data obtained within 1 week before surgery. An optimal cut-off value stratified patients into high (≥560) and low (<560) preoperative SII groups. The widely used EORTC QLQ-C30 and QLQ-OES18 were utilized to assess QOL at cancer diagnosis and 36 months after surgery. Generalized estimating equations (GEEs) were used to evaluate the association of SII with QOL. Kaplan-Meier method and Cox proportional regression were used to analyze the prognostic value of SII.
RESULTS: Kaplan-Meier analyses revealed that higher SII correlated significantly with poorer overall survival (OS) (p < 0.001) and disease-free survival (DFS) (p < 0.001) in patients with ESCC. Multivariate analysis identified SII as an independent prognostic factor for OS (p < 0.001; HR 2.578; 95% CI 1.625-4.088) and DFS (p < 0.001; HR 2.699; 95% CI 1.726-4.223). In addition, patients with high SII exhibited notably deteriorating QOL (p < 0.05).
CONCLUSIONS: The preoperative SII is a promising biomarker for predicting survival and QOL of patients with ESCC. It may help to identify the high-risk patients for treatment strategy decisions.

PMID: 28601935 [PubMed - as supplied by publisher]

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From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

J Neuroimmunol. 2017 Aug 15;309:77-81

Authors: Wallwitz U, Brock S, Schunck A, Wildemann B, Jarius S, Hoffmann F

Abstract
In 2010, a novel anti-neuronal autoantibody, termed anti-Ca, was described in a patient with subacute cerebellar ataxia, and Rho GTPase-activating protein 26 (ARHGAP26) was identified as the target antigen. Recently, three additional cases of anti-Ca-positive cerebellar ataxia have been published. In addition to ataxia, cognitive decline and depression have been observed in some patients. Here, we report two new cases of anti-Ca-associated autoimmune cerebellar ataxia. Patient 1 presented with dizziness and acute yet mild limb and gait ataxia. Symptoms stabilized with long-term oral corticosteroid therapy but transiently worsened when steroids were tapered. Interestingly, both initial occurrence and worsening of the patient's neurological symptoms after steroid withdrawal were accompanied by spontaneous cutaneous hematomas. Patient 2 initially presented with an increased startle response and myoclonic jerks, and subsequently developed severe limb and gait ataxia, dysarthria, oculomotor disturbances, head and voice tremor, dysphagia, cognitive symptoms and depression. Steroid treatment was started five years after disease onset. The symptoms then responded only poorly to corticosteroids. At most recent follow-up, 19 years after disease onset, the patient was wheelchair-bound. These cases extend the clinical spectrum associated with anti-ARHGAP26 autoimmunity and suggest that early treatment may be important in patients with this rare syndrome.

PMID: 28601293 [PubMed - in process]

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Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology.

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology.

J Neuroimmunol. 2017 Aug 15;309:12-22

Authors: Hendrickx DAE, van Eden CG, Schuurman KG, Hamann J, Huitinga I

Abstract
HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due to differences in gene regulation, they may identify different activation stages of microglia. Here, we directly compared the expression of HLA-DR, Iba1 and CD68 in microglia with different phenotypes, ranging from ramified to amoeboid, to foamy phagocytizing macrophages, in adjacent sections immunocytochemically double stained for two of the markers. Material was used from patients diagnosed with multiple sclerosis (MS) and Alzheimer's disease (AD) patients and control subjects because together they contain all the microglia activation stages in an acute and a chronic inflammatory setting. We found a similar, yet not identical, overall expression pattern. All three markers were expressed by ramified/amoeboid microglia around chronic active MS lesions, but overlap between HLA-DR and Iba1 was limited. Foamy macrophages in the demyelinating rims of active MS lesions of MS expressed more HLA-DR and CD68 than Iba1. All markers were expressed by small microglia accumulations (nodules) in MS NAWM. Dense core AD plaques in the hippocampus were mostly associated with microglia expressing HLA-DR. Diffuse AD plaques were not specifically associated with microglia at all. These results indicate that microglia markers have different potential for neuropathological analysis, with HLA-DR and CD68 reflecting immune activation and response to tissue damage, and Iba1 providing a marker more suited for structural studies in the absence of pathology.

PMID: 28601280 [PubMed - in process]

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The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway.

The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway.

Iran J Allergy Asthma Immunol. 2017 Apr;16(2):147-158

Authors: Li AL, Sun YQ, Du P, Meng XC, Guo L, Li S, Zhang C

PMID: 28601055 [PubMed - in process]

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From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

J Neuroimmunol. 2017 Aug 15;309:77-81

Authors: Wallwitz U, Brock S, Schunck A, Wildemann B, Jarius S, Hoffmann F

PMID: 28601293 [PubMed - in process]

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The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

Surg Radiol Anat. 2017 Jun 10;:

Authors: Natsis K, Konstantinidis GA, Symeonidis PD, Totlis T, Anastasopoulos N, Stavrou P

PMID: 28601923 [PubMed - as supplied by publisher]

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New Frontiers in Surgical Innovation.

New Frontiers in Surgical Innovation.

Otolaryngol Clin North Am. 2017 Jun 07;:

Authors: Jackson RS, Schmalbach CE

Abstract
It is an exciting time for head and neck surgical innovation with numerous advances in the perioperative planning and intraoperative management of patients with cancer, trauma patients, and individuals with congenital defects. The broad and rapidly changing realm of head and neck surgical innovation precludes a comprehensive summary. This article highlights some of the most important innovations from surgical planning with sentinel node biopsy and three-dimensional, stereolithic modeling to intraoperative innovations, such as transoral robotic surgery and intraoperative navigation. Future surgical innovations, such as intraoperative optical imaging of surgical margins, are also highlighted.

PMID: 28601195 [PubMed - as supplied by publisher]

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A universal bias in adult vowel perception - By ear or by eye.

A universal bias in adult vowel perception - By ear or by eye.

Cognition. 2017 Jun 08;166:358-370

Authors: Masapollo M, Polka L, Ménard L

Abstract
Speech perceivers are universally biased toward "focal" vowels (i.e., vowels whose adjacent formants are close in frequency, which concentrates acoustic energy into a narrower spectral region). This bias is demonstrated in phonetic discrimination tasks as a directional asymmetry: a change from a relatively less to a relatively more focal vowel results in significantly better performance than a change in the reverse direction. We investigated whether the critical information for this directional effect is limited to the auditory modality, or whether visible articulatory information provided by the speaker's face also plays a role. Unimodal auditory and visual as well as bimodal (auditory-visual) vowel stimuli were created from video recordings of a speaker producing variants of /u/, differing in both their degree of focalization and visible lip rounding (i.e., lip compression and protrusion). In Experiment 1, we confirmed that subjects showed an asymmetry while discriminating the auditory vowel stimuli. We then found, in Experiment 2, a similar asymmetry when subjects lip-read those same vowels. In Experiment 3, we found asymmetries, comparable to those found for unimodal vowels, for bimodal vowels when the audio and visual channels were phonetically-congruent. In contrast, when the audio and visual channels were phonetically-incongruent (as in the "McGurk effect"), this asymmetry was disrupted. These findings collectively suggest that the perceptual processes underlying the "focal" vowel bias are sensitive to articulatory information available across sensory modalities, and raise foundational issues concerning the extent to which vowel perception derives from general-auditory or speech-gesture-specific processes.

PMID: 28601721 [PubMed - as supplied by publisher]

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From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

J Neuroimmunol. 2017 Aug 15;309:77-81

Authors: Wallwitz U, Brock S, Schunck A, Wildemann B, Jarius S, Hoffmann F

PMID: 28601293 [PubMed - in process]

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The effect of environmental enrichment in the CaMKIIT286A mutant mouse

Parsley, SL; (2006) The effect of environmental enrichment in the CaMKIIT286A mutant mouse. Doctoral thesis, UCL (University College London). Green open access

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BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

J Voice. 2017 Jun 07;:

Authors: Lou Z, Yu X, Li Y, Duan H, Zhang P, Lin Z

PMID: 28601417 [PubMed - as supplied by publisher]

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Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia

Abstract

Study Objective

To examine the impact of multiple risk alleles for cognitive dysfunction and cardiovascular disease risk on cognitive function, and to determine if these relationships varied by cognitive reserve (CR) or concomitant medication use in patients with schizophrenia.

Design

Cross-sectional study.

Setting

Ambulatory mental health centers.

Patients

A total of 122 adults with a schizophrenia spectrum diagnosis who were maintained on a stable antipsychotic regimen for at least 6 months prior to study enrollment; patients were divided into three CR groups based on years of formal education: no high school completion or equivalent (low-education group [18 patients]); completion of high school or equivalent (moderate-education group [36 patients]; or any degree of post–high school education (high-education group [68 patients]).

Measurements and Main Results

The following pharmacogenomic variants were genotyped for each patient: AGT M268T (rs699), ACE insertion/deletion (or ACE I/D, rs1799752), and APOE ε2, ε3, and ε4 (rs429358 and rs7412). Risk allele carrier status (identified per gene as AGT M268 T carriers, ACE D carriers, and APOE ε4 carriers) was not significantly different among CR groups. The Brief Assessment of Cognition in Schizophrenia (BACS) scale was used to assess cognitive function. The mean ± SD patient age was 43.9 ± 11.6 years. Cardiovascular risk factors such as hypertension and hyperlipidemia diagnoses, and use of antihypertensive and lipid-lowering agents, did not significantly differ among CR groups. Mixed modeling revealed that risk allele carrier status was significantly associated with lower verbal memory scores for ACE D and APOE ε4 carriers, but AGT T carrier status was significantly associated with higher verbal memory scores (p=0.0188, p=0.0055, and p=0.0058, respectively). These results were only significant in the low-education group. Additionally, medication-gene interactions were not significant predictors of BACS scores.

Conclusion

ACE D and APOE ε4 carrier status, independent of medication use, was associated with lower verbal memory scores in patients with schizophrenia who had relatively lower CR, as identified by formal education. These results suggest that increasing CR may be protective against cognitive impairment that may be worsened by select cardiovascular risk alleles in patients with schizophrenia.

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The business development manager as a value creation worker

Smyth, HJ; (2016) The business development manager as a value creation worker. In: Chan, PW and Neilson, CJ, (eds.) Proceedings 32nd Annual ARCOM Conference. (pp. pp. 1069-1078). Association of Researchers in Construction Management (ARCOM): Manchester, UK. Green open access

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Clinical Trial Designs to Support Clinical Utility of Pharmacogenomic Testing

Abstract

Advancing the use of biomarkers and pharmacogenomics has been a key priority area for the Food and Drug Administration (FDA). The FDA offers prescribing recommendations to manage approximately 100 gene-drug interactions, and multiple institutions around the United States and abroad have incorporated genomic testing into patient care. However, the penetration of pharmacogenomic testing remains incomplete. In this perspective, we summarize the evidence streams to support the clinical utility of pharmacogenomic testing and its transition into clinical practice.

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The business development management function: processes at the front of the front end of the management of projects

Smyth, HJ; (2016) The business development management function: processes at the front of the front end of the management of projects. In: Kähkönen, K and Keinänen, M, (eds.) Proceedings of the 20th CIB World Building Congress - Intelligent Built Environment for Life. International Council for Research and Innovation in Building and Construction (CIB): Tampere, Finland.

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Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex

Kikuchi, Y; Attaheri, A; Wilson, B; Rhone, AE; Nourski, KV; Gander, PE; Kovach, CK; Kikuchi, Y; Attaheri, A; Wilson, B; Rhone, AE; Nourski, KV; Gander, PE; Kovach, CK; Kawasaki, H; Griffiths, TD; Howard, MA; Petkov, CI; - view fewer (2017) Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex. PLOS Biology , 15 (4) , Article e2000219. 10.1371/journal.pbio.2000219 . Green open access

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The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

Surg Radiol Anat. 2017 Jun 10;:

Authors: Natsis K, Konstantinidis GA, Symeonidis PD, Totlis T, Anastasopoulos N, Stavrou P

PMID: 28601923 [PubMed - as supplied by publisher]

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The gendering of Nigerian-ness in a Yorbouth scene

King, S; (2006) The gendering of Nigerian-ness in a Yorbouth scene. Doctoral thesis, UCL (University College London). Green open access

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Osteoarthritis and spontaneous fusion of facet joints after percutaneous instrumentation in thoracolumbar fractures

Abstract

Purpose

Methods

Results

Conclusions

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Functional evidence that the self-renewal gene NANOG regulates esophageal squamous cancer development.

Functional evidence that the self-renewal gene NANOG regulates esophageal squamous cancer development.

Biochem Biophys Res Commun. 2017 Jun 07;:

Authors: Li D, Xiang X, Yang F, Xiao D, Liu K, Chen Z, Zhang R, Feng G

Abstract
Cancer cell molecular mimicry of stem cells (SC) follows with enhanced proliferative and renewal capacities. In support, numerous mediators of SC self-renewal have been evinced to exhibit oncogenic potential. More and more researches showed that the embryonic stem cell self-renewal genes express in various cancer cells. In this study, we sought to test the tumorigenic functions of NANOG, particularly, in esophageal cancer (EC). Using quantitative RT-PCR and western blotting, we confirmed that EC cells highly express NANOG mRNA and protein. We then constructed a shRNA-mediated plasmid to knockdown of NANOG mRNA. We observed that NANOG deficiency in Eca109 cells decreased clone formation, cell proliferation, and showed G1 arrest. To further investigate the functions and mechanisms of NANOG in Eca109 cells, we detected the change of multiple signaling molecules when NANOG deficiency. We foud that NANOG deficiency affected multiple genes, particularly, promoted drug-resistance via ABCG2 in Eca109 cells, and caused G1 arrest by down-regulated cyclin D1 (CCND1) expression. The present loss-of-function work, establish the integral role for NANOG in Eca109 cell proliferation, drug resistance, and shed light on its mechanisms of action.

PMID: 28601640 [PubMed - as supplied by publisher]

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The evolution of the lactase persistence phenotype

Mulcare, C; (2006) The evolution of the lactase persistence phenotype. Doctoral thesis, UCL (University College London). Green open access

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The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

Surg Radiol Anat. 2017 Jun 10;:

Authors: Natsis K, Konstantinidis GA, Symeonidis PD, Totlis T, Anastasopoulos N, Stavrou P

PMID: 28601923 [PubMed - as supplied by publisher]

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Prevalence of CYP3A5 Genomic Variances and Their Impact on Tacrolimus Dosing Requirements among Kidney Transplant Recipients in Eastern North Carolina

Abstract

Study Objective

To assess the prevalence of CYP3A5 genomic variances and their impact on tacrolimus dosing requirements among kidney transplant recipients in eastern North Carolina.

Design

Single-center, retrospective cohort study.

Setting

Large tertiary care medical center.

Patients

A total of 162 adults who received a kidney transplant between March 1, 2013, and February 28, 2015, and received oral tacrolimus as part of their maintenance immunosuppression; of these patients, 85 patients expressed a genotype with a CYP3A5*1 variant (CYP3A5*1 group), and 77 patients expressed genotypes with other CYP3A5 variants (nonexpressor group).

Measurements And Main Results

All patients were followed for 1 year posttransplantation. The primary endpoint was the tacrolimus total daily dose (TDD) required to achieve the first therapeutic trough level based on the presence or absence of the CYP3A5*1 variant. The prevalence of different CYP3A5 variants across race-ethnicities in the study cohort was determined by CYP3A5 genotyping for each patient. The CYP3A5*1 and nonexpressor groups did not differ significantly with respect to sex, mean age, or mean weight. The CYP3A5*1 group was largely African-American (93%, p<0.0005) compared with other race-ethnicities. Among the CYP3A5*1 expressors compared with nonexpressors, the mean tacrolimus TDD in milligrams at the first therapeutic tacrolimus level was significantly higher (12 vs 8 mg/day, p≤0.001). Similarly, the mean tacrolimus TDD in milligrams/kilogram was 50% greater among CYP3A5*1 expressors (0.15 vs. 0.1 mg/kg/day, p≤0.0005). The predominant genotypic variants were CYP3A5*3/*3 (33%), CYP3A5*1/*3 (20%), and CYP3A5*1/*1 (19%).

Conclusion

This study illustrates the prevalence of the CYP3A5*1 variant among African-American kidney transplant recipients and the effect of this gene expression on the tacrolimus TDD. Patients with the CYP3A5*1 variant require higher tacrolimus doses, on average, to achieve desirable drug levels. In addition, this study provides transplant clinicians with insight and support to dose tacrolimus more aggressively in African-American kidney transplant recipients who may be at higher risk for both toxicities as well as poor clinical outcomes related to inadequate immunosuppression.

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From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.

J Neuroimmunol. 2017 Aug 15;309:77-81

Authors: Wallwitz U, Brock S, Schunck A, Wildemann B, Jarius S, Hoffmann F

PMID: 28601293 [PubMed - in process]

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BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

J Voice. 2017 Jun 07;:

Authors: Lou Z, Yu X, Li Y, Duan H, Zhang P, Lin Z

PMID: 28601417 [PubMed - as supplied by publisher]

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Innovation and the co-creation of value in construction

Smyth, HJ; Razmdoost, K; Kusuma, I; (2016) Innovation and the co-creation of value in construction. In: RICS COBRA 2016: The Construction, Building and Real Estate Research Conference of the Royal Institution of Chartered Surveyors. Royal Institution of Chartered Surveyors (RICS): Toronto, Canada.

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Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder associated with esophageal cancer.

Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder associated with esophageal cancer.

J Neuroimmunol. 2017 Aug 15;309:38-40

Authors: Kon T, Ueno T, Suzuki C, Nunomura J, Igarashi S, Sato T, Tomiyama M

Abstract
Autoimmune diseases are sometimes associated with neoplasms. A 70-year-old Japanese woman with myelitis, seropositive for aquaporin-4 (AQP4) antibody, was diagnosed with neuromyelitis optica spectrum disorder (NMOSD); thereafter an esophageal squamous cell carcinoma was identified. Immunohistochemically, her cancer was anti-AQP4 antibody negative. Her symptoms, imaging findings and AQP4 titer markedly improved with corticosteroid and anti-cancer therapies. Although AQP4 may be a paraneoplastic antigen, paraneoplastic syndrome could not be definitively diagnosed in this case. Nevertheless, this is the first report of an association between AQP4 antibody-seropositive NMOSD and esophageal cancer. The possibility of underlying malignancy should be considered in patients diagnosed with NMOSD.

PMID: 28601284 [PubMed - in process]

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BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

BMI May Be the Risk Factor for Arytenoid Dislocation Caused by Endotracheal Intubation: A Retrospective Case-Control Study.

J Voice. 2017 Jun 07;:

Authors: Lou Z, Yu X, Li Y, Duan H, Zhang P, Lin Z

PMID: 28601417 [PubMed - as supplied by publisher]

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Response to DC Whiteman, CM Olsen and AC Green: In-Deed Wise To Get Some Sensible Sun Exposure

Abstract

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A phase I study of olaparib in addition to cisplatin-based concurrent chemoradiotherapy for patients with high risk locally advanced squamous cell carcinoma of the head and neck (HNSCC)

Forster, M; Mendes, R; Harrington, K; Guerrero-Urbano, T; Baines, H; Spanswick, V; Ensell, L; Forster, M; Mendes, R; Harrington, K; Guerrero-Urbano, T; Baines, H; Spanswick, V; Ensell, L; Hartley, J; Adeleke, S; Gougis, P; Leader, D; Lopes, A; Teague, J; Forsyth, S; Beare, S; - view fewer (2016) A phase I study of olaparib in addition to cisplatin-based concurrent chemoradiotherapy for patients with high risk locally advanced squamous cell carcinoma of the head and neck (HNSCC). Presented at: 2016 ASCO Annual Meeting, Chicago, IL, USA. Green open access

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Assessment of evidence-based practice among hospital pharmacists in Saudi Arabia: attitude, awareness, and practice

Abstract

Background Many studies have previously looked at the perceptions, attitude, and use of Evidence-based Practice (EBP) among healthcare providers. However, limited data is available on the implementation of EBP among pharmacists in general, and Saudi Arabia in particular. Objective To evaluate the awareness, attitude, and practice of EBP among hospital practicing pharmacists in Saudi Arabia. Setting Secondary and tertiary care hospitals in Saudi Arabia with a bed capacity of ≥200 Methods This is a cross sectional, survey-based study where a validated selfadministrated questionnaire was utilized. Pharmacists working in secondary and tertiary care hospitals with a bed capacity of ≥200 were targeted. The descriptive data consisted of percentages for discrete and medians for continuous statistics. Results The survey was distributed to a total of 1136 pharmacists. Total number of respondents is 228 which represent a response rate of 20%. Most of them (75% median score = 8) have a positive attitude toward EBP. In addition to clinical expertise, only 48.6% of them were able to identify EBP resource as the second component of EBP concept, while only 1.7% of the respondents were able to identify patient preference as a third component. Lack of personal time, critical appraisal skills, and resources, (40%, 15.6% and 13.9% respectively) are considered as the major barriers to implementing EBP in pharmacy. Conclusion The majority of pharmacists in Saudi Arabia hold a positive attitude of EBP. Unfortunately, most of pharmacists do not consider patients' values as a component of EBP. The major barriers to practicing EBP are lack of personal time, critical appraisal skills, and resources availability.

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The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

The accessory tendon of extensor hallucis longus muscle and its correlation to hallux valgus deformity: a cadaveric study.

Surg Radiol Anat. 2017 Jun 10;:

Authors: Natsis K, Konstantinidis GA, Symeonidis PD, Totlis T, Anastasopoulos N, Stavrou P

PMID: 28601923 [PubMed - as supplied by publisher]

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Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia

Abstract

Study Objective

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Cross-sectional study.

Setting

Ambulatory mental health centers.

Patients

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Neuropraxia following resection of a retroperitoneal liposarcoma.

Neuropraxia following resection of a retroperitoneal liposarcoma.

Int J Surg Case Rep. 2017 Jun 01;36:170-174

Authors: Tsiao S, Aydin N, Misra S

Abstract
BACKGROUND: This is a unique case of neuropraxia of femoral nerve seen after resection of retroperitoneal liposarcoma which has not been reported before in the literature.
INTRODUCTION: Neuropraxia, a transient paralysis due to blockage of nerve conduction, commonly associated with athletes and orthopedic procedures, has not been previously reported as a complication following resection of retroperitoneal sarcoma.
CASE: This is an 81-year-old female who, on CT for evaluation of her atherosclerosis, was found to have an incidental right-sided retroperitoneal mass extending from the right renal capsule inferiorly through the inguinal canal. At this point, the patient reported mild right sided abdominal pain and right lower back pain, but reported no neuromotor deficits of the right lower extremity. Given the symptoms of the patient as well as the size, location and the density of the lesion, surgical intervention was pursued. On exploration, the lipomatous lesion, suggestive of liposarcoma, was invading the right genitofemoral nerve and ilioinguinal nerve which were sacrificed to ensure a complete oncologic resection. Following complete removal of the mass, she developed right side femoral nerve neuropraxia, suffering complete loss of motor function in the femoral distribution. Pathology revealed the mass to be a low grade liposarcoma.
DISCUSSION: The patient required only physical therapy and oral prednisone following surgery for treatment of the neuropraxia. She responded well and has regained significant neuromotor function of the affected limb. Cases presenting with post-resection neurological sequelae without any known intraoperative nerve injury may respond very well to conservative treatment. Hence, it is very important to collaborate with Neurology and Physical Therapy to achieve best possible outcome.

PMID: 28601782 [PubMed - as supplied by publisher]

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A phase I study of olaparib in addition to cisplatin-based concurrent chemoradiotherapy for patients with high risk locally advanced squamous cell carcinoma of the head and neck (HNSCC)

Forster, M; Mendes, R; Harrington, K; Guerrero-Urbano, T; Baines, H; Spanswick, V; Ensell, L; Forster, M; Mendes, R; Harrington, K; Guerrero-Urbano, T; Baines, H; Spanswick, V; Ensell, L; Hartley, J; Adeleke, S; Gougis, P; Leader, D; Lopes, A; Teague, J; Forsyth, S; Beare, S; - view fewer (2016) A phase I study of olaparib in addition to cisplatin-based concurrent chemoradiotherapy for patients with high risk locally advanced squamous cell carcinoma of the head and neck (HNSCC). Presented at: 2016 ASCO Annual Meeting, Chicago, IL, USA. Green open access

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Αρχειοθήκη ιστολογίου

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Δευτέρα 12 Ιουνίου 2017

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