Αρχειοθήκη ιστολογίου

Δευτέρα 11 Δεκεμβρίου 2017

Factors affecting the outcomes of direct pulp capping using Biodentine

Abstract

Introduction

This study aimed to evaluate the prognostic value of factors with regard to the treatment outcome of direct pulp capping using Biodentine (Septodont, Saint-Maur-des-Fossés, France), in permanent teeth in which the pulps were exposed during caries removal.

Methods

Between 2010 and 2014, 112 teeth with deep carious lesions underwent direct pulp capping. The patients were followed up at 2–3 months and 1–1.5 years with a routine examination on both recall visits. Periapical radiographs were taken at 1–1.5 years. Lack of patient complaints, positive reactions to cold and electric testing, no sensitivity to percussion, and no widening of the periapical ligament indicated success. The Fisher exact test was used for statistical analysis. The significance level was P = .05.

Results

Eighty-six teeth were available for 1–1.5 years follow-up. The overall success rate was 82.6%. Only age had a significant effect on the pulpal survival rate: the success rate was 90.9% in patients younger than 40 years and 73.8% in patients 40 years or older (P = .0480). Sex, initial or secondary caries treatment, occlusal or cervical/proximal caries, delayed placement of permanent filling, tooth position, and arch type did not influence the outcome.

Conclusions

A patient's age influenced the outcome of direct pulp capping using this new calcium silicate cement.

Clinical relevance

Asymptomatic vital permanent teeth with cariously exposed pulp can be treated successfully by direct pulp capping using Biodentine.



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Efficacy and Safety of Photoselective Vaporization of the Prostate with 120 W 532 nm Laser in Patients with Benign Prostatic Hyperplasia on Anticoagulation or Antiplatelet Therapy: Observations on Long-Term Outcomes

Photomedicine and Laser Surgery , Vol. 0, No. 0.


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A novel technique for superior-based pharyngeal flaps: 10-year results with formal speech outcomes assessment

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Publication date: Available online 11 December 2017
Source:American Journal of Otolaryngology
Author(s): Ryan Winters, John Carter, J. Lindhe Guarisco
PurposeDescribe a novel technique for superior-based pharyngeal flaps allowing restoration of bulk to the soft palate and intraoperative fine-tuning of lateral port size, while avoiding midline palate-splitting. Validated speech assessment tools are employed for quantitative analysis.MethodsRetrospective review of all patients who underwent superior-based pharyngeal flap in a 10-year period by a single surgeon. Pittsburgh Weighted Values for Speech Symptoms Associated with VPI and the Goldman-Fristoe Test of Articulation were used for formal speech assessment.Results78 patients met inclusion criteria with clinical data up to 10years postoperatively. 31 patients had congenital velopharyngeal insufficiency (VPI), and the remainder acquired VPI after cleft palate repair or adenoidectomy. 37 patients had a recognized syndrome. All patients noted subjective improvement in nasality, and evaluation with the validated speech assessment tools demonstrated statistically significant improvement in speech. Only one flap takedown was required in a patient with severe midface hypoplasia who developed sleep apnea several years postoperatively.ConclusionsThis technique is successful in congenital and acquired VPI, and in patients with complex craniofacial syndromes. Customization of lateral ports based on preoperative nasopharyngoscopy, and avoidance of a midline palate splitting incision, make this an attractive option for superior-based flap surgery.



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Gastro-pharyngeal reflux and total laryngectomy. Increasing knowledge about its management

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Publication date: Available online 11 December 2017
Source:American Journal of Otolaryngology
Author(s): Giuditta Mannelli, Roberto Santoro, Francesco Segala, Elisabetta Surrenti, Oreste Gallo
PurposeInvestigate the incidence, the degree and the effect of gastro-pharyngeal reflux (GPR) in laryngectomised patients.Materials and methodsBehavioral and 24-hour pH- and impedance-monitoring data were prospectively analyzed for 25 laryngectomised patients with no previous history of GER in outpateints' setting. Reflux detected was characterized as either acid, weakly acidic or nonacid. Proximal reflux was found at 15cm above the LES.Results40% of patients presented a pathological number of reflux episodes in the upright position (p<0.0001); 9 of them presented a pathologic bolus exposure time. Bolus exposure at the proximal sphincter was one fourth-fold lower than 5cm above the LES (p=0.3593). There was a prevalence of acid reflux at both sphincters (p<0.0001); liquid reflux was prevalent at the LES (p=0.003) and mixed reflux at the UES (p=0.0001). Median REs was higher than time acid exposure (p=0.0013).ConclusionsPre- and post-surgical reflux investigation could identify preexisting reflux severity and screen potential high-risk cancer patients for postoperative complications. This might allow the early onset of acid suppressive therapy in presence of pathologic findings in high-complication risk cancer patients.



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Differences in the Alignment Pattern of the Maxillary Dental Arch Following Fixed Orthodontic Treatment in Patients With Bilateral Cleft Lip and Palate: Anteroposterior-Collapsed Arch Versus Transverse-Collapsed Arch

Abstract The purpose of this study was to investigate differences in the alignment pattern of the collapsed maxillary arch following fixed orthodontic treatment (FOT) in bilateral cleft lip and palate (BCLP) patients according to collapse type. Fifteen BCLP patients were divided into Group 1 (anteroposterior-collapsed arch, n = 7) and Group 2 (transverse-collapsed arch, n = 8) according to maxillary arch shape before FOT. Linear and angular variables of lateral cephalograms and dental models were evaluated before (T1) and after FOT (T2), and statistical analysis was performed. In cephalometric measurements at T1, both the groups exhibited retrusive maxillae, a Class III relationship, and lingual inclination of U1-SN. At T2, significant improvement of U1-SN was observed in both the groups (P 

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Unexpected Blooming Artifact in Brain Magnetic Resonance Imaging

Abstract Unexpected foreign bodies are occasionally discovered during magnetic resonance imaging (MRI). These are often present unknown to the patient, missed during routine pre-MRI screening and result in unnecessary delay during MRI. The authors present a patient with traumatically embedded foreign body in the scalp that escaped pre-MRI screening and caused susceptibility artifacts during brain MRI. The object was surgically removed to allow the imaging to be completed. Patients with suspicion or history of facial trauma or with dental restorations are referred to concerned specialists for compatibility of hardware, restorations and for assessing risks during MRI due to these. This patient is presented as a reminder for clinicians to probe further during anamnesis and have a high index of suspicion for foreign bodies that may be present even after trivial injuries. Address correspondence and reprint requests to Akilesh Ramasamy, MDS, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Puducherry, India; E-mail: akident@gmail.com Received 22 April, 2017 Accepted 4 August, 2017 The authors report no conflicts of interest. © 2017 by Mutaz B. Habal, MD.

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A Three-Dimensional Anthropometric Evaluation of Facial Morphology

Objectives: The aims of this study were to evaluate sexual dimorphism for facial features within Italian and Egyptian populations and to compare the facial morphology by sex between these 2 populations. Materials and Methods: Three-dimensional (3D) facial images were acquired by using the portable 3dMDface System, which captured 259 subjects from 2 population groups of Italian (n = 139) and Egyptian (n = 120). Each population was categorized into male and female groups for evaluation. All subjects in the groups were aged between 18 and 30 years and had no apparent facial anomalies. A total of 23 anthropometric landmarks were identified on the 3D faces of each subject. The independent t test was used to analyze each data set obtained within each subgroup. Results: Egyptian women tend to have distinct facial features when compared with Italian women; they had less prominent eyes, more nasal width, more height of upper and lower faces and more height of upper and lower vermilion lengths. Egyptian and Italian males demonstrated very close facial features. However, Egyptian males had more nasal width, length of alare, and mandibular height. Conclusions: Sexual dimorphism for facial features was presented in both the Italian and Egyptian populations. In addition, there were significant differences in facial morphology between these 2 populations, especially in females. Address correspondence and reprint requests to Dr. Chung How Kau, DDS, MSD, MBA, PhD, MOrth, FDS, FFD, FAMS, Department of Orthodontics, University of Alabama at Birmingham, School of Dentistry, 1919 Seventh Ave. S. Birmingham, AL 35294; E-mail: ckau@uab.edu Received 13 March, 2017 Accepted 14 August, 2017 The authors report no conflicts of interest. © 2017 by Mutaz B. Habal, MD.

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The Hybrid Technical Management of Large and Complicated Traumatic Arteriovenous Fistula of Preauricular Region

Background: Arteriovenous fistula (AVF) is defined as an abnormal communication between the high flow arterial system and the low flow venous network, which directly connects the arterial feeding vessels and the near draining veins without normal intervening capillary bed. Arteriovenous fistula incurs in preauricular region is exceeding rare. Most of these fistulae occur as a result of an iatrogenic injury, the volume is small, feeding and draining vessels of feeding and draining are simple, and can be cured easily. However, the treatment of the large and complicated AVF after incidental trauma in preauricular region is a challenge even for senior neurosurgeon. In this study, the authors discuss the management of a traumatic AVF through combined therapeutic method of surgical ligation and transarterial embolization. It is fed by ipsilateral superficial temporal artery, internal maxillary artery, posterior auricular artery, and their accessory branches and is drained by ipsilateral common facial vein and external jugular vein. Also the etiology, clinical manifestations, pathology, diagnosis, and management are summarized. Conclusion: Large and complicated traumatic AVF in preauricular region is rare, often due from an injury in maxillofacial region, combined therapy needed. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://ift.tt/OBJ4xP Address correspondence and reprint requests to Jinlong Sun, Shandong Provincial Qianfoshan Hospital, Jinan, China; E-mail: jinlongsun@hotmail.com Received 16 July, 2017 Accepted 19 August, 2017 The authors report no conflicts of interest. © 2017 by Mutaz B. Habal, MD.

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Recurrent Lower Eyelid Ectropion After Graft Surgery Using Autogenous Palmaris Longus Tendon

Abstract A 78-year-old male experienced right lower eyelid ectropion following right facial trauma from a fall 5 years ago, for which he underwent autogenous palmaris longus tendon graft surgery at another clinic. Recurrence was noted 3 years after surgery. On first examination, there was outward turning of the lateral half of the right lower eyelid margin. We performed a lateral tarsal strip procedure with removal of the graft. Intraoperatively, the lateral part of the graft was located along the inferior tarsal border, whereas the medial part was located on the tarsal surface. The lateral stump had bifurcated; 1 branch had passed through a bony hole drilled at the base of the rim; and both branches had been ligated together on the rim surface. The medial side had been fixed to the medial canthal tendon. Postoperatively, the apposition of eyelid and ocular surface was good, and the patient experienced no recurrence after 1 year. Address correspondence and reprint requests to Hiromichi Matsuda, MD, Department of Ophthalmology, Daisan Hospital, The Jikei University School of Medicine, 4-11-1 Izumihonchou, Komae, Tokyo 201-8601, Japan; E-mail: thkmmm@yahoo.co.jp Received 21 June, 2017 Accepted 6 October, 2017 The authors report no conflicts of interest. © 2017 by Mutaz B. Habal, MD.

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Intraoral Pleomorphic Adenoma in Young Patients

Background: Intraoral pleomorphic adenoma (PA) is rare in young individuals, with only single clinical reports or small patient series reported previously. Aim: The aim of this study was to describe the clinicopathological features of PA in 4 patients under 18 years of age, and to discuss the differential diagnosis of pediatric patients presenting with intraoral submucosal nodules. Methods: Between 2000 and 2015, all patients of intraoral PA in patients aged ≤18 years diagnosed in the Oral Pathology Laboratory of the Universidade Federal de Pernambuco, Brazil, were retrieved for the study. Clinical data were recorded from the clinical charts. Histopathological slides stained with hematoxylin and eosin were reviewed to confirm the diagnosis. Results: There were 4 cases of PA in patients aged ≤18 years. All patients in this patient series were males, with a mean age of 16.7 years. Three cases occurred in the palate, and in 1 case, the upper lip was affected. All PAs appeared as a painless, smooth surface, well-circumscribed, and submucosal nodule. All patients were surgically excised and subsequent histopathological analysis revealed well-circumscribed tumors composed of cells that were arranged in ducts within a fibromyxoid stroma. No signs of recurrence were observed in 3 patients after a mean follow-up of 30 months. One patient is lost to follow-up. Conclusion: Although PAs are unusual in young patients, they should be considered in the differential diagnosis of oral submucosal nodules. Address correspondence and reprint requests to Danyel Elias da Cruz Perez, PhD, 4a Travessa Professor Artur de Sá, Departamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, s/n—Cidade Universitária, CEP: 50740-521, Recife, Pernambuco, Brazil; E-mail: danyel.perez@ufpe.br Received 11 September, 2017 Accepted 8 October, 2017 The authors report no conflicts of interest. © 2017 by Mutaz B. Habal, MD.

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Osseous Convexity at the Anterior Fontanelle: A Presentation of Metopic Fusion?

Background: Craniosynostosis, or a premature fusion of 1 or more cranial vault sutures, results in characteristic head shape deformities. In previous reports, an osseous prominence at the anterior fontanelle has been suggestive of adjacent suture fusion and local elevation in intracranial pressure (ICP). This prominence has been termed the "volcano" sign, and has been described in the anterior fusion of the sagittal suture and serves as an indication for surgery. Methods: Two patients presented for head shape evaluation with mild metopic ridging and anterior fontanellar osseous convexities consistent with the volcano sign. Low-dose computed tomography imaging was performed in both patients due to concern for underlying craniosynostosis with elevated locoregional ICP. Results: In both patients, imaging was significant for a localized, superior forehead metopic fusion, as well as a bony, convex prominence at the site of the ossified anterior fontanelle. There were no other clinical or radiologic signs or symptoms to suggest elevated ICP. Surgery was not indicated in either patient. Conclusions: Here the authors present 2 patients with osseous convexities at the site of the closed anterior fontanelle without signs or symptoms of elevated ICP, or classic signs of metopic synostosis. The authors hypothesize that this pattern may be due to a form of mechanically induced premature fusion of a normal metopic suture that is focused superiorly at the bregma, with minimal resultant restriction of overall skull growth. This is in contrast to metopic synostosis, which primarily has a sutural pathology and leads to characteristic findings of hypotelorism and trigonocephaly. Address correspondence and reprint requests to John A. Persing, MD, Yale Plastic Surgery, PO Box 208062, New Haven, CT 06510; E-mail: john.persing@yale.edu Received 25 February, 2017 Accepted 9 June, 2017 The authors report no conflicts of interest. © 2017 by Mutaz B. Habal, MD.

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Dr. Jay Oza opening a new Dental Clinic in Midlothian

MIDLOTHIAN, TX, USA, December 11, 2017 / EINPresswire.com / -- Dr Jay Oza is opening a brand new Dental Clinic in Midlothian, TX and is accepting new patients. Dr. Oza lived in Fort Worth for almost one and half years while going to school at UNT's Health Science Center.



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Cochrane Qualitative and Implementation Methods Group Guidance Series - paper 1: Introduction

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Publication date: Available online 11 December 2017
Source:Journal of Clinical Epidemiology
Author(s): Jane Noyes, Andrew Booth, Margaret Cargo, Kate Flemming, Ruth Garside, Karin Hannes, Angela Harden, Janet Harris, Simon Lewin, Tomas Pantoja, James Thomas




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Cochrane Qualitative and Implementation Methods Group Guidance Paper 4: Methods for integrating qualitative and implementation evidence within intervention effectiveness reviews

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Publication date: Available online 11 December 2017
Source:Journal of Clinical Epidemiology
Author(s): Angela Harden, James Thomas, Margaret Cargo, Janet Harris, Tomas Pantoja, Kate Flemming, Andrew Booth, Ruth Garside, Karin Hannes, Jane Noyes
The Cochrane Qualitative and Implementation Methods Group (CQIMG) develops and publishes guidance on the synthesis of qualitative and mixed-method evidence from process evaluations. Despite a proliferation of methods for the synthesis of qualitative research, less attention has focused on how to integrate these syntheses within intervention effectiveness reviews. In this paper we report updated guidance from the group on approaches, methods and tools which can be used to integrate the findings from quantitative studies evaluating intervention effectiveness with those from qualitative studies and process evaluations. We draw on conceptual analyses of mixed methods systematic review designs and the range of methods and tools that have been used in published reviews that have successfully integrated different types of evidence. We outline five key methods and tools as devices for integration which vary in terms of the levels at which integration takes place; the specialist skills and expertise required within the review team; and their appropriateness in the context of limited evidence. In situations where the requirement is the integration of qualitative and process evidence within intervention effectiveness reviews, we recommend the use of a sequential approach. Here evidence from each tradition is synthesised separately using methods consistent with each tradition before integration takes place using a common framework. Reviews which integrate qualitative and process evaluation evidence alongside quantitative evidence on intervention effectiveness in a systematic way are rare. This guidance aims to support review teams to achieve integration and we encourage further development through reflection and formal testing.



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Physical and psychosomatic health outcomes in people bereaved by suicide compared to people bereaved by other modes of death: a systematic review

Little research has been conducted into the physical health implications of suicide bereavement compared to other causes of death. There is some evidence that suicide bereaved parents have higher morbidity, pa...

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Narratives of community engagement: a systematic review-derived conceptual framework for public health interventions

Government policy increasingly supports engaging communities to promote health. It is critical to consider whether such strategies are effective, for whom, and under what circumstances. However, 'community eng...

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Factors affecting the achievement of fertility intentions in urban Nigeria: analysis of longitudinal data

Maternal mortality ratio in Nigeria is among the highest in the world with an estimated 160 women dying every day of complications related to pregnancy and childbirth. In addition to appropriate management of ...

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Do objective neighbourhood characteristics relate to residents’ preferences for certain sports locations? A cross-sectional study using a discrete choice modelling approach

The number of sports facilities, sports clubs, or city parks in a residential neighbourhood may affect the likelihood that people participate in sports and their preferences for a certain sports location. This...

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ADA Working to Help Dentists Meet End of Year CE Requirements

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Sometimes life just gets too busy.  You know how it is.  Suddenly the end of the year approaches and you realize that for whatever reason, you're lacking on the number of hours of continuing education you need to fulfill licensure requirements.  
 
If that is something that is causing you angst as we head into the holiday season, fear not!  The ADA is coming to your rescue.
 
That rescue consists of an awesome discount on online CE that you can watch at your leisure and earn those needed CE credits.  You can take any course between now and December 31, 2017 and get a 30 percent discount!  That's a heck of a deal for CE from people like Dr. Stanley Malamed, Dr. Ray Padilla, Dr. Steve Carsten and others.  Heck you might just find a couple of courses by me in there.
 
  


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Mannitol and the blood-labyrinth barrier

Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically diffi...

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Project Rose Carries the Ball Forward in the Fight Against Sleep Apnea

David Gergen and NFL Legend Earl Campbell

David Gergen and NFL Legend Earl Campbell

Considerable money, expertise, and even star power has been poured into a new venture in the Texas cities of Tyler/Dallas/Houston/Austin and many more to come, all in an effort to fight sleep apnea and bring oral appliances to the forefront of treatment. Thanks to NFL greats Gary Baxter and Earl Campbell, the Project Rose Sports Science Center is now open in conjunction with Texas Spine & Joint.

 

Officials at the American Sleep & Breathing Academy (ASBA) are working closely with Baxter and Campbell to help stock the facility with top-notch dentists who are experts in the treatment of sleep apnea. And while all appropriate treatment modalities will be on the table, these dentists are well aware of the effectiveness (and excellent compliance rates) of oral appliances in the successful treatment of obstructive sleep apnea (OSA).

 

"By some studies, about 70% of people who get a CPAP machine are not wearing it in six months," says Harry Sugg, DDS, owner of Dallas-based Wheatland Dental, and a dentist at Project Rose. "That is too many people left untreated. Oral appliances can treat them."

 

Not all clinicians agree with Sugg, but Rebecca Lauck, DDS, believes that is mostly due to a lack of education. "Most medical professionals are not even aware of oral appliances," says Lauck, who owns a traditional dental practice, as well as a dental sleep practice. "They have never seen them or heard of them, and they are oblivious. They have only learned about CPAP."

 

In her area of Keller, Texas, Lauck does her part to spread awareness by speaking with physicians and educating them about her patients who are benefitting by wearing oral appliances. "But there are not many people like me around spreading the message," says Lauck, who will be treating Project Rose patients when the concept expands to her region of the Lone Star state. "They [physicians] would rather just refer their patients to a sleep doctor and be done with it."

 

The mere existence of Project Rose, as a facility-based sleep center with dentists on staff, will contribute to the increasing level of respect enjoyed by dental sleep medicine. When the "Rose" banner spreads to a planned 100 facilities across the nation, oral appliance awareness will only be that much higher.

 

Baxter and Campbell will no doubt boost that awareness among sports fans who remember Baxter as a star cornerback/safety on the stalwart defense of the Baltimore Ravens, while Campbell is a past Heisman Trophy winner and all pro running back with the Houston Oilers.

 

Both men care deeply about current and retired athletes, but Project Rose is designed to reach the entire patient demographic. David Gergen, CEO of the ASBA and Gergen's Orthodontic Lab, estimates that the ratio will likely be 99% general population to 1% premier athletes. "The ultimate goal," says Gergen, "is to integrate dentists into hospitals and make oral appliance therapy the true go-to line of defense for obstructive sleep apnea."

 

Coaches have long set curfews as a way of ensuring proper slumber and better performance on the field, but these days coaches are recognizing the importance of clinically proper sleep. It's not enough to be horizontal, because physical recovery depends on real sleep. Sugg points out that all of this applies to active and retired athletes.

 

"Some of those linemen at 300 pounds stop playing and they have a very high incidence of sleep apnea," he says. "Project Rose is an avenue that Campbell and Baxter see as an opportunity to create something positive and useful for athletes and the public. They are doing it in a top-notch way, because they have the backing of the former NFL legends and Olympians. If it's good enough for NFL greats, then it'll surely be good enough for us. The scope of what they are doing here is phenomenal. Texas was just the beginning."

 

NFL Legend Earl Campbell and Dr. Rebecca Lauck

NFL Legend Earl Campbell and Dr. Rebecca Lauck

Into the Hospital Setting

Project Rose in Tyler is firmly in the hospital environment, which streamlines billing, and more importantly, streamlines the treatment process. "The sleep beds are right there and take-home sleep studies are also there for mild to moderate cases," says Sugg. "Then the oral appliance gets made and it gets titrated over a couple of visits. The NFL stars, Eric Dickerson, Marcus Allen and Roy Green just to name  a few, will be helping with the promotion."

 

Encompassing about 25,000 square feet, the facilities include physical therapy and rehabilitation. For example, at the Tyler location, the top floor is the Texas Spine and Joint Hospital, recently bought out by Baylor University. "It's a whole new way of doing sleep medicine in a hospital environment," enthuses Sugg.

 

Project Rose is a "Center for Excellence" built with Texas Spine & Joint and partner Baylor Scott and White. Baxter told a local newspaper: "For Earl and myself, this is a dream come true. We've done a lot of hard work on this. We wanted to bring something special…We're raising money to do research in the field of sports. We want to make sure for the next generation that we are helping to prevent injuries and stop injuries through education. Then even after guys get hurt or injured, we want to be there to help them return to the field and/or return to normal life."

 

Phase 2 will feature a Bio-Mechanic Lab where researchers will work on everything from muscle tears to helping prevent and lessen the effects of concussions. "My hometown means the world to me, and to be able to give back is what life is all about," said Earl Campbell. "My goal for this non-profit is to help as many people as possible, while we contribute to the study of sports science. I am so thankful for the opportunity."

 

With the academic backing of ASBA and the promotional heft of NFL star power, Campbell's goal fits in with what ASBA member dentists believe is a nationwide trend toward greater acceptance of oral appliances in the fight against sleep apnea. Rebecca Lauck points out that sleep apnea is a relatively young field when compared to cardiology and other facets of pulmonology. As such, it's not surprising that acceptance is still not at particularly high levels—at least not yet.

 

"It's a shame, but dentists are not really trained extensively on sleep," says Lauck. "They might go to a quick course and learn how to do an appliance, and they may offhandedly make an appliance and not know how to really get it to work for a patient. We need to do more to help them. It needs to be a specialty within dentistry so that oral appliances are treated the way they should be."

 

Project Rose Team: Gary Baxter, Dr. Rebecca Lauck, Dr. Brandon Hedgecock, Isiah Robertson, Dr. Harry Sugg, D. Gergen, Dr. Ed Hobbs, Eric Dickerson

Project Rose Team: Gary Baxter, Dr. Rebecca Lauck, Dr. Brandon Hedgecock, Isiah Robertson, Dr. Harry Sugg, D. Gergen, Dr. Ed Hobbs, Eric Dickerson

Assembling the Team

The Arizona-based ASBA has quickly made its mark as a zealous proponent of oral appliances for the treatment of sleep apnea. CEO David Gergen bristles at the "CPAP gold standard" comment, frequently pointing out that nothing can be a true gold standard if it's not being worn.

 

Harnessing the considerable popularity of the National Football League, Gergen and executive director Alan Hickey have been able to advance the cause beyond academic shows to encompass football fans, many of whom come to sleep apnea awareness via their gridiron heroes.

 

Project Rose is heavily dependent on expert clinicians such as Sugg, Lauck, Edward H. Hobbs, DDS, MS, and others. Hobbs echoes a familiar story about his initial involvement with the Project Rose endeavor. "Dave Gergen, who owns a dental lab out in Phoenix, called and wanted to discuss something," says Hobbs, owner of DENTACARE Dental Group, Longview, Texas. "He described their plans, and how it was set up to help a lot of people. The people involved were well known—Earl Campbell and Gary Baxter—and I said yes."

 

Like so many of his colleagues, Hobbs heard little about sleep medicine in the early days of the dental profession. About 20 years ago, however, he decided to "Go take a sleep course in Dallas and learn something about these 'sleep appliance' things." He learned from an experienced doc and this initial exposure led to mini residencies at prestigious universities. And yet, even in 2017, there is much work to be done.

 

"The level of respect for oral appliances has a long way to go among members of the medical community," laments Hobbs. "These people are so busy that they have a hard time keeping up with ancillary fields such as oral appliances. They are just overwhelmed. They don't totally understand the use of these appliances and the dentist's role—and how successful they are.

 

"The lack of compliance in the CPAP world shows us that patients are using it less than 7 hours," continues Hobbs. "The oral appliance has tremendous opportunity to help a lot of people in treating their sleep apnea and breathing disorders. The more we can get people to understand, the better for the patients, and that's what it's all about. Project Rose treatment centers will be instrumental in spreading this crucial awareness."

 

 

 



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Comprehensive analysis of ectopic mandibular third molar: a rare clinical entity revisited

Ectopic mandibular third molar is a rare clinical entity with incompletely known etiology. Here, we sought to delineate its epidemiological, clinical and radiographic characteristics, and therapy by integratin...

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Gapo Syndrome -A Rare Cause of Osteomyelitis of Jaws; Report of Four Cases With Brief Review of Literature

The GAPO syndrome is characterised by growth retardation, alopecia, pseudoanodontia and ophthalmic abnormalities. This very rarely reported syndrome is known to affect various ethnic groups and may present with manifestations other than the usually reported. Pseudoanodontia is a rare clinico-radiologic manifestation known to be always associated with GAPO syndrome. Osteomyelitis of jaws is a less common disease that is usually attributed to odontogenic causes. This case report illustrates osteomyelitis of the mandible in a patient with GAPO syndrome.

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Fixed, fiber-reinforced resin bridges on 5.0mm implants in severely atrophic mandibles: up to 5-years follow-up of a prospective cohort study

The aim of this study is to evaluate the midterm outcomes of fixed full arch fiber-reinforced resin bridges on ultrashort implants in terms of marginal bone loss and overall implant survival.

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Using An In-House Approach to Cad/Cam Reconstruction of the Maxilla

Computer-assisted design (CAD) and computer-aided manufacturing (CAM) techniques are now in widespread use for maxillofacial reconstruction. However, CAD/CAM-manufactured surgical guides are commercially available only in the limited areas. To use this technology in areas where these commercial guides are not available, we have developed a CAD/CAM technique in which all processes are performed by the surgeon (in-house approach).

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Do postoperative antibiotics decrease the frequency of inflammatory complications following third molar removal?

The purpose of this study was to answer the following clinical question: Among patients having their third molars (M3s) removed, do those who receive only postoperative antibiotics compared to those who receive no perioperative antibiotics have a lower frequency of postoperative inflammatory complications?

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Cochrane Qualitative and Implementation Methods Group Guidance Paper 4: Methods for integrating qualitative and implementation evidence within intervention effectiveness reviews

The Cochrane Qualitative and Implementation Methods Group (CQIMG) develops and publishes guidance on the synthesis of qualitative and mixed-method evidence from process evaluations. Despite a proliferation of methods for the synthesis of qualitative research, less attention has focused on how to integrate these syntheses within intervention effectiveness reviews. In this paper we report updated guidance from the group on approaches, methods and tools which can be used to integrate the findings from quantitative studies evaluating intervention effectiveness with those from qualitative studies and process evaluations.

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Cochrane Qualitative and Implementation Methods Group Guidance Series - paper 1: Introduction



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Kissner receives dental association recognition

Mary J. Kissner, CDA, LDA, FADAA, of New Ulm, is the recipient of an American Dental Assistants Association Fellows Award. Kissner has been involved in dentistry for 34 years and has been employed for over 30 years by New Ulm Dental Clinic.



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Influence of Physical Activity, Sedentary Behaviour and Diet Quality in Childhood on the Incidence of Internalizing and Externalizing Disorders during Adolescence: a Population-based Cohort Study

Studies among youth suggest that physical inactivity, sedentary behaviours and poor diet quality are associated with poor mental health. Few population-based studies have investigated these relationships longitudinally. We examined the association between physical activity, sedentary behaviours, and diet quality in childhood and the incidence of internalizing and externalizing disorders throughout adolescence.

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Relationship between sjögren's syndrome and periodontal status- a systematic review

This study aimed to evaluate if Sjögren's syndrome is related to periodontal status.

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The clinical significant of pre-surgical imaging in oral squamous cell carcinoma compared with lymph node status: a comparative retrospective study

The accuracy and sensitivity of commonly used imaging modalities in evaluating oral cavity cancer was evaluated by comparing the pre-surgical radiological findings and the post-surgical pathological report.

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A well-circumscribed lobulated tumor on the hard palatal mucosa in a child

A 9-year-old Caucasian female presented with a non-tender, slow growing mass on the right hard and soft palate, measuring 2.0 × 1.5 cm. The patient was otherwise healthy. On examination, the lesion presented as a well-circumscribed, soft tissue tumor with a lobulated appearance covered by normal-appearing oral mucosa (Figure 1). There was no ulceration and no induration. Adjacent teeth were vital, and a source of infection was not identified. There was no palpable lymphadenopathy. Computed tomography images showed that there was no bone erosion or tooth resorption.

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Microbial population changes in patients with medication-related osteonecrosis of the jaw treated with systemic antibiotics

This study aimed to investigate the bacterial population in patients with medication-related osteonecrosis of the jaw (MRONJ) after treatment with doxycycline and metronidazole.

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How to Manage a Negative Online Review

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Step 1: Relax - A negative review is not the end of the world or the end of your practice. In fact, you can actually turn a negative review into a positive for your practice if you handle it correctly!

Step 2: Respond - After you have taken some time to consider the feedback and do some of your own research, respond to the review on the 3rd party website where it was posted.

Step 3: Thank Them for Their Feedback - First step in your response is a sincere thank-you for them taking the time to provide feedback.

Step 4: Don't Argue - Don't ever argue, make excuses, or blame someone else. Even if they are wrong or their complaints aren't fair, your response to a negative review will say more about your practice than what the negative review says. Other who read the negative review, will also be reading your response. They want to see that you are respectful, understanding and willing to do what's best for the patient.

Step 5: Remember HIPPA - Remember that patients can talk about your practice, but you can't share patient information online. But that doesn't matter because you are not going to argue with the patient but to show the patient and the world you are listening and they are your priority. You may need explain that you will need to discuss their concerns in private, but you can assure them that you will help them resolve their concern.

Step 6: Do The Right Thing - This might be apologize for falling short on customer service, give a refund, offer to re-evaluate a situation or simply express empathy. Only you can decide what the right thing to do is, but remember, this decision will speak volumes about your practice.

Use your response to educate patients about your values. Tell the world what your values/standards are and what you are striving for your practice. If you fell short of your regular standards, own it. People will respect that. Turn the response to a negative review into a promotion for your practice.

Step 7: Ask For A Revision - If you have properly taken care of your patient's concerns, it would be totally appropriate to ask if they would be willing to revise their review. If they don't, can't or won't revise the review, go back to Step 1: Relax.

You have shown the world you are listening to your patients, are responsive to their feedback and are trying to do the right thing. That is how you turn a negative review into a positive for your practice!

PS. There are those who say that if you don't have any negative reviews, then you look like a "fake". Patients who are reading reviews are smart. They can spot a reviewer who is unreasonable just like they can spot a practice who does the right thing for its patients.


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Gastro-pharyngeal reflux and total laryngectomy. Increasing knowledge about its management

Investigate the incidence, the degree and the effect of gastro-pharyngeal reflux (GPR) in laryngectomised patients.

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A novel technique for superior-based pharyngeal flaps: 10-year results with formal speech outcomes assessment

Describe a novel technique for superior-based pharyngeal flaps allowing restoration of bulk to the soft palate and intraoperative fine-tuning of lateral port size, while avoiding midline palate-splitting. Validated speech assessment tools are employed for quantitative analysis.

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Prognostic impact of baseline urinary albumin excretion rate in patients with resistant hypertension: a prospective cohort study

Prognostic impact of baseline urinary albumin excretion rate in patients with resistant hypertension: a prospective cohort study

Prognostic impact of baseline urinary albumin excretion rate in patients with resistant hypertension: a prospective cohort study, Published online: 11 December 2017; doi:10.1038/s41371-017-0013-2

Prognostic impact of baseline urinary albumin excretion rate in patients with resistant hypertension: a prospective cohort study

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Prevalence, treatment patterns, and risk factors of hypertension and pre-hypertension among Bangladeshi adults

Prevalence, treatment patterns, and risk factors of hypertension and pre-hypertension among Bangladeshi adults

Prevalence, treatment patterns, and risk factors of hypertension and pre-hypertension among Bangladeshi adults, Published online: 11 December 2017; doi:10.1038/s41371-017-0018-x

Prevalence, treatment patterns, and risk factors of hypertension and pre-hypertension among Bangladeshi adults

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Pulse pressure, arterial stiffening, and the efficacy of renin–angiotensin system inhibitor combinations

Pulse pressure, arterial stiffening, and the efficacy of renin–angiotensin system inhibitor combinations

Pulse pressure, arterial stiffening, and the efficacy of renin–angiotensin system inhibitor combinations, Published online: 11 December 2017; doi:10.1038/s41371-017-0014-1

Pulse pressure, arterial stiffening, and the efficacy of renin–angiotensin system inhibitor combinations

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Smile Train: Making the Grade in Global Cleft Care

Cranial Maxillofac Trauma Reconstruction
DOI: 10.1055/s-0037-1608700

The global medical and psychological burden of cleft lip and palate is large, especially in low- and middle-income countries. For decades, medical missions have sought to alleviate this burden; however, there are significant barriers to providing sustainable, high-quality cleft care using the mission model. Smile Train, an international children's charity founded in 1999, has developed a scalable model which provides support to local partner hospitals and surgeons around the world. Smile Train partners with hospitals to support cleft care treatment across the developing world. Partner hospitals are held to strict safety and quality standards. Local or regional providers are primarily used to train medical personnel. A quality assurance process developed by the Smile Train's Medical Advisory Board is used to assess cleft surgery cases and suggest additional review and training as needed. Surgical candidates are systematically evaluated and must meet specific medical criteria to ensure safety. Experienced anesthetists adhere to Smile Train's safety and quality protocols including anesthesia guidelines.Smile Train and its partners have provided more than 1.2 million safe, high-quality cleft surgical treatments since 1999. Smile Train has sponsored more than 3,000 hands-on training opportunities, 30,000 opportunities to participate in cleft conferences, and 40,000 virtual cleft training opportunities. Through rigorous self-governance and its sustainable, scalable model, this organization has elevated the standard of cleft care in the developing world.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



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How to manage anaphylaxis in primary care

Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different com...

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Lie bumps (transient lingual papillitis): What to know

Lie bumps or transient lingual papillitis refers to small red or white bumps that occur on the tongue and cause discomfort. Learn more.

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Utah's dentist workforce 'overwhelmingly male,' new study states

"I felt everybody was really supportive except for my own mom. She was not supportive," Brown said during recent interview.



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UC San Diego 3D prints world’s first sea turtle brace for rescued reptile

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An injured Loggerhead sea turtle has been given a new lease of life thanks to a 3D printed brace manufactured by the Geisel Library Digital Media Lab at UC San Diego and fitted by staff at the Birch Aquarium at the Scripps Institute of Oceanography. The brace, apparently the first of its kind in the […]

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​​​​​​​Warming could foil wind energy

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Moving on from adversity: an understanding of resilience in rural Thai older people

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Profiles by suicide methods: an analysis of older adults

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Systematic review of the diagnostic accuracy of the non-English versions of Addenbrooke's cognitive examination – revised and III

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Moving on from adversity: an understanding of resilience in rural Thai older people

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Profiles by suicide methods: an analysis of older adults

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Systematic review of the diagnostic accuracy of the non-English versions of Addenbrooke's cognitive examination – revised and III

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When Forensic Odontology met Biochemistry: Multidisciplinary approach in Forensic Human Identification

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Publication date: Available online 9 December 2017
Source:Archives of Oral Biology
Author(s): Joe Adserias-Garriga, Christian Thomas, Douglas H. Ubelaker, Sara C. Zapico
When human remains are found, the priority of the investigation is to ascertain the identity of the deceased. A positive identification is a key factor in providing closure for the family of the deceased; it is also required to issue the death certificate and therefore, to settle legal affairs. Moreover, it is difficult for any forensic investigation involving human remains to be solved without the determination of an identity. Therefore, personal identification is necessary for social, legal and forensic reasons.In the last thirty years forensic odontology has experienced an important transformation, from primarily involving occasional dental identification into a broader role, contributing to the determination of the biological profile. In the same way, "DNA fingerprinting" has evolved not only in terms of improving its technology, but also in its application beyond the "classical": helping with the estimation of sex, age and ancestry. As these two forensic disciplines have developed independently, their pathways have crossed several times through human identification operations, especially the ones that require a multidisciplinary approach. Thus, the aim of this review is to describe the contributions of both forensic odontology and molecular biology/biochemistry to human identification, demonstrating how a multidisciplinary approach can lead to a better and more efficient identification.



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Molecular Testing for Oncogenic Gene Alterations in Pediatric Thyroid Lesions

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Thyroid , Vol. 0, No. 0.


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Dentists have a Naughty and Nice food and beverage list

The festive party season is already underway, but how do you enjoy all the socializing and celebrations without turning your teeth into lumps of coal? The Ontario Dental Association looks at the traditional holiday treats and how you can enjoy all the goodies this magical time has to offer while still caring for your mouth. Prevent tooth rot this December with this helpful list.



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A well-circumscribed lobulated tumor on the hard palatal mucosa in a child

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Publication date: Available online 11 December 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Alfonso Salcines, Sook-Bin Woo, Vikki Noonan, Michael J. Mansfield, Chia-Cheng Li




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Microbial population changes in patients with medication-related osteonecrosis of the jaw treated with systemic antibiotics

Publication date: Available online 11 December 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Lieselotte De Bruyn, Ruxandra Coropciuc, Wim Coucke, Constantinus Politis
ObjectiveThis study aimed to investigate the bacterial population in patients with medication-related osteonecrosis of the jaw (MRONJ) after treatment with doxycycline and metronidazole.Study DesignThirty-eight patients with MRONJ (age range 55–88, mean age 73 + 8.82 SD) treated with doxycycline first and secondly with metronidazole were enrolled in this study. Two swabs were taken at the margin of the infected MRONJ lesion after applying pressure on the marginal mucosa and visible pus was secreted. RT-PCR was used to analyse 20 perio-pathogenic and commensal species and the total bacterial level. Bacterial counts were compared between antibiotic treatments and with a control group of orally healthy patients that didn't have periodontal pockets of more than 3 mm (n=29) by means of a Mann-Whitney U test. Comparisons between the two antibiotic treatments were performed by a paired Wilcoxon signed rank test.ResultsThe total bacterial level was significantly higher in the MRONJ patients treated with systemic antibiotics compared with the control group. However, significant lower bacterial amounts were found for 12 of the 20 investigated bacteria. We couldn't establish a significant advantage of metronidazole administration after doxycycline treatment.ConclusionOur findings suggest that the total bacterial level in MRONJ patients is higher even when treated with systemic antibiotics. The significantly different bacterial amounts of the selected species suggest an alteration in the microbial population.



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PhotoBioModulation: How Many Sessions and How Often?

Photomedicine and Laser Surgery , Vol. 0, No. 0.


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Two-Step Irradiance Treatment Can Achieve Excellent Pain Control During Red Light 5-Aminolevulinic Acid Photodynamic Therapy for Actinic Keratoses

Photomedicine and Laser Surgery , Vol. 0, No. 0.


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Mannitol and the blood-labyrinth barrier

Abstract

Background

Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically difficult to perform. In this report, we demonstrated a unique method of controlling the BLB, and established the pharmacokinetics of gentamicin in perilymph, cerebrospinal fluid (CSF) and blood with and without mannitol.

Study design

Controlled animal research project.

Methods

Permeability of the BLB and the blood brain barrier (BBB) to gentamicin with and without mannitol was studied by collecting 175 samples from 44 guinea pigs using concentrations relevant to human clinical situations. Samples were taken from two groups of 22 animals, with each animal undergoing sampling at a different time after administration of either 10 mg/ml gentamicin (4 mg/kg) (Gardena, CA) alone or gentamicin with 20% mannitol (250 mg/kg) (Mallinckrodt Inc., KY). The sample times varied from 0.5 to 17.5 h post-infusion. Samples were also taken from 4 animals as negative controls after administration of normal saline. Our goal was to simultaneously assess the pharmacokinetics of gentamicin in each of three different fluid samples in the same animal. Thus at the pre-determined post-infusion sampling time, each animal was sampled once for perilymph, CSF, and blood before being euthanized. Each animal contributed to a single time point on the subsequent pharmacokinetic curves with more than one animal per time point.

Results

Mannitol increased the rate of entry and egress of gentamicin through BLB significantly (p = 0.0044) but the effects on the BBB did not reach statistical significance (p = 0.581). Mannitol did not alter renal clearance of gentamicin from the blood (p = 0.433). The concentration of gentamicin in perilymph and CSF was always significantly lower than in blood.

Conclusions

Mannitol administration transiently increases the permeability of the BLB. Potential clinical benefits may accrue from selected timing of administration of osmotic agents such as mannitol augmenting the rate of entry and egress of compounds such as gentamicin into and out of perilymph.



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Prognostic impact of baseline urinary albumin excretion rate in patients with resistant hypertension: a prospective cohort study



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Prevalence, treatment patterns, and risk factors of hypertension and pre-hypertension among Bangladeshi adults



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Pulse pressure, arterial stiffening, and the efficacy of renin–angiotensin system inhibitor combinations



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Effects of primitive photosynthesis on Earth’s early climate system



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Atmospheric science looks to Venus



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Forest extent and deforestation in tropical Africa since 1900



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Global variation in the cost of increasing ecosystem carbon



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Methane multiplication



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Creeping subduction zones are weaker than locked subduction zones



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Exploring ocean worlds on Earth and beyond



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The far reach of ice-shelf thinning in Antarctica



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Fire frequency drives decadal changes in soil carbon and nitrogen and ecosystem productivity



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Abundance and richness of key Antarctic seafloor fauna correlates with modelled food availability



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Southward shift of the global wind energy resource under high carbon dioxide emissions



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Scientific agreement can neutralize politicization of facts



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The health of Antarctic ice shelves



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Regulated hunting re-shapes the life history of brown bears



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Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study

Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study

Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study, Published online: 11 December 2017; doi:10.1038/s41430-017-0042-5

Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study

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Increased histopathological yield for granulomatosis with polyangiitis based on nasal endoscopy of suspected active lesions

Abstract

Purpose

To present the results of an endoscopic and histopathologic evaluation of suspected nasal active granulomatosis with polyangiits (GPA) lesions, describe them as seen by the ENT specialist, and propose a guide for tissue sampling of the nasal cavity to improve the yield of confirmatory histology.

Methods

Randomly selected patients seen from December 1997–October 2007 had a thorough endoscopic nasal evaluation, preceded by careful cleansing of the nasal cavity. Endoscopic lesions were described; sensitivities, specificities, and predictive values of the composites of endoscopic and histological activity were determined.

Results

Six lesions, some not previously described in detail, were observed: white submucosal nodules, mucosal swelling, polypoid nodules, vascular submucosal dilatations, bloody submucosal patches, and ulcers. Of these, polypoid nodules (PPV 100%), persistent white submucosal nodules (PPV 81%), and bloody submucosal patches (PPV 93%) had the better diagnostic performance with confirmed histological diagnosis.

Conclusions

Careful nasal cavity preparation, observation, and description of the nasal mucosa can guide tissue sampling documenting active GPA. This can lead to a better histological yield when definitive proof of the disease is needed.



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Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil

C. M. Barbosa et al.

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Increased histopathological yield for granulomatosis with polyangiitis based on nasal endoscopy of suspected active lesions

Abstract

Purpose

To present the results of an endoscopic and histopathologic evaluation of suspected nasal active granulomatosis with polyangiits (GPA) lesions, describe them as seen by the ENT specialist, and propose a guide for tissue sampling of the nasal cavity to improve the yield of confirmatory histology.

Methods

Randomly selected patients seen from December 1997–October 2007 had a thorough endoscopic nasal evaluation, preceded by careful cleansing of the nasal cavity. Endoscopic lesions were described; sensitivities, specificities, and predictive values of the composites of endoscopic and histological activity were determined.

Results

Six lesions, some not previously described in detail, were observed: white submucosal nodules, mucosal swelling, polypoid nodules, vascular submucosal dilatations, bloody submucosal patches, and ulcers. Of these, polypoid nodules (PPV 100%), persistent white submucosal nodules (PPV 81%), and bloody submucosal patches (PPV 93%) had the better diagnostic performance with confirmed histological diagnosis.

Conclusions

Careful nasal cavity preparation, observation, and description of the nasal mucosa can guide tissue sampling documenting active GPA. This can lead to a better histological yield when definitive proof of the disease is needed.



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Influence of different types of light on the response of the pulp tissue in dental bleaching: a systematic review

Abstract

Objectives

This systematic review (PROSPERO register: CRD42016053140) investigated the influence of different types of light on the pulp tissue during dental bleaching.

Materials and methods

Two independent authors conducted a systematic search and risk of bias evaluations. An electronic search was undertaken (PubMed/Medline, Embase, The Cochrane Library, and other databases) until May 2017. The population, intervention, comparison, outcomes (PICO) question was: "Does the light in dental bleaching change the response of the pulp to the bleaching procedure?" The intervention involved pulp tissue/cells after bleaching with light, while the comparison involved pulp tissue/cells after bleaching without light. The primary outcome was the inflammation/cytotoxicity observed in pulp after bleaching.

Results

Out of 2210 articles found, 12 articles were included in the review; four were in vivo studies (one study in dogs/others in human), and eight were in vitro studies (cell culture/with artificial pulp chamber or not). The light source used was halogen, light-emitting diode (LED), and laser. Only one in vivo study that used heat to simulate light effects showed significant pulp inflammation. Only two in vitro studies demonstrated that light influenced cell metabolism; one using halogen light indicated negative effects, and the other using laser therapy indicated positive effects. Given that animal and in vitro studies have been identified, there remain some limitations for extrapolation to the human situation. Furthermore, different light parameters were used.

Conclusions

The effects of dental bleaching on the pulp are not influenced by different types of light, but different light parameters can influence these properties.

Clinical relevance

There is insufficient evidence about the influence of different types of light on inflammation/cytotoxicity of the pulp.



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SSM Health Cardinal Glennon Children’s Hospital and Stratasys open medical 3D printing Center of Excellence

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Stratasys and SSM Health Cardinal Glennon Children's Hospital, based in St. Louis, Missouri, have opened an advanced 3D printing "Center of Excellence". The pediatric academic medical center was named by the U.S. News and World Report as a "Best Children's Hospital."  With the Stratasys J750 3D printer purchased by the hospital realistic, patient-specific anatomical models […]

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Laudation on Prof. Alexander Berghaus



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Paul Meier: My Journey to Now

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The role of adjuvant chemotherapy in locally advanced bladder cancer

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Early results of a phase-II study of modified short-course radiotherapy combined with capecitabine and delayed surgery for T3M0 lower rectal cancer

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Assessment of communication abilities in multilingual children: Language rights or human rights?

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HCA contract means EIT 3D printed medical devices will be available at largest GPO in US

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Emerging Implant Technologies GmbH (EIT), a German medical 3D printing enterprise, has announced an important contract with the largest group purchasing organization (GPO) in the United States. Working with Ortho Sales Partners, EIT has successfully concluded the contracting process with HealthTrust related to an HCA contract. The Hospital Corporation of America (HCA) has 177 hospitals […]

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Issue Information



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Speak along without the song: what promotes fluency in people with aphasia?

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Effect of whole milk compared with skimmed milk on fasting blood lipids in healthy adults: a 3-week randomized crossover study



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CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue

Abstract

Central nervous system high-grade neuroepithelial tumors with BCOR alteration (CNS HGNET-BCOR) are a recently reported rare entity, identified as a small fraction of tumors previously institutionally diagnosed as so-called CNS primitive neuroectodermal tumors. Their genetic characteristic is a somatic internal tandem duplication in the 3' end of BCOR (BCOR ITD), which has also been found in clear cell sarcomas of the kidney (CCSK) and soft tissue undifferentiated round cell sarcomas/primitive myxoid mesenchymal tumors of infancy (URCS/PMMTI), and these BCOR ITD-positive tumors have been reported to share similar pathological features. In this study, we performed a clinicopathological and molecular analysis of 6 cases of CNS HGNET-BCOR, and compared them with their counterparts in the kidney and soft tissue. Although these tumors had histologically similar structural patterns and characteristic monotonous nuclei with fine chromatin, CNS HGNET-BCOR exhibited glial cell morphology, ependymoma-like perivascular pseudorosettes, and palisading necrosis, whereas these features were not evident in CCSK or URCS/PMMTI. Immunohistochemically, diffuse staining of Olig2 with a mixture of varying degrees of intensity, and only focal staining of GFAP, S-100 protein, and synaptophysin were observed in CNS HGNET-BCOR, whereas these common neuroepithelial markers were negative in CCSK and URCS/PMMTI. Therefore, although CNS HGNET-BCOR, CCSK, and URCS/PMMTI may constitute a group of BCOR ITD-positive tumors, only CNS HGNET-BCOR has histological features suggestive of glial differentiation. In conclusion, we think CNS HGNET-BCOR are a certain type of neuroepithelial tumor relatively close to glioma, not CCSK or URCS/PMMTI occurring in the CNS. This article is protected by copyright. All rights reserved.



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University of Wollongong launches 3D bioprinter to combat diabetes

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A Pancreatic Islet Cell Transplantation (PICT) 3D bio-printer has been developed by researchers from the University of Wollongong's ARC Centre of Excellence for Electromaterials Science (ACES) and will be used to treat diabetes at the Royal Adelaide Hospital (RAH) in Australia. The bio-printer, which is capable of producing pancreatic islets suitable for transplantation to diabetes sufferers […]

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Lebensqualität und Schwindel bei bilateraler Cochleaimplantation

Zusammenfassung

Hintergrund

Persistierende Schwindelbeschwerden nach Cochleaimplantation sind bekannte Einflussfaktoren auf die Lebensqualität. Mit in diesen Patientenkollektiven bisher nur teilweise eingesetzten Fragebogeninstrumenten werden die Effekte einer bilateralen Versorgung mit einem Cochleaimplantat (CI) auf die Lebensqualität sowie subjektive Schwindelbeschwerden analysiert.

Ziel der Arbeit

Es sollte untersucht werden, ob Fragebogeninstrumente eine erfolgreiche Methode zur Dokumentation von Schwindelbeschwerden und der Lebensqualität im Rahmen der Qualitätssicherung darstellen.

Material und Methoden

Es wurden 32 bilateral versorgte CI-Patienten bezüglich ihrer Schwindelsymptomatik und Lebensqualität befragt. Dabei kam der Nijmegen-Cochlear-Implant-Fragebogen (NCIQ) zum Einsatz. Bei berichteten, regelmäßigen Schwindelbeschwerden wurden zusätzlich der Schwindel-Handicap-Fragebogen (VHQ) und der Vertigo-Symptom-Scale(VSS)-Fragebogen erhoben.

Ergebnisse

Acht von 32 Patienten zeigten persistierende Schwindelbeschwerden. Die Lebensqualität, gemessen mit dem NCIQ, verbesserte sich signifikant (p < 0,001) um 23,7 % durch eine Versorgung mit dem zweiten CI. Die Schwindelbeschwerden veränderten sich geringfügig (VHQ –11,2 %; VSS +16,4%) nach der zweiten Implantation.

Schlussfolgerung

Die Ergebnisse zeigen, dass mit den Fragebögen praktikable Instrumente vorliegen, mit denen sich Lebensqualität und Schwindelbeschwerden zur Qualitätssicherung dokumentieren lassen und die möglicherweise ergänzend oder alternativ zur apparativen Schwindeldiagnostik sinnvoll angewendet werden können.



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A novel method for treatment of Class III malocclusion in growing patients

Management of Class III malocclusion is one of the most challenging treatments in orthodontics, and several methods have been advocated for treatment of this condition. A new treatment protocol involves the us...

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Nordic Cancer Registries – an overview of their procedures and data comparability

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Preventing the N-terminal processing of human interferon α-2b and its chimeric derivatives expressed in Escherichia coli.

Preventing the N-terminal processing of human interferon α-2b and its chimeric derivatives expressed in Escherichia coli.

Bioorg Chem. 2017 Nov 23;76:294-302

Authors: Ahsan F, Gardner QA, Rashid N, Towers GJ, Akhtar M

Abstract
We have previously shown that human interferon α-2b (IFN) produced in Escherichia coli (E. coli) is heterogeneous at the N-terminal, with three major species (Ahsan et al., 2014). These are: (a) the direct translation product of the gene retaining the N-terminal methionine, (b) a species from which the methionyl residue has been removed by E. coli methionyl aminopeptidase to give the native interferon α-2b and (c) in which the N-terminal Cys residue of the latter contains an acetyl group. In this paper we overcome this heterogeneity, using engineered interferon derivatives with phenylalanine residue directly downstream of the N-terminal methionine (Met-Phe-IFN). This modification not only prevented the removal of the N-terminal methionine by E. coli methionyl aminopeptidase but also the subsequent N-acetylation. Critically, Met-Phe-IFN had enhanced activity in a biological assay. N-terminal stabilization was also achieved by fusing human cytochrome b5 at the N-terminal of interferon (b5-IFN-chimera). In this case also, the protein was more active than a reciprocal chimera with cytochrome b5 at the C-terminal of interferon (Met-IFN-b5-chimera). This latter protein also had a heterogeneous N-terminal but addition of phenylalanine following Met, (Met-Phe-IFN-b5-chimera), resolved this problem and gave enhanced biological activity.

PMID: 29223806 [PubMed - as supplied by publisher]



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Springfield residents receive free dental care at STCC Community Dental Day

Now that holiday shopping has begun across the nation, it's the perfect time to kick off our 12 DAYS OF GIFTS WITH YANKEE CANDLE VILLAGE SPRINGFIELD, Mass. - Despite the weather, the first ever community dental day was a big success at Springfield Technical Community College .



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Functional reduction in pollination through herbivore-induced pollinator limitation and its potential in mutualist communities

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Aerosols cause intraseasonal short-term suppression of Indian monsoon rainfall

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Single Crystal Organic Nanoflowers



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Comparative genome analysis of the vineyard weed endophyte Pseudomonas viridiflava CDRTc14 showing selective herbicidal activity



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A new high-pressure form of Mg2SiO4 highlighting diffusionless phase transitions of olivine



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Continuous Radar Tracking Illustrates the Development of Multi-destination Routes of Bumblebees

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Live bearing promotes the evolution of sociality in reptiles



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Skeletal fluorosis in relation to drinking water in rural areas of West Azerbaijan, Iran



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A neuronal signature of accurate imitative learning in wild-caught songbirds (swamp sparrows, Melospiza georgiana)

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Sporadic low-velocity volumes spatially correlate with shallow very low frequency earthquake clusters



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Dietary Habits and Cooking Methods Could Reduce Avoidable Exposure to PCBs in Maternal and Cord Sera



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Efficient dissolved organic carbon production and export in the oligotrophic ocean



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Design of plasmonic Ag-TiO2/H3PW12O40 composite film with enhanced sunlight photocatalytic activity towards o-chlorophenol degradation

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A mechanistic theory for aquatic food chain length

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Natural Erosion of Sandstone as Shape Optimisation

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Understanding population structure and historical demography of Litsea auriculata (Lauraceae), an endangered species in east China



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Mapping the ecological networks of microbial communities

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Cigarette smoke extract induces oral squamous cell carcinoma cell invasion in a receptor for advanced glycation end-products-dependent manner

Oral squamous cell carcinoma (OSCC) affects approximately 30,000 people and is associated with tobacco use. Little is known about the mechanistic effects of second-hand smoke in the development of OSSC. The receptor for advanced glycation end-products (RAGE) is a surface receptor that is upregulated by second-hand smoke and inhibited by semi-synthetic glycosaminoglycan ethers (SAGEs). Our objective was to determine the role of RAGE during cigarette smoke extract-induced cellular responses and to use SAGEs as a modulating factor of Ca9-22 OSCC cell invasion. Ca9-22 cells were cultured in the presence or absence of cigarette smoke extract and SAGEs. Cell invasion was determined and cells were lysed for western blot analysis. Ras and nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-κB) activation were determined. Treatment of cells with cigarette smoke extract resulted in: (i) increased invasion of OSCC; (ii) increased RAGE expression; (iii) inhibition of cigarette smoke extract-induced OSCC cell invasion by SAGEs; (iv) increased Ras, increased AKT and NF-κB activation, and downregulation by SAGEs; and (v) increased expression of matrix metalloproteinases (MMPs) 2, 9, and 14, and downregulation by SAGEs. We conclude that cigarette smoke extract increases invasion of OSCC cells in a RAGE-dependent manner. Inhibition of RAGE decreases the levels of its signaling molecules, which results in blocking the cigarette smoke extract-induced invasion.



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Calcium chloride-enriched calcium aluminate cement promotes in vitro osteogenesis

Abstract

Aim

To evaluate the effects of 2.8% or 10% calcium chloride (CaCl2) in calcium aluminate cement (CAC) with either bismuth oxide (Bi2O3) or zinc oxide (ZnO) as radiopacifiers on the progression of osteogenic cell cultures.

Methodology

Rat calvaria-derived cells were grown on Thermanox® coverslips for 24 h and exposed to samples of 1) CACb: with 2.8% CaCl2 and 25% Bi2O3; 2) CACb+: with 10% CaCl2 and 25% Bi2O3; 3) CACz: with 2.8% CaCl2 and 25% ZnO; or 4) CACz+: with 10% CaCl2 and 25% ZnO, placed on inserts. Non-exposed cultures served as control. Calcium and phosphorus contents in culture media were quantified. The effects of the cements on cell apoptosis, cell viability, and acquisition of the osteogenic cell phenotype were evaluated. Data were compared by Kruskal-Wallis test (α = 5%).

Results

CACb+ promoted the highest levels of calcium in the culture media; CACz+, the lowest levels of phosphorus (p < 0.05). CACz+ and CACb increased cell apoptosis (p < 0.05). CACb reduced cell viability (p < 0.05) and the expression of the osteoblastic phenotype. CACz+ and CACb+ promoted greater cell differentiation and matrix mineralization compared to CACz and CACb (p < 0.05).

Conclusion

For calcium aluminate cement with the lower CaCl2 content, the use of Bi2O3 was detrimental for osteoblastic cell survival and differentiation compared to ZnO, while calcium aluminate cement with the higher CaCl2 content supported the acquisition of the osteogenic cell phenotype in vitro regardless of the radiopacifier used. Thus, calcium aluminate cement with 10% CaCl2 would potentially promote bone repair in the context of endodontic therapies.

This article is protected by copyright. All rights reserved.



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A Study on Omentin-1 and Prostate Specific Antigen in Women on Treatment for Polycystic Ovary Syndrome

Abstract

Omentin-1 and prostate specific antigen (PSA) are known to be markers of insulin resistance and hyperandrogenism respectively in polycystic ovary syndrome (PCOS). This study aimed to assess the changes in serum omentin-1 and PSA levels in PCOS patients while on treatment. Serum omentin-1, PSA, BMI and Ferriman gallwey score (FG score) were measured in 80 women with PCOS. The subjects were treated depending on their presenting complaints. The parameters were analysed at baseline and after 3 months of treatment viz. lifestyle modification (Group I), oral contraceptive pills (OCP) (Group II), clomiphene citrate (Group III), medroxy progesterone acetate (Group IV) or metformin (Group V) and was compared using paired-t test. Group II showed significant increase in serum omentin-1 (271.7 ± 112.2 vs 378.1 ± 242 ng/ml; P = 0.025) and decrease in serum PSA (0.014 ± 0.02 vs 0.005 ± 0.008 ng/ml; P = 0.027) after 3 cycles of OCP. Group I and IV also showed a decrease in serum PSA while FG score decreased in group II and group III. There was a negative correlation observed between serum omentin-1 and BMI. To conclude, PCOS women showed increase in serum omentin-1 levels after 3 cycles of OCP while serum PSA decreased after 3 months of lifestyle modification or on treatment with OCP or medroxy progesterone acetate.



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The limitations of some European healthcare databases for monitoring the effectiveness of pregnancy prevention programmes as risk minimisation measures

Abstract

Purpose

Pregnancy prevention programmes (PPPs) exist for some medicines known to be highly teratogenic. It is increasingly recognised that the impact of these risk minimisation measures requires periodic evaluation. This study aimed to assess the extent to which some of the data needed to monitor the effectiveness of PPPs may be present in European healthcare databases.

Methods

An inventory was completed for databases contributing to EUROmediCAT capturing pregnancy and prescription data in Denmark, Norway, the Netherlands, Italy (Tuscany/Emilia Romagna), Wales and the rest of the UK, to determine the extent of data collected that could be used to evaluate the impact of PPPs.

Results

Data availability varied between databases. All databases could be used to identify the frequency and duration of prescriptions to women of childbearing age from primary care, but there were specific issues with availability of data from secondary care and private care. To estimate the frequency of exposed pregnancies, all databases could be linked to pregnancy data, but the accuracy of timing of the start of pregnancy was variable, and data on pregnancies ending in induced abortions were often not available. Data availability on contraception to estimate compliance with contraception requirements was variable and no data were available on pregnancy tests.

Conclusion

Current electronic healthcare databases do not contain all the data necessary to fully monitor the effectiveness of PPP implementation, and thus, special data collection measures need to be instituted.



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Αναζήτηση αυτού του ιστολογίου

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