The effect of short radiation treatment breaks on chemo‐radiotherapy for oropharyngeal cancers

xlomafota13 shared this article with you from Inoreader The effect of short radiation treatment breaks on chemo‐radiotherapy for oropharyngeal cancers Via Head & Neck Abstract Background Numerous studies and guidelines suggest an outcome detriment from radiation treatment breaks (rTBs) and the need for compensatory dosing in patients with head and neck cancer. Methods In a consecutive cohort of 521 patients with oropharyngeal squamous cell carcinoma (OPSCC), we investigated the impact of rTBs and prolongation of overall treatment time (OTT) on OS, DFS, LRC, and cancer recurrence using competing risk and multivariate analyses. Results Neither OTT prolongation by ≤2 days nor rTBs of ≤3 days were associated with detriments to clinical outcomes. Consecutive breaks of ≥3 days were also not significantly associated with detriment to clinical outcomes. There was significantly increased competing mortality in those with longer breaks. Conclusions In OPSCC patients treated with definitive concurrent chemoradiotherapy, there is no significant association between disease failure and total rTBs of ≤3 consecutive or scattered days. Further investigation is needed for longer breaks. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Office‐based Transnasal Oesophagoscopy: evaluating the safety, efficacy and application in head and neck cancer patients

xlomafota13 shared this article with you from Inoreader Office‐based Transnasal Oesophagoscopy: evaluating the safety, efficacy and application in head and neck cancer patients Via Clinical Otolaryngology Abstract Transnasal Oesophagoscopy (TNO) is an approach to inspect the upper aerodigestive tract, especially in the head and neck cancer (HNCA) population that present with dysphagia. Twenty-five (25) office-based TNO procedures were performed, with a same-day discharge rate of 96% (24/25) and no reported complications. This case series is the first to compare preoperative and postoperative outcomes (EAT-10) following stricture dilatation using TNO in the UK. Our results show a statistically significant improvement in symptom severity (EAT-10 scores) (n=11, P=0.001). Nearly half (45.5%) of patients undergoing dilatation developed strictures due to post-radiation/post-laryngectomy complications. Biopsy in 4/5 patients was sufficient for diagnosis/ruling out disease. Of these patients, 5/5 had a previous HNCA. This study identifies the remit for a new 'one-stop' TNO service for suspected cancer referrals, of which a large proportion are patients with a previous HNCA. Surveillance, therapeutics and diagnostics can be achieved in a single visit. Earlier staging or treatment may be achieved due to a fast turnover in clinic View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hybrid Ameloblastoma Arising from a Treated Odontogenic Keratocyst of the Mandible: A Case Report With Literature Review

xlomafota13 shared this article with you from Inoreader Hybrid Ameloblastoma Arising from a Treated Odontogenic Keratocyst of the Mandible: A Case Report With Literature Review Via Otolaryngology Indian Abstract Odontogenic Keratocyst (OKC) is an odontogenic cyst of developmental origin arising from remnants of the dental lamina. Malignant or benign transformations though rare have been noticed from their epithelium. Ameloblastomatous transformation from an OKC is extremely rare with such lesions being referred to as combined/"hybrid" odontogenic lesions. In this article, we present an intriguing case of a 60-year-old male who was operated on for OKC of the anterior mandible 3 years before, who came back with a complaint of swelling over the same site. Incisional biopsy revealed the acanthomatous type of ameloblastoma for which segmental resection with immediate reconstruction using recon plate was done. Excision biopsy revealed a plexiform variant as well, thus exhibiting a hybrid pattern. Surgeons should be aware of this hybrid presentation of ameloblastoma arising from the epithelium of OKC as the acanthomatous subtype is known for its notorious genetic behav ior leading to recurrence and aggressive nature of this tumor. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extensive Pneumocephalus Secondary to Petrous Bone Cholesteatoma

xlomafota13 shared this article with you from Inoreader Extensive Pneumocephalus Secondary to Petrous Bone Cholesteatoma Via leak of cerebrospinal fluid Ear Nose Throat J. 2021 Sep 29:1455613211048966. doi: 10.1177/01455613211048966. Online ahead of print. ABSTRACT Pneumocephalus refers to air inside the cranium; however, otogenic pneumocephalus is rarely reported in the literature. The neurological presentations of pneumocephalus include headache, lethargy, confusion, disorientation, and seizure. Here, we have reported a case of a 42-year-old woman with extensive pneumocephalus and cerebrospinal fluid leak secondary to petrous bone cholesteatoma. She presented to the emergency department with sudden headache and left ear discharge. Physical examination revealed watery otorrhea through a hole in the tympanic membrane. Radiological studies demonstrated extensive soft tissue in the left middle ear and mastoid extending to the internal auditory canal. Free intracranial air was observed, and bony destruction was seen in the cochlea, vestibule, and semicircular canals. The patient was managed surg ically via the transotic approach and fully recovered. Although otogenic pneumocephalus is rarely encountered in clinical practice, early diagnosis and urgent management are important to prevent fatal complications. PMID:34587824 | DOI:10.1177/01455613211048966 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Basal cell adenoma of the parotid gland: A rare entity

xlomafota13 shared this article with you from Inoreader Basal cell adenoma of the parotid gland: A rare entity Via ear nose throat Ear Nose Throat J. 2021 Sep 29:1455613211045524. doi: 10.1177/01455613211045524. Online ahead of print. ABSTRACT Basal cell adenoma (BCA) is a rare benign salivary gland tumor accounting for only 1-2% of all salivary gland tumors. We report a case of a 50-year-old man presenting a BCA of the parotid gland. A pleomorphic adenoma was initially suspected based on radiological features and fine needle aspiration cytology findings (FNAC). PMID:34587790 | DOI:10.1177/01455613211045524 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extensive Pneumocephalus Secondary to Petrous Bone Cholesteatoma

xlomafota13 shared this article with you from Inoreader Extensive Pneumocephalus Secondary to Petrous Bone Cholesteatoma Via ear nose throat Ear Nose Throat J. 2021 Sep 29:1455613211048966. doi: 10.1177/01455613211048966. Online ahead of print. ABSTRACT Pneumocephalus refers to air inside the cranium; however, otogenic pneumocephalus is rarely reported in the literature. The neurological presentations of pneumocephalus include headache, lethargy, confusion, disorientation, and seizure. Here, we have reported a case of a 42-year-old woman with extensive pneumocephalus and cerebrospinal fluid leak secondary to petr ous bone cholesteatoma. She presented to the emergency department with sudden headache and left ear discharge. Physical examination revealed watery otorrhea through a hole in the tympanic membrane. Radiological studies demonstrated extensive soft tissue in the left middle ear and mastoid extending to the internal auditory canal. Free intracranial air was observed, and bony destruction was seen in the cochlea, vestibule, and semicircular canals. The patient was managed surgically via the transotic approach and fully recovered. Although otogenic pneumocephalus is rarely encountered in clinical practice, early diagnosis and urgent management are important to prevent fatal complications. PMID:34587824 | DOI:10.1177/01455613211048966 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Case of Nasal Rhinosporidiosis in the United States

xlomafota13 shared this article with you from Inoreader A Case of Nasal Rhinosporidiosis in the United States Via ear nose throat Ear Nose Throat J. 2021 Sep 29:1455613211049004. doi: 10.1177/01455613211049004. Online ahead of print. ABSTRACT Rhinosporidiosis, an infectious granulomatous disease, is seldom encountered in the United States. We present a case of rhinosporidiosis in a 26-year-old man, who presented with an unusual mass in his nasal cavity. Suspicion for rhinosporidiosis was high due to the patient's travel and activity history. After imaging and proper diagnosis, surgery was performed to excise the lesion. As international travel resumes during the COVID-19 pandemic, the potential for encountering this rare organism is heightened. PMID:34587820 | DOI:10.1177/01455613211049004 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

COVID-19 and anosmia: The story so far

xlomafota13 shared this article with you from Inoreader COVID-19 and anosmia: The story so far Via ear nose throat Ear Nose Throat J. 2021 Sep 29:1455613211048998. doi: 10.1177/01455613211048998. Online ahead of print. ABSTRACT OBJECTIVES: The pandemic has affected over 182 million coronavirus disease 2019 (COVID-19) cases worldwide. Accumulated evidence indicates that anosmia is one of the significant characteristics of COVID-19 with a high prevalence. However, many aspects of COVID-19-induced anosmia are still far from being fully understood. The purpose of this review is to summarize recent developments in COVID-19-induced anosmia to increase awareness of the condition. METHODS: A literature search was carried out using the PubMed, Embase, Web of Science, and Scopus. We reviewed the latest literature on COVID-19-induced anosmia, including mechanisms of pathogenesis, olfactory testing, anosmia as predictive tool, pathological examinations, imaging findings, affected factors, co-existing diseases, treatments, prognosis, hypothesis theories, and future directions. RESULTS: The possible pathogenesis of COVID-19-induced anosmia may involve inflammation of the olfactory clefts and damage to the olfactory epithelium or olfactory central nervous system by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The D614G spike variant may also play a role in the increased number of anosmia patients. Anosmia may also be an essential indicator of COVID-19 spread and an early indicator of the effectiveness of political decisions. The occurrence and develop ment of COVID-19-induced anosmia may be influenced by smoking behaviors and underlying diseases such as type 2 diabetes, gastroesophageal disorders, and rhinitis. Most patients with COVID-19-induced anosmia can fully or partially recover their olfactory function for varying durations. COVID-19-induced anosmia can be treated with various approaches such as glucocorticoids and olfactory training. CONCLUSION: Anosmia is one of the main features of COVID-19 and the underlying disease of the patient may also influence its occurrence and development. The possible pathogenesis of COVID-19-induced anosmia is very complicated, which may involve inflammation of the olfactory clefts and damage to the olfactory epithelium or olfactory central nervous system. PMID:34587819 | DOI:10.1177/01455613211048998 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cartilaginous Choristoma of the External Auditory Canal

xlomafota13 shared this article with you from Inoreader Cartilaginous Choristoma of the External Auditory Canal Via ear nose throat Ear Nose Throat J. 2021 Sep 29:1455613211048974. doi: 10.1177/01455613211048974. Online ahead of print. ABSTRACT Cartilaginous choristoma is a rare benign lesion of the external auditory canal, generally found incidentally on physical exam in an asymptomatic patient. Our patient had the largest cartilaginous choristomas described in the literature to date. Additionally, this reviews the nomenclature and differential diagnoses of masses within the external auditory canal. PMID:34587769 | DOI:10.1177/01455613211048974 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Continuous Intraoperative Vasopressor Use in Head and Neck Free-Flap Reconstruction

xlomafota13 shared this article with you from Inoreader Continuous Intraoperative Vasopressor Use in Head and Neck Free-Flap Reconstruction Via JAMA Otolaryngology–Head & Neck Surgery Online First This cohort study investigates the association between continu ous vasopressor use and the incidence of reoperation in the early postoperative period for patients undergoing free-flap reconstruction. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy

xlomafota13 shared this article with you from Inoreader Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy Via JAMA Otolaryngology–Head & Neck Surgery Online First This multicenter cohort study of adult patients with laryngeal cancer uses data from a national database to identify nonclinical risks associated with the formation of pharyngocutaneous fistula after total laryngectomy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Unusual Case of Bilateral Chylothorax After Neck Dissection

xlomafota13 shared this article with you from Inoreader An Unusual Case of Bilateral Chylothorax After Neck Dissection Via JAMA Otolaryngology–Head & Neck Surgery Online First This case report describes a woman in her 30s who underwent to tal thyroidectomy with modified radical neck dissection due to papillary thyroid cancer and was subsequently diagnosed with bilateral chylothorax secondary to cervical thoracic duct injury. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.