There are few published studies on the relationship between occupational lumbar load and facet joint degeneration (FJD). This cross-sectional study was conducted to evaluate the effect of physical lumbar load ...
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Παρασκευή 23 Ιουνίου 2017
Comparison of facet joint degeneration in firefighters and hospital office workers
The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea
Although recent studies have investigated the influence of vitamin D on sleep patterns, there is a lack of research on the relationship between vitamin D and sleep patterns in Korean workers. This study focuse...
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Perception of and attitude toward ethical issues among Korean occupational physicians
Occupational physicians (OPs) have complex relationships with employees, employers, and the general public. OPs may have simultaneous obligations towards third parties, which can lead to variable conflicts of ...
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Mike Blevins did much more than just make great barbecue - Johnson City Press (subscription)
| Mike Blevins did much more than just make great barbecue Johnson City Press (subscription) Blevins, 67, died on June 15 after a hard struggle with cancer. Blevins was well known in the community. For 38 years he had ... When he was only 7 or 8 he had his tonsils taken out. The first time he was able to go out and eat after the surgery, Jeff ... |
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Pure intraductal carcinoma of the parotid gland: Cytologic findings on FNA sample. Report of one case
One case of intraductal carcinoma of the parotid gland in a 67-year-old male patient is here introduced. The patient, who had a one-year history of a parotid mass, had undergone ultrasound and MRI examination that disclosed a 13x4x3 mm well delimited nodular mass of the accessory lobe of his left parotid gland. Ultrasound-guided Fine Needle Aspiration (FNA) had been performed by the clinician. The obtained smears showed widespread cellular necrosis in which cellular clusters with moderate and focally severe atypias displayed papillary and cribriform architecture and were admixed with sheets of epithelial cells with less striking nuclear atypias, squamous, or apocrine metaplasia. Histopathological examination disclosed a pure intraductal carcinoma of the parotid gland with classical morphology, which was radically excised. The differential cytological diagnosis of pure intraductal carcinoma of salivary glands may be difficult and comprises mucoepidermoid carcinoma as well as "in situ" carcinomas developping in the context of sclerosing polycystic adenosis, mammary analogue secretory carcinoma (MASC) of the salivary glands and cystic variants of salivary adenocarcinoma NOS (formerly called cystadenocarcinomas).
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Former executives of Chandler company face investigations over opioid spray, patient deaths - AZCentral.com
AZCentral.com | Former executives of Chandler company face investigations over opioid spray, patient deaths AZCentral.com Subsys is approved by the U.S. Food and Drug Administration for cancer patients with "breakthrough" pain. The user sprays the drug beneath the tongue so it can be instantly absorbed, bringing immediate relief for pain spikes that aren't controlled by ... |
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GoFundMe to reimburse those who gave to woman's cancer fund - WNCN
WNCN | GoFundMe to reimburse those who gave to woman's cancer fund WNCN (KOIN) — After a KOIN investigation into an Oregon woman who claimed to have cancer, GoFundMe said it will reimburse people who donated to her fundraising effort. Jennifer Gaskin of Tualatin told friends and police she was treated for thyroid cancer ... and more » |
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Donors to Tualatin cancer GoFundMe to get reimbursed - KOIN.com
KOIN.com | Donors to Tualatin cancer GoFundMe to get reimbursed KOIN.com (KOIN) — After a KOIN 6 News investigation into a local woman who claimed to have cancer, GoFundMe said they will reimburse people who donated to her fundraising effort. Jennifer Gaskin of Tualatin told friends and police she was treated for thyroid ... |
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Table of Contents
Head and neck cancer cured with THIS treatment: Swollen glands were only symptoms - Express.co.uk
Express.co.uk | Head and neck cancer cured with THIS treatment: Swollen glands were only symptoms Express.co.uk The mum-of-one, from Southampton, underwent months of gruelling chemotherapy and image-guided radiotherapy which appeared to stop the cancer - the size of a large marble - in its tracks. Sylvia and her husband Neil, a Professor in Electronics and ... |
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Massive Middle Cerebral Artery Infarction After Surgically Assisted Rapid Palatal Expansion: A Case Report
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Kenneth Kufta, Luis Perez Melean, M. Sean Grady, Neeraj Panchal
Dentofacial deformities have a marked impact on a patient's quality of life. Fortunately, these deformities often can be corrected through orthodontic and surgical treatment. In adults, transverse maxillary discrepancies are often corrected by performing a surgically assisted rapid palatal expansion (SARPE) procedure. This procedure is accompanied by many of the same complications involved in performing a Le Fort I osteotomy. Although major complications from maxillary surgery are uncommon, severe hemorrhage and cerebrovascular accidents are real risks accompanied by serious sequelae. The purpose of this case report is to describe a case in which a patient developed a massive middle cerebral artery infarct after a SARPE procedure. The authors discuss the possible etiology and pathogenesis of the complication. They also aim to remind surgeons of this rare complication to ensure prompt recognition and management to prevent delays in care.
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Editorial Board Page
Antibiotic Prophylaxis in Blepharoplasty: Review of the Current Literature
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Elie M. Ferneini, Steven Halepas, Steven I. Aronin
The purpose of this study was to provide an evidence-based overview of antibiotic prophylaxis in blepharoplasty. We performed a literature search that evaluated the risk of infection associated with blepharoplasty, as well as the risks and benefits of antibiotic prophylaxis. The overall infection rate associated with eyelid surgery is extremely low. However, the use of antibiotic prophylaxis has increased over the past 25 years in esthetic facial procedures. There is no standard of care for or against antibiotic prophylaxis, and routine practices vary widely. This leads to the question of whether reducing the risk of surgical-site infection to near zero outweighs the real danger of antibiotic-related complications, including the escalating emergence of antibiotic-resistant bacteria. No direct consensus can be drawn from the current literature; thus, at this time, there is no current standard of care for oral and maxillofacial surgeons to adhere to in terms of when and if antibiotic prophylaxis is needed when performing blepharoplasty.
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Antibiotic Prophylaxis in Blepharoplasty: Review of the Current Literature
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Elie M. Ferneini, Steven Halepas, Steven I. Aronin
The purpose of this study was to provide an evidence-based overview of antibiotic prophylaxis in blepharoplasty. We performed a literature search that evaluated the risk of infection associated with blepharoplasty, as well as the risks and benefits of antibiotic prophylaxis. The overall infection rate associated with eyelid surgery is extremely low. However, the use of antibiotic prophylaxis has increased over the past 25 years in esthetic facial procedures. There is no standard of care for or against antibiotic prophylaxis, and routine practices vary widely. This leads to the question of whether reducing the risk of surgical-site infection to near zero outweighs the real danger of antibiotic-related complications, including the escalating emergence of antibiotic-resistant bacteria. No direct consensus can be drawn from the current literature; thus, at this time, there is no current standard of care for oral and maxillofacial surgeons to adhere to in terms of when and if antibiotic prophylaxis is needed when performing blepharoplasty.
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Massive Middle Cerebral Artery Infarction After Surgically Assisted Rapid Palatal Expansion: A Case Report
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Kenneth Kufta, Luis Perez Melean, M. Sean Grady, Neeraj Panchal
Dentofacial deformities have a marked impact on a patient's quality of life. Fortunately, these deformities often can be corrected through orthodontic and surgical treatment. In adults, transverse maxillary discrepancies are often corrected by performing a surgically assisted rapid palatal expansion (SARPE) procedure. This procedure is accompanied by many of the same complications involved in performing a Le Fort I osteotomy. Although major complications from maxillary surgery are uncommon, severe hemorrhage and cerebrovascular accidents are real risks accompanied by serious sequelae. The purpose of this case report is to describe a case in which a patient developed a massive middle cerebral artery infarct after a SARPE procedure. The authors discuss the possible etiology and pathogenesis of the complication. They also aim to remind surgeons of this rare complication to ensure prompt recognition and management to prevent delays in care.
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Table of Contents
Alternative Distraction Osteogenesis Technique After Implant Placement for Alveolar Ridge Augmentation of the Maxilla
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Renato Luiz Maia Nogueira, Rafael Lima Verde Osterne, Ricardo Teixeira Abreu, Phelype Maia Araújo
An alternative technique to reconstruct atrophic alveolar vertical bone after implant placement is presented. The technique consists of distraction osteogenesis or direct surgical repositioning of an implant-and-bone block segment after segmental osteotomies that can be used in esthetic or unesthetic cases. Initially, casts indicating the implant position are obtained and the future ideal prosthetic position is determined to guide the model surgery. After the model surgery, a new provisional prosthesis is fabricated, and an occlusal splint, which is used as a surgical guide and a device for distraction osteogenesis, is custom fabricated. Then, the surgery is performed. For mobilization of the implant-and-bone block segment, 2 vertical osteotomies are performed and then joined by a horizontal osteotomy. The implant-and-bone block segment is moved to the planned position. If a small movement is planned, then the implant-and-bone segment is stabilized; for larger movements, the implant-and-bone segment can be gradually moved to the final position by distraction osteogenesis. This technique has good predictability of the final position of the implant-and-bone segment and relatively fast esthetic rehabilitation. It can be considered for dental implants in regions of vertical bone atrophy.
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Alternative Distraction Osteogenesis Technique After Implant Placement for Alveolar Ridge Augmentation of the Maxilla
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Renato Luiz Maia Nogueira, Rafael Lima Verde Osterne, Ricardo Teixeira Abreu, Phelype Maia Araújo
An alternative technique to reconstruct atrophic alveolar vertical bone after implant placement is presented. The technique consists of distraction osteogenesis or direct surgical repositioning of an implant-and-bone block segment after segmental osteotomies that can be used in esthetic or unesthetic cases. Initially, casts indicating the implant position are obtained and the future ideal prosthetic position is determined to guide the model surgery. After the model surgery, a new provisional prosthesis is fabricated, and an occlusal splint, which is used as a surgical guide and a device for distraction osteogenesis, is custom fabricated. Then, the surgery is performed. For mobilization of the implant-and-bone block segment, 2 vertical osteotomies are performed and then joined by a horizontal osteotomy. The implant-and-bone block segment is moved to the planned position. If a small movement is planned, then the implant-and-bone segment is stabilized; for larger movements, the implant-and-bone segment can be gradually moved to the final position by distraction osteogenesis. This technique has good predictability of the final position of the implant-and-bone segment and relatively fast esthetic rehabilitation. It can be considered for dental implants in regions of vertical bone atrophy.
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AAOMS Author Disclosure forms
AAOMS Author Disclosure forms
The Dynamic Landscape of Health Care Insurance—Implications for Our Specialty
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): James R. Hupp
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The Dynamic Landscape of Health Care Insurance—Implications for Our Specialty
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): James R. Hupp
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Endoscope-Assisted Resection of Elongated Styloid Process Through a Retroauricular Incision: A Novel Surgical Approach to Eagle Syndrome
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Renhui Chen, Faya Liang, Ping Han, Qian Cai, Shitong Yu, Xiaoming Huang
PurposeConventional resection of the elongated styloid process is associated with large-scale tissue dissection and poor surgical exposure. The purpose of this study was to show the feasibility, efficacy, and safety of a novel surgical approach using an endoscopic technique to treat Eagle syndrome.Materials and MethodsThe authors implemented a retrospective cohort study composed of 133 patients undergoing endoscope-assisted styloidectomy (EAS) from June 2010 to August 2015 at a university teaching hospital. Outcome measurements included the length of the styloid process, blood loss, and duration of surgery. The simple verbal response scale for symptom relief, cosmetic appearance of the incision, and postoperative incision pain was used for the assessment of patients' subjective satisfaction.ResultsAll patients underwent EAS without conversion to conventional surgery. One hundred seven patients (80.5%) achieved complete relief of symptoms, with 20 (15%) achieving partial relief. The residual length of the styloid process was 10.1 ± 4.4 mm. One hundred seventy-two incision sides (75.8%) had no pain during the postoperative evaluation. One side (0.4%) showed slight transient facial paresis and 4 sides (1.8%) presented transient ear numbness. The vast majority of patients (122 of 133; 91.7%) considered the cosmetic appearance of the incision to be excellent.ConclusionsThe results of this study suggest that EAS provides a viable surgical approach for Eagle syndrome in efficacy and safety.
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Endoscope-Assisted Resection of Elongated Styloid Process Through a Retroauricular Incision: A Novel Surgical Approach to Eagle Syndrome
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Renhui Chen, Faya Liang, Ping Han, Qian Cai, Shitong Yu, Xiaoming Huang
PurposeConventional resection of the elongated styloid process is associated with large-scale tissue dissection and poor surgical exposure. The purpose of this study was to show the feasibility, efficacy, and safety of a novel surgical approach using an endoscopic technique to treat Eagle syndrome.Materials and MethodsThe authors implemented a retrospective cohort study composed of 133 patients undergoing endoscope-assisted styloidectomy (EAS) from June 2010 to August 2015 at a university teaching hospital. Outcome measurements included the length of the styloid process, blood loss, and duration of surgery. The simple verbal response scale for symptom relief, cosmetic appearance of the incision, and postoperative incision pain was used for the assessment of patients' subjective satisfaction.ResultsAll patients underwent EAS without conversion to conventional surgery. One hundred seven patients (80.5%) achieved complete relief of symptoms, with 20 (15%) achieving partial relief. The residual length of the styloid process was 10.1 ± 4.4 mm. One hundred seventy-two incision sides (75.8%) had no pain during the postoperative evaluation. One side (0.4%) showed slight transient facial paresis and 4 sides (1.8%) presented transient ear numbness. The vast majority of patients (122 of 133; 91.7%) considered the cosmetic appearance of the incision to be excellent.ConclusionsThe results of this study suggest that EAS provides a viable surgical approach for Eagle syndrome in efficacy and safety.
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Improving Surgeons' Comfort With Prismatic Glasses During Cleft Palate Surgery: Preliminary Findings
Source:Journal of Oral and Maxillofacial Surgery, Volume 75, Issue 7
Author(s): Hai Kuang, Guosheng Chen, Qitao Wen, Shuai Li, Lei Chen, Feixin Liang
PurposeWe aimed to observe the effect of prismatic glasses on improving surgeons' comfort during cleft palate surgery.Materials and MethodsA within-subjects design was used. We included 3 oral-maxillofacial surgeons and 6 patients with complete cleft palate in the study. One group of cleft palate patients (3 complete cleft palates) was allocated to each of the 3 surgeons not wearing prismatic glasses, and another similar group of cleft palate patients was allocated to the same 3 surgeons wearing prismatic glasses. The push-back method was performed in all cleft palate patients by all surgeons. The degree of neck flexion exhibited by all surgeons was digitally video recorded. Screen-capture images of the video recordings were collected, and neck flexion in all video recordings was analyzed. All surgeons completed a questionnaire based on a visual analog scale to assess their discomfort symptoms of the neck, shoulders, and back. Operative time and bleeding volume were recorded to assess operational efficiency.ResultsUse of prismatic glasses significantly reduced surgeons' working time spent in pronounced neck flexion during cleft palate surgery (P < .05), and there was a statistically significant reduction in the visual analog scale discomfort scores for the neck, back, and shoulders with the use of prismatic glasses (P < .05). However, no significant difference was found in operational time (P = .337) and bleeding volume (P = .183) attributable to the presence or absence of prismatic glasses.ConclusionsAn ergonomic approach to cleft palate surgery in which surgeons wore prismatic glasses improved neck, back, and shoulder comfort.
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HBF Run for a Reason: Peter Symonds wants to raise $10000 to help other cancer patients - Perth Now
Perth Now | HBF Run for a Reason: Peter Symonds wants to raise $10000 to help other cancer patients Perth Now At 56-years-old my Dad, Peter Symonds – a loving father of six and a devoted husband of 10 years to my beautiful step mum, had found a lump in his neck one day and a biopsy had revealed he had squamous cell carcinoma that had already spread from his ... |
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Parenting 101: Should my child get the HPV vaccine? - WBIR-TV
WBIR-TV | Parenting 101: Should my child get the HPV vaccine? WBIR-TV "Boys and men get lots of head, neck, throat and tongue cancers from the HPV virus," explained Dr. Kilgore. Can you get HPV from the vaccine? "Nope. No," said Dr. Patterson. "It's biologically impossible because it's only a piece of the virus." "So ... and more » |
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Esami e visite, l'Uib apre lo sportello sanitario - La Stampa
La Stampa | Esami e visite, l'Uib apre lo sportello sanitario La Stampa ... 14 strutture specialistiche dell'Azienda sanitaria: cardiologia, chirurgia generale, ortopedia, psicologia clinica, radioterapia, chirurgia vascolare, urologia, ostetricia, dermatologia, medicina riabilitativa, neurologia radiologia, pediatria, e ... and more » |
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Hearing loss in enlarged vestibular aqueduct and incomplete partition type II
Source:American Journal of Otolaryngology
Author(s): Emily Ahadizadeh, Mustafa Ascha, Nauman Manzoor, Amit Gupta, Maroun Semaan, Cliff Megerian, Todd Otteson
PurposeThe purpose of this work is to identify the role of incomplete partition type II on hearing loss among patients with enlarged vestibular aqueduct (EVA).BackgroundEVA is a common congenital inner ear malformation among children with hearing loss, where vestibular aqueduct morphology in this population has been shown to correlate to hearing loss. However, the impact of incomplete partition between cochlear turns on hearing loss has not been, despite meaningful implications for EVA pathophysiology.MethodsA retrospective review of radiology reports for patients who had computed tomography (CT) scans with diagnoses of hearing loss at a tertiary medical center between January 2000 and June 2016 were screened for EVA. CT scans of the internal auditory canal (IAC) for those patients with EVA were examined for evidence of incomplete partition type II (IP-II), measurements of midpoint width and operculum width a second time, and patients meeting Cincinnati criteria for EVA selected for analysis. Statistical analysis including chi-square, Wilcoxon rank-sum, and t-tests were used to identify differences in outcomes and clinical predictors, as appropriate for the distribution of the data. Linear mixed models of hearing test results for all available tests were constructed, both univariable and adjusting for vestibular aqueduct morphometric features, with ear-specific intercepts and slopes over time.ResultsThere were no statistically significant differences in any hearing test results or vestibular aqueduct midpoint and operculum widths. Linear mixed models, both univariable and those adjusting for midpoint and operculum widths, did not indicate a statistically significant effect of incomplete partition type II on hearing test results.ConclusionsHearing loss due to enlarged vestibular aqueduct does not appear to be affected by the presence of incomplete partition type II. Our results suggest that the pathophysiological processes underlying hearing loss in enlarged vestibular aqueduct may not be a result of cochlear malformation, and instead are more likely to involve vestibular aqueduct or cellular and molecular-level mechanisms of hearing loss.
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Listing ongoing research experience in AMCAS
Hi, I am filling out my research experience in AMCAS but I am a little bit confused about listing ongoing research. I am currently working on a research project with a cancer research. However, we are still at the early stages of the research (Specifically, we have IRB approval and currently working to sort out data from a national database). I am working on exporting the data and sorting them in a meaningful manner. - Should I include this as a research experience? - How should I... Listing ongoing research experience in AMCAS (Source: Student Doctor Network)
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Most Popular NEJM Group Feature This Week: Colorectal Cancer Screening Guidelines (FREE)
By the Editors Here's the most clicked-on item we featured from … (Source: Physician's First Watch current issue)
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WAMC/ MD List
I am wondering if I am a good enough candidate to apply to some MD schools and could really use some help with a list. Any advice or schools or in general? I already have some DO schools but was hoping to still apply for some MD. cGPA: 3.7 sGPA: 3.55 MCAT: 502 (not so great and but I am afraid it will be late if I retake) State of residence: AZ Undergrad: Biomedical Engineering Minor Dance Clinical experience: 50 hours volunteer scribe at free clinics Research: 800 hours biochem/cancer lab... WAMC/ MD List (Source: Student Doctor Network)
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Study: ACA leads to earlier breast cancer diagnoses
The Affordable Care Act (ACA) is being credited for a shift to earlier breast...Read more on AuntMinnie.comRelated Reading: Study links ACA with earlier cancer diagnosis U.S. House passes bill to repeal and replace ACA How do high-deductible health plans affect radiology? What's next for U.S. healthcare regulation? Mammography use rises with ACA; colonoscopy, not so much (Source: AuntMinnie.com Headlines)
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The High Cost of Ageing
Veena S. Kulkarni is Associate Professor, Department of Criminology, Sociology, & Geography, Arkansas State University, U.S.; Vani S. Kulkarni is Lecturer, Department of Sociology, University of Pennsylvania, U.S.; and Raghav Gaiha is (Hon.) Professorial Fellow, Global Development Institute, University of Manchester, EnglandBy Veena S. Kulkarni, Vani S. Kulkarni and Raghav GaihaNEW DELHI, Jun 23 2017 (IPS)Evidence shows that health systems must be recast to accommodate the needs of chronic disease prevention. Disability is the umbrella term for impairments, activity limitations and participation restrictions. (Representational image) | Photo Credit: Getty ImagesThe National Health Policy (NHP), 2017, is long on banalities and short on specifics. In a somewhat glaring omission, little has b...
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FDA approves Rituxan Hycela (rituximab and hyaluronidase human) for subcutaneous injection in certain blood cancers
Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the US Food and Drug Administration (FDA) approved Rituxan Hycela™ (rituximab and hyaluronidase human) for subcutaneous (under the skin) injection, for the treatment of adults with the following blood cancers: previously untreated and relapsed or refractory follicular lymphoma, previously untreated diffuse large B-cell lymphoma (DLBCL), and previously untreated and previously treated chronic lymphocytic leukaemia (CLL). (Source: World Pharma News)
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Kopchicks give $10.5 million gift to MD Anderson UTHealth Graduate School for fellows
(University of Texas Health Science Center at Houston) Just as he has changed the lives of people suffering from a devastating genetic disease, molecular endocrinologist John J. Kopchick, Ph.D., and his wife, Charlene, of Athens, Ohio, are paving the way for future scientists to do the same with a transformative $10.5 million gift to The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. (Source: EurekAlert! - Medicine and Health)
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Immunotherapy kinder than chemotherapy for patients with head and neck cancer
(Institute of Cancer Research) The immunotherapy nivolumab is kinder than chemotherapy for people with advanced head and neck cancer -- easing many of the negative effects of the disease on patients' quality of life. (Source: EurekAlert! - Medicine and Health)
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Most Popular NEJM Group Feature This Week: Colorectal Cancer Screening Guidelines (FREE)
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Study: ACA leads to earlier breast cancer diagnoses
The Affordable Care Act (ACA) is being credited for a shift to earlier breast...Read more on AuntMinnie.comRelated Reading: Study links ACA with earlier cancer diagnosis U.S. House passes bill to repeal and replace ACA How do high-deductible health plans affect radiology? What's next for U.S. healthcare regulation? Mammography use rises with ACA; colonoscopy, not so much (Source: AuntMinnie.com Headlines)
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The High Cost of Ageing
Veena S. Kulkarni is Associate Professor, Department of Criminology, Sociology, & Geography, Arkansas State University, U.S.; Vani S. Kulkarni is Lecturer, Department of Sociology, University of Pennsylvania, U.S.; and Raghav Gaiha is (Hon.) Professorial Fellow, Global Development Institute, University of Manchester, EnglandBy Veena S. Kulkarni, Vani S. Kulkarni and Raghav GaihaNEW DELHI, Jun 23 2017 (IPS)Evidence shows that health systems must be recast to accommodate the needs of chronic disease prevention. Disability is the umbrella term for impairments, activity limitations and participation restrictions. (Representational image) | Photo Credit: Getty ImagesThe National Health Policy (NHP), 2017, is long on banalities and short on specifics. In a somewhat glaring omission, little has b...
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FDA approves Rituxan Hycela (rituximab and hyaluronidase human) for subcutaneous injection in certain blood cancers
Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the US Food and Drug Administration (FDA) approved Rituxan Hycela™ (rituximab and hyaluronidase human) for subcutaneous (under the skin) injection, for the treatment of adults with the following blood cancers: previously untreated and relapsed or refractory follicular lymphoma, previously untreated diffuse large B-cell lymphoma (DLBCL), and previously untreated and previously treated chronic lymphocytic leukaemia (CLL). (Source: World Pharma News)
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Immunotherapy kinder than chemotherapy for patients with head and neck cancer
(Institute of Cancer Research) The immunotherapy nivolumab is kinder than chemotherapy for people with advanced head and neck cancer -- easing many of the negative effects of the disease on patients' quality of life. (Source: EurekAlert! - Medicine and Health)
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Kopchicks give $10.5 million gift to MD Anderson UTHealth Graduate School for fellows
(University of Texas Health Science Center at Houston) Just as he has changed the lives of people suffering from a devastating genetic disease, molecular endocrinologist John J. Kopchick, Ph.D., and his wife, Charlene, of Athens, Ohio, are paving the way for future scientists to do the same with a transformative $10.5 million gift to The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. (Source: EurekAlert! - Medicine and Health)
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Should we be taking the p (value) out of statistics?
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): A.B. Smith
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Health-related quality of life, fear of recurrence, and emotional distress in patients treated for thyroid cancer
Publication date: Available online 23 June 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): S.N. Rogers, V. Mepani, S. Jackson, D. Lowe
Diagnosis of differentiated thyroid carcinoma (papillary or follicular) and its treatment may be associated with a poor health-related quality of life (HRQoL), and with fear of recurrence (FoR), and distress. To our knowledge, this is the first time a single FoR screening question (written to complement a HRQoL questionnaire), has been reported with HRQoL and levels of distress in patients treated for the disease. In April 2014 we did a cross-sectional survey of patients who had presented to the Merseyside and Cheshire thyroid cancer network between April 2009 and November 2013. Questionnaires comprised the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, the THYCA-QoL, the Emotion Thermometers, and the new FoR screening item. A total of 249 surveys were sent and 169 patients responded (68%). The most prevalent issues included tiredness, problems with sleep and needing to rest, pain (particularly in muscles and joints), a dry mouth, hot flushes and tolerating heat, gaining weight, and feeling slowed down or weak; also, having trouble taking long walks or doing strenuous activities, feeling tense, worried, irritable, and anxious, and having difficulty remembering things. One in seven patients (95% CI 9% to 21%) responded to the single FoR question that they "had a lot of fears of recurrence that really preoccupied their thoughts" or were "fearful all the time that their cancer might return and that they struggled with this". Distress overall was relatively low. In conclusion, the HRQoL issues reported by these patients were different from those reported by patients with other cancers of the head and neck. It would be helpful to identify FoR in a subgroup of patients with differentiated thyroid cancer so that they could be given additional support.
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Should we be taking the p (value) out of statistics?
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): A.B. Smith
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Health-related quality of life, fear of recurrence, and emotional distress in patients treated for thyroid cancer
Publication date: Available online 23 June 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): S.N. Rogers, V. Mepani, S. Jackson, D. Lowe
Diagnosis of differentiated thyroid carcinoma (papillary or follicular) and its treatment may be associated with a poor health-related quality of life (HRQoL), and with fear of recurrence (FoR), and distress. To our knowledge, this is the first time a single FoR screening question (written to complement a HRQoL questionnaire), has been reported with HRQoL and levels of distress in patients treated for the disease. In April 2014 we did a cross-sectional survey of patients who had presented to the Merseyside and Cheshire thyroid cancer network between April 2009 and November 2013. Questionnaires comprised the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, the THYCA-QoL, the Emotion Thermometers, and the new FoR screening item. A total of 249 surveys were sent and 169 patients responded (68%). The most prevalent issues included tiredness, problems with sleep and needing to rest, pain (particularly in muscles and joints), a dry mouth, hot flushes and tolerating heat, gaining weight, and feeling slowed down or weak; also, having trouble taking long walks or doing strenuous activities, feeling tense, worried, irritable, and anxious, and having difficulty remembering things. One in seven patients (95% CI 9% to 21%) responded to the single FoR question that they "had a lot of fears of recurrence that really preoccupied their thoughts" or were "fearful all the time that their cancer might return and that they struggled with this". Distress overall was relatively low. In conclusion, the HRQoL issues reported by these patients were different from those reported by patients with other cancers of the head and neck. It would be helpful to identify FoR in a subgroup of patients with differentiated thyroid cancer so that they could be given additional support.
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Amlexanox downregulates S100A6 to sensitize KMT2A/AFF1-positive acute lymphoblastic leukemia to TNF-{alpha} treatment
Acute lymphoblastic leukemias (ALL) positive for KMT2A/AFF1 (MLL/AF4) translocation, which constitute 60% of all infant ALL cases, have a poor prognosis even after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This poor prognosis is due to one of two factors, either resistance to TNF-α which mediates a graft-versus-leukemia (GVL) response after allo-HSCT, or immune resistance due to upregulated expression of the immune escape factor S100A6. Here we report an immune stimulatory effect against KMT2A/AFF1-positive ALL cells by treatment with the anti-allergy drug amlexanox, which we found to inhibit S100A6 expression in the presence of TNF-α. In KMT2A/AFF1-positive transgenic (Tg) mice, amlexanox enhanced tumor immunity and lowered the penetrance of leukemia development. Similarly, in a NOD/SCID mouse model of human KMT2A/AFF1-positive ALL, amlexanox broadened GVL responses and extended survival. Our findings show how amlexanox degrades the resistance of KMT2A/AFF1-positive ALL to TNF-α by downregulating S100A6 expression, with immediate potential implications for improving clinical management of KMT2A/AFF1-positive ALL.
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NF1+/- hematopoietic cells accelerate malignant peripheral nerve sheath tumor development without altering chemotherapy response
Haploinsufficiency in the tumor suppressor NF1 contributes to the pathobiology of type 1 neurofibromatosis, but a related role has not been established in malignant peripheral nerve sheath tumors (MPNST) where NF1 mutations also occur. Patients with NF1-associated MPNST appear to have worse outcomes than patients with sporadic MPNST, but the mechanism underlying this correlation is not understood. To define the impact of stromal genetics on the biology of this malignancy, we developed unique mouse models that reflect the genetics of patient-associated MPNST. Specifically, we used adenovirus-cre injections to generate MPNST in Nf1 Flox/Flox ; Ink4a/Arf Flox/Flox and Nf1 Flox/- ; Ink4a/Arf Flox/Flox paired littermate mice to model tumors from NF1-wildtype and NF1-associated patients, respectively. In these models, Nf1 haploinsufficiency in hematopoietic cells accelerated tumor onset and increased levels of tumor-infiltrating immune cells comprised of CD11b+ cells, monocytes and mast cells. We observed that mast cells were also enriched in human NF1-associated MPNST. In a co-clinical trial to examine how the tumor microenvironment influences the response to multi-agent chemotherapy, we found that stromal Nf1 status had no effect. Taken together, our results clarify the role of the NF1-haploinsufficient tumor microenvironment in MPNST.
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MCAM mediates chemoresistance in small cell lung cancer via the PI3K/AKT/SOX2 signaling pathway
Despite favorable responses to initial therapy, small cell lung cancer (SCLC) relapse occurs within a year and exhibits resistance to multiple drugs. Due to limited accessibility of patient tissues for research purposes, SCLC-patient derived xenografts (PDX) have provided the best opportunity to address this limitation. Here we sought to identify novel mechanisms involved in SCLC chemoresistance. Through in-depth proteomic profiling, we identified MCAM as a markedly upregulated surface receptor in chemoresistant SCLC cell lines and in chemoresistant PDX compared to matched treatment-naïve tumors. MCAM depletion in chemoresistant cells reduced cell proliferation and reduced the IC50 inhibitory concentration of chemotherapeutic drugs in vitro. This MCAM-mediated sensitization to chemotherapy occurred via SOX2-dependent upregulation of mitochondrial 37S ribosomal protein 1/ATP binding cassette subfamily C member 1 (MRP1/ABCC1) and the PI3/AKT pathway. Metabolomic profiling revealed that MCAM modulated lactate production in chemoresistant cells that exhibit a distinct metabolic phenotype characterized by low oxidative phosphorylation. Our results suggest that MCAM may serve as a novel therapeutic target to overcome chemoresistance in SCLC.
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EIF1AX and NRAS mutations co-occur and cooperate in low-grade serous ovarian carcinomas
Low-grade serous ovarian carcinomas (LGSC) are associated with a poor response to chemotherapy and are molecularly characterized by RAS pathway activation. Using exome and whole genome sequencing we identified recurrent mutations in the protein translational regulator EIF1AX and in NF1, USP9X, KRAS, BRAF and NRAS. RAS pathway mutations were mutually exclusive, however we found significant co-occurrence of mutations in NRAS and EIF1AX. Missense EIF1AX mutations were clustered at the N-terminus of the protein in a region associated with its role in ensuring translational initiation fidelity. Co-expression of mutant NRAS and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer.
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Functionally null RAD51D missense mutation associates strongly with ovarian carcinoma
RAD51D is a key player in DNA repair by homologous recombination (HR) and RAD51D truncating mutation carriers have an increased risk for ovarian cancer (OC). However, the contribution of non-truncating RAD51D variants to cancer predisposition remains uncertain. Using deep sequencing and case-control genotyping studies, we show that in French Canadians, the missense RAD51D variant c.620C>T;p.S207L is highly prevalent and is associated with a high risk for ovarian high-grade serous carcinoma (HGSC) (3.8% cases vs 0.2% controls). The frequency of the p.S207L variant did not significantly differ from that of controls in breast, endometrial, pancreas or colorectal adenocarcinomas. Functionally, we show for the first time that this mutation impairs HR by disrupting the RAD51D-XRCC2 interaction and confers PARP-inhibitor sensitivity. These results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR and prevent the development of HGSC. This study identifies c.620C>T;p.S207L as the first bona fide pathogenic RAD51D missense cancer susceptibility allele and supports the use of targeted PARP-inhibitor therapies in OC patients carrying deleterious missense RAD51D mutations.
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Immunotherapy kinder than chemotherapy for patients with head and neck cancer - Medical Xpress
Daily Mail | Immunotherapy kinder than chemotherapy for patients with head and neck cancer Medical Xpress Both head and neck cancer and the treatment for it can have a huge impact on patients - affecting their speech, breathing, eating and drinking, facial appearance, and general wellbeing. All of this can cause substantial psychological, as well as ... Will NHS approve the new cancer drug which avoids the pain of chemotherapy?Daily Mail all 8 news articles » |
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Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery
AbstractSensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome. The primary goal of the present study was to assess that risk in rhesus monkeys, which closely approximates humans with regard to midd...
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NCI's Center for Cancer Research (CCR) Grand Rounds Special Lecture
NCI ' s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Air date: 7/28/2017 12:00:00 PM (Source: Videocast - All Events)
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HIV Dynamics and Replication Program Conference on Innate Immunity: Sensing, Signaling, and Selection
The HIV Dynamics and Replication Program is hosting this half-day conference to showcase the latest findings in the broad field of innate immunity. The presentations will highlight recent advances in understanding cell-intrinsic immune strategies by which hosts counteract viral and bacterial infections and the mechanisms by which pathogens circumvent or overcome these immune barriers. Specific areas of focus will include immune sensing, mutational escape, paleovirology, interferon-induced effector specificity, inflammasomes, and evolutionary conflicts between pathogens and host restriction factors. An in-depth discussion of recent progress in our understanding host-pathogen interactions within infected cells should lead to new insights into the roles that cellular factors play in preventin...
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Celebrating 21 Years of the CURE Program
The National Cancer Institute ' s (NCI ' s) Center to Reduce Cancer Health Disparities (CRCHD) will host the " Celebrating 21 Years of the Continuing Umbrella of Research Experiences (CURE) Program " on June 27, 2017, at the NIH Natcher Conference Center on the NIH Bethesda campus. The celebration will recognize an exemplary group of current and former CURE scholars, mentors, and champions, with opening addresses by NCI and CURE leadership. Honorees include CURE scholars from the very earliest stages of the CURE pipeline to those who have made a significant impact in the fields of cancer and cancer health disparities research, as well as mentors and champions who are vital to CURE ' s success.For more information go tohttp://www.cancermeetings.org/PDW2017Air date: 6/27/2017 9:00:00 A...
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Hematopoietic Stem Cells Aging – Mechanisms, Consequences and Interventions
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its summer seminar, featuring Dr. Emmanuelle Passegu é . Dr. Passegue is a Professor in the Department of Genetics and Development at the Columbia University Medical Center and Director of the Columbia Stem Cell Initiative (CSCI) in New York. She is widely recognized for her expertise on hematopoietic stem cell (HSC) biology. Her research over the past 10-years has focused on understanding the cellular and molecular processes controlling HSC activity during homeostasis, and addressing how these regulations are changed in myeloid malignancies and physiological aging. Her laboratory employs a variety of cross-disciplinary approaches using mouse models and human patient samples to identify genetic and/or molecular path...
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Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mouse models of STAT5 deficiency have affirmed these findings and have been instrumental in defining its broad homeostatic and metabolic functions, as well as lineage-restr...
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Torino, Malan (FI): “M5S inadeguato a governare la città” - Torino Oggi
Torino Oggi | Torino, Malan (FI): "M5S inadeguato a governare la città" Torino Oggi Lucio Malan, senatore di Forza Italia, ha dichiarato: "L'inadeguatezza del governo M5S di Torino si dimostra ogni giorno più costosa per la Città e per i Cittadini. Oltre all'irrimediabile vita perduta e ai 1500 feriti, oggi scopriamo che non c'era ... and more » |
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Verità su Rete ospedali, Primario Cascio: Assenso deputati in 1 ora scarsa - Messina Oggi (Comunicati Stampa) (Blog)
Messina Oggi (Comunicati Stampa) (Blog) | Verità su Rete ospedali, Primario Cascio: Assenso deputati in 1 ora scarsa Messina Oggi (Comunicati Stampa) (Blog) A relazionarci la sua versione e di altri colleghi sul riordino degli ospedali è il primario dell'Unità di Otorinolaringoiatria dell'Azienda Papardo, Felice Cascio che rimarca l'esistenza di due documenti sottoscritti tra tutte le Aziende cittadine a ... and more » |
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Health-related quality of life, fear of recurrence, and emotional distress in patients treated for thyroid cancer
Diagnosis of differentiated thyroid carcinoma (papillary or follicular) and its treatment may be associated with a poor health-related quality of life (HRQoL), and with fear of recurrence (FoR), and distress. To our knowledge, this is the first time a single FoR screening question (written to complement a HRQoL questionnaire), has been reported with HRQoL and levels of distress in patients treated for the disease. In April 2014 we did a cross-sectional survey of patients who had presented to the Merseyside and Cheshire thyroid cancer network between April 2009 and November 2013. (Source: The British Journal of Oral and Maxillofacial Surgery)
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Why don ’t we mention “impact on intimacy” when we ask patients to give consent for treatment of oral cancer?
About a third of patients, usually younger rather than older, have reported serious concerns that sexual interest or enjoyment will be diminished after treatment of head and neck cancer.1 Ironically, as oncogenic variants of the human papillomavirus become more common, younger patients are more likely to be affected.2 (Source: The British Journal of Oral and Maxillofacial Surgery)
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Clinical and genetic analysis of patients with cherubism
ConclusionThree different point mutations in the SH3BP2 gene were detected with variable clinical involvement. Genotype‐phenotype association studies in larger population with cherubism are necessary to provide important knowledge about molecular mechanisms related to the disease.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
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Hearing loss in enlarged vestibular aqueduct and incomplete partition type II
Source:American Journal of Otolaryngology
Author(s): Emily Ahadizadeh, Mustafa Ascha, Nauman Manzoor, Amit Gupta, Maroun Semaan, Cliff Megerian, Todd Otteson
PurposeThe purpose of this work is to identify the role of incomplete partition type II on hearing loss among patients with enlarged vestibular aqueduct (EVA).BackgroundEVA is a common congenital inner ear malformation among children with hearing loss, where vestibular aqueduct morphology in this population has been shown to correlate to hearing loss. However, the impact of incomplete partition between cochlear turns on hearing loss has not been, despite meaningful implications for EVA pathophysiology.MethodsA retrospective review of radiology reports for patients who had computed tomography (CT) scans with diagnoses of hearing loss at a tertiary medical center between January 2000 and June 2016 were screened for EVA. CT scans of the internal auditory canal (IAC) for those patients with EVA were examined for evidence of incomplete partition type II (IP-II), measurements of midpoint width and operculum width a second time, and patients meeting Cincinnati criteria for EVA selected for analysis. Statistical analysis including chi-square, Wilcoxon rank-sum, and t-tests were used to identify differences in outcomes and clinical predictors, as appropriate for the distribution of the data. Linear mixed models of hearing test results for all available tests were constructed, both univariable and adjusting for vestibular aqueduct morphometric features, with ear-specific intercepts and slopes over time.ResultsThere were no statistically significant differences in any hearing test results or vestibular aqueduct midpoint and operculum widths. Linear mixed models, both univariable and those adjusting for midpoint and operculum widths, did not indicate a statistically significant effect of incomplete partition type II on hearing test results.ConclusionsHearing loss due to enlarged vestibular aqueduct does not appear to be affected by the presence of incomplete partition type II. Our results suggest that the pathophysiological processes underlying hearing loss in enlarged vestibular aqueduct may not be a result of cochlear malformation, and instead are more likely to involve vestibular aqueduct or cellular and molecular-level mechanisms of hearing loss.
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The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis
Source:Auris Nasus Larynx
Author(s): Norio Kondo, Toshio Yoshihara, Yukie Yamamura, Kaoru Kusama, Eri Sakitani, Yukako Seo, Mayako Tachikawa, Keiko Kujirai, Erika Ono, Yasuyo Maeda, Tomohito Nojima, Akiko Tamiya, Emiri Sato, Manabu Nonaka
ObjectiveTo assess the general guidelines for removal of sialoliths in parotid gland sialolithiasis using sialendoscopy alone.MethodsWe analyzed 34 sialoliths treated using sialendoscopy in 26 patients with parotid gland sialolithiasis. We divided the Stensen's duct and parotid gland into for parts using computed tomography findings: (A) front of the masseter, (B) anterior and lateral to the center (anterolateral) of the masseter, (C) posterior and lateral to the center (posterolateral) of the masseter, (D) behind of the masseter. The location and size of each sialolith was assessed.ResultsThe removal rates of sialoliths in the different locations by sialendoscopy alone were as follows: front of the masseter, 68.8%; anterolateral of the masseter, 60.0%; posterolateral of the masseter, 0%; and behind of the masseter, 33.3%. The removal rate using sialendoscopy alone was significantly higher in the sections anterior to the center of the masseter than in those posterior to the center of the masseter (66.7% [14/21] vs. 20.0% [2/10]; P=0.019). The size of the sialolith was not correlated to the removal rate by sialendoscopy alone.ConclusionSialoliths of the parotid gland located in positions anterior to the center of the masseter are significantly easier to remove by sialendoscopy alone. The center of the masseter is a general landmark for removal of sialoliths from the parotid gland using sialendoscopy alone. The size of the sialolith is not correlated with removal, except rare huge sialoliths.
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The outcomes of endoscopic management in young children with subglottic stenosis
Publication date: August 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 99
Author(s): Chao Chen, Wei-hua Ni, Tan-le Tian, Zheng-min Xu
Subglottic stenosis (SGS) is a common cause of obstructed airway in children, and the treatment of pediatric SGS, especially congenital SGS, remains a challenge for the otolaryngologist.ObjectiveTo analyze the outcomes of endoscopic management in young children with SGS.MethodsWe performed a retrospective review of treatment with endoscopic balloon dilation (EBD) or EBD combined with endoscopic anterior cricoid split (EACS) for young SGS children, from December 2008 to December 2015. The ages of patients ranged from 2 days to 12 years, median age was 5 months. The grade of them ranged from II to IV.ResultsFor acute acquired SGS, 19 cases received EBD alone and the other 3 cases received EBD and EACS, the success rate was about 95.5%; For chronic acquired SGS, EBD and EACS was performed in 6 patients with a success rate of 66.7%; For congenital SGS, EBD and EACS was performed in 28 patients with a success rate of 85.7%. Overall, the success rate of endoscopic management in 56 young children was about 87.5%. Besides, No procedure-related complications were observed in any patients.ConclusionsEndoscopic surgical technique offers a safe and effective approach for treatment of young children with SGS, especially in congenital SGS.
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Hearing loss in enlarged vestibular aqueduct and incomplete partition type II
Source:American Journal of Otolaryngology
Author(s): Emily Ahadizadeh, Mustafa Ascha, Nauman Manzoor, Amit Gupta, Maroun Semaan, Cliff Megerian, Todd Otteson
PurposeThe purpose of this work is to identify the role of incomplete partition type II on hearing loss among patients with enlarged vestibular aqueduct (EVA).BackgroundEVA is a common congenital inner ear malformation among children with hearing loss, where vestibular aqueduct morphology in this population has been shown to correlate to hearing loss. However, the impact of incomplete partition between cochlear turns on hearing loss has not been, despite meaningful implications for EVA pathophysiology.MethodsA retrospective review of radiology reports for patients who had computed tomography (CT) scans with diagnoses of hearing loss at a tertiary medical center between January 2000 and June 2016 were screened for EVA. CT scans of the internal auditory canal (IAC) for those patients with EVA were examined for evidence of incomplete partition type II (IP-II), measurements of midpoint width and operculum width a second time, and patients meeting Cincinnati criteria for EVA selected for analysis. Statistical analysis including chi-square, Wilcoxon rank-sum, and t-tests were used to identify differences in outcomes and clinical predictors, as appropriate for the distribution of the data. Linear mixed models of hearing test results for all available tests were constructed, both univariable and adjusting for vestibular aqueduct morphometric features, with ear-specific intercepts and slopes over time.ResultsThere were no statistically significant differences in any hearing test results or vestibular aqueduct midpoint and operculum widths. Linear mixed models, both univariable and those adjusting for midpoint and operculum widths, did not indicate a statistically significant effect of incomplete partition type II on hearing test results.ConclusionsHearing loss due to enlarged vestibular aqueduct does not appear to be affected by the presence of incomplete partition type II. Our results suggest that the pathophysiological processes underlying hearing loss in enlarged vestibular aqueduct may not be a result of cochlear malformation, and instead are more likely to involve vestibular aqueduct or cellular and molecular-level mechanisms of hearing loss.
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The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis
Source:Auris Nasus Larynx
Author(s): Norio Kondo, Toshio Yoshihara, Yukie Yamamura, Kaoru Kusama, Eri Sakitani, Yukako Seo, Mayako Tachikawa, Keiko Kujirai, Erika Ono, Yasuyo Maeda, Tomohito Nojima, Akiko Tamiya, Emiri Sato, Manabu Nonaka
ObjectiveTo assess the general guidelines for removal of sialoliths in parotid gland sialolithiasis using sialendoscopy alone.MethodsWe analyzed 34 sialoliths treated using sialendoscopy in 26 patients with parotid gland sialolithiasis. We divided the Stensen's duct and parotid gland into for parts using computed tomography findings: (A) front of the masseter, (B) anterior and lateral to the center (anterolateral) of the masseter, (C) posterior and lateral to the center (posterolateral) of the masseter, (D) behind of the masseter. The location and size of each sialolith was assessed.ResultsThe removal rates of sialoliths in the different locations by sialendoscopy alone were as follows: front of the masseter, 68.8%; anterolateral of the masseter, 60.0%; posterolateral of the masseter, 0%; and behind of the masseter, 33.3%. The removal rate using sialendoscopy alone was significantly higher in the sections anterior to the center of the masseter than in those posterior to the center of the masseter (66.7% [14/21] vs. 20.0% [2/10]; P=0.019). The size of the sialolith was not correlated to the removal rate by sialendoscopy alone.ConclusionSialoliths of the parotid gland located in positions anterior to the center of the masseter are significantly easier to remove by sialendoscopy alone. The center of the masseter is a general landmark for removal of sialoliths from the parotid gland using sialendoscopy alone. The size of the sialolith is not correlated with removal, except rare huge sialoliths.
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The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis
Source:Auris Nasus Larynx
Author(s): Norio Kondo, Toshio Yoshihara, Yukie Yamamura, Kaoru Kusama, Eri Sakitani, Yukako Seo, Mayako Tachikawa, Keiko Kujirai, Erika Ono, Yasuyo Maeda, Tomohito Nojima, Akiko Tamiya, Emiri Sato, Manabu Nonaka
ObjectiveTo assess the general guidelines for removal of sialoliths in parotid gland sialolithiasis using sialendoscopy alone.MethodsWe analyzed 34 sialoliths treated using sialendoscopy in 26 patients with parotid gland sialolithiasis. We divided the Stensen's duct and parotid gland into for parts using computed tomography findings: (A) front of the masseter, (B) anterior and lateral to the center (anterolateral) of the masseter, (C) posterior and lateral to the center (posterolateral) of the masseter, (D) behind of the masseter. The location and size of each sialolith was assessed.ResultsThe removal rates of sialoliths in the different locations by sialendoscopy alone were as follows: front of the masseter, 68.8%; anterolateral of the masseter, 60.0%; posterolateral of the masseter, 0%; and behind of the masseter, 33.3%. The removal rate using sialendoscopy alone was significantly higher in the sections anterior to the center of the masseter than in those posterior to the center of the masseter (66.7% [14/21] vs. 20.0% [2/10]; P=0.019). The size of the sialolith was not correlated to the removal rate by sialendoscopy alone.ConclusionSialoliths of the parotid gland located in positions anterior to the center of the masseter are significantly easier to remove by sialendoscopy alone. The center of the masseter is a general landmark for removal of sialoliths from the parotid gland using sialendoscopy alone. The size of the sialolith is not correlated with removal, except rare huge sialoliths.
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Hearing loss in enlarged vestibular aqueduct and incomplete partition type II
Source:American Journal of Otolaryngology
Author(s): Emily Ahadizadeh, Mustafa Ascha, Nauman Manzoor, Amit Gupta, Maroun Semaan, Cliff Megerian, Todd Otteson
PurposeThe purpose of this work is to identify the role of incomplete partition type II on hearing loss among patients with enlarged vestibular aqueduct (EVA).BackgroundEVA is a common congenital inner ear malformation among children with hearing loss, where vestibular aqueduct morphology in this population has been shown to correlate to hearing loss. However, the impact of incomplete partition between cochlear turns on hearing loss has not been, despite meaningful implications for EVA pathophysiology.MethodsA retrospective review of radiology reports for patients who had computed tomography (CT) scans with diagnoses of hearing loss at a tertiary medical center between January 2000 and June 2016 were screened for EVA. CT scans of the internal auditory canal (IAC) for those patients with EVA were examined for evidence of incomplete partition type II (IP-II), measurements of midpoint width and operculum width a second time, and patients meeting Cincinnati criteria for EVA selected for analysis. Statistical analysis including chi-square, Wilcoxon rank-sum, and t-tests were used to identify differences in outcomes and clinical predictors, as appropriate for the distribution of the data. Linear mixed models of hearing test results for all available tests were constructed, both univariable and adjusting for vestibular aqueduct morphometric features, with ear-specific intercepts and slopes over time.ResultsThere were no statistically significant differences in any hearing test results or vestibular aqueduct midpoint and operculum widths. Linear mixed models, both univariable and those adjusting for midpoint and operculum widths, did not indicate a statistically significant effect of incomplete partition type II on hearing test results.ConclusionsHearing loss due to enlarged vestibular aqueduct does not appear to be affected by the presence of incomplete partition type II. Our results suggest that the pathophysiological processes underlying hearing loss in enlarged vestibular aqueduct may not be a result of cochlear malformation, and instead are more likely to involve vestibular aqueduct or cellular and molecular-level mechanisms of hearing loss.
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The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis
Source:Auris Nasus Larynx
Author(s): Norio Kondo, Toshio Yoshihara, Yukie Yamamura, Kaoru Kusama, Eri Sakitani, Yukako Seo, Mayako Tachikawa, Keiko Kujirai, Erika Ono, Yasuyo Maeda, Tomohito Nojima, Akiko Tamiya, Emiri Sato, Manabu Nonaka
ObjectiveTo assess the general guidelines for removal of sialoliths in parotid gland sialolithiasis using sialendoscopy alone.MethodsWe analyzed 34 sialoliths treated using sialendoscopy in 26 patients with parotid gland sialolithiasis. We divided the Stensen's duct and parotid gland into for parts using computed tomography findings: (A) front of the masseter, (B) anterior and lateral to the center (anterolateral) of the masseter, (C) posterior and lateral to the center (posterolateral) of the masseter, (D) behind of the masseter. The location and size of each sialolith was assessed.ResultsThe removal rates of sialoliths in the different locations by sialendoscopy alone were as follows: front of the masseter, 68.8%; anterolateral of the masseter, 60.0%; posterolateral of the masseter, 0%; and behind of the masseter, 33.3%. The removal rate using sialendoscopy alone was significantly higher in the sections anterior to the center of the masseter than in those posterior to the center of the masseter (66.7% [14/21] vs. 20.0% [2/10]; P=0.019). The size of the sialolith was not correlated to the removal rate by sialendoscopy alone.ConclusionSialoliths of the parotid gland located in positions anterior to the center of the masseter are significantly easier to remove by sialendoscopy alone. The center of the masseter is a general landmark for removal of sialoliths from the parotid gland using sialendoscopy alone. The size of the sialolith is not correlated with removal, except rare huge sialoliths.
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ASCO 2017: Most impactful studies on lung cancer
George R. Simon, MD, FACP, FCCP of MD Anderson Cancer Center gives an overview of the most promising data on lung cancer presented at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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How and when do you begin the conversation with patients about financial toxicity?
Leonard Saltz, MD of Memorial Sloan Kettering Cancer Center discusses how and when he beings to speak with his patients about financial toxicity at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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The optimal duration of adjuvant chemotherapy in colon cancer
Leonard Saltz, MD of Memorial Sloan Kettering Cancer Center explains the optimal duration of adjuvant chemotherapy in colon cancer at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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What have we learned about duration of therapy in the adjuvant CRC setting?
Philip Philip, MD of Karmanos Cancer Institute discusses duration of therapy and whether or not shorter treatments will have the same outcomes for patients with stage III colon cancer. This was record... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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The outcomes of endoscopic management in young children with subglottic stenosis
Publication date: August 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 99
Author(s): Chao Chen, Wei-hua Ni, Tan-le Tian, Zheng-min Xu
Subglottic stenosis (SGS) is a common cause of obstructed airway in children, and the treatment of pediatric SGS, especially congenital SGS, remains a challenge for the otolaryngologist.ObjectiveTo analyze the outcomes of endoscopic management in young children with SGS.MethodsWe performed a retrospective review of treatment with endoscopic balloon dilation (EBD) or EBD combined with endoscopic anterior cricoid split (EACS) for young SGS children, from December 2008 to December 2015. The ages of patients ranged from 2 days to 12 years, median age was 5 months. The grade of them ranged from II to IV.ResultsFor acute acquired SGS, 19 cases received EBD alone and the other 3 cases received EBD and EACS, the success rate was about 95.5%; For chronic acquired SGS, EBD and EACS was performed in 6 patients with a success rate of 66.7%; For congenital SGS, EBD and EACS was performed in 28 patients with a success rate of 85.7%. Overall, the success rate of endoscopic management in 56 young children was about 87.5%. Besides, No procedure-related complications were observed in any patients.ConclusionsEndoscopic surgical technique offers a safe and effective approach for treatment of young children with SGS, especially in congenital SGS.
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ASCO 2017: Promising data on colorectal cancer
Leonard Saltz, MD of Memorial Sloan Kettering Cancer Center gives an overview of the most intriguing and most promising clinical data on colorectal cancer presented at the 2017 ASCO Annual Meeting in ... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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The outcomes of endoscopic management in young children with subglottic stenosis
Publication date: August 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 99
Author(s): Chao Chen, Wei-hua Ni, Tan-le Tian, Zheng-min Xu
Subglottic stenosis (SGS) is a common cause of obstructed airway in children, and the treatment of pediatric SGS, especially congenital SGS, remains a challenge for the otolaryngologist.ObjectiveTo analyze the outcomes of endoscopic management in young children with SGS.MethodsWe performed a retrospective review of treatment with endoscopic balloon dilation (EBD) or EBD combined with endoscopic anterior cricoid split (EACS) for young SGS children, from December 2008 to December 2015. The ages of patients ranged from 2 days to 12 years, median age was 5 months. The grade of them ranged from II to IV.ResultsFor acute acquired SGS, 19 cases received EBD alone and the other 3 cases received EBD and EACS, the success rate was about 95.5%; For chronic acquired SGS, EBD and EACS was performed in 6 patients with a success rate of 66.7%; For congenital SGS, EBD and EACS was performed in 28 patients with a success rate of 85.7%. Overall, the success rate of endoscopic management in 56 young children was about 87.5%. Besides, No procedure-related complications were observed in any patients.ConclusionsEndoscopic surgical technique offers a safe and effective approach for treatment of young children with SGS, especially in congenital SGS.
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Gayle Jameson, MSN, ACNP-BC, AOCN - Breaking the Barriers to Patient-Centric Pancreatic Cancer Care: Nurses Transforming Practice From the Front Lines
Breaking the Barriers to Patient-Centric Pancreatic Cancer Care: Nurses Transforming Practice From the Front Lines (Source: PeerView CME/CE Audio Podcast - Oncology)
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NSCLC Patients May Benefit From Single Dose of SBRT
Anurag Singh, MD, shares new research indicating that non-small cell lung cancer (NSCLC) patients may benefit from a single dose of stereotactic body radiation therapy (SBRT) as much as they would fro... Author: roswellpark Added: 06/23/2017 (Source: Oncology Tube)
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Study: Stereotactic Radiation and Surgery Can Treat Kidney Cancer
Stereotactic body radiation therapy (SBRT) combined with surgery can be used to treat metastatic kidney cancer, according to Roswell Park researchers. <br /><br />The study is the first clinical trial to eval... Author: roswellpark Added: 06/23/2017 (Source: Oncology Tube)
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Overview of Checkmate 032 & amp; CTONG 1104 for NSCLC
George R. Simon, MD, FACP, FCCP of MD Anderson Cancer Center gives an overview of the Checkmate 032 and CTONG 1104 studies on non-small cell lung cancer. This was recorded at the 2017 ASCO Annual Meet... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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Can pomalidomide be effective salvage therapy for multiple myeloma patients progressing on lenalidomide?
David S. Siegel, MD, PhD of John Theurer Cancer Center discusses the use of pomalidomide for multiple myeloma patients progressing on lenalidomide. This was recorded at the 2017 ASCO Annual Meeting in... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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Is CAR T-Cell therapy effective in treating multiple myeloma patients?
David S. Siegel, MD, PhD of John Theurer Cancer Center discusses the use of CAR T-cell therapy in treating multiple myeloma at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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Is combining pembrolizumab and lenalidomide effective when managing multiple myeloma patients?
David S. Siegel, MD, PhD of John Theurer Cancer Center discusses the combination of pembrolizumab and lenalidomide for treating patients with multiple myeloma at the 2017 ASCO Annual Meeting in Chicag... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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Do CAR T-Cell therapies look promising for the treatment of NHL?
Jeff Sharman, MD of Willamette Valley Cancer Center discusses whether or not CAR T-cell therapy is promising for the treatment of non-hodgkin lymphoma. This was recorded at the 2017 ASCO Annual Meetin... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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Results of GENUINE study for CLL
Jeff Sharman, MD of Willamette Valley Cancer Center gives an overview of his presentation, which focused on the GENUINE trial for patients with chronic lymphocytic leukemia. This was recorded at the 2... Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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What are the emerging trends in CLL management?
Jeff Sharman, MD of Willamette Valley Cancer Center discusses the emerging trends for management of chronic lymphocytic leukemia at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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The outcomes of endoscopic management in young children with subglottic stenosis
Publication date: August 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 99
Author(s): Chao Chen, Wei-hua Ni, Tan-le Tian, Zheng-min Xu
Subglottic stenosis (SGS) is a common cause of obstructed airway in children, and the treatment of pediatric SGS, especially congenital SGS, remains a challenge for the otolaryngologist.ObjectiveTo analyze the outcomes of endoscopic management in young children with SGS.MethodsWe performed a retrospective review of treatment with endoscopic balloon dilation (EBD) or EBD combined with endoscopic anterior cricoid split (EACS) for young SGS children, from December 2008 to December 2015. The ages of patients ranged from 2 days to 12 years, median age was 5 months. The grade of them ranged from II to IV.ResultsFor acute acquired SGS, 19 cases received EBD alone and the other 3 cases received EBD and EACS, the success rate was about 95.5%; For chronic acquired SGS, EBD and EACS was performed in 6 patients with a success rate of 66.7%; For congenital SGS, EBD and EACS was performed in 28 patients with a success rate of 85.7%. Overall, the success rate of endoscopic management in 56 young children was about 87.5%. Besides, No procedure-related complications were observed in any patients.ConclusionsEndoscopic surgical technique offers a safe and effective approach for treatment of young children with SGS, especially in congenital SGS.
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How to control rising drug prices without impacting value and innovation
Leonard Saltz, MD of Memorial Sloan Kettering Cancer Center discusses how to control rising drug prices without impacting the value of the drug at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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What interventions can alleviate financial toxicity?
Leonard Saltz, MD of Memorial Sloan Kettering Cancer Center discusses the interventions to alleviate financial toxicity at the 2017 ASCO Annual Meeting in Chicago, IL. Author: obr Added: 06/22/2017 (Source: Oncology Tube)
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ACOG Guidance: Individualize Breast Cancer Screening ACOG Guidance: Individualize Breast Cancer Screening
Decisions on when to start and end screening and on screening frequency should be made jointly by patients and providers, given the wide variation in major guidelines, ACOG said.Medscape Medical News (Source: Medscape Medical News Headlines)
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Obstructive sleep apnoea in craniofacial microsomia: analysis of 755 patients
This study included a population of 755 patients with CFM from three craniofacial centres. Medical charts were reviewed for severity of the deformity, types of breathing difficulty, age at which breathing difficulty first presented, treatment for OSA, and treatment outcome. In total, 133 patients (17.6%) were diagnosed with OSA. (Source: International Journal of Oral and Maxillofacial Surgery)
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Are wealthier people more likely to receive a diagnosis of cancer? - Science Daily
Science Daily | Are wealthier people more likely to receive a diagnosis of cancer? Science Daily A research team examined incidence and mortality trends for four types of cancers: breast cancer, prostate cancer, thyroid cancer and melanoma. They then compared incidence and mortality of the four cancers in high- vs. low-income counties and found ... |
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