Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174: 06/20/17

Τρίτη 20 Ιουνίου 2017

Muscle activity and masticatory efficiency with bilateral extension base removable partial dentures with different cusp angles

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Mahmoud K. AL-Omiri
Statement of problemWhether masticatory efficiency and electromyographic activity are influenced by type of artificial teeth and food is unclear.PurposeThe purpose of this clinical study was to evaluate the influence of extension base removable partial dentures (RPDs) with different cusp angles: anatomic (33 degrees), semianatomic (20 degrees), and nonanatomic (0 degrees) teeth on masticatory efficiency and muscle activity during the mastication of test foods with different textures.Material and methodsTwelve participants with RPDs were selected to perform masticatory efficiency and electromyographic tests. Surface electromyograms (EMGs) were used to record the activities of the masseter and temporalis muscles during the mastication of different types of test foods. The maximal voltage and duration were measured on the integrated EMG signal in each muscle during food mastication, and the mean reading of both sides was then recorded. Analysis of variance and the Tukey post hoc test were used to perform statistical analyses (α=.05).ResultsThe masticatory efficiency of RPDs with nonanatomic teeth was significantly inferior to that of RPDs with anatomic and semianatomic teeth (P<.05). However, masticatory efficiency did not differ between anatomic and semianatomic teeth (P>.05). Also, muscle activity (according to EMG) with RPDs with NA teeth was significantly higher than that with anatomic and semianatomic teeth (P<.05).ConclusionsRPDs with NA teeth were associated with higher EMG muscle activity and reduced masticatory efficiency than anatomic or semianatomic teeth.

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Effect of different restorative crown and customized abutment materials on stress distribution in single implants and peripheral bone: A three-dimensional finite element analysis study

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Necati Kaleli, Duygu Sarac, Safak Külünk, Özgür Öztürk
Statement of problemIn recent years, the use of resin-matrix ceramics and polyetheretherketone (PEEK) abutments has been suggested to absorb excessive stresses on dental implants. However, only a few studies have evaluated the effect of these materials on stress distribution in implants and peripheral bone structure.PurposeThe purpose of this finite element analysis was to evaluate the biomechanical behaviors of resin-matrix ceramics and PEEK customized abutments in terms of stress distribution in implants and peripheral bone.Material and methodsThree-dimensional (3D) models of a bone-level implant system and a titanium base abutment were created by using the standard tessellation language (STL) data of original implant components. An anatomic customized abutment and a maxillary right second premolar crown were then modeled over the titanium base abutment. A bone block representing the maxillary right premolar area was created, and the implant was placed in the bone block with 100% osseointegration. Six different models were created according to combinations of restoration materials (translucent zirconia [TZI], lithium disilicate glass ceramic [IPS], polymer-infiltrated hybrid ceramic [VTE]), and customized abutment materials (PEEK and zirconia). In each model, the implants were loaded vertically (200 N) and obliquely (100 N). The stress distribution in the crown, implant, and abutments was evaluated through the von Mises stress analysis, and the stress distribution in the peripheral bone was examined through the maximum and minimum principal stress analyses.ResultsThe oblique load resulted in high stress values in the implant components, restorative crown, and cortical bone. Low stress values were observed in the VTE crowns. Zirconia customized abutments exhibited higher stress values than PEEK customized abutments. The stress distributions in the implant and peripheral bone were similar in all models.ConclusionsChanges in restoration and customized abutment material did not affect stress distribution in the implant and peripheral bone.

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Muscle activity and masticatory efficiency with bilateral extension base removable partial dentures with different cusp angles

Experimental evaluation of stress distribution with narrow diameter implants: A finite element analysis

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Sezgi Cinel, Ersan Celik, Elcin Sagirkaya, Onur Sahin
Statement of problemNarrow diameter implants were developed to allow placement in narrow alveolar ridges. Clinicians may have concerns about the durability and function of such implants.PurposeThe purpose of this finite element study was to compare the stress values occurring on the implant and at the implant bone interface after the application of the static and dynamic forces on narrow diameter, titanium and titanium-zirconia implants in the maxillary and mandibular second premolar region.Material and methodsTitanium (Ti) and titanium-zirconium (Ti-Zr) narrow diameter implants (3.3 mm in diameter, 10 mm in length) were simulated in the maxillary and mandibular second premolar region, and metal-ceramic crown restorations were designed. Forces of 100 N were applied to crowns in a vertical and oblique (45-degree angle to the long axis) direction. Maximum and minimum principal stresses in the cortical and trabecular bone and the von Mises stresses and fatigue strength of the implants were evaluated with 3-dimensional finite element analysis.ResultsIn vertical and oblique static loading, Ti and Ti-Zr implants showed similar stress distribution within the same jaw models. However, the von Mises stresses in Ti-Zr implants were slightly higher than for Ti implants in all models. In oblique static and dynamic loading, all stresses were found higher than vertical loading, and fatigue failure results were found to be more critical than vertical forces.ConclusionsBased on a numerical simulation, Ti and Ti-Zr alloys can be used successfully as narrow diameter implants in the second premolar area.

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Experimental evaluation of stress distribution with narrow diameter implants: A finite element analysis

Multidisciplinary approach to oral rehabilitation with dental implants after gunshot injury: A clinical report

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Lélis Gustavo Nícoli, Suzane Cristina Pigossi, Raphael Ferreira de Souza Bezerra Araújo, Cláudio Marcantonio, Élcio Marcantonio, Élcio Marcantonio
This clinical report describes a multidisciplinary approach to treat a patient with edentulism and a severe anatomic defect in the mandible caused by a gunshot injury by using an implant-fixed complete dental prosthesis. An immediate loading interim implant-fixed complete dental prosthesis in the mandible associated with a maxillary removable complete denture prosthesis was initially provided to restore the intermaxillary relation. Nasal floor elevation and maxillary sinus augmentation were subsequently performed to increase the maxillary bone volume. Definitive implant-fixed complete dental prostheses were placed in both arches in order to rehabilitate this initially compromised anatomic condition, which ensured patient satisfaction and improvement in masticatory function and esthetics.

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Multidisciplinary approach to oral rehabilitation with dental implants after gunshot injury: A clinical report

Comments regarding: Cooper LF, Stanford C, Feine J, McGuire M. Prospective assessment of CAD-CAM zirconia abutment and lithium disilicate crown restorations: 2.4 year results. J Prosthet Dent 2016;116:33-9

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Kelvin I. Afrashtehfar, Raphael Freitas de Souza

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Comments regarding: Cooper LF, Stanford C, Feine J, McGuire M. Prospective assessment of CAD-CAM zirconia abutment and lithium disilicate crown restorations: 2.4 year results. J Prosthet Dent 2016;116:33-9

Fracture resistance of CAD-CAM monolithic ceramic and veneered zirconia molar crowns after aging in a mastication simulator

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Merve Bankoğlu Güngör, Secil Karakoca Nemli
Statement of problemThe demand for ceramic restorations has increased over the past years, and now various machinable materials can be used for chairside computer-aided design and computer aided manufacturing (CAD-CAM) systems. Limited studies of these new materials make it difficult to evaluate their mechanical performance, advantages, and limitations.PurposeThe purpose of this in vitro study was to investigate the fracture resistance of CAD-CAM monolithic ceramic and veneered zirconia molar crowns after thermomechanical aging.Material and methodsA mandibular first molar tooth was prepared, and 12 different experimental groups were generated (n=10). An aging procedure was performed by subjecting the specimens to 12×10⁵ mechanical cycles and 5000 thermal cycles. Survival analysis was performed according to the thermomechanical aging. The fracture resistance (load at fracture) of all specimens was evaluated with 1-way analysis of variance after the means had been compared using the Tukey honest significant difference test and Weibull distributions of the experimental groups (α=.05).ResultsAccording to the results, the differences between the fracture resistance of the groups were found to be significant. Restorations in the dual network ceramic crown group fractured catastrophically during thermomechanical aging. In all groups, the highest value was found for monolithic zirconia, followed by monolithic lithium disilicate crowns (P<.05). Both of the monolithic crowns made of lithium disilicate derivates and zirconia crowns veneered with lithium disilicate ceramic showed no differences from each other (P>.05). The Weibull modulus (m) ranged from 4.22 to 8.58, and conventionally veneered and overpressed zirconia showed the lowest Weibull modulus values among the tested groups, indicating greater variation of the data.ConclusionsThe highest fracture resistance was observed for yttria-stabilized zirconia crowns, followed by lithium disilicate derivates. Veneered zirconia restorations generally showed lower resistance than these ceramics. The dual network ceramic crowns fractured during thermomechanical aging.

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Fracture resistance of CAD-CAM monolithic ceramic and veneered zirconia molar crowns after aging in a mastication simulator

Titration technique using endoscopy for an oral appliance treatment of obstructive sleep apnea

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Kentaro Okuno, Kazuki Ikai, Erika Matsumura-Ai, Takafumi Araie
The degree of mandibular protrusion for an oral appliance (OA) should be customized for each patient with obstructive sleep apnea (OSA). This article describes the mandibular titration technique for OAs to effectively treat OSA by using endoscopy to evaluate the change in the airway at the velopharynx. This technique may minimize the degree of mandible protrusion and contribute to both the efficacy of and compliance with OA therapy.

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Titration technique using endoscopy for an oral appliance treatment of obstructive sleep apnea

Interim rehabilitation of occlusal vertical dimension using a double-crown-retained removable dental prosthesis with polyetheretherketone framework

Publication date: Available online 20 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Sebastian Hahnel, Christian Scherl, Martin Rosentritt
Polyetheretherketone (PEEK) is a polymeric material that has recently been introduced in dentistry and can be used as framework material for fixed and removable dental prostheses. This clinical report describes the fabrication of a double-crown–retained prosthesis with a PEEK framework in a patient with a substantially diminished occlusal vertical dimension. The insertion of the removable dental prosthesis with a PEEK framework resulted in the functional and esthetic rehabilitation of the patient; however, removable dental prostheses fabricated from PEEK should currently be regarded as interim restorations because of the limited available scientific evidence.

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Interim rehabilitation of occlusal vertical dimension using a double-crown-retained removable dental prosthesis with polyetheretherketone framework

Unifying mechanism in the initiation of breast cancer by metabolism of estrogen (Review).

Authors: Wen C, Wu L, Fu L, Wang B, Zhou H Abstract Excessive exposure to estrogen is associated with increased risk of breast cancer. The mechanisms of carcinogenesis in the breast caused by estrogen metabolism include formation of depurinating adducts which are released from DNA to generate apurinic sites, and production of reactive oxygen species (ROS). Excess ROS not only exerts genotoxicity by indirectly increasing genomic instability, but also stimulates progression of mammary carcinogenicity by inducing a redox‑associated signaling pathway. Estrogen metabolism enzymes serve an important role in estrogen metabolism. Alterations in the expression and activity of estrogen metabolism enzymes may influence estrogen metabolism homeostasis. The present review discusses the proces...

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Effects of salinomycin and 17 ‑AAG on proliferation of human gastric cancer cells in vitro.

In conclusion, the individual use of salinomycin and combined use with 17‑AAG may significantly inhibit SGC‑7901 gastric cancer cell proliferation and induce cell apoptosis. The potential mechanisms may be associated with upregulation of Fas‑L and downregulation of NF‑κB. These results provide a basis for the potential use of salinomycin in gastric cancer treatment. PMID: 28627587 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)

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Integrated analysis of the potential roles of miRNA ‑mRNA networks in triple negative breast cancer.

Integrated analysis of the potential roles of miRNA‑mRNA networks in triple negative breast cancer. Mol Med Rep. 2017 Jun 09;: Authors: Zhu H, Dai M, Chen X, Chen X, Qin S, Dai S Abstract Triple negative breast cancer (TNBC) is a type of breast cancer where the tumor cells are negative for the estrogen, progesterone and human epidermal growth factor 2 receptors. To date, expression profiling of microRNA (miRNA/miR) and mRNA sequences have been widely applied for the diagnosis of TNBC. In the present study, an integrated analysis of miRNA‑mRNA profiling arrays was performed. A total of five dysregulated miRNAs in patients with TNBC were identified, including upregulated miR‑558 expression and downregulated miR‑320d‑1, miR‑548v, miR‑99a and miR‑21 expres...

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Hypoxia inducible factor-1 α regulates autophagy via the p27-E2F1 signaling pathway.

Hypoxia inducible factor-1α regulates autophagy via the p27-E2F1 signaling pathway. Mol Med Rep. 2017 Jun 15;: Authors: Wang P, Long M, Zhang S, Cheng Z, Zhao X, He F, Liu H, Ming L Abstract Autophagy is a highly conserved process by which the cell contents are delivered to lysosomes for degradation, or are used to provide macromolecules for energy generation under conditions of nutritional starvation. It has previously been demonstrated that cancer cells in hypoxic regions, with an oxygen concentration below the normal physiological level, express hypoxia inducible factor (HIF)‑1α, in order to adapt and survive. HIF‑1α is important in the regulation of oxygen homeostasis and the transcription of hundreds of genes in response to conditions of hypoxia, hence main...

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Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3 β signaling pathway.

In conclusion, an altered TRAF6‑TAK1 axis and its corresponding downstream AKT/GSK3β signaling molecules may contribute to breast cancer progression. Therefore, TRAF6 may represent a potential therapeutic target for the treatment of breast cancer. PMID: 28627683 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)

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Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells.

Authors: Lee YJ, Lee SH Abstract Sulforaphane (SFN) is an isothiocyanate compound derived from glucoraphanin, which is found in cruciferous vegetables, and has been heralded as a chemopreventive and/or chemotherapeutic agent. The present study investigated the effects of SFN on enhancing the anticancer role of cisplatin (cis-dichlorodiammineplatinum; CDDP) in H‑28 malignant mesothelioma cells. At concentrations demonstrating limited toxicity in MeT‑5A normal human mesothelial cells, combination treatment with the two compounds exhibited synergistic growth‑inhibiting and apoptosis‑promoting activities, as demonstrated by a series of proapoptotic events, including reactive oxygen species accumulation, loss of mitochondrial membrane potential, upregulation of p53 expression, i...

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microRNA ‑205 acts as a tumor suppressor and directly targets YAP1 in glioma.

microRNA‑205 acts as a tumor suppressor and directly targets YAP1 in glioma. Mol Med Rep. 2017 Jun 09;: Authors: Ji T, Zhang X, Li W Abstract Glioma is the most common form of primary malignant tumor that occurs in the central nervous system. The underlying molecular mechanism of the carcinogenesis and progression of glioma remains to be elucidated. It is well‑established that microRNAs (miRs) are associated with the regulation of glioma initiation and progression, and may represent a novel effective therapeutic strategy for the treatment of glioma. In the present study, the expression, roles and molecular mechanisms of miR‑205 in glioma were investigated. The expression levels of miR‑205 in glioma tissues, normal brain tissues, human glioma and normal HEB glia...

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A Study of BMS-986205 Given in Combination With Nivolumab in Patients With Advanced Tumors

Condition: Advanced Cancer Interventions: Drug: BMS-986205; Biological: Nivolumab Sponsor: Bristol-Myers Squibb Not yet recruiting - verified June 2017 (Source: ClinicalTrials.gov)

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Breast and Ovarian Cancer Risks Quantified for BRCA Mutation Carriers (FREE)

By the Editors Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Carriers of the BRCA mutation have a … (Source: Physician's First Watch current issue)

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Reconstruction of the bony chin using sagittal split osteotomies of the remaining mandible ─a new technique for a special indication: Case report

In this report, a new technique is described using pedicled bone flaps from both sagittally split mandibular stumps following chin resection. These flaps were pedicled on the mylohyoid muscles and advanced to restore the continuity of the mandible. An advantage of this procedure was minimization of the soft tissue defect, making repair easier. Morbidity of the resection and reconstruction was thus reduced, and recovery of the patient was very quick. (Source: Journal of Cranio Maxillofacial Surgery)

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NCI Center for Strategic Scientific Initiatives (CCSI) Science Day 2017

Since 2013, the NCI Center for Strategic Scientific Initiatives (CSSI) has hosted Science Day meetings to convene extramural investigators and NIH/NCI program staff with the goal of facilitating scientific conversations and identifying needs and opportunities across cancer research. The 2017 meeting is focused on cancer technology needs over the next 5-10 years and is aligned with three thematic areas: health data and computation, prevention and early detection, and immunotherapy. The meeting is supported by the CSSI Office of the Director, Office of Cancer Nanotechnology Research, Office of Cancer Clinical Proteomics Research, and Knowledge Management and Special Projects Branch, with input from across the NCI divisions, offices, and centers.Air date: 6/28/2017 9:00:00 AM (Source: Videoca...

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NCI Board of Scientific Advisors and the National Cancer Advisory Board - June 2017 (Day 2)

The 9th Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory BoardAir date: 6/21/2017 9:00:00 AM (Source: Videocast - All Events)

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NCI Board of Scientific Advisors and the National Cancer Advisory Board - June 2017 (Day 1)

The 9th Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory BoardAir date: 6/20/2017 8:30:00 AM (Source: Videocast - All Events)

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MIF Signaling Pathway as a Pathogenic Driver and Potential Target in Pancreatic Cancer

NCI ' s Center for Cancer Research (CCR) Grand Rounds Dr. Hussain is a Tenure Track investigator in the Laboratory of Human Carcinogenesis, CCR, NCI. He received his Ph.D. degree in Cancer Biology from Jawaharlal Nehru University, New Delhi, India. Dr. Hussain received his post-doctoral training at the Swiss Institute for Cancer Research (ISREC), Lausanne, Switzerland, and the Laboratory of Human Carcinogenesis, CCR and then worked as a Clinical Instructor at the University of Maryland School of Medicine in Baltimore. He was appointed as a Tenure Track investigator at the Laboratory of Human Carcinogenesis in 2009. Dr. Hussain ' s research program investigates the underlying mechanisms of pancreatic cancer progression and disease aggressiveness with a focus on the role of inflammatory ...

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Triplet Combo Active in Lenalidomide/Refractory Multiple Myeloma

Combining bendamustine, pomalidomide, and dexamethasone achieved a promising overall response rate in patients with heavily pretreated lenalidomide refractory multiple myeloma, according to the results of a phase I/II trial. (Source: CancerNetwork)

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Triplet Combo Active in Lenalidomide/Refractory Multiple Myeloma

Age-specific overall risk of breast, ovarian cancer among women with BRCA1/2 genetic mutations

(The JAMA Network Journals) Researchers conducted an analysis that included nearly 10,000 women with the BRCA1 or BRCA2 genetic mutations to estimate the age-specific risk of breast or ovarian cancer for women with these mutations, according to a study published by JAMA. (Source: EurekAlert! - Cancer)

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Family history and location of genetic fault affect risk for carriers of cancer genes

(University of Cambridge) A large scale study of women carrying faults in important cancer genes should enable doctors to provide better advice and counselling for treatments and lifestyle changes aimed at reducing this risk. (Source: EurekAlert! - Cancer)

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When Is Risk Highest for Women With Breast Cancer Gene Mutations?

Study narrows down peak times, possibly aiding in preventive treatment decisions (Source: The Doctors Lounge - Oncology)

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Could Certain Hair Dyes, Relaxers Raise Breast Cancer Risk?

Study findings differ by race, but one expert says they're inconclusive (Source: The Doctors Lounge - Oncology)

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Imaging of Pelvis Has Limited Value in Hepatocellular Cancer

More than 80 percent of patients had no findings on MRI or CT; findings rarely linked to metastatic dz (Source: The Doctors Lounge - Oncology)

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NSAID Use, Survival Link Varies With KRAS Status in CRC Patients

Use of NSAIDs tied to better survival for colorectal cancer survivors with KRAS wild - type tumors (Source: The Doctors Lounge - Oncology)

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Many Chronic Illnesses Linked to Suicide Risk

Odds 9 times higher for people with traumatic brain injury, study suggests (Source: Cancercompass News: Other Cancer)

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Could Certain Hair Dyes, Relaxers Raise Breast Cancer Risk?

Study findings differ by race, but one expert says they're inconclusive (Source: Cancercompass News: Breast Cancer)

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When Is Risk Highest for Women With Breast Cancer Gene Mutations?

Study narrows down peak times, possibly aiding in preventive treatment decisions (Source: Cancercompass News: Breast Cancer)

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Childhood Chemo May Have Lasting Effects on Memory

Study found timing of treatment seemed to play a role (Source: Cancercompass News: Other Cancer)

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Response to the letter to the editor regarding ‘‘Evaluation of vitamin D levels in children with primary epistaxis’’

We would like to thank Mr. Akdo ğan and Mr. Hızal for their interest in our study entitled ''Evaluation of vitamin D levels in children with primary epistaxis,'' and we appreciate their valuable comments [1]. (Source: International Journal of Pediatric Otorhinolaryngology)

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Comparison of home sleep apnea testing versus laboratory polysomnography for the diagnosis of obstructive sleep apnea in children

Obstructive sleep apnea (OSA) affects 1-5% of pediatric patients. Laboratory polysomnography is expensive, not always available, and is inconvenient for patients. Our study investigates the diagnostic ability of an unattended ambulatory monitor for the diagnosis of pediatric OSA. (Source: International Journal of Pediatric Otorhinolaryngology)

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GSE100223 Assessing the developmental and malignant potential of human pluripotent stem cells by RNA-seq analysis of Teratomas

Contributor : Paul RobsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe International Stem Cell Initiative compared three common approaches for assessing pluripotent stem cells (PSC). The formation of teratomas in vivo, or embryoid bodies (EB) in vitro, provide direct tests of differentiation, whereas PluriTest predicts pluripotency through bioinformatic analysis of transcriptomes of undifferentiated cells. We studied the teratomas by histology and TeratoScore, which analyzes gene expression in each tumor. For the EB assay, we assessed differentiation under neutral conditions and under conditions promoting differentiation to ectoderm, mesoderm, or endoderm lineages. Comparison of each method showed that all assays predict pluripotency, but they h...

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Otoplasty for prominent ears – demographics and surgical timing in different populations

Prominent ears are seen in approximately 5% of the population. This benign condition can be treated surgically to reduce or prevent psychological and social problems, most commonly in children before the start of school. Our aim was to examine the demographic characteristics of patients undergoing prominent ear surgery in Finland, and compare findings with international data. (Source: International Journal of Pediatric Otorhinolaryngology)

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Adenotonsillectomy outcomes in children with sleep apnea and narcolepsy

To identify improvements in daytime sleepiness following adenotonsillectomy in children with non-severe obstructive sleep apnea and narcolepsy. (Source: International Journal of Pediatric Otorhinolaryngology)

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Transmission analysis of TGFB1 gene polymorphisms in non-syndromic cleft lip with or without cleft palate

Transforming growth factor beta1 (TGF- β1) plays a significant role in craniofacial development. Previous linkage studies reported that the TGF-β1-locus at 19q13.1 harbour predisposing genes for non-syndromic oral clefts. In the present study case parents triads were evaluated to find the transmission effects of genetic variants in TGF - β1 towards non-syndromic cleft lip or palate (NSCL/P). (Source: International Journal of Pediatric Otorhinolaryngology)

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Letter to the editor regarding ‘Evaluation of vitamin D levels in children with primary epistaxis’

We are writing in reference to the paper titled ''Evaluation of vitamin D levels in children with primary epistaxis'' [1]. Almis et al. aimed to investigate whether there is a relationship between serum 25-hydroxy vitamin D [25(OH)D 3] values and incidences of primary epistaxis among children. For that purpose, the authors compared 42 pri mary epistaxis cases and 55 matched controls, retrospectively, and found that serum 25(OH)D 3 values were lower in the primary epistaxis group compared with the healthy control group. (Source: International Journal of Pediatric Otorhinolaryngology)

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Utilization and trends in surgical instrument use in pediatric adenotonsillectomy

Examine trends in surgical instrument usage for pediatric adenotonsillectomy. (Source: International Journal of Pediatric Otorhinolaryngology)

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The maximum standardized uptake value increment calculated by dual-time-point (18)F-fluorodeoxyglucose positron emission tomography predicts survival in patients with oral tongue squamous cell carcinoma.

Authors: Yonezawa N, Minamikawa T, Kitajima K, Takahashi Y, Sasaki R, Nibu KI, Komori T Abstract The aim of this study was to investigate the prognostic value of dual-time-point (DTP) (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) imaging in primary oral tongue squamous cell carcinoma (OTSCC). The study included 52 patients who underwent preoperative (18)F-FDG PET scans at two time points, namely 1 h and 2 h after injection. The following PET parameters were calculated: maximum standardized uptake value (SUVmax) for both time points (SUV early, SUV delayed); retention index (RI); and SUVmax increment (ΔSUVmax). Receiver operating characteristic (ROC) curve analysis was performed to define the optimal cutoff point for these parameters. Overall survival was ca...

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Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer.

Authors: Miyauchi R, Itoh Y, Kawamura M, Hirakawa A, Shibata K, Kajiyama H, Nakahara R, Kubota S, Ito J, Okada T, Kikkawa F, Naganawa S Abstract The purpose of this retrospective study was to analyze data in patients with stage IB-IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy (CCRT) with high dose cisplatin and fluorouracil as postoperative adjuvant therapy. Between February 2003 and November 2011, 76 patients with FIGO stage IB-IIB cervical cancer were analyzed. Seventy patients were treated with postoperative CCRT and 6 patients were treated with radiation therapy alone. Data related to overall survival (OS), disease-free survival (DFS), toxicity, and failure pattern were analyzed. The median patient age was 45 years (range, 20-80 years). The medi...

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Underlying Cause of Death Recorded during 2013 to 2015 at a Tertiary General Hospital in Vientiane Capital, Lao PDR.

This study aimed to report the underlying cause of death in a tertiary general hospital (Mittaphab Hospital) in Vientiane capital. Mittaphab hospital is a governmental teaching hospital with 300 beds for inpatient services specialized in orthopedics, neurology, and hemodialysis. Since a children hospital exists beside Mittaphab Hospital, severe pediatric cases are referred to the child hospital. HIV-positive cases and sputum positive tuberculosis are also transferred to the other specialized hospitals. All of the subjects in this study were patients who died in 2013-2015 at Mittaphab Hospital. Paper-based medical charts were examined by a medical doctor and staff from the medical records division. This chart review revealed that 1,509 patients (1,006 males and 503 females) died in this hos...

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A case of API2-MALT1-positive gastric MALT lymphoma with concomitant diffuse large B-cell lymphoma.

Authors: Fujita A, Tajika M, Tanaka T, Ishihara M, Hirayama Y, Mizuno N, Hara K, Hijioka S, Imaoka H, Yoshida T, Okuno N, Hieda N, Hirayama T, Shibuya H, Kondo H, Suzuki H, Toriyama K, Yatabe Y, Yamao K, Niwa Y Abstract API2-MALT1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma is thought to transform to diffuse large B-cell lymphoma (DLBCL) rarely. A 69-year-old man presented with epigastralgia. Esophagogastroduodenoscopy showed multiple ulcerations in the stomach. Endoscopic biopsies revealed MALT lymphoma, with Helicobacter pylori infection. The patient underwent eradication therapy with no improvement, and was thereafter followed without additional therapy at his request. Twelve years after initial diagnosis, follow-up...

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A case of metachronous left ovarian metastasis 8 years after surgery for cecal cancer and right ovarian metastasis: Report of a case.

Authors: Shigeyoshi I, Komori K, Kinoshita T, Oshiro T, Ito S, Abe T, Senda Y, Misawa K, Ito Y, Uemura N, Natsume S, Kawakami J, Ouchi A, Tsutsuyama M, Hosoi T, Akazawa T, Hayashi D, Tanaka H, Yatabe Y, Shimizu Y Abstract Metachronous ovarian metastasis of colorectal adenocarcinoma is mostly identified within 3 years. Here we present a case of a 64-year-old woman with cecal cancer who underwent right oophorectomy for ovarian metastasis. Imaging was performed because of abdominal bloating; it detected a swollen right ovary with ascites. On laparotomy, a right ovarian tumor and cecal cancer were identified. After right oophorectomy, a diagnosis of unilateral ovarian metastasis from colon cancer was made. One month later, right hemicolectomy was performed. Eight years after initial su...

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(11)C-Choline positive but (18)F-FDG negative pancreatic metastasis from renal cell carcinoma on PET.

We report a 61-year-old woman with a metastatic pancreatic tumor from renal cell carcinoma, measuring 35×40 mm. PET scans demonstrated accumulation of (11)C-choline in the metastatic pancreatic tumor, but no accumulation of (18)F-FDG. Choline PET/CT may play a useful and complementary imaging modality, especially when FDG-PET/CT does not show expected findings or when the evaluation of tumor viability is needed, in patients with renal cell carcinoma. PMID: 28626263 [PubMed - in process] (Source: Nagoya Journal of Medical Science)

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Multi-center rater-blinded study of early intervention with the Hand Incubator for breast cancer-related lymphedema (the BEAT-EDEMA trial): Proposal of a research protocol.

This study may help establish a standard treatment for postoperative lymphedema. PMID: 28626257 [PubMed - in process] (Source: Nagoya Journal of Medical Science)

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Polymer nanoassemblies with hydrophobic pendant groups in the core induce false positive siRNA transfection in luciferase reporter assays

This study elucidates a cause of the false positive effect in luciferase assays by using polymer nanoassemblies (PNAs) made from PEG, PEI, poly-(l-lysine) (PLL), palmitate (PAL), and deoxycholate (DOC): PEG-PEI (2P), PEG-PEI-PAL (3P), PEG-PLL (2P'), PEG-PLL-PAL (3P'), and PEG-PEI-DOC (2PD). In vitro transfection and western blot assays of luciferase using a colorectal cancer cell line expressing luciferase (HT29/LUC) concluded that 2P and 2P' caused no luciferase expression reduction while hydrophobically modified PNAs induced a 35–50% reduction (3P'<2PD<3P). Although cell viability remained stagnant, 3P triggered cellular stress responses including increased membrane porosity and decreased ATP and cellular protein concentrations. Raman spectroscopy suggested that h...

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Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells

Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.7b00277 (Source: Molecular Pharmaceutics)

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GSE83647 Aneuploidy triggers an immune response

Contributors : Stefano Santaguida ; Amelia Richardson ; Divya Iyer ; Ons M'Saad ; Lauren Zasadil ; Kristin Knouse ; Yao Wong ; Nick Rhind ; Arshad Desai ; Angelika AmonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome evolution. Given the potential of cells with abnormal karyotypes to become cancerous, do pathways exist that limit the prevalence of such cells? By investigating the immediate consequences of aneuploidy on cell physiology, we identified mechanisms that eliminate aneuploid cells. We find that chromosome mis-segregation leads t...

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GSE100193 Novel chimeric transcript RRM2-c2orf48 promotes metastasis in nasopharyngeal carcinoma

Contributors : Ping Han ; Ren-Hui Chen ; Fang Wang ; Jia-Yi Zeng ; Tian-Liang Xia ; Qian Zhong ; Xiao-Ming HuangSeries Type : Expression profiling by arrayOrganism : Homo sapiensA microarray analysis was performed on the vector and over-expressing RRM2-c2orf48 NPC cell samples(CNE2-PMSCV-Vector and CNE2-PMSCV-RRM2-c2orf48).Total RNA was extracted from 1 × 106 cells using TRIzol reagent and was further purified using a Qiagen RNeasy Mini Kit according to the manufactures' instructions. RNA quality was assessed by formaldehyde agarose gel electrophoresis and was quantitated spectrophotometrically. Total RNA was labeled and hybridized to the Capita lBio Corporation's Affymetrix GeneChip Human Genome U133 Plus 2.0 Array (Affymetrix). We applied a two class unpaired method available throug...

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GSE46234 Expression data from human pancreatic tissue from healthy subjects and pancreatic ductal adenocarcinoma patients

Contributor : Helge RaederSeries Type : Expression profiling by arrayOrganism : Homo sapiensCEL mutation carriers may have increased pancreatic cancer risk.We used microarrays to detail the global programme of gene expression underlying pancreatic cancer progression in a CEL mutation carrier and non-CEL mutation pancreatic cancer patients + controls. (Source: GEO: Gene Expression Omnibus)

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Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study we evaluated the composition of the gut microbiota and the mucosal-associated regulatory cells in estrogen or sham treated female mice before and after autoimmune encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces changes in the composition and diversity of gut microbiota. Additionally, estrogen prevents EAE-associated changes in the gut microbiota and might promote the enrichment of bacteria that are associated with immune regulation. (Source: Journal of Neuroimmunology)

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TLR4 signal ablation attenuated neurological deficits by regulating microglial M1/M2 phenotype after traumatic brain injury in mice

Traumatic brain injury (TBI) initiates inflammatory responses that result in an enduring cascade of secondary neuronal loss and behavioural impairment. Toll-like receptor 4 (TLR4), predominantly expressed by microglia, recognizes damage-associated molecular patterns (DAMPs) and regulates inflammatory processes. Interestingly, the switch of microglial M1/M2 phenotypes after TBI is highly important regarding damage and restoration of neurological function. Therefore, we investigated the role and mechanisms of the TLR4 signalling pathway in regulating microglial M1/M2 phenotypes. (Source: Journal of Neuroimmunology)

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Tumor necrosis factor-alpha -863C/A polymorphism is associated with Guillain –Barré syndrome in Bangladesh

Guillain-Barr é syndrome (GBS) is a post-infectious autoimmune polyneuropathy regulated by pro- and anti-inflammatory cytokines; TNFA polymorphisms may exert immune pathogenic roles in GBS. We assessed TNFA promoter region polymorphisms (-238G/A, -308G/A, -857C/T, -863C/A) in Bangladeshi patients with GBS (n=300 ) and healthy controls (n=300) by PCR-RFLP and ASO-PCR. TNFA -863CA was significantly associated with GBS disease susceptibility (P=0.0154) and disease severity (P=0.0492). TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P=0.0092) and -863AA associated wi th AMAN subtype of GBS (P=0.0398). (Source: Journal of Neuroimmunology)

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The Serum Analysis of Dampness Syndrome in Patients with Coronary Heart Disease and Chronic Renal Failure Based on the Theory of “Same Syndromes in Different Diseases”

Aim. To analyze the serum metabolites in patients with coronary heart disease (CHD) showing dampness syndrome and patients with chronic renal failure (CRF) showing dampness syndrome and to seek the substance that serves as the underlying basis of dampness syndrome in "same syndromes in different diseases." Methods. Metabolic spectrum by GC-MS was performed using serum samples from 29 patients with CHD showing dampness syndrome and 32 patients with CRF showing dampness syndrome. The principal component analysis and statistical analysis of partial least squares were performed to detect the metabolites with different levels of expression in patients with CHD and CRF. Furthermore, by comparing the VIP value and data mining in METLIN and HMDB, we identified the common metabolites in both patient groups. Results. (1) Ten differential metabolites were found in patients with CHD showing dampness syndrome when compared to healthy subjects. Meanwhile, nine differential metabolites were found in patients with CRF showing dampness syndrome when compared to healthy subjects. (2) There were 9 differential metabolites identified when the serum metabolites of the CHD patients with dampness syndrome were compared to those of CRF patients with dampness syndrome. There were 4 common metabolites found in the serums of both patient groups.

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Geographical Variation and Factors Associated with Non-Small Cell Lung Cancer in Manitoba

Background. Screening decreases non-small cell lung cancer (NSCLC) deaths and is recommended by the Canadian Task Force on Preventive Health Care. We investigated risk factor prevalence and NSCLC incidence at a small region level to inform resource allocation for lung cancer screening. Methods. NSCLC diagnoses were obtained from the Canadian Cancer Registry, then geocoded to 283 small geographic areas (SGAs) in Manitoba. Sociodemographic characteristics of SGAs were obtained from the 2006 Canadian Census and Canadian Community Health Survey. Geographical variation was modelled using a Bayesian spatial Poisson model. Results. NSCLC incidence in SGAs ranged from 1 to 343 cases per 100,000 population per year. The highest incidence rates were in the Southeastern, Southwestern, and Central regions of Manitoba, while most of Northern Manitoba had lower rates. Poisson regression suggested areas with higher proportions of Aboriginal people and higher average income, and immigrants had lower NSCLC incidence whereas areas with higher proportions of smokers had higher incidence. Conclusion. On an SGA level, smoking rates remain the most significant factor driving NSCLC incidence. Socioeconomic status and proportions of immigrants or Aboriginal peoples independently impact NSCLC rates. We have identified SGAs in Manitoba to target in policy and infrastructure planning for lung cancer screening.

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Multipass Turning Operation Process Optimization Using Hybrid Genetic Simulated Annealing Algorithm

For years, there has been increasing attention placed on the metal removal processes such as turning and milling operations; researchers from different areas focused on cutting conditions optimization. Cutting conditions optimization is a crucial step in Computer Aided Process Planning (CAPP); it aims to select optimal cutting parameters (such as cutting speed, feed rate, depth of cut, and number of passes) since these parameters affect production cost as well as production deadline. This paper deals with multipass turning operation optimization using a proposed Hybrid Genetic Simulated Annealing Algorithm (HSAGA). The SA-based local search is properly embedded into a GA search mechanism in order to move the GA away from being closed within local optima. The unit production cost is considered in this work as objective function to minimize under different practical and operational constraints. Taguchi method is then used to calibrate the parameters of proposed optimization approach. Finally, different results obtained by various optimization algorithms are compared to the obtained solution and the proposed hybrid evolutionary technique optimization has proved its effectiveness over other algorithms.

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Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling

Diabetes is a complex disease that is characterized with hyperglycemia, dyslipidemia, and insulin resistance. These pathologies are associated with significant cardiovascular implications that affect both the macro- and microvasculature. It is therefore important to understand the effects of various pathologies associated with diabetes on the vasculature. Here we directly test the effects of hyperglycemia on vascular smooth muscle (VSM) Ca2+ signaling in an isolated in vitro system using the A7r5 rat aortic cell line as a model. We find that prolonged exposure of A7r5 cells to hyperglycemia (weeks) is associated with changes to Ca2+ signaling, including most prominently an inhibition of the passive ER Ca2+ leak and the sarcoplasmic reticulum Ca2+-ATPase (SERCA). To translate these findings to the in vivo condition, we used primary VSM cells from normal and diabetic subjects and find that only the inhibition of the ER Ca2+ leaks replicates in cells from diabetic donors. These results show that prolonged hyperglycemia in isolation alters the Ca2+ signaling machinery in VSM cells. However, these alterations are not readily translatable to the whole organism situation where alterations to the Ca2+ signaling machinery are different.

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Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke

We explored the comparative effects of minocycline treatment and intrastriatal BMMC transplantation after experimental striatal stroke in adult rats. Male Wistar adult rats were divided as follows: saline-treated (), minocycline-treated (), and BMMC-transplanted () animals. Animals received intrastriatal microinjections of 80 pmol of endothelin-1 (ET-1). Behavioral tests were performed at 1, 3, and 7 days postischemia. Animals were treated with minocycline (50 mg/kg, i.p.) or intrastriatal transplants of 106 BMMCs at 24 h postischemia. Animals were perfused at 7 days after ischemic induction. Coronal sections were stained with cresyl violet for gross histopathological analysis and immunolabeled for the identification of neuronal bodies (NeuN), activated microglia/macrophages (ED1), and apoptotic cells (active caspase-3). BMMC transplantation and minocycline reduced the number of ED1+ cells (, ANOVA-Tukey), but BMMC afforded better results. Both treatments afforded comparable levels of neuronal preservation compared to control (). BMMC transplantation induced a higher decrease in the number of apoptotic cells compared to control and minocycline treatment. Both therapeutic approaches improved functional recovery in ischemic animals. The results suggest that BMMC transplantation is more effective in modulating microglial activation and reducing apoptotic cell death than minocycline, although both treatments are equally efficacious on improving neuronal preservation.

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Effects of Injection Rate Profile on Combustion Process and Emissions in a Diesel Engine

When multi-injection is implemented in diesel engine via high pressure common rail injection system, changed interval between injection pulses can induce variation of injection rate profile for sequential injection pulse, though other control parameters are the same. Variations of injection rate shape which influence the air-fuel mixing and combustion process will be important for designing injection strategy. In this research, CFD numerical simulations using KIVA-3V were conducted for examining the effects of injection rate shape on diesel combustion and emissions. After the model was validated by experimental results, five different shapes (including rectangle, slope, triangle, trapezoid, and wedge) of injection rate profiles were investigated. Modeling results demonstrate that injection rate shape can have obvious influence on heat release process and heat release traces which cause different combustion process and emissions. It is observed that the baseline, rectangle (flat), shape of injection rate can have better balance between NOx and soot emissions than the other investigated shapes. As wedge shape brings about the lowest NOx emissions due to retarded heat release, it produces the highest soot emissions among the five shapes. Trapezoid shape has the lowest soot emissions, while its NOx is not the highest one. The highest NOx emissions were produced by triangle shape due to higher peak injection rate.

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Bone Marrow Mesenchymal Stem Cells Inhibit the Function of Dendritic Cells by Secreting Galectin-1

This study aimed to investigate whether bone marrow-derived mesenchymal stem cells (BM-MSCs) can inhibit function of dendritic cells (DCs) by secreting Galectin-1 (Gal-1). BM-MSCs have been shown to inhibit the maturation and function of DCs, further inhibiting the activation and proliferation of T cells. However, the detailed mechanism remains unknown. In this current study, MSCs and DCs derived from mouse bone marrow were cocultured using Transwell culture plates under different in vitro conditions. The results showed that as the ratio of MSC to DC of the coculture system increased and the coculture time of the two cells prolonged, the concentrations of Gal-1, interleukin- (IL-) 10, and IL-12 in the supernatants were increased and the protein expression of Gal-1 on and within DCs was also enhanced. The phosphorylation of extracellular signal-regulated kinase (ERK) pathway in DCs was boosted, whereas p38 mitogen-activated protein kinase (MAPK) pathway phosphorylation was weakened. Meanwhile, the expression of costimulatory molecules on the surface of DCs was decreased, and the proliferative effect of DCs on allogeneic T cells was also decreased. Therefore, this present study indicated that Gal-1 secreted from MSCs upregulated expression of Gal-1 and stimulated formation of tolerance immunophenotype on DCs, where the underlying mechanism was the regulation of the MAPK signaling pathway in DCs, thereby inhibiting the function of DCs.

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Periapical Status and Quality of Root Canal Fillings in a Moroccan Subpopulation

Aim. The aim of the study was to assess the prevalence of apical periodontitis (AP) and quality of root canal fillings in an adult Moroccan subpopulation. Methods. In the study 508 patients were included, attending the Conservative Dentistry Clinic at the Faculty of Dentistry of Casablanca. 508 panoramic and 709 periapical radiographs were observed. The periapical status of all teeth (with the exception of third molars) was examined according to Ørstavik's periapical index. The statistical analysis was performed with the software Epi Info Version 6.04dfr, April 2001. Results. A total of 12719 teeth were examined. 45.3% of patients had apical periodontitis. 4.2% of teeth were treated endodontically and 70.4% of these treatments were inadequate. 91,5% with inadequate endodontic treatment presented apical periodontitis, while only 8,2% with adequate endodontic treatment had apical periodontitis. The lower molars and the upper premolars were the most affected teeth. The presence of apical periodontitis was correlated significantly with insufficient root canal fillings (). Conclusions. The present study found a high prevalence of apical periodontitis in this Moroccan population. Inadequate root canal fillings were associated with an increased prevalence of apical periodontitis.

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Targeting Adult Mesenchymal Stem Cells Plasticity for Tissue Regeneration

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Identification of glyceraldehyde ‐3‐phosphate and alcohol dehydrogenases as autoantigens in Doberman hepatitis

This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)

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Skewed invariant natural killer T (iNKT) cells, impaired iNKT:B ‐cell help and decreased SAP expression in blood lymphocytes from patients with common variable immunodeficiency

Supreme Court ruling threatens massive talc litigation against J & J

(Reuters) - Johnson& Johnson is seizing upon a U.S. Supreme Court ruling from Monday limiting where injury lawsuits can be filed to fight off claims it failed to warn women that talcum powder could cause ovarian cancer. (Source: Reuters: Health)

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Fundamental Frequency and Formants Before and After Prolonged Voice Use in Teachers

This study aimed to describe and correlate the fundamental frequency behavior and the first four formants before and after exposure to usual and routinely prolonged voice use from teachers with over 4 years of experience in teaching.

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Fundamental Frequency and Formants Before and After Prolonged Voice Use in Teachers

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Phosphoproteomic profiling reveals ALK and MET as novel actionable targets across synovial sarcoma subtypes

Despite intensive multi‐modal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor. Candidate-based targeted treatments have demonstrated limited clinical success, urging an unbiased and comprehensive analysis of oncogenic signaling networks to reveal therapeutic targets and personalized treatment strategies. Here we applied mass spectrometry-based phosphoproteomic profiling to the largest and most heterogeneous set of sarcoma cell lines characterized to date and identified novel tyrosine phosphorylation patterns, enhanced tyrosine kinases in specific subtypes, and potential driver kinases. ALK was identified as a novel driver in the Aska-SS synovial sarcoma (SS) cell line via expression of an ALK variant with a large extracellular domain deletion (ALKΔ2-17). Functional ALK dependency was confirmed in vitro and in vivo with selective inhibitors. Importantly, ALK immunopositivity was detected in 6/43 (14%) of SS patient specimens, one of which exhibited an ALK rearrangement. High PDGFRα phosphorylation also characterized SS cell lines, which was accompanied by enhanced MET activation in Yamato-SS cells. Although Yamato-SS cells were sensitive to crizotinib (ALK/MET-inhibitor) but not pazopanib (VEGFR/PDGFR-inhibitor) monotherapy in vitro, synergistic effects were observed upon drug combination. In vivo, both drugs were individually effective, with pazopanib efficacy likely attributable to reduced angiogenesis. MET or PDGFRα expression was detected in 58% and 84% of SS patients, respectively, with co-expression in 56%. Consequently, our integrated approach has led to the identification of ALK and MET as promising therapeutic targets in SS.

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Oral Cancer & its Prevention - Greater Kashmir

Greater Kashmir

Oral Cancer & its Prevention
Greater Kashmir
Notwithstanding tremendous advancement in scientific/medical research in present day world, cancer stares in our eyes as one of the most predominant causes of morbidity and mortality, thus are we confronted with it as a formidable challenge in our ...

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Supreme Court ruling threatens massive talc litigation against J & J

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Evaluation of cancer-associated myositis and scleroderma autoantibodies in breast cancer patients without rheumatic disease.

CONCLUSIONS: Our results suggest that scleroderma and dermatomyositis autoantibodies are cancer biomarkers only in patients with clinical manifestations of specific rheumatic diseases and are unlikely to improve risk stratification for cancer in the general population. However, prospective studies are needed to examine whether scleroderma and dermatomyositis autoantibodies are markers of malignancy in other cancer types. PMID: 28628466 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)

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Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions.

Authors: Steiger K, Schlitter AM, Weichert W, Esposito I, Wester HJ, Notni J Abstract ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer. PMID: 28627323 [PubMed - in process] (Source: Molecular Imaging)

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Triphenylamines Induce Cell Death Upon 2-Photon Excitation.

Authors: Chennoufi R, Mahuteau-Betzer F, Tauc P, Teulade-Fichou MP, Deprez E Abstract Photodynamic therapy (PDT) is a promising therapeutic method for several diseases, in particular for cancer. This approach uses a photosensitizer, oxygen, and an external light source to produce reactive oxygen species (ROS) at lethal doses to induce cell death. One drawback of current PDT is the use of visible light which has poor penetration in tissues. Such a limitation could be overcome by the use of novel organic compounds compatible with photoactivation under near-infrared light excitation. Triphenylamines (TPAs) are highly fluorescent compounds that are efficient to induce cell death upon visible light excitation (458 nm), but outside the biological spectral window. Interestingly, we recent...

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Changes in pediatric tracheostomy tubes exposed to home dishwashing

Determine the effects of household dishwashing on Tracheostomy Tube safety.

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A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury.

Authors: Parker AL, Pugh T, Hirsch MA Abstract Leiomyosarcoma (LMS) is a rare but well-recognized malignant soft tissue sarcoma of smooth muscle origin. Metastases commonly occur in the lungs, liver, kidney, brain, and bone. Cases of metastatic osseous lesions or other extradural space-occupying masses secondary to LMS leading to neurologic compromise are relatively commonplace in the literature. Conversely, cases of intramedullary spinal cord metastasis (ISCM), an unusual entity as a sequela of any cancer, are exceedingly rare as a consequence of LMS. Only 2 cases of an ISCM from LMS are currently documented in the literature, and to the best of our knowledge, no case is described in the rehabilitation literature. This case report presents a patient with a history of longstanding ...

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Evaluating Disability Insurance Assistance as a Specific Intervention by Physiatrists at a Cancer Center.

This study is the first of its kind and provides an initial look at work-related discussions and support with disability insurance paperwork as a specific intervention provided by physiatrists at a cancer center. The results are compelling and demonstrate that physiatrists frequently provide these interventions. These interventions take considerable time and effort but are generally successful. PMID: 28628540 [PubMed - in process] (Source: Medical Physics)

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Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors

Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.177

Authors: Anna M van Eggermond, Michael Schaapveld, Cécile PM Janus, Jan Paul de Boer, Augustinus DG Krol, Josée M Zijlstra, Richard WM van der Maazen, Leontien C Kremer, Monique E van Leerdam, Marieke WJ Louwman, Otto Visser, Marie L De Bruin, Berthe MP Aleman & Flora E van Leeuwen

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Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment

Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.160

Authors: Richard Kim, E Gabriela Chiorean, Manik Amin, Caio Max S Rocha-Lima, Jitendra Gandhi, William P Harris, Tao Song & David Portnoy

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Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer

Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.163

Authors: Tsuyoshi Hata, Ichiro Takemasa, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Yuichiro Doki & Masaki Mori

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MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer

MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.181

Authors: P Zhang, W M Tang, H Zhang, Y Q Li, Y Peng, J Wang, G N Liu, X T Huang, J J Zhao, G Li, A M Li, Y Bai, Y Chen, Y X Ren, G X Li, Y D Wang, S D Liu & J D Wang

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Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study

Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.169

Authors: Chaya S Moskowitz, Joanne F Chou, Charles A Sklar, Dana Barnea, Cécile M Ronckers, Danielle Novetsky Friedman, Joseph P Neglia, Lucie Turcotte, Rebecca M Howell, Tara O Henderson, Gregory T Armstrong, Wendy M Leisenring, Leslie L Robison, Flora E van Leeuwen, Malcolm C Pike & Kevin C Oeffinger

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Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas

Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.174

Authors: Nadège Presneau, Laure Alice Duhamel, Hongtao Ye, Roberto Tirabosco, Adrienne M Flanagan & Malihe Eskandarpour

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Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics

Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.172

Authors: Mayank Saraswat, Antti Mäkitie, Rahul Agarwal, Sakari Joenväärä & Suvi Renkonen

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The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab

The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.178

Authors: Laura Demurtas, Marco Puzzoni, Riccardo Giampieri, Pina Ziranu, Valeria Pusceddu, Alessandra Mandolesi, Chiara Cremolini, Gianluca Masi, Fabio Gelsomino, Carlotta Antoniotti, Cristian Loretelli, Fausto Meriggi, Alberto Zaniboni, Alfredo Falcone, Stefano Cascinu & Mario Scartozzi

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CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients

CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients

British Journal of Cancer advance online publication, June 20 2017. doi:10.1038/bjc.2017.173

Authors: Lourdes Barrera, Edgar Montes-Servín, Juan-Manuel Hernandez-Martinez, María de los Ángeles García-Vicente, Elizabeth Montes-Servín, Marytere Herrera-Martínez, José C Crispín, José Rafael Borbolla-Escoboza & Oscar Arrieta

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Most Precise Estimates Ever of Cancer Risks With BRCA Most Precise Estimates Ever of Cancer Risks With BRCA

The first really large prospective study has provided more detail on breast and ovarian cancer risks in women harboring BRCA1 and BRCA2 mutations.Medscape Medical News (Source: Medscape Medical News Headlines)

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Breast cancer risk higher at certain ages for women with gene mutations: Study

Researchers say they have defined at what age genetic mutations post the greatest risk for women to develop breast and ovarian cancers. (Source: Health News - UPI.com)

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Hair Dyes Tied to Higher Breast Cancer Risk

Study findings differ by race, but one expert says they're inconclusive (Source: WebMD Health)

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Cyclooxygenase-2 inhibitors and free flap complications after autologous breast reconstruction, a retrospective cohort study

Publication date: Available online 20 June 2017
Source:Journal of Plastic, Reconstructive & Aesthetic Surgery
Author(s): Christian Bonde, Hoda Khorasani, Jens Hoejvig, Henrik Kehlet
BackgroundA key component of modern analgesics is the use of multimodal opioid sparing analgesia (MOSA). In the past, our analgesic regime after autologous breast reconstruction (ABR) included either NSAID or a selective cyclooxygenase-2 inhibitor (COX-2). COX-2 inhibitors could be superior to NSAID due to the well-known side effects from NSAID (bleeding/gastrointestinal ulcers). However, COX-2 inhibitors have been suggested to increase flap failure rates. We report our experience with using COX-2 inhibitors as part of our postoperative MOSA after ABR using free flaps.Materials and Methods132 unilateral, secondary, ABR were performed (DIEP or MS-TRAM) in the NSAID period (2007-2011) and 128 in the COX-2 inhibitor period (2006, 2012-2014). The same surgical team operated all patients. Data were collected prospectively and reviewed to compare the two periods with special focus on re-operations due to bleeding/haematomas and flap thrombosis/failure. Comparisons between the COX-2 inhibitor and NSAID were performed.ResultsMedian age, ischaemia time, blood loss and operating time were similar in the two periods. Significantly more patients were re-operated due to postoperative haematoma in the NSAID group (n= 13/132, 9.8%) compared to the COX-2 inhibitor group, (n=4/128, 3.1 %), (p=0.02). We found no difference in flap loss between the NSAID (n=2/132; 1.5%) and the COX-2 inhibitor group (n=3/128, 2.3%), (p=0.63). No patients suffered thromboembolic complications or gastrointestinal bleeding.ConclusionsMultimodal analgesia using a COX-2 inhibitor is safe in ABR with free flaps and does not increase in flap failure. COX-2 inhibitors seems superior to NSAID with reduced risk of postoperative haematomas.

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Dr. Ries’ study in the news!

"SDSU neuroscientist Stephanie Ries explores the complex brain connections employed during word retrieval.

When you look at a picture of a mug, the neurons that store your memory of what a mug is begin firing. But it's not a pinpoint process; a host of neurons that code for related ideas and items—bowl, coffee, spoon, plate, breakfast—are activated as well. The word mug must then be selected among its neighbors. Dr Ries' study shows these two processes, word activation and selection, co-occur in time and space."

See the full article on SDSU NewsCenter>>

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JDP students at the International Symposium on Biligualism

Our JDP students in Language and Communicative Disorders, Irina Potapova, Philip Combiths, and Jonathan Robinson Anthony, had a great time at the International Symposium on Biligualism in Limerick, Ireland, last week. Great job everyone!

[See image gallery at slhs.sdsu.edu]

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Dr. Ries’ study in the news!

"SDSU neuroscientist Stephanie Ries explores the complex brain connections employed during word retrieval.

See the full article on SDSU NewsCenter>>

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JDP students at the International Symposium on Biligualism

[See image gallery at slhs.sdsu.edu]

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Oh, Lovely: The Tick That Gives People Meat Allergies Is Spreading

By Megan Molteni for WIRED. First comes the unscratchable itching, and the angry blossoming of hives. Then stomach cramping, and — for the unluckiest few — difficulty breathing, passing out, and even death. In the last decade and a half, thousands of previously protein-loving Americans have developed a dangerous allergy to meat. And they all have one thing in common: the lone star tick. Red meat, you might be surprised to know, isn't totally sugar-free. It contains a few protein-linked saccharides, including one called galactose-alpha-1,3-galactose, or alpha-gal, for short. More and more people are learning this the hard way, when they suddenly develop a life-threatening allergy to that pesky sugar molecule after a tick bite. Yep, one bite from the lone star tick &mdash...

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South Africa: DA Considering Concourt Challenge Against KZN Health for Cancer Treatment Failure

[News24Wire] The Democratic Alliance (DA) is considering taking the Kwazulu-Natal health department to the Constitutional Court after the province failed to provide adequate cancer treatment to patients for over two years. (Source: AllAfrica News: Health and Medicine)

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South Africa: DA Calls for KZN Health MEC to Be Fired

[News24Wire] The Democratic Alliance in KwaZulu-Natal wants Health MEC Dr Sibongiseni Dhlomo fired following the recent findings of the South African Human Rights Commission (SAHRC) into oncology crisis in the province, the party said on Monday. (Source: AllAfrica News: Health and Medicine)

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Papers of note in Science Translational Medicine 9 (394)

This week's articles describe how broccoli can combat type 2 diabetes, how monocytes contribute to the failure of organ transplant grafts, and how to more durably treat RET- or KRAS-driven lung cancer. (Source: Signal Transduction Knowledge Environment)

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Sports of The Times: Chemotherapy, Then the U.S. Championships, for Gabriele Grunewald

Like any professional runner, Grunewald is competitive and fierce down the stretch. But a huge obstacle sets her apart: She ' s battling cancer for the fourth time. (Source: NYT Health)

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06/19/17 PHD comic: 'Reader Reviews'

Piled Higher & Deeper by Jorge Cham		www.phdcomics.com

title: "Reader Reviews" - originally published 6/19/2017 For the latest news in PHD Comics, CLICK HERE!

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Risk Tool IDs Candidates for Adjuvant RT in Prostate Cancer (CME/CE)

(MedPage Today) -- Combines tumor pathology, genomic data to reduce overtreatment (Source: MedPage Today Urology)

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The Most Important Thing You're Not Discussing With Your Doctor

This article was originally published on The Conversation. Read the original article. type=type=RelatedArticlesblockTitle=Related... + articlesList=59447396e4b0d188d027fe80,592db98de4b07c4c731385fc,5644e394e4b08cda3487ed70 -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Healthy Living - The Huffington Post)

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Can a Breath Test Diagnose Mesothelioma in the Early Stages?

Much of mesothelioma research centers on identifying new and noninvasive biomarkers for earlier detection of the asbestos-related cancer. Progress has been made in finding biomarkers in blood and pleural effusions, but researchers in Belgium now believe the next breakthrough in early diagnosis for mesothelioma cancer may be a breath test. Researchers at Ghent University Hospital and Antwerp University Hospital recently highlighted the potential of breath analysis, called breathomics, as a noninvasive screening tool for malignant pleural mesothelioma. The Oncotarget medical journal published the study in May. Breath tests or electronic noses are not a new innovation, but the science behind them — especially as an early detection device for cancer — is improving. The tool uses spectro...

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Task Force presents new ranking of colorectal cancer screening tests

(American Society for Gastrointestinal Endoscopy) In its latest recommendations, the US Multi-Society Task Force (MSTF) on Colorectal Cancer (CRC) Screening confirms that people at average risk should be screened beginning at age 50, and recommends colonoscopy and fecal immunochemical testing (FIT) as the " first tier " screening tests for this group. Screening continues to be a first line of defense against CRC, as it can detect pre-cancerous growths as well as cancer, which is highly treatable if caught early. (Source: EurekAlert! - Medicine and Health)

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Electronic patient-reported outcomes and toxicities during radiotherapy for head-and-neck cancer

ConclusionsHead-and-neck RT, particularly CCRT, negatively impacts patients ' overall QOL, social activity, and fatigue, with frequent grade 3 AEs, weight loss, intravenous hydration, feeding tube placement, ED visits, and hospitalization. Real-time ePROs allow providers to monitor QOL at multiple time points during RT, potentially allowing early intervention to improve Q OL and mitigate AEs. (Source: Quality of Life Research)

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Interactions between primary sclerosing cholangitis and inflammatory bowel disease: implications in the adult liver transplant setting.

Authors: Liu K, Strasser SI, Koorey DJ, Leong RW, Solomon M, McCaughan GW Abstract INTRODUCTION: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease which is associated with inflammatory bowel disease (IBD) in most cases. As there is currently no medical therapy which alters the natural history of PSC, liver transplantation may be required. Areas covered: We searched for articles in PubMed and critically reviewed current literature on the interrelationship between PSC and IBD with a specific focus on considerations for patients in the liver transplant setting. Expert commentary: PSC is an uncommon disease which limits available studies to be either retrospective or contain relatively small numbers of patients. Based on observations from these studies, the be...

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The Cancer Loneliness Scale and Cancer-related Negative Social Expectations Scale: development and validation

ConclusionsThe resulting measures have both clinical and research utility. (Source: Quality of Life Research)

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The longitudinal course of depression symptomatology following a palliative rehabilitation program

ConclusionPatients who undergo a palliative rehabilitation program may experience relief of mild depressive symptomatology, maintainable 3-month post-PRP. The sample was exhibiting mild symptomatology and these results may not be generalizable to those with higher scores; a lack of specialized psychosocial clinician may have affected the acquired sample. Experimental designs are needed to more thoroughly compare these findings to independent rehabilitation interventions. (Source: Quality of Life Research)

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Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life

ConclusionsAlthough visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I –III CRC survivors. (Source: Quality of Life Research)

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Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study

ConclusionsMost of the breast cancer patients experience multiple symptoms associated with radiation dermatitis. Hyperpigmentation was the most common and uncomfortable symptom followed by erythema. Majority of patients wanted management for radiation dermatitis and patients who experienced dryness, burning feelings, irritation, roughness, and hyperpigmentation had higher needs for radiation dermatitis management. (Source: Quality of Life Research)

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Τρίτη 20 Ιουνίου 2017

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