Αρχειοθήκη ιστολογίου

Τρίτη 26 Μαΐου 2020


Knockdown SNHG20 Suppresses Nonsmall Cell Lung Cancer Development by Repressing Proliferation, Migration and Invasion, and Inducing Apoptosis by Regulating miR-2467-3p/E2F3
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
29m
lncRNA IGF2-AS Promotes Cell Proliferation, Migration, and Invasion of Gastric Cancer by Modulating miR-937/EZH2 Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
29m
Examination of the Association Between 3,4-Divanillyltetrahydrofuran Lignan (Urtica dioica Origin) and Prostate Cancer Cells by 131I Radiolabeling
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
8h
Antimicrobial Resistance of Serial Isolates of Acinetobacter baumannii Colonizing the Rectum of Adult Intensive Care Unit Patients in a Teaching Hospital in Kuwait
Microbial Drug Resistance, Ahead of Print.
Microbial Drug Resistance - Table of Contents
38m
Mechanisms of Linezolid Resistance Among Clinical Staphylococcus spp. in Spain: Spread of Methicillin- and Linezolid-Resistant S. epidermidis ST2
Microbial Drug Resistance, Ahead of Print.
Microbial Drug Resistance - Table of Contents
2h
Phenotypic and Genotypic Prevalence of Extended-Spectrum β-Lactamase-Producing Escherichia coli: A Systematic Review and Meta-analysis in Iran
Microbial Drug Resistance, Ahead of Print.
Microbial Drug Resistance - Table of Contents
2h
Elective late open conversion after EVAR is associated with comparable outcomes to primary open repair of abdominal aortic aneurysms
Three out of four patients with infrarenal abdominal aortic aneurysm (AAA) are now treated with endovascular aneurysm repair (EVAR). The incidence of secondary procedures and surgical conversions is increasing for a population theoretically unfit for open surgery. The indications and outcomes of late open surgical conversions (LOC) after EVAR in a high volume tertiary vascular unit are reported.
Journal of Vascular Surgery
39m
Dual Fluoroscopy with Live-Image Digital Zooming Significantly Reduces Patient and Operating Staff Radiation During Fenestrated/Branched Endovascular Aortic Aneurysm Repair (F-BEVAR)
Fenestrated/branched endovascular aneurysm repair (F-BEVAR) is a complex procedure that generates high radiation doses. Magnification aids in vessel cannulation but increases radiation. The aim of the study was to compare radiation doses to patients and operating room staff from two fluoroscopic techniques, standard magnification vs. dual fluoroscopy with live-image digital zooming during F-BEVAR.
Journal of Vascular Surgery
39m
A systematic review of fasciotomy in chronic exertional compartment syndrome.
Chronic exertional compartment syndrome (CECS) is an overuse injury typically seen in young and athletic patients. The five cardinal symptoms are pain, tightness, cramping, weakness and paraesthesia. These classically occur during exertion and disappear with cessation of the activity, with no permanent damage to tissues within the compartment; nonetheless, CECS presents a significant functional impairment to those affected. Regulating exercise has been shown to alleviate symptoms but this may not...
Journal of Vascular Surgery
39m
Outcomes of the elective use of the chimney endovascular technique in pararenal aortic pathologic processes.
In the treatment of pararenal abdominal aortic aneurysms and aortic pathological processes (PAAs), the chimney EVAR (CHEVAR) represents an alternative technique for the urgent cases. Aim of the study was the evaluation of the outcomes of CHEVAR in the elective setting.
Journal of Vascular Surgery
39m
Performance of Viabahn Balloon Expandable Stent (VBX) Compared to Self-Expandable Covered (SES) Stents for Branched Endovascular Aortic Repair
The objective of this study is to compare the performance between Viabahn balloon-expandable stents (VBX) and self-expandable covered stents (SES) (Viabahn and Fluency) used as bridging stents for directional branches during F-BEVAR of complex aortic aneurysms (CAA).
Journal of Vascular Surgery
39m
Increased Hospital Volume Is Associated with Reduced Mortality After Thoracoabdominal Aortic Aneurysm Repair
Contemporary data on outcomes in open thoracoabdominal aortic aneurysm (TAAA) repair is limited to reports from major aortic referral centers showing excellent outcomes. This study aims to characterize the national experience of open TAAA repair using national outcomes data, with a primary focus to examine the association of hospital volume with mortality and morbidity.
Journal of Vascular Surgery
39m
Complex Relationship Between Low Albumin and Poor Outcome Following Lower Extremity Procedures for Peripheral Arterial Disease
Low albumin has been associated with poor outcome, including death, in surgical patients. The mechanistic relationship, however, is more complex than simply nutritional. As studies are scant in the vascular population, we sought to examine the association of low albumin with outcomes in patients undergoing open and endovascular lower extremity procedures for peripheral arterial disease (PAD).
Journal of Vascular Surgery
6h
Midterm evaluation of perigraft arterial sac embolization in endovascular aneurysm repair
Management of clinically significant endoleaks (ELs) remains costly, time-consuming, and morbid. Unresolved ELs can result in rupture and mortality after endovascular aneurysm repair (EVAR). Perigraft arterial sac embolization (PASE) has been used to treat ELs diagnosed at the time of EVAR or during surveillance.
Journal of Vascular Surgery
7h
Safety of carotid artery revascularization procedures in patients with atrial fibrillation
Atrial fibrillation (Afib) is a major contributor to cerebrovascular events. Coexisting carotid artery disease is not uncommon in Afib patients, yet they have been excluded from major randomized clinical trials. Therefore, the aim of this study was to evaluate the safety of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in Afib patients.
Journal of Vascular Surgery
7h
The selection of patients for ambulatory endovascular aneurysm repair of elective asymptomatic abdominal aortic aneurysm
To identify candidates undergoing elective endovascular aneurysm repair (EVAR) of asymptomatic infrarenal abdominal aortic aneurysm who are eligible for early (≤6 hours) hospital discharge or to have EVAR performed in free-standing ambulatory surgery centers.
Journal of Vascular Surgery
7h
Una guía para la práctica | Recomendaciones sobre evaluación inicial con imágenes en pacientes con sospecha de COVID-19
IntraMed RSS -
1h
Simulating the Influence of Conjugative Plasmids Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model [Mechanisms of Resistance]
Bacterial plasmids harboring antibiotic resistance genes are critical in the spread of antibiotic resistance. It is known that plasmids differ in their kinetic values i.e. conjugation rate, segregation rate by copy-number incompatibility with related plasmids, and rate of stochastic loss during replication. They also differ in cost to the cell in terms of reducing fitness and in the frequency of compensatory mutations compensating plasmid cost. However, we do not know how variation in these values...
AAC Accepts: Articles Published Ahead of Print
1h
Emergence of novel mutations in extensively drug resistant Salmonella Typhi from Pakistan [Letters]
In response to the recent discussion on xdr typhoid in Pakistan1, we would like to bring attention towards critical genotypic evolution in Salmonella Typhi strains from Pakistan which would be of interest to healthcare community....
AAC Accepts: Articles Published Ahead of Print
1h
TCP1{gamma} subunit is indispensable for growth and infectivity of Leishmania donovani [Experimental Therapeutics]
T-complex protein-1 (TCP1) is a ubiquitous group II chaperonin and is known to fold various proteins like actin and tubulin. In Leishmania donovani, subunit of TCP1 (LdTCP1) has been cloned and characterized. It forms high molecular weight, homo-oligomeric complex that performs ATP dependent protein folding. In the present study, we evaluated the essentiality of LdTCP1 gene. Gene replacement studies indicate that LdTCP1 is essential for parasite survival. The LdTCP1 single-allele replacement mutants...
AAC Accepts: Articles Published Ahead of Print
1h
Antibiotic substrate selectivity of Pseudomonas aeruginosa MexY and MexB efflux systems is determined by a Goldilocks affinity [Mechanisms of Resistance]
Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. Here, we combine evolutionary sequence analyses, computational structural modeling and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity differences between two Pseudomonas aeruginosa RND transporters, MexY and MexB. For efficient efflux, antibiotic substrates must possess a "Goldilocks affinity": binding strong enough to allow interaction...
AAC Accepts: Articles Published Ahead of Print
1h
Chromosomal Resistance to Metronidazole in Clostridioides difficile can be Mediated by Epistasis Between Iron Homeostasis and Oxidoreductases [Mechanisms of Resistance]
Chromosomal resistance to metronidazole has emerged in clinical Clostridioides difficile, but the genetic mechanisms remain unclear. This is further hindered by the inability to generate spontaneous metronidazole-resistant mutants in the lab to interpret genetic variations in clinical isolates. We therefore constructed a mismatch repair mutator, in non-toxigenic ATCC 700057, to survey the mutational landscape for de novo resistance mechanisms. In separate experimental evolutions, the mutator adopted...
AAC Accepts: Articles Published Ahead of Print
1h
Open-Label Crossover Oral Bioequivalence PK Comparison for a 3-Day Loading Dose Regimen and 15-Day Steady-State Administration of SUBA™-Itraconazole and Conventional Itraconazole Capsules in Healthy Adults [Clinical Therapeutics]
SUBA™-itraconazole (S-ITZ) which releases drug in the duodenum compared to conventional ITZ (C-ITZ) in the stomach were compared in two PK studies: a 3-day loading dose and a 15-day steady-state. These were crossover, oral bioequivalence studies under fed conditions in healthy adult volunteers. In the loading dose study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered TID for 3 days and once on day 4 (N=15). For the steady-state study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered...
AAC Accepts: Articles Published Ahead of Print
1h
KPC-50 confers resistance to ceftazidime-avibactam associated with reduced carbapenemase activity [Mechanisms of Resistance]
KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. As compared to KPC-3, KPC-50 shows i) a three amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277 amino acid sequence, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) associated to a sharp reduction of its carbapenemase activity.
AAC Accepts: Articles Published Ahead of Print
1h
Novel antiparasitic activity of the antifungal lead occidiofungin [Experimental Therapeutics]
Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (EC50 = 120 nM vs. TC50 = 988 nM), and its treatment disrupted the parasite morphology. Besides expanded activity spectrum, occidiofungin as a glycolipopeptide is characterized by poor absorbability and its ability to retain in gastrointestinal tract, making it worth to also investigate its potential...
AAC Accepts: Articles Published Ahead of Print
1h
Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae. [Mechanisms of Resistance]
Colistin resistance in Klebsiella pneumoniae is predominantly caused by mutations that increase expression of the arn (also known as pbg or pmrF) operon. Expression is activated by the PhoPQ and PmrAB two-component systems. Constitutive PhoPQ activation occurs directly by mutation or following loss of MgrB. PhoPQ may also cross-activate PmrAB via the linker protein PmrD. Using proteomics, we show that MgrB loss causes a wider proteomic effect than direct PhoPQ activation, suggesting additional targets...
AAC Accepts: Articles Published Ahead of Print
1h
The use of capacitance measurement in fermentation monitoring
Matthew, Gavin Bruce; (1999) The use of capacitance measurement in fermentation monitoring. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
1h
Enhanced bioprocessing of viable nematodes
Young, John Matthew; (1999) Enhanced bioprocessing of viable nematodes. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
1h
Scale-down of a bioprocess sequence for the recovery and purification of an intracellular protein
Maybury, John Paul; (1999) Scale-down of a bioprocess sequence for the recovery and purification of an intracellular protein. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
3h
A detailed chemical model for the combustion of n-heptane in a low pressure reactor
Fernandes, Carlos Inacio De Griffin; (1998) A detailed chemical model for the combustion of n-heptane in a low pressure reactor. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
3h
The influence of agitation on morphology, rheology and erythromycin production in Saccharopolyspora erythraea culture
Heydarian, Seyed Mohammad; (1998) The influence of agitation on morphology, rheology and erythromycin production in Saccharopolyspora erythraea culture. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
3h
Pollutant formation and interaction in the combustion of heavy liquid fuels
Molero de Blas, Luis Javier; (1998) Pollutant formation and interaction in the combustion of heavy liquid fuels. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
4h
Theoretical and experimental studies of drop breakage in two-liquid phase dispersions in mechanically agitated vessels
Lo-Yim, Mei Yee Aideo; (1998) Theoretical and experimental studies of drop breakage in two-liquid phase dispersions in mechanically agitated vessels. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
4h
On-line monitoring and control of fractional protein precipitation and recovery processes
Chard, Stephen John; (1998) On-line monitoring and control of fractional protein precipitation and recovery processes. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
5h
Linking metal centres with π-conjugated diimido bridges
Redmond, Simon Paul; (1998) Linking metal centres with π-conjugated diimido bridges. Doctoral thesis (Ph.D), UCL (University College London). Green open access
UCL Discovery: No conditions
5h
A prospective evaluation of the implantable cardioverter defibrillator: Factors affecting implant success, outcome, therapy delivery, social adjustment and cost efficacy
Anderson, Mark; (1994) A prospective evaluation of the implantable cardioverter defibrillator: Factors affecting implant success, outcome, therapy delivery, social adjustment and cost efficacy. Doctoral thesis (M.D), UCL (University College London). Green open access
UCL Discovery: No conditions
8h

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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