Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mark above section as read
Microbial Drug Resistance, Ahead of Print.
Microbial Drug Resistance, Ahead of Print.
Microbial Drug Resistance, Ahead of Print.
Mark above section as read
Three out of four patients with infrarenal abdominal aortic aneurysm (AAA) are now treated with endovascular aneurysm repair (EVAR). The incidence of secondary procedures and surgical conversions is increasing for a population theoretically unfit for open surgery. The indications and outcomes of late open surgical conversions (LOC) after EVAR in a high volume tertiary vascular unit are reported.
Fenestrated/branched endovascular aneurysm repair (F-BEVAR) is a complex procedure that generates high radiation doses. Magnification aids in vessel cannulation but increases radiation. The aim of the study was to compare radiation doses to patients and operating room staff from two fluoroscopic techniques, standard magnification vs. dual fluoroscopy with live-image digital zooming during F-BEVAR.
Chronic exertional compartment syndrome (CECS) is an overuse injury typically seen in young and athletic patients. The five cardinal symptoms are pain, tightness, cramping, weakness and paraesthesia. These classically occur during exertion and disappear with cessation of the activity, with no permanent damage to tissues within the compartment; nonetheless, CECS presents a significant functional impairment to those affected. Regulating exercise has been shown to alleviate symptoms but this may not...
In the treatment of pararenal abdominal aortic aneurysms and aortic pathological processes (PAAs), the chimney EVAR (CHEVAR) represents an alternative technique for the urgent cases. Aim of the study was the evaluation of the outcomes of CHEVAR in the elective setting.
The objective of this study is to compare the performance between Viabahn balloon-expandable stents (VBX) and self-expandable covered stents (SES) (Viabahn and Fluency) used as bridging stents for directional branches during F-BEVAR of complex aortic aneurysms (CAA).
Contemporary data on outcomes in open thoracoabdominal aortic aneurysm (TAAA) repair is limited to reports from major aortic referral centers showing excellent outcomes. This study aims to characterize the national experience of open TAAA repair using national outcomes data, with a primary focus to examine the association of hospital volume with mortality and morbidity.
Low albumin has been associated with poor outcome, including death, in surgical patients. The mechanistic relationship, however, is more complex than simply nutritional. As studies are scant in the vascular population, we sought to examine the association of low albumin with outcomes in patients undergoing open and endovascular lower extremity procedures for peripheral arterial disease (PAD).
Management of clinically significant endoleaks (ELs) remains costly, time-consuming, and morbid. Unresolved ELs can result in rupture and mortality after endovascular aneurysm repair (EVAR). Perigraft arterial sac embolization (PASE) has been used to treat ELs diagnosed at the time of EVAR or during surveillance.
Atrial fibrillation (Afib) is a major contributor to cerebrovascular events. Coexisting carotid artery disease is not uncommon in Afib patients, yet they have been excluded from major randomized clinical trials. Therefore, the aim of this study was to evaluate the safety of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in Afib patients.
To identify candidates undergoing elective endovascular aneurysm repair (EVAR) of asymptomatic infrarenal abdominal aortic aneurysm who are eligible for early (≤6 hours) hospital discharge or to have EVAR performed in free-standing ambulatory surgery centers.
Mark above section as read
Mark above section as read
Mark above section as read
Bacterial plasmids harboring antibiotic resistance genes are critical in the spread of antibiotic resistance. It is known that plasmids differ in their kinetic values i.e. conjugation rate, segregation rate by copy-number incompatibility with related plasmids, and rate of stochastic loss during replication. They also differ in cost to the cell in terms of reducing fitness and in the frequency of compensatory mutations compensating plasmid cost. However, we do not know how variation in these values...
In response to the recent discussion on xdr typhoid in Pakistan1, we would like to bring attention towards critical genotypic evolution in Salmonella Typhi strains from Pakistan which would be of interest to healthcare community....
T-complex protein-1 (TCP1) is a ubiquitous group II chaperonin and is known to fold various proteins like actin and tubulin. In Leishmania donovani, subunit of TCP1 (LdTCP1) has been cloned and characterized. It forms high molecular weight, homo-oligomeric complex that performs ATP dependent protein folding. In the present study, we evaluated the essentiality of LdTCP1 gene. Gene replacement studies indicate that LdTCP1 is essential for parasite survival. The LdTCP1 single-allele replacement mutants...
Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. Here, we combine evolutionary sequence analyses, computational structural modeling and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity differences between two Pseudomonas aeruginosa RND transporters, MexY and MexB. For efficient efflux, antibiotic substrates must possess a "Goldilocks affinity": binding strong enough to allow interaction...
Chromosomal resistance to metronidazole has emerged in clinical Clostridioides difficile, but the genetic mechanisms remain unclear. This is further hindered by the inability to generate spontaneous metronidazole-resistant mutants in the lab to interpret genetic variations in clinical isolates. We therefore constructed a mismatch repair mutator, in non-toxigenic ATCC 700057, to survey the mutational landscape for de novo resistance mechanisms. In separate experimental evolutions, the mutator adopted...
SUBA™-itraconazole (S-ITZ) which releases drug in the duodenum compared to conventional ITZ (C-ITZ) in the stomach were compared in two PK studies: a 3-day loading dose and a 15-day steady-state. These were crossover, oral bioequivalence studies under fed conditions in healthy adult volunteers. In the loading dose study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered TID for 3 days and once on day 4 (N=15). For the steady-state study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered...
KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. As compared to KPC-3, KPC-50 shows i) a three amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277 amino acid sequence, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) associated to a sharp reduction of its carbapenemase activity.
Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (EC50 = 120 nM vs. TC50 = 988 nM), and its treatment disrupted the parasite morphology. Besides expanded activity spectrum, occidiofungin as a glycolipopeptide is characterized by poor absorbability and its ability to retain in gastrointestinal tract, making it worth to also investigate its potential...
Colistin resistance in Klebsiella pneumoniae is predominantly caused by mutations that increase expression of the arn (also known as pbg or pmrF) operon. Expression is activated by the PhoPQ and PmrAB two-component systems. Constitutive PhoPQ activation occurs directly by mutation or following loss of MgrB. PhoPQ may also cross-activate PmrAB via the linker protein PmrD. Using proteomics, we show that MgrB loss causes a wider proteomic effect than direct PhoPQ activation, suggesting additional targets...
Mark above section as read
Matthew, Gavin Bruce; (1999) The use of capacitance measurement in fermentation monitoring. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Young, John Matthew; (1999) Enhanced bioprocessing of viable nematodes. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Maybury, John Paul; (1999) Scale-down of a bioprocess sequence for the recovery and purification of an intracellular protein. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Fernandes, Carlos Inacio De Griffin; (1998) A detailed chemical model for the combustion of n-heptane in a low pressure reactor. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Heydarian, Seyed Mohammad; (1998) The influence of agitation on morphology, rheology and erythromycin production in Saccharopolyspora erythraea culture. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Molero de Blas, Luis Javier; (1998) Pollutant formation and interaction in the combustion of heavy liquid fuels. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Lo-Yim, Mei Yee Aideo; (1998) Theoretical and experimental studies of drop breakage in two-liquid phase dispersions in mechanically agitated vessels. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Chard, Stephen John; (1998) On-line monitoring and control of fractional protein precipitation and recovery processes. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Redmond, Simon Paul; (1998) Linking metal centres with π-conjugated diimido bridges. Doctoral thesis (Ph.D), UCL (University College London). Green open access
Anderson, Mark; (1994) A prospective evaluation of the implantable cardioverter defibrillator: Factors affecting implant success, outcome, therapy delivery, social adjustment and cost efficacy. Doctoral thesis (M.D), UCL (University College London). Green open access
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,