Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174: 07/21/17

Παρασκευή 21 Ιουλίου 2017

Vocal and gestural productions of 24-month-old children with sex chromosome trisomies.

CONCLUSIONS & IMPLICATIONS: The study showed the importance of early detection of language risk factors in children with SCT, while also considering the use of compensatory strategies (e.g., the use of communicative gestures). PMID: 28726283 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

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Early Postimplant Speech Perception and Language Skills Predict Long-Term Language and Neurocognitive Outcomes Following Pediatric Cochlear Implantation.

Conclusion: Speech perception and language skills measured very early postimplantation, and early postimplant growth in speech perception and language, may be clinically relevant markers of long-term language and neurocognitive outcomes in users of cochlear implants. Supplemental materials: http://ift.tt/2tHGBXk. PMID: 28724130 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Applying an Integrative Framework of Executive Function to Preschoolers With Specific Language Impairment.

Conclusion: The pattern of results suggests that preschoolers with SLI have deficits in executive functioning compared with typical peers, and deficits are not limited to verbal tasks. A significant linear relationship between group differences across executive function components supports the possibility of a hierarchical relationship between executive function skills. PMID: 28724132 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Appendicitis presenting as the first manifestation of colorectal carcinoma: a 13-year retrospective study.

CONCLUSION: This is the first study of its kind conducted in Australasia. This study found patients ≥45 years who present with appendicitis have significantly increased risk of underlying colorectal cancer. Until further research is conducted the authors recommend clinicians consider colonic investigation for older adults following a diagnosis of appendicitis. PMID: 28727691 [PubMed - in process] (Source: New Zealand Medical Journal)

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Managing metastatic bone pain: New perspectives, different solutions

Publication date: September 2017 Source:Biomedicine & Pharmacotherapy, Volume 93 Author(s): Iwona Zaporowska-Stachowiak, Jacek Łuczak, Karolina Hoffmann, Katarzyna Stachowiak, Wiesław Bryl, Maciej Sopata Bone metastases are the most frequent cause of cancer-induced bone pain (CIBP). Although palliative radiotherapy and pharmacotherapy conducted according to World Health Organization (WHO) analgesic ladder are the treatment of choice for CIBP reduction, these methods are not always successful, especially with regard to alleviation of incidental pain. Antiresorptive drugs (bisphosphonates) are able to inhibit bone destruction (loss), proliferation of cancer cells and angiogenesis, but their prolonged use may lead to a spectrum of adverse effects. In this paper, types of bone metas...

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Free flap reconstruction for patients aged 85 years and over with head and neck cancer: clinical considerations for comprehensive care

Publication date: Available online 21 July 2017 Source:British Journal of Oral and Maxillofacial Surgery Author(s): X.F. Chen, Y.M. Chen, S. Gokavarapu, Q.C. Shen, T. Ji We aimed to identify and evaluate the clinical challenges involved in microvascular flap reconstructions of defects caused by resection of head and neck cancer among patients aged 85 and over. We designed a retrospective study of patients who were treated in the head and neck department of a tertiary referral centre from 2005 to 2015, and all patients aged 85 years and over who had reconstructions with microvascular flaps for head and neck cancer were entered into the study. A total of 24 patients fulfilled the criteria, of whom 15 were men and nine were women. The median (range) duration of stay in hospital was 23 (14-59...

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Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A

SummaryChemotherapeutic agents can induce accelerated senescence in tumor cells, an irreversible state of cell cycle arrest. Paclitaxel, a microtubule-stabilizing agent used to treat solid tumors of the breast, ovary, and lung and discodermolide, another stabilizing agent from a marine sponge, induce senescence in cultured cancer cells. The aim of this study was to determine if the microtubule-stabilizing agent peloruside A, a polyketide natural product from a marine sponge, can induce accelerated senescence in a breast cancer cell line MCF7. Doxorubicin, a DNA-damaging agent, paclitaxel, and discodermolide were used as positive controls. Senescence-associated- β-galactosidase activity was increased by peloruside A, similar to paclitaxel, discodermolde, and doxorubicin, with a potency hei...

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Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors

In this study, we first examined the invasive characteristics of NSCLC cells with suppressed p53 and PTEN activity using wound healing, gelatin degradation and invasion assays. Further, changes in the expression of CXCR4 and FAK were evaluated by RT-qPCR and Western Blot analysis. Finally, we tested the ability of CXCR4 and FAK inhibitors (WZ811 and PF-573228, respectively) to suppress the migratory and invasive potential of p53/PTEN deficient NSCLC cells, in vitro and in vivo using metastatic models of human NSCLC. Our results showed that cells with mutually inactive p53 and PTEN have significantly increased invasive potential associated with hyperactivation of CXCR4 and FAK signaling pathways. Treatments with WZ811 and PF-573228 inhibitors significantly reduced migratory and invasive cap...

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An Update on the Use of Immunotherapy in the Treatment of Lymphoma

AbstractPurpose of ReviewThroughout the field of oncology, immunotherapy is moving further towards the first-line setting, and there is encouraging data for the use of these novel therapies in the management of lymphomas, utilizing treatments approved for both solid and hematologic malignancies. Herein, we review promising advances in this rapidly moving field from the past year.Recent FindingsIn the last year, we have seen promising clinical data on engineered antibody therapies for the treatment of lymphomas, as well as further optimization of engineered antibody fragments fused onto linkers or chimeric T cell receptors, both of the modalities capable of transforming non-specific T cells into tumor-specific, serial killer cells.SummaryHere we will review the promising data on these advan...

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Prostate Cancer in the Elderly Male: Diagnostic and Management Considerations

AbstractPurpose of ReviewAlong with an aging US population comes the growing need for clinical guidelines inclusive of and specific to this unique group. Prostate cancer (PCa) is increasingly recognized as a substantial cause of mortality and morbidity in the elderly. This review seeks to address the unmet need for standardized PCa screening and management protocols for geriatric men and to synthesize recommendations based on recent literature.Recent FindingsGuidelines regarding PCa screening in elderly men are still being optimized, with many organizations moving toward inclusion of pre-screening global health assessment. Physician compliance with screening and treatment of PCa in geriatric patients is suboptimal, despite advanced age being a predictor of advanced disease. Elderly patient...

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Parents Have Critical Role in Preventing Teen Drinking - Newswise (press release)

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Parents Have Critical Role in Preventing Teen Drinking
Newswise (press release)
Newswise — Fewer Australian teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Aussie school students, based on the findings of the latest study by Adelaide researchers. More than 2800 South Australian students ...

and more »

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Voice Improvement in Patients with Functional Dysphonia Treated with the Proprioceptive-Elastic (PROEL) Method

The objective of the study was to analyze the outcome of the proprioceptive-elastic (PROEL) voice therapy method in patients with functional dysphonia (FD). Fifty-two patients with FD were involved in the study; they were composed of three subgroups of patients with (1) FD without glottal insufficiency (n = 28), (2) FD and glottal insufficiency (n = 9), and (3) FD, glottal insufficiency, and vocal nodules (n = 15). A multidimensional assessment protocol including videolaryngostroboscopy; maximum phonation time; perceptual evaluation of dysphonia with the Grade, Instability, Roughness, Br eathiness, Asthenia, and Strain (GIRBAS) scale; and 10-item version of the Voice Handicap Index was conducted before and after 15 sessions of voice therapy. (Source: Journal of Voice)

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Effects of Voice Therapy: A Comparison Between Individual and Group Therapy

The primary aim of this clinical evaluation project is to study the effect of voice therapy given in the speech-language pathology clinic, as individual and group therapy, as well as finding out some of the reasons for not attending the recommended therapy. (Source: Journal of Voice)

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AMA Module Offers Help for Adding Pharmacist to Practice

New education module offers six steps for integration of pharmacists into health care team (Source: The Doctors Lounge - Psychiatry)

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Perceived Physical Activity Level Predicts Mortality

Association persists even after adjustment for confounders, including actual physical activity (Source: The Doctors Lounge - Psychiatry)

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Senator McCain Faces a Tough Cancer Foe

Title: Senator McCain Faces a Tough Cancer FoeCategory: Health NewsCreated: 7/20/2017 12:00:00 AMLast Editorial Review: 7/21/2017 12:00:00 AM (Source: MedicineNet Cancer General)

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Is That Possible to Stop or Cease the NASH to Turn into HCC?

(Source: Journal of Gastrointestinal Cancer)

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Outcomes of preexisting diabetes mellitus in breast, colorectal, and prostate cancer

Conclusions and implicationsThere is no evidence that incident cancer had an adverse impact on the long-term outcomes of preexisting diabetes.Implications for Cancer SurvivorsThese findings are important for cancer survivors with preexisting diabetes because they suggest that substantial improvements in the relative survival of several of the most common types of cancer are not undermined by excess diabetes morbidity and mortality. (Source: Journal of Cancer Survivorship)

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AMA Module Offers Help for Adding Pharmacist to Practice

New education module offers six steps for integration of pharmacists into health care team (Source: The Doctors Lounge - Psychiatry)

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Perceived Physical Activity Level Predicts Mortality

Senator McCain Faces a Tough Cancer Foe

Springston: Byus a good hire at PHS - Parkersburg News

Springston: Byus a good hire at PHS
Parkersburg News
Springston was diagnosed with Stage 4A cancer in 2013 at the age of 56. The cancer was in the back of his tongue near the throat. He was teaching and coaching football at Walkertown High School in Winston-Salem, N.C., at the time. Springston said he ...

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States begin to allow sunscreen in schools - Washington Examiner

Washington Examiner

States begin to allow sunscreen in schools
Washington Examiner
... in the U.S. each year, according to the Skin Cancer Foundation. In 2017, an estimated 87,110 new cases of invasive melanoma will be diagnosed. Until 2014, the FDA listed tanning beds in the same, low-risk class as Band-Aids and tongue depressors.

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Doctors: Sen. John McCain diagnosed with aggressive brain cancer - Lincoln Journal Star

Lincoln Journal Star

Doctors: Sen. John McCain diagnosed with aggressive brain cancer
Lincoln Journal Star
He had largely held his tongue earlier in the campaign when Trump questioned his status as a war hero by saying: "He was a war hero because he was captured. I like people who weren't captured." McCain said that was offensive to veterans, but "the best ...
'Toughest man' in US Senate John McCain battling brain cancerChicago Sun-Times
Senator John McCain vows 'I'll be back' after brain cancer diagnosisIrish Examiner
Sen. John McCain diagnosed with cancerThe Charlottesville Newsplex

all 34 news articles »

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Discover the Growth of the Head & Neck Cancer (HNC) Market 2025 - Digital Journal

Discover the Growth of the Head & Neck Cancer (HNC) Market 2025
Digital Journal
Albany, NY -- (SBWIRE) -- 07/21/2017 -- Head & neck cancer is characterized as a group of cancers, which initiate in squamous cells that line the mucosal surface of head and neck. It is also called squamous cell carcinoma. In the head & neck cancer, ...

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A Single 10 mg Oral Dose of Biotin Interferes with Thyroid Function Tests

Thyroid , Vol. 0, No. 0.

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Differential Connectivity of Gene Regulatory Networks Distinguishes Corticosteroid Response in Asthma

Almost half of asthmatic patients do not respond well to standard treatment. We proposed a network approach to identify key transcription factors and their target genes that may determine differential drug response in asthmatic patients. (Source: Journal of Allergy and Clinical Immunology)

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Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma

Gamma tocopherol supplementation in mild asthmatics reduced inflammatory features of asthma as well as the acute response to inhaled LPS and should be further studied as a potential treatment for asthma. (Source: Journal of Allergy and Clinical Immunology)

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Proteogenomic analysis and discovery of immune antigens in Mycobacterium vaccae [Research]

Tuberculosis (TB) is one of the leading causes of death worldwide, especially in developing countries. Neonatal BCG vaccination occurs in various regions, but the level of protection varies in different populations. Recently, Mycobacterium vaccae is found to be an immunomodulating therapeutic agent that could confer a significant level of protection against TB. It is the only vaccine in a phase III trial from WHO to assess its efficacy and safety in preventing TB disease in people with latent TB infection. However, the mechanism of immunotherapy of M. vaccae remains poorly understood. In this study, the full genome of M. vaccae was obtained by next-generation sequencing technology, and a proteogenomic approach was successfully applied to further perform genome annotation using high resolution and high accuracy MS data. A total of 3,387 proteins (22,508 unique peptides) were identified, and 581 proteins annotated as hypothetical proteins in the genome database were confirmed. Furthermore, thirty-eight novel protein products not annotated at the genome level were detected and validated. Additionally, the translational start sites of 445 proteins were confirmed, and 98 proteins were validated through extension of their translational start sites based on N-terminus-derived peptides. The physicochemical characteristics of the identified proteins were determined. Thirty-five immunogenic proteins of M. vaccae were identified by immunoproteomic analysis, and twenty of them were selected to be expressed and validated by Western blot for immunoreactivity to serum from patients infected with M. tuberculosis. The results revealed that eight of them showed strong specific reactive signals on the immunoblots. Furthermore，cellular immune response was further examined and one protein displayed a higher cellular immune level in pulmonary TB patients. Twelve identified immunogenic proteins have orthologous in H37Rv and BCG. This is the first study to obtain the full genome and annotation of M. vaccae using a proteogenomic approach, and some immunogenic proteins that were validated by immunoproteomic analysis could contribute to the understanding of the mechanism of M. vaccae immunotherapy.

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Atypical preference for infant-directed speech as an early marker of autism spectrum disorders? A literature review and directions for further research.

Authors: Filipe MG, Watson L, Vicente SG, Frota S Abstract Autism spectrum disorders (ASD) refer to a complex group of neurodevelopmental disorders causing difficulties with communication and interpersonal relationships, as well as restricted and repetitive behaviours and interests. As early identification, diagnosis, and intervention provide better long-term outcomes, early markers of ASD have gained increased research attention. This review examines evidence that auditory processing enhanced by social interest, in particular auditory preference of speech directed towards infants and young children (i.e. infant-directed speech - IDS), may be an early marker of risk for ASD. Although this review provides evidence for IDS preference as, indeed, a potential early marker of ASD, the e...

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Visual speech fills in both discrimination and identification of non-intact auditory speech in children.

Authors: Jerger S, Damian MF, McAlpine RP, Abdi H Abstract To communicate, children must discriminate and identify speech sounds. Because visual speech plays an important role in this process, we explored how visual speech influences phoneme discrimination and identification by children. Critical items had intact visual speech (e.g. bæz) coupled to non-intact (excised onsets) auditory speech (signified by /-b/æz). Children discriminated syllable pairs that differed in intactness (i.e. bæz:/-b/æz) and identified non-intact nonwords (/-b/æz). We predicted that visual speech would cause children to perceive the non-intact onsets as intact, resulting in more same responses for discrimination and more intact (i.e. bæz) responses for identification in the audiovisual than auditory ...

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Tense Marking in the English Narrative Retells of Dual Language Preschoolers.

Conclusions: These findings suggest that young DLLs can achieve high tense-marking accuracy assuming 2 years of immersive exposure to English. Monitoring the growth in tense-marking accuracy over time and considering productive tense-marking errors as partially correct more precisely captured the emergence of English tense marking in this population with highly variable expressive language skills. Supplemental Materials: http://ift.tt/2tIdOly. PMID: 28724145 [PubMed - as supplied by publisher] (Source: Language, Speech, and Hearing Services in Schools)

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Erratum to: What Type of Food Can Older Adults Masticate?: Evaluation of Mastication Performance Using Color-Changeable Chewing Gum

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Expression of calcium-binding proteins S100A8, S100A9 and S100A12 in otitis media

Calgranulins (calcium-binding proteins S100A8, S100A9 and S100A12) are predominant cytoplasmic proteins of neutrophils and produced by various cells, playing multiple functions in innate immunity and the inflammatory process. Although up-regulated expression of S100A8 and S100A9 genes were observed in an animal model of otitis media (OM), their expressions have not been studied in human middle ear epithelial cells in response to the OM pathogen or in patients with recurrent or chronic OM (recurrent OM/RecOM or chronic OM with effusion/COME).

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Homozygous mutations in PJVK and MYO15A genes associated with non-syndromic hearing loss in Moroccan families

Autosomal recessive non-syndromic hearing loss is a heterogeneous disorder and the most prevalent human genetic sensorineural defect. In this study, we investigated the geneticcause of sensorineural hearing loss in Moroccan patients and presented the importance of whole exome sequencing (WES) to identify candidate genes in two Moroccan families with profound deafness.

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Vowel intelligibility in children with cochlear implants: An acoustic and articulatory study

In child cochlear implant (CI) users, early implantation generally results in highly intelligible speech. However, for some children developing a high level of speech intelligibility may be problematic. Studies of speech production in CI users have principally been based on perceptual judgment and acoustic measures. Articulatory measures, such as those collected using ultrasound provide the opportunity to more precisely evaluate what makes child CI users more intelligible. This study investigates speech production and intelligibility in children with CI using acoustic and articulatory measures.

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The association between the parenting stress of the mother and the incidence of allergic rhinitis in their children

The prevalence of allergic rhinitis and the social burden related to the management of allergic rhinitis have persistently increased. There are many studies investigating the association between the allergic diseases of children and the stress of their parent. However, the relationship between parenting stress and the incidence of allergic rhinitis among children requires further investigation. We aimed to investigate the significance of parenting stress for mothers with children treated for allergic rhinitis.

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Direct percutaneous endoscopic jejunostomy using single-balloon enteroscopy without fluoroscopy: a case series.

CONCLUSION: DPEJ can be carried out successfully via SBE without fluoroscopy with a low rate of significant adverse events. Although, leaving the overtube in place during the bumper pulling can be useful for distal jejunal loops, it can be safely removed in proximal loops to minimize complications. PMID: 28724303 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)

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Synchronous intraductal papillary mucinous neoplasm and a pancreatic neuroendocrine tumor: more than a coincidence?

We report a case of synchronous IPMN and a PNET which were diagnosed preoperatively and discuss the tumorigenesis, clinicopathological features and management of these rare tumors based on the published literature. A 56-year-old male was incidentally diagnosed with a 14 mm branch duct IPMN and a 3.6 mm non-functional PNET during an evaluation due to persistent upper abdominal pain via endoscopic ultrasound. Close follow-up of the patient was decided as the IPMN had no worrisome features. A review of twenty-two previously reported cases of synchronous IPMN and PNET indicated that: a) only seven cases were diagnosed preoperatively; b) abdominal pain was the main presenting symptom; c) IPMN was the dominant tumor and presented with low grade dysplasia; d) the PNET was small and non-functional...

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Management of Benign and Malignant Pancreatic Duct Strictures.

Authors: Dawod E, Kahaleh M Abstract The diagnosis and management of pancreatic strictures, whether malignant or benign, remain challenging. The last 2 decades have seen dramatic progress in terms of both advanced imaging and endoscopic therapy. While plastic stents remain the cornerstone of the treatment of benign strictures, the advent of fully covered metal stents has initiated a new wave of interest in calibrating the pancreatic duct with fewer sessions. In malignant disease, palliation remains the priority and further data are necessary before offering systematic pancreatic stenting. PMID: 28724280 [PubMed - as supplied by publisher] (Source: Clinical Endoscopy)

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Multispectral open-air intraoperative fluorescence imaging

Intraoperative fluorescence imaging informs decisions regarding surgical margins by detecting and localizing signals from fluorescent reporters, labeling targets such as malignant tissues. This guidance reduces the likelihood of undetected malignant tissue remaining after resection, eliminating the ... (Source: Optics Letters)

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A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers

The incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) has increased more than 200% in the past 20 years. Recent genetic sequencing efforts have elucidated relevant genes in head and neck cancer, but HPV-related tumors have consistently shown few DNA mutations. In this study, we sought to analyze alternative splicing events (ASE) that could alter gene function independent of mutations. To identify ASE unique to HPV-related tumors, RNA sequencing was performed on 46 HPV-positive OPSCC and 25 normal tissue samples. A novel algorithm using outlier statistics on RNA-sequencing junction expression identified 109 splicing events, which were confirmed in a validation set from the Cancer Genome Atlas (TCGA). Because the most common type of splicing event identified was an alternative start site (39%), MBD-seq genome-wide CpG methylation data were analyzed for methylation alterations at promoter regions. ASE in six genes showed significant negative correlation between promoter methylation and expression of an alternative transcriptional start site, including AKT3. The novel AKT3 transcriptional variant and methylation changes were confirmed using qRT-PCR and qMSP methods. In vitro silencing of the novel AKT3 variant resulted in significant growth inhibition of multiple head and neck cell lines, an effect not observed with wild type AKT3 knockdown. Analysis of ASE in HPV-related OPSCC identified multiple alterations likely involved in carcinogenesis, including a novel, functionally active transcriptional variant of AKT3. Our data indicate that ASEs represent a significant mechanism of oncogenesis with untapped potential for understanding complex genetic changes that result in development of cancer.

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Intraosseous spindle cell lipoma of the mandible: case report

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): T.J. Cooper, T. Lincoln, D.T. James, S. Borgna
We describe what is to our knowledge the first reported intraosseous spindle cell lipoma of the mandible. It is the first spindle cell lipoma we have seen that shows dental resorption, and the largest that we have seen published (60×30×20mm).

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Use of cyanoacrylate tissue adhesive to orientate histopathological specimens

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): W. Rodgers, K. Mitsimponas, K. Shakib

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Traction with bilateral reverse eyelets: a simple technique for management of sagittal palatal fractures

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): A. Jain, S. Sharma

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Severe distortion of an orbital titanium mesh implant after recurrent facial trauma: a potential threat to the orbital contents?

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): J.M. Foletti, P. Scolozzi
Titanium mesh implants have proved their effectiveness in the reconstruction of fractures of the orbital wall, and their compromise between stiffness and elasticity allows for optimal support of the orbital contents. However, after recurrent orbital trauma, these implants (even when properly positioned) can become a potential "penetrating object" that threatens the critical adjacent anatomical structures. We report the case of a patient with recurrent facial trauma whose orbit had previously been reconstructed with a titanium implant, and which resulted in severe deformation.

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Free flap reconstruction for patients aged 85 years and over with head and neck cancer: clinical considerations for comprehensive care

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): X.F. Chen, Y.M. Chen, S. Gokavarapu, Q.C. Shen, T. Ji
We aimed to identify and evaluate the clinical challenges involved in microvascular flap reconstructions of defects caused by resection of head and neck cancer among patients aged 85 and over. We designed a retrospective study of patients who were treated in the head and neck department of a tertiary referral centre from 2005 to 2015, and all patients aged 85 years and over who had reconstructions with microvascular flaps for head and neck cancer were entered into the study. A total of 24 patients fulfilled the criteria, of whom 15 were men and nine were women. The median (range) duration of stay in hospital was 23 (14-59) days. Eighteen patients had an American Society of Anesthesiologists (ASA) score grade II and six patients grade III. The median (range) operating time was 420 (310-705)minutes, and operative blood loss 550 (200-1500)ml. Sixteen patients had prophylactic tracheostomies, nine of whom developed postoperative surgical complications, seven associated with the tracheostomy (p=0.005). Resections of head and neck cancer and microvascular reconstructions in patients aged 85 and over are associated with a high incidence of postoperative complications. Medical complications tend to be associated with the tracheostomy while surgical complications are potentially associated with the ASA score. Although the morbidity is high, complex resections and microvascular reconstructions are successful with optimum recovery, and age did not seem to influence the outcome. However, it is necessary to avoid prophylactic tracheostomy if possible in these patients.

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Minimally-invasive removal of a screw in the mandibular condyle using computer-assisted navigation

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): D.-D. Xu, J.-H. Dai, Z.-B. Li, Z. Li

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Management of upper and lower molars that are displaced into the neighbouring spaces

Publication date: Available online 21 July 2017
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): P. Bozkurt, E. Erdem
Our aim was to describe our experience of retrieval of accidental displacements of upper and lower molars into neighbouring anatomical spaces. Thirteen patients were evaluated retrospectively in terms of age, sex, affected side, jaw (mandible or maxilla), surgeon's experience, whether the extracted teeth had erupted, which portion of the tooth or teeth was displaced, the anatomical space into which the fragment was displaced, postoperative complaints, timing of the retrieval, type of anaesthesia, and surgical approach. There were no significant differences in sex, affected side, which part of the tooth was displaced, whether the extracted teeth had erupted, type of anaesthesia, or timing of retrieval. We conclude that this condition should be treated, although follow-up alone may be an option. The intraoral lingual pouch approach for complications of mandibular third molars and the intraoral Caldwell-Luc operation for those in the maxilla could be successful options for retrieval.

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Congressional Hearing on Medicare Addresses Therapy Cap, Speech-Generating Devices

The Medicare cap on outpatient rehabilitation therapy services and coverage of speech-generating devices were among the topics discussed at a House Subcommittee on Health hearing yesterday that examined 11 bipartisan bills seeking to improve Medicare. These issues directly affect the Medicare patients/clients that ASHA members serve. Therapy Cap In Chairman Michael C. Burgess' opening statement, Burgess addressed the Medicare therapy cap and a need for a permanent policy solution. Chairman Burgess went on to say, "Much like the SGR [Sustainable Growth Rate to control spending by Medicare], we have a policy inherent to the therapy cap that no one supports and each year we must find offsets in the Medicare program to simply protect beneficiaries from a policy harmful to their access t...

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Austin biotech company loses CEO as disease treatments work through regulatory process

David Lowe helped guide Aeglea through the initial phases of the regulatory process, and its 2016 IPO that raised millions of dollars to develop treatments for cancer and rare genetic diseases. (Source: bizjournals.com Health Care:Biotechnology headlines)

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Effect of ageing and Single Nucleotide Polymorphisms associated with risk of aggressive prostate cancer in a New Zealand population

Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00203C, PaperVenkatesh Vaidyanathan, Vijay Naidu, Nishi Karunasinghe, Chi Hsiu-Juei Kao, Radha Pallati, Anower Jabed, Gareth Marlow, Prasanna Kallingappa, Lynette Ferguson Prostate cancer is one of the most significant male health concerns worldwide, various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)

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Inositol hexaphosphate (InsP6) as an effective topical treatment for patients receiving adjuvant chemotherapy after breast surgery.

CONCLUSIONS: Topical InsP6 treatment has demonstrated to be effective and safe in preventing and/or mitigating chemotherapy-induced side effects as well as the preserving quality of life in women with ductal breast cancer. PMID: 28724186 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Doctors: Sen. John McCain diagnosed with aggressive brain cancer - Bismarck Tribune

Bismarck Tribune

Doctors: Sen. John McCain diagnosed with aggressive brain cancer
Bismarck Tribune
He had largely held his tongue earlier in the campaign when Trump questioned his status as a war hero by saying: "He was a war hero because he was captured. I like people who weren't captured." McCain said that was offensive to veterans, but "the best ...
'Toughest man' in US Senate John McCain battling brain cancerChicago Sun-Times
Senator John McCain vows 'I'll be back' after brain cancer diagnosisIrish Examiner
Sen. John McCain diagnosed with cancerThe Charlottesville Newsplex

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Vaccini: Gallera, a settembre tavolo per campagna informativa - Milleunadonna.it

Vaccini: Gallera, a settembre tavolo per campagna informativa
Milleunadonna.it
Per questo "il vaccino anti-Hpv assume un ruolo fondamentale nella prevenzione di questo e di tutta una serie di tumori (della vulva e della vagina, anale, del pene, testa-collo), anche nei maschi, che registrano nella maggior parte dei casi tassi di ...

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A Positive Perspective In The Face Of Cancer

Cancer doesn't seem to be going anywhere, but that doesn't mean it has the power to replace joy. (Source: Healthy Living - The Huffington Post)

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Cancer patients' grey hair unexpectedly darkens in drug study

Spanish study suggests side effects of new immunotherapy drugs may include restoring hair pigmentA group of cancer patients ' grey hair has unexpectedly darkened after they took new types of drugs, researchers have revealed.Chemotherapy is known to make patients ' hair fall out, but the 14 people involved were all being treated with new immunotherapy drugs that work differently and have different side effects from chemotherapy. A Spanish study suggests those may include restoring hair pigment, at least in patients with lung cancer.Continue reading... (Source: Guardian Unlimited Science)

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A Positive Perspective In The Face Of Cancer

Cancer patients' grey hair unexpectedly darkens in drug study

Vocoder Simulations Explain Complex Pitch Perception Limitations Experienced by Cochlear Implant Users

AbstractPitch plays a crucial role in speech and music, but is highly degraded for people with cochlear implants, leading to severe communication challenges in noisy environments. Pitch is determined primarily by the first few spectrally resolved harmonics of a tone. In implants, access to this pitch is limited by poor spectral resolution, due to the limited number of channels and interactions between adjacent channels. Here we used noise-vocoder simulations to explore how many channels, and how little channel interaction, are required to elicit pitch. Results suggest that two to four times the number of channels are needed, along with interactions reduced by an order of magnitude, than available in current devices. These new constraints not only provide insights into the basic mechanisms ...

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Endoscopic transcanal myringoplasty for tympanic perforations: An outpatient minimally invasive procedure

Publication date: Available online 21 July 2017
Source:Auris Nasus Larynx
Author(s): Chih-Chieh Tseng, Ming-Tang Lai, Chia-Che Wu, Sheng-Po Yuan, Yi-Fang Ding
ObjectiveSince the 1950s, microscopic myringoplasty has been the standard surgery for repairing a perforated tympanic membrane. In addition to conventional microscopic myringoplasty, endoscopic myringoplasty has been an emerging technique since the late 1990s. This study evaluated the efficacy of endoscopic transcanal myringoplasty for repairing tympanic perforations and examined the minimally invasive feature of this technique (no postauricular incision, no canalplasty).MethodsWe retrospectively reviewed the medical records of patients who underwent endoscopic transcanal myringoplasty for perforations of the tympanic membrane. The main outcome was the overall rate of graft success of endoscopic transcanal myringoplasty.ResultsA total of 181 patients were included in the analysis. The overall graft success was determined in 163 of 181 patients (92.8%). The mean preoperative and postoperative air-bone gaps were 19.3dB and 7.8dB, respectively, revealing a significant improvement of 11.5dB (Cohen's d, 1.27; 95% CI, 1.03–1.50; P<0.05; paired t test) in the air-bone gap. The rate of graft success with partial visualization of the perforation margin was comparable to that with complete visualization of the perforation margin. Larger sizes of perforations were significantly associated with lower rates of graft success (P<0.01).ConclusionOur study revealed that the rate of graft success and hearing results of endoscopic transcanal myringoplasty and microscopic myringoplasty are comparable for repairing perforations of the tympanic membrane. Visualization of the perforation margin by otoscopy did not affect the rate of graft success. However, endoscopic transcanal myringoplasty is less invasive because this technique does not require postauricular incision, canalplasty, and general anesthesia.

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Lesser-known gene mutations may boost breast cancer risk in Jewish women

(Reuters Health) - Jewish women of European descent may be at risk for additional genetic mutations that increase their risk of breast cancer, according to a new study. (Source: Reuters: Health)

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New Journal, Kidney Cancer, Launched With Expert Editorial Board

Kidney Cancer is an international multidisciplinary journal to facilitate progress in understanding the epidemiology/etiology, genetics, molecular correlates, pathogenesis, pharmacology, ethics, patient advocacy and survivorship, diagnosis and treatment of tumors of the kidney.07/21/2017 (Source: Kidney Cancer Association)

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OncLive ® Presents State of the Science Summit™ on Genitourinary Malignancies

This educational event will discuss some of the most pressing issues faced by oncologists and other medical experts when dealing with genitourinary malignancies. The summit will discuss critical topics such as bone targeting, treatment of castration-resistant metastatic prostate cancer, kidney cancer and new clinical trials.07/21/2017 (Source: Kidney Cancer Association)

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University Of Maryland School Of Medicine Scientist Receives Top Award for His Pioneering Work on Improving Radiation Therapy Outcome

Søren M. Bentzen, PhD, DMSc, a professor in the Department of Epidemiology and Public Health (EPH) at the University of Maryland School of Medicine (UM SOM), has been awarded a gold medal from the American Society for Radiation Oncology (ASTRO). This is the highest honor bestowed upon ASTRO members. It recognizes a distinguished scientist who has made major contributions to the field of radiation oncology. (Source: University of Maryland School of Medicine News Headlines)

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Lesser-known gene mutations may boost breast cancer risk in Jewish women

(Reuters Health) - Jewish women of European descent may be at risk for additional genetic mutations that increase their risk of breast cancer, according to a new study. (Source: Reuters: Health)

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New Journal, Kidney Cancer, Launched With Expert Editorial Board

Exelixis Announces Settlement of Dispute with Genentech Regarding Companies ’ Collaboration

Effective July 1, 2017, as part of the settlement the companies entered into an amendment (the "Amendment") to the existing Collaboration Agreement, dated December 22, 2006, to revise the revenue and cost-sharing arrangements for the collaboration. The Amendment resolves the companies' dispute pursuant to the arbitration demand filed on June 3, 2016, and aligns both companies' interes ts in advancing cobimetinib as a promising therapy for patients with multiple forms of cancer.07/21/2017 (Source: Kidney Cancer Association)

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OncLive ® Presents State of the Science Summit™ on Genitourinary Malignancies

University Of Maryland School Of Medicine Scientist Receives Top Award for His Pioneering Work on Improving Radiation Therapy Outcome

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PD ‐1 Checkpoint Blockade in Combination with an mTOR Inhibitor Restrains Hepatocellular Carcinoma Growth Induced by Hepatoma Cell‐Intrinsic PD‐1

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The significance of De Ritis (aspartate transaminase/alanine transaminase) ratio in predicting pathological outcomes and prognosis in localized prostate cancer patients

ConclusionHigher De Ritis ratio could be predictive for worse pathological outcomes and higher BCR in localized prostate cancer patients. A predictive model which incorporates De Ritis ratio, Gleason Score and pathological tumor stage could help risk stratification for BCRFS. (Source: International Urology and Nephrology)

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Treatment trends, determinants, and survival of partial and radical nephrectomy for stage I renal cell carcinoma: results from the National Cancer Data Base, 2004 –2013

ConclusionsThe use of PN for stage I RCC has continued to increase and is associated with an overall survival advantage. Multivariable analysis showed that disparities exist among sociodemographic groups that are also associated with treatment type and survival. (Source: International Urology and Nephrology)

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[DIS-17-0023] The Enduring Health Challenges of Afghan Immigrants and Refugees in Iran: A Systematic Review

This article does not contain any studies with human participants or animals performed by the author. Data Availability All national (MagIran, Science Information Database (SID) and Iranmedex) and international (PubMed, Scopus) databases were searched from November 2010 to November 2016 using keywords both in English and Persian: Afghan immigrants, Afghan refugees, Iran, infectious diseases, tuberculosis, HIV, Hepatitis B and C, non-communicable disease, food security, mental health, barriers, health insurance, access to health service. All related websites and webpages were also searched by Google with the same keywords and used back-tracking to find earlier relevant sources from 2001. Corresponding Author Frederick M. Burkle, Jr. Email: burkle@hsph.harvard.edu Tel: 1-808-262-2098 (Hawa...

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Hurthle thyroid cancer requires tissue sample for diagnosis - News ... - Sarasota Herald-Tribune

Hurthle thyroid cancer requires tissue sample for diagnosis - News ...
Sarasota Herald-Tribune
Dear Dr. Roach: Recently, I underwent a needle biopsy of a thyroid nodule. The cytology report reads ''suspicious for Hurthle cell neoplasm (Bethesda Category ...

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Role of TGF- β in Self-Peptide Regulation of Autoimmunity

AbstractTransforming growth factor (TGF)- β has been implicated in regulation of the immune system, including autoimmunity. We have found that TGF-β is readily produced by T cells following immunization with self-peptide epitopes that downregulate autoimmune responses in type 1 diabetes (T1D) prone nonobese diabetic (NOD) mice. These incl ude multiple peptide epitopes derived from the islet β-cell antigens GAD65 (GAD65 p202-221, GAD65 p217-236), GAD67 (GAD67 p210-229, GAD67 p225-244), IGRP (IGRP p123-145, IGRP p195-214) and insulin B-chain (Ins. B:9-23) that protected NOD mice from T1D. Immunization of NOD mice with the self-MHC cla ss II I-Ag7β-chain-derived peptide, I-Aβg7 p54-76 also induced large amounts of TGF- β and also protected these mice from diabetes development. These res...

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Possible Immunomodulating Effect of Retinol on Cytokines Secretion in Patients with Recurrent Furunculosis

AbstractRecurrent furunculosis is an infection of hair follicles which results in formation of abscesses. Previous studies showed that the pathogenesis of the disease may include an immune-mediated component as the proliferative response of peripheral blood lymphocytes to staphylococcal antigen is depressed. The aim of our study was to evaluate cytokines concentration in the plasma of patients with recurrent furunculosis and to determine whether retinol affects the secretion of those cytokines in patients with recurrent furunculosis and healthy subjects. Blood samples were taken from 15 patients with recurrent furunculosis and 15 age-matched healthy subjects. A quantitative determination of selected cytokines (IL-17, 13, 2, 10, 4, IFN- γ, TNF-α) was performed in the plasma at baseline an...

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Austin biotech company loses CEO as disease treatments work through regulatory process

David Lowe helped guide Aeglea through the initial phases of the regulatory process, and its 2016 IPO that raised millions of dollars to develop treatments for cancer and rare genetic diseases. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

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Friday Feedback: Why Does Pharma Love Cancer So Much?

(MedPage Today) -- Experts debate clinical versus profit-driven priorities in drug development (Source: MedPage Today Primary Care)

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Lexicon Collaborator Ipsen Receives Positive CHMP Opinion For Xermelo(R) (Telotristat Ethyl)

First -in-Class Oral Tryptophan Hydroxylase Inhibitor to be Considered for Approval in Europe for the Treatment of Carcinoid Syndrome Diarrhea in Combination with Somatostatin Analog Therapy Decision on Marketing Authorization Application Expected in Q3... Biopharmaceuticals, Regulatory Lexicon Pharmaceuticals, XERMELO, carcinoid syndrome diarrhea (Source: HSMN NewsFeed)

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Scuola laser contro tumori testa-collo - Sardegna - ANSA.it - ANSA.it

ANSA.it

Scuola laser contro tumori testa-collo - Sardegna - ANSA.it
ANSA.it
(ANSA) - CAGLIARI, 14 LUG - Al Policlinico Duilio Casula si tiene in questi giorni un corso internazionale diretto dal professor Roberto Puxeddu, direttore di ...

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Detection of human polyomaviruses JC and BK in liver pretransplant patients

ConclusionCirrhotic patients on the liver transplant waiting list did not show higher prevalence of BKPyV and JCPyV compared to normoreactive controls. (Source: Oral Diseases)

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Febbre da drone - RSI.ch Informazione

Febbre da drone
RSI.ch Informazione
Librarsi nell'aria, guardare il mondo dall'alto: il sogno di volare accompagna l'uomo dall'alba dei tempi, ma solo i recenti progressi tecnologici hanno permesso anche al grande pubblico di provare l'ebbrezza di pilotare un velivolo. L'occasione la ...

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Pediatric MATCH: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations

Conditions: Advanced Malignant Solid Neoplasm; BRAF NP_004324.2:p.V600X; Ependymoma; Ewing Sarcoma; Hepatoblastoma; Histiocytosis; Langerhans Cell Histiocytosis; Malignant Germ Cell Tumor; Malignant Glioma; Osteosarcoma; Peripheral Primitive Neuroectodermal Tumor; Recurrent Childhood Central Nervous System Neoplasm; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Refractory Central Nervous System Neoplasm; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Refractory Non-Hodgkin Lymphoma; Rhabdoid Tumor; Rhabdomyosarcoma; Soft Tissue Sarcoma; Stage III Childhood Non-Hodgkin Lymphoma; Stage IV Childhood Non-Hodgki...

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Clinical Analysis of HIPEC for T4 Colorectal Cancer After Surgery

Condition: Colorectal Neoplasms Interventions: Procedure: Surgery and HIPEC with Lobaplatin; Procedure: Surgery without HIPEC Sponsors: Sixth Affiliated Hospital, Sun Yat-sen University; Second Affiliated Hospital, Sun Yat-Sen University; Zhujiang Hospital; First Affiliated Hospital of Jinan University; The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine; Second Affiliate d Hospital of Guangzhou Medical University; Guangzhou General Hospital of Guangzhou Military Command; Tcm-integrated Cancer Center of Southern Medical University; Affiliated Tumor Hospital of Guangzhou Medical University; Nanfang Hospital of Southern Medical University; Guangdong Provincial Hospital of Traditional Chinese Me...

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Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)

Conditions: Gastric Cancer; Gastroesophageal Junction Cancer Interventions: Biological: Pembrolizumab; Drug: Placebo; Drug: Cisplatin; Drug: Capecitabine; Drug: 5-fluorouracil Sponsor: Merck Sharp & Dohme Corp. Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma

Conditions: Cervical Carcinoma; Esophageal Carcinoma; Mucosal Melanoma; Mucosal Melanoma of the Head and Neck; Oral Cavity Mucosal Melanoma; Recurrent Melanoma; Stage II Vulvar Cancer; Stage III Vulvar Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Ca ncer; Stage IIIC Vulvar Cancer; Stage IV Oral Cavity Cancer AJCC v6 and v7; Stage IV Vulvar Cancer; Stage IVA Oral Cavity Cancer AJCC v6 and v7; Stage IVB Oral Cavity Cancer AJCC v6 and v7; Stage IVC Oral Cavity Cancer AJCC v6 and v7; Vagina l Carcinoma Interventions: Procedure: Conventional Surgery; Biological: Ipilimumab; Other: Laboratory Biomarker Analysis; Biological: Nivolumab; Other: Patient Ob...

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HPV Self-Sampling for Cervical Cancer Screening Among Transgender Men and Transmasculine Individuals

Condition: Cervical Cancer Screening Intervention: Behavioral: HPV self-sampling Sponsor: University of Miami Recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy.

Condition: Intracranial Pressure Increase Intervention: Device: Medical Device Vittamed 205 Sponsors: Kienzler Jenny; Schweizer National Fond Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Distribution of Lymph Node Metastases in Esophageal Carcinoma

Conditions: Esophageal Neoplasms; Lymph Node Metastases Intervention: Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Ibrutinib, Rituximab, Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride in Treating Patients With HIV-Positive Stage II-IV Diffuse Large B-Cell Lymphomas

Conditions: AIDS-Related Lymphoma; CD20 Positive; HIV Positivity; Stage II Diffuse Large B-Cell Lymphoma; Stage III Diffuse Large B-Cell Lymphoma; Stage IV Diffuse Large B-Cell Lymphoma Interventions: Drug: Cyclophosphamide; Drug: Doxorubicin Hydrochloride; Drug: Etoposide; Biological: Filgrastim; Drug: Ibrutinib; Other: Laboratory Biomarker Analysis; Biological: Pegfilgrastim; Other: Pharmacological Study; Drug: Prednisone; Biological: Rituximab; D rug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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SBRT + PD-1/PDL-1 Inhibiting Therapy for Advanced Solid Tumors After Progression on PD-1/PDL-1 Tx

Condition: Solid Tumor Interventions: Radiation: Stereotactic radiotherapy; Other: Biological: humanized anti-PD-1 monoclonal antibody; Other: Biological: humanized anti-PD-L1 monoclonal antibody Sponsors: Virginia Commonwealth University; National Cancer Institute (NCI) Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Pembrolizumab (Immunotherapy Drug) in Combination With Guadecitabine and Mocetinostat (Epigenetic Drugs) for Patients With Advanced Lung Cancer.

Condition: Lung Cancer Interventions: Drug: Pembrolizumab; Drug: Guadecitabine; Drug: Mocetinostat Sponsors: Memorial Sloan Kettering Cancer Center; Merck Sharp & Dohme Corp.; Astex Pharmaceuticals; Mirati Therapeutics Inc. Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Adipose Tissue Content of Fatty Acids Present in Dairy Fat and Risk of Stroke. The Danish Diet, Cancer and Health Cohort

Condition: Stroke Intervention: Other: Fatty acids present in adipose tissue samples Sponsor: University of Aarhus Completed - verified July 2017 (Source: ClinicalTrials.gov)

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" En Bloc " Resection of NMIBC: a Prospective ， Single Centre，Randomized Study

Condition: Non-muscle Invasive Bladder Cancer Intervention: Device: Laser ERBT; Hydroknife ERBT;cTURBT Sponsor: Tongji Hospital Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

Conditions: Advanced Malignant Solid Neoplasm; Estrogen Receptor Negative; Estrogen Receptor Positive; HER2/Neu Negative; Metastatic Malignant Solid Neoplasm; Progesterone Receptor Negative; PTEN Gene Mutation; Triple-Negative Breast Carcinoma; Unresectable Solid N eoplasm Interventions: Drug: Docetaxel; Other: Laboratory Biomarker Analysis; Other: Pharmacological Study; Drug: PI3Kbeta Inhibitor AZD8186 Sponsor: National Cancer Institute (NCI) Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Comprehensive Yoga Program (SKY) as Adjunct Therapy for Prostate Cancer

Condition: Prostate Carcinoma Intervention: Other: Yoga Sponsor: Emory University Recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Electroacupuncture for Postoperative Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer

Conditions: Postoperative Ileus; Rectal Cancer Interventions: Procedure: Electroacupuncture; Procedure: Sham Acupuncture Sponsor: Chinese University of Hong Kong Recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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MethylphenIdate for Fatigue in Haematological Cancer

Condition: Hematological Cancer Interventions: Drug: Methylphenidate; Drug: Placebo Sponsor: Odense University Hospital Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor

Condition: Thymic Cancer Intervention: Drug: Palbociclib Sponsor: Samsung Medical Center Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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SAGE Publishing reports continued strong growth in 2017

SAGE Publishing, one of the world's leading independent academic and professional publishers, today reported continued strong performance and growth across its journals portfolio in the 2017 Journal Citation Reports (Source: 2016 Web of Science Data). SAGE continues to see consistent growth within the reports. This year 70% of SAGE journals received an increased ranking with 49% of SAGE journals now ranking within the top half of their subject category. 233 titles now place in the top 30% of the JCR and over 100 SAGE journals received a top 10-category rank. 566 titles are now listed totaling a 40% increase in SAGE journals indexed titles over the last five years. In an increase from the 2016 reports, this year also saw 21 titles receive their first ranking. In the SSCI category SAGE now...

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Finding a life after losing your voice: Throat cancer survivors speak out - The Nelson Mail

The Nelson Mail

Finding a life after losing your voice: Throat cancer survivors speak out
The Nelson Mail
But Burns sees the damage the virus can do – in some cases causing oro-pharyngeal and laryngeal cancers which require invasive surgery and ongoing radiation. "[Which] hopefully cures the cancer, but there are ongoing side effects from the treatment ...

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Proton Tx Plus Chemo Seen Beneficial in NSCLC (CME/CE)

(MedPage Today) -- Median overall survival of 26.5 months in inoperable stage III disease (Source: MedPage Today Hematology/Oncology)

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7 medtech stories we missed this week: July 21, 2017

[Image from unsplash.com]From Second Sight's South Korean market entry to Sanuwave's Indonesian distribution deal, here are seven medtech stories we missed this week but thought were still worth mentioning. 1. Second Sight enters South Korea market Second Sight announced in a July 5 press release that it has entered the market in South Korea with the implantation of two patients with its Argus II Retinal Prosthesis System in Seoul. The implants were made possible by the country's distribution partner Kisantech Co. 2. K2M touts Japan distribution deal with Mitsubishi K2M signed a new, long-term exclusive agreement with Mitsubishi to distribute its spinal technologies in Japan, according to a July 10 press release. The agreement names Japan Medicalnext as the exclusive distribu...

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NERLYNX (neratinib) Tablets Approved for HER2+ Breast Cancer in the Extended Adjuvant Setting

CARY, N.C. (July 21, 2017) — Biologics, Inc., a McKesson Specialty Health oncology pharmacy services company, announced today it has been selected to be in the limited distribution network for Puma Biotechnology, Inc.'s new product, NERLYNX, a kinase inhibitor approved by the U.S. Food and Drug Admi... (Source: McKesson News)

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Breast Mass Found in 48-Year-Old Patient

A 48-year-old woman presents with a mass in her right breast, and a biopsy is obtained. What is your diagnosis? (Source: CancerNetwork)

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CML Patients Approach Normal Life Expectancy With Imatinib Treatment

Treatment with imatinib results in good overall survival in patients with chronic myeloid leukemia, approaching a normal life expectancy, according to the CML-IV study. (Source: CancerNetwork)

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The Prevalence of CCR5 ‐Δ32 Mutation in a Cohort of Saudi Stem Cell Donors

In this study, our aim was to investigate the frequency of CCR5‐Δ32 mutation in a cohort of stem cell donors from cord blood bank and stem cell donor registry. A total of 3025 samples were collected from healthy stem cell donors (2625) and from cord blood units (400). DNA was extracted and the CCR5 gene was amplified by polymerase chain reaction (PCR) in a light cycler system using SYBR Green dye. The mutated gene was further confirmed by direct gene sequencing. We found 38 heterozygous for CCR5‐Δ32 and one homozygous CCR5 mutation (Δ32/Δ32) out of the 3025 tested individuals. We conclude that the protective CCR5‐Δ32 allele appears to be rarely present in Saudi Arabia. (Source: Tissue Antigens)

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Detection of a novel allele, HLA ‐A*24:198, by sequence‐based typing in a Chinese individual

HLA‐A*24:198 has one nucleotide change from HLA‐A*24:02:01 where Aspartic Acid (29) is changed to Asparagine. (Source: Tissue Antigens)

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Human leukocyte antigen distribution and genomic ancestry in Brazilian patients with sickle cell disease

Hematopoietic stem‐cell transplantation (HSCT) is currently the only established curative treatment for sickle cell disease (SCD), but is limited by donor availability. Ethnicity is thought to have an impact on the complications experienced by patients that undergo HSCT and on the likelihood of identifying an HLA matched donor. In the present study, we investigated the genomic ancestry and the distribution of HLA allele groups in Brazilian patients with SCD, compared these HLA profiles to worldwide populations and evaluate the availability of HLA‐matched donors. A broad intercontinental admixture of patients with SCD was observed, with African ancestry ranging from 6.7% to 93.4%. In a dendrogram based on HLA frequencies, Brazilian patients with SCD were included in a branch containing ...

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SAGE Publishing reports continued strong growth in 2017

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Proton Tx Plus Chemo Seen Beneficial in NSCLC (CME/CE)

(MedPage Today) -- Median overall survival of 26.5 months in inoperable stage III disease (Source: MedPage Today Hematology/Oncology)

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‘Significant’ rise in cancer patient confidence in nursing staff

There has been a significant annual increase in the percentage of cancer patients who say they trust and have confidence in all the nursing staff treating them, according to a national survey. (Source: Nursing Times)

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7 medtech stories we missed this week: July 21, 2017

NERLYNX (neratinib) Tablets Approved for HER2+ Breast Cancer in the Extended Adjuvant Setting

5 Essential Oils for Relieving Your Allergy Symptoms - Reader's Digest

01-lavendar-Five-Essential-Oils-for-Alle

5 Essential Oils for Relieving Your Allergy Symptoms
Reader's Digest
The minty scent can also unstuff your sinuses and may even relieve a scratchy sore throat. "This is a great one ... While lumps and bumps are among the most common breast cancer symptoms, there are other potential signs that you need to see a doctor, stat.

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It's a question of endurance - Patients with head and neck cancer experiences of (18)F-FDG PET/CT in a fixation mask.

CONCLUSIONS: PET/CT examnation in a fixation mask may be strenuous for some patients. Patients need more detailed information, including suggestions for coping behaviours, prior to the examination, as well as higher level of support during and after the examination. The results of this study may be used to improve patient care and optimize the procedure of PET/CT examination in a fixation mask. PMID: 28720271 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Art in cancer care: Exploring the role of visual art-making programs within an Energy Restoration Framework.

CONCLUSIONS: Involvement in an activity that was expansive, new, beautiful and fascinating was highly valued in addition to the appreciation for being with and belonging to a supportive and accepting group facilitated by dynamic artists. There is much scope for continued research and promotion of art-making programs as an adjunct to cancer treatment. PMID: 28720268 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Empowering survivors after colorectal and lung cancer treatment: Pilot study of a Self-Management Survivorship Care Planning intervention.

CONCLUSIONS: The SM-SCP intervention was feasible and acceptable for colorectal and lung cancer survivors after treatment completion. Survivorship care interventions have potential to fulfill the unmet needs of colorectal and lung cancer survivors. Their effectiveness might be greater by integrating conceptually-based models of care, such as self-management skills building. PMID: 28720259 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Efficacy of a hydroactive colloid gel versus historical controls for the prevention of radiotherapy-induced moist desquamation in breast cancer patients.

CONCLUSIONS: These findings confirm our previous results: applying the hydroactive colloid gel, rather than dexpanthenol, delayed the onset and reduced the incidence of RIMD in breast cancer patients. However, applying the hydrogel preventively offered no statistically significant advantages over applying it curatively. PMID: 28720256 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Cancer survivorship: Advancing the concept in the context of colorectal cancer.

CONCLUSIONS: The results highlight core similarities between survivorship in the context of CRC and other tumour groups, but underlines issues specific to CRC survivorship. Communication and support are key issues in survivorship care which may detrimentally affect CRC survivors' well-being if they are inadequately addressed. Healthcare professionals (HCP's) therefore have a duty to ensure cancer survivors' health, information and supportive care needs are met in the aftermath of treatment. PMID: 28720260 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer.

CONCLUSION: Overall, the patients with newly diagnosed lung cancer had poorer sleep quality, higher depression levels, lower salivary melatonin levels, higher cortisol levels, and flatter melatonin and cortisol slopes than did the controls. The fatigue level and cortisol slope significantly predicted sleep quality. Therefore, the assessment of cortisol and melatonin rhythms and levels could provide crucial information that may be beneficial for managing symptoms in patients with newly diagnosed lung cancer. PMID: 28720269 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Feasibility of advanced practice nursing in lung cancer consultations during early treatment: A phase II study.

CONCLUSION: Results were promising for the feasibility of the APNLC consultation and the ability to collect PROMs. Further investigations are needed to increase the impact of the APNLC consultations on symptom intensity and sexual and psychological needs. PMID: 28720257 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Meeting psychosocial and health information needs to ensure quality of cancer care in outpatients.

CONCLUSIONS: This study revealed the need for an approach based on health-promotion principles, with a particular focus on patient wellbeing and quality of life. The study increases awareness about the influence that an environment has on patient health, thus suggesting that changes in culture, attitude, and health services re-organization are crucial to meet total needs of the individual as a whole process. PMID: 28720273 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Nothing is more important than my partner's health: Turkish men's perspectives on partner's appearance after mastectomy and alopecia.

CONCLUSIONS: The changes in the partners' physical appearance after mastectomy and chemotherapy affected males differently in psychological, emotional and social terms. Since nurses working in this field are in contact with patients during all phases of treatment and care, it would be positive and beneficial to plan nursing interventions that give emotional support for male partners of patients with breast cancer. PMID: 28720262 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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A systematic review of the supportive care needs of people living with and beyond cancer of the colon and/or rectum.

CONCLUSIONS: Investing time to sensitively inquire about the supportive care needs of this patient population is key, whilst evaluating and re-shaping clinical interactions based on patients' priorities is equally essential. The diverse needs identified require a multi-professional and multi-agency approach to ensure unmet needs are addressed or measures offered. PMID: 28720267 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Aiming for a holistic integrated service for men diagnosed with prostate cancer - Definitions of standards and skill sets for nurses and allied healthcare professionals.

CONCLUSIONS: Specialist nurses and allied healthcare professionals play a vital role alongside urologists and oncologists to provide care to men with prostate cancer and their families. We present a set of standards and consensus recommendations for the roles and skill-set required for these practitioners to provide gold-standard prostate cancer care. These recommendations could form the basis for development of comprehensive integrated prostate cancer pathways in prostate cancer centres as well as providing guidance for any units treating men with prostate cancer. PMID: 28720263 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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Cancer through black eyes - The views of UK based black men towards cancer: A constructivist grounded theory study.

CONCLUSIONS: Cancer services and related public-health campaigns aimed at black men need to understand cancer through black eyes. Public health campaigns based solely on the clinical meaning of cancer are incongruent with black men's understandings of cancer, and therefore ineffective at reducing health inequality. PMID: 28720270 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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An ethnographic exploration of the delivery of psychosocial care to children with cancer in Argentina.

CONCLUSIONS: The study highlighted the barriers psychosocial care providers encounter while attempting to deliver services to children and their families. Further work needs to be carried out to fully integrate psychosocial care in national health policies and ensure this type of support is available for all patients and their families. PMID: 28720272 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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The mediating role of resilience in the relationship between social support and posttraumatic growth among colorectal cancer survivors with permanent intestinal ostomies: A structural equation model analysis.

CONCLUSIONS: Moderate to high PTG was found in CRC survivors with permanent intestinal ostomies. The most important implication of this study was that improving social support and resilience might be scientific intervention strategies for promoting PTG among CRC survivors. PMID: 28720265 [PubMed - in process] (Source: European Journal of Oncology Nursing)

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‘ Expansion Pathology ’ Method Could Mean Earlier Intervention

Clinically optimized expansion pathology supports nanoscale imaging of human tissue samples (Source: The Doctors Lounge - Oncology)

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Complications Up With Immediate Reconstruction After Mastectomy

Risk up for SSI, noninfectious wound complication for IR versus delayed, secondary reconstruction (Source: The Doctors Lounge - Oncology)

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Breast Mass Found in 48-Year-Old Patient

CML Patients Approach Normal Life Expectancy With Imatinib Treatment

SAGE Publishing reports continued strong growth in 2017

Offer of $100 boosts rates of colon cancer screenings

(University of Pennsylvania School of Medicine) Offering $100 to patients eligible for a preventive colonoscopy screening more than doubled the rate of screening when compared to a simple emailed request, according to new research from the Perelman School of Medicine at the University of Pennsylvania. (Source: EurekAlert! - Cancer)

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Colistin Resistance in KPC-2- and SHV-5-Producing < b > < i > Klebsiella pneumoniae < /i > < /b > Clinical Isolates in Bulgaria

Conclusions: Although colistin use in Bulgaria only started moderately during 2014, the findings of the current study notify the appearance of colistin resistance among carbapenemase-producingKlebsiella species in another European region.Chemotherapy 2017;62:339-342 (Source: Chemotherapy)

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VACCINI, IN LOMBARDIA A SETTEMBRE TAVOLO PER CAMPAGNA INFORMATIVA - ROMA on line

VACCINI, IN LOMBARDIA A SETTEMBRE TAVOLO PER CAMPAGNA INFORMATIVA
ROMA on line
Per questo "il vaccino anti-Hpv assume un ruolo fondamentale nella prevenzione di questo e di tutta una serie di tumori (della vulva e della vagina, anale, del pene, testa-collo), anche nei maschi, che registrano nella maggior parte dei casi tassi di ...

and more »

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Proteogenomic analysis and discovery of immune antigens in Mycobacterium vaccae [Research]

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Immunome Research

Volume 13, Issue 2 (Source: Immunome Research)

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Prediction and Conservancy Analysis of Multiepitope Based PeptideVaccine Against Merkel Cell Polyomavirus An ImmunoinformaticsApproach

Mawadda AbdElraheem AwadElkareem, Soada Ahmed Osman, Hanaa Abdalla Mohamed, Hadeel AbdElrahman Hassan, Ahmed Hamdi Abuharaz, Khoubieb Ali Abdelrahman and Mohamed Ahmed Salih (Source: Immunome Research)

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Immunoinformatics Prediction of PeptideBased Vaccine Against AfricanHorse Sickness Virus

Malaz Abdelbagi, Tarteel Hassan, Mohammed Shihabeldin, Sanaa Bashir, Elkhaleel Ahmed, Elmoez Mohamed, Shawgi Hafiz, Abdah Abdelmonim, Tassneem Hamid, Shimaa Awad, Ahmed Hamdi, Khoubieb Ali and Mohammed A Hassan (Source: Immunome Research)

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Targeting Developmental Pathways: The Achilles Heel of Cancer?

Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF- β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental pathways are highly conserved cell signalling syste ms present in almost all multicellular organisms. In addition, they have a crucial role in cell proliferation, apoptosis, differentiation, and finally in organ development. Of note, almost all of these pathways promote oncogenesis through synergistic associations with the Hippo signalling pathway, a nd several lines of evidence have also indicated that these pathways (e.g., Wnt/β-catenin) may be implicated in checkpoint inhibi...

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“Independent” reanalysis of landmark starch solutions trial was published by original authors

Academics who refused calls to share the data underlying their landmark trial that triggered the downfall of starches for fluid resuscitation have announced an "independent reanalysis," which...

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Παρασκευή 21 Ιουλίου 2017

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