Laser Doppler vibrometric measurements on human temporal bones

xlomafota13 shared this article with you from Inoreader [Laser Doppler vibrometric measurements on human temporal bones]. Via hno Related Articles [Laser Doppler vibrometric measurements on human temporal bones]. HNO. 2021 Feb 10;: Authors: Schraven SP, Dohr D, Weiss NM, Mlynski R, Dalhoff E Abstract Laser Doppler vibrometric (LDV) measurements on human temporal bones represent the standard method for predicting the performance of active middle ear implants (AMEI) and are used as preclinical tests in the development, approval process, and indication expansion of AMEI. The quality of the coupling of the floating mass transducer to the mobile structures of the middle ear is decisive for the performance of the implant and patients' hearing perception. The cochlea can be stimulated via the oval window (forward stimulation) or the round window (reverse stimulation). For forward stimulation, the ASTM standard F2504-05 defines a method to ensure physiologically normal properties of the temporal bones used in the experiments. For reverse stimulation, which depends even more critically on the quality of the temporal bone, a comparable standard method is lacking. Appropriate preparation and storage of the human petrous bone as well as suitable LDV test setups with respect to calibration and reproducibility of measuring positions and angles provide results that allow a comparison of different types of coupling and also correlate well with clinical data. PMID: 33566127 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Iodine effective diffusion coefficients through volcanic rock: Influence of iodine speciation and rock geochemistry.

xlomafota13 shared this article with you from Inoreader Iodine effective diffusion coefficients through volcanic rock: Influence of iodine speciation and rock geochemistry. Via radioactive iodine Related Articles Iodine effective diffusion coefficients through volcanic rock: Influence of iodine speciation and rock geochemistry. J Contam Hydrol. 2020 Nov;235:103714 Authors: Neil CW, Telfeyan K, Sauer KB, Ware SD, Reimus P, Boukhalfa H, Roback R, Brug WP Abstract Accurate prediction of the subsurface transport of iodine species is important for the assessment of long-term nuclear waste repository performance, as well as monitoring compliance with the Comprehensive Nuclear-Test-Ban Treaty, given that radioiodine decays into radioxenon. However, the transport of iodine through intact geologic media is not well understood, compromising our ability to assess risk associated with radioiodine migration. The current study's goal is to quantify the matrix diffusion of iodine species through saturated volcanic rock, with particular attention paid to the redox environment and potential speciation changes. Diffusion experiments were run for iodide through lithophysae-rich lava, lithophysae-poor lava, and welded tuff, whereas iodate diffusion was studied through welded tuff. Iodine transport was compared with a conservative tracer, HDO, and effective diffusion coefficients were calculated. Likely due to a combination of size and anion exclusion e ffects, iodine species diffused more slowly than the conservative tracer through all rock types tested. Furthermore, oxidation of iodide to iodate was observed in the lithophysae-poor lava, affecting transport. Results provide much needed data for subsurface transport models that predict radioiodine migration from underground sources, and indicate the pressing need for geochemical and redox interactions to be incorporated into these models. PMID: 32987236 [PubMed - indexed for MEDLINE] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Surgical Treatment of Advanced Thyroid Cancer with Tracheal Invasion.

xlomafota13 shared this article with you from Inoreader Surgical Treatment of Advanced Thyroid Cancer with Tracheal Invasion. Via radioactive iodine Related Articles Surgical Treatment of Advanced Thyroid Cancer with Tracheal Invasion. Case Rep Endocrinol. 2021;2021:8823405 Authors: Nguyen HX, Le Trinh H, Nguyen HX, Nguyen HV, Le QV Abstract Introduction: Tracheal invasion in thyroid cancer occurs in one-third of locally advanced cases and is the third most common site of infiltration following strap muscles and recurrent laryngeal nerves. Surgical resection plays an important role in the management strategy followed by either radioactive iodine or external beam radiotherapy. Nonetheless, there has been still controversy about the optimal extension of the surgery. Case Presentation. Total thyroidectomy, airway resection and bilateral neck dissection were performed in two cases diagnosed as advanced thyroid cancer with tracheal invasion (stage IV according to McCaffrey). The first case underwent partial tracheal resection and direct anastomosis by the V-shape technique, while the latter one required tracheal resection and permanent tracheotomy. After one-year follow-up, no evidence of tumor recurrence or any postoperative complications were found. Conclusion: Surgical resection still remains the mainstay of management for advanced thyroid cancer in general and for tracheal invasion cases in particular. The decision of surgical resection and tracheal reconstruction methods mostly depends on the extent of tracheal invasion. PMID: 33564480 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radioiodine therapy of Graves' disease.

xlomafota13 shared this article with you from Inoreader Radioiodine therapy of Graves' disease. Via radioactive iodine Related Articles Radioiodine therapy of Graves' disease. Q J Nucl Med Mol Imaging. 2021 Feb 10;: Authors: Piccardo A, Ugolini M, Altrinetti V, Righi S, Fiz F, Foppiani L, Giovanella L Abstract Graves' disease (GD), the most common cause of hyperthyroidism, is an autoimmune disease directly caused by circulating autoantibodies that bind and activate the TSH receptor, inducing metabolic activation of the thyroid gland; this may be associated with important cardiac (atrial fibrillation) and ocular (ophthalmopathy) complications. Treating GD with real curative intent implies the full elimination of the functioning thyroid parenchyma using surgery or radioactive iodine therapy (RAI). RAI has been used in humans with hyperthyroidism since 1941, thanks to the pioneering work of a physician (Dr. Saul Hertz) and a physicist (Dr. Arthur Roberts). The rationale of RAI is based on the effect of radiation of 131I on target cells leading to DNA damage, both directly, through breakage of molecular bonds, and indirectly through the formation of free radicals. In particular, irradiation causes a broad spectrum of cellular damage due to the production of reactive oxygen species and lipid peroxidation of the plasma membrane. Thus, RAI-related cellular death takes place through both apoptosis and necrosis. The aim of this review is to summarize indications, efficacy, safety profile, and dosimetric aspects of RAI treatment in patients affected by GD. PMID: 33565844 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Facial paralysis as the only symptom of COVID-19: A prospective study

xlomafota13 shared this article with you from Inoreader Facial paralysis as the only symptom of COVID-19: A prospective study Via American Journal of Otolaryngology Publication date: Available online 10 February 2021 Source: American Journal of Otolaryngology Author(s): Yuce Islamoglu, Burak Celik, Muzaffer Kiris View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A proposal for a new classification of coracobrachialis muscle morphology.

xlomafota13 shared this article with you from Inoreader A proposal for a new classification of coracobrachialis muscle morphology. Via radiol anat Related Articles A proposal for a new classification of coracobrachialis muscle morphology. Surg Radiol Anat. 2021 Feb 09;: Authors: Szewczyk B, Polguj M, Paulsen F, Podgórski M, Duparc F, Karauda P, Olewnik Ł Abstract INTRODUCTION: The coracobrachialis muscle (CRM) originates from the apex of the coracoid process, in common with the short head of the biceps brachii muscle, and from the intermuscular septum. It inserts to the medial part of the humerus between the attachment of the medial head of the triceps brachii and the brachial muscle. Both the proximal and distal attachments of the CRM, as well as its relationship with the musculocutaneus nerve, demonstrate morphological variability. MATERIAL AND METHODS: One hundred and one upper limbs (52 left, and 49 right) fixed in 10% formalin solution were examined. RESULTS: Three main types, with subtypes, were identified. The most common was Type I (49.5), characterized by a single muscle belly with a classical origin from the coracoid process, medially and posteriorly to the tendon of the biceps brachii. Type II (42.6%), characterized by two heads, was divided into two subtypes (A-B) depending on its origin: Type IIA, where one head originated from the coracoid process posteriorly to the tendon of the biceps brachii and the second head from the short head of the biceps brachii, and Type IIB, in which both heads originated from the coracoid process; however, the superficial head fused with the insertion of a short head of the biceps brachii, while the deep head was directly originating. Finally, Type III (7.9%) was characterized by three heads: two originated from the coracoid process (superficial and deep), and the third from a short head of the biceps brachii. Two types of insertion and two types of musculocutaneous nerve (MCN) relat ive to CRM could be distinguished. CONCLUSION: An adapted classification is needed for all clinicians working in this area, as well as for anatomists. The CRM demonstrates morphological variability in both its proximal and distal attachments, as well as the variable course of the MCN relative to the CRM. WHAT IS KNOWN ABOUT THIS SUBJECT "AND" WHAT THIS STUDY ADDS TO EXISTING KNOWLEDGE: Not much is known about the variability of coracobrachialis muscle. The present paper introduces a completely new classification, both clinical and anatomical. PMID: 33564931 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is there still a place for conventional histopathology in the age of molecular medicine? Laurén classification, inflammatory infiltration and other current topics in gastric cancer diagnosis and prognosis.

xlomafota13 shared this article with you from Inoreader Is there still a place for conventional histopathology in the age of molecular medicine? Laurén classification, inflammatory infiltration and other current topics in gastric cancer diagnosis and prognosis. Via Cellular and Molecular Biology Related Articles Is there still a place for conventional histopathology in the age of molecular medicine? Laurén classification, inflammatory infiltration and other current topics in gastric cancer diagnosis and prognosis. Histol Histopathol. 2021 Feb 10;:18309 Authors: Díaz Del Arco C, Ortega Medina L, Estrada Muñoz L, García Gómez de Las Heras S, Fernández Aceñero MJ Abstract Gastric cancer (GC) is the fifth most common cancer and the third cause of cancer-related deaths worldwide. In western countries, more than half of GC patients are diagnosed at advanced stages and 5-year survival rates range between 20-30%. The only curative treatment is surgery, and despite recent advances in oncological therapies, GC prognosis is still poor. The main prognostic tool for patient categorization and treatment selection is the TNM classification, but its limitations are being increasingly recognized. Early recurrences may occur in early-stage disease, and patients at the same stage show heterogeneous outcomes. Thus, there is a need to improve GC stratification and to identify new prognostic factors, which may allow us to select drug-susceptible populations, refine patient grouping for clinical trials and discover new therapeutic targets. Molecular classifications have been developed, but they have not been translated to the clinical practice. On the other hand, histological assessment is cheap and widely available, and it is still a mainstay in the era of molecular medicine. Furthermore, histological features are acquiring new roles as reflectors of the genotype-phenotype correlation, and their potential impact on patient management is currently being analyzed. The aim of this literature review is to provide a modern overview of the histological assessment of GC. In this study, we discuss recent topics on the histological diagnosis of GC, focusing on the current role of Laurén classification and the potential value of new histological features in GC, such as inflammatory infiltration and tumor budding. PMID: 33565601 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of Effortful Swallowing Exercise with Progressive Anterior Tongue Press Using Iowa Oral Performance Instrument (IOPI) on the Strength of Swallowing-Related Muscles in the Elderly: A Preliminary Study.

xlomafota13 shared this article with you from Inoreader Effects of Effortful Swallowing Exercise with Progressive Anterior Tongue Press Using Iowa Oral Performance Instrument (IOPI) on the Strength of Swallowing-Related Muscles in the Elderly: A Preliminary Study. Via swallowing exercises Related Articles Effects of Effortful Swallowing Exercise with Progressive Anterior Tongue Press Using Iowa Oral Performance Instrument (IOPI) on the Strength of Swallowing-Related Muscles in the Elderly: A Preliminary Study. Dysphagia. 2021 Feb 10;: Authors: Oh JC Abstract The purpose of this study was to confirm the effect of effortful swallowing (ES) exercise programs applied to increase the swallowing-related muscle strength in the elderly. In this study, 20 healthy elderly people (76.65 ± 5.87 years; 10 women and 10 men) participated and exercised for 7 weeks. The experimental group performed ES exercise combined with external resistance using Iowa Oral Performance Instrument (IOPI), and the control group performed pure ES without external resistance. The exercises were performed for 20 min a day, 2 days a week for 7 weeks in both groups. ES was repeated 60 times in weeks 1 and 2, 80 times in week 3 and 4, and 120 times in weeks 5-7. In the experimental group, the isometric and swallowing tongue pressures at week 8 were significantly improved compared to baseline. At week 8, the anterior and swallowing tongue pressures and anterior tongue endurance were significantly higher than those of the control group. In t he control group, no significant change in tongue pressure-related variables was observed after 7 weeks of exercise. ES exercise combined with IOPI resistance for 7 weeks tended to increase the suprahyoid muscle activation level without statistical significance. For clinical application of this exercise protocol, further studies including more elderly people and patients with dysphagia are required. PMID: 33566219 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Combined sialendoscopic/mini-preauricular microscopic approach for large proximal parotid sialolithiasis

xlomafota13 shared this article with you from Inoreader Combined sialendoscopic/mini-preauricular microscopic approach for large proximal parotid sialolithiasis Via Auris Nasus Larynx Publication date: Available online 10 February 2021 Source: Auris Nasus Larynx Author(s): Emad A. Magdy, Mahmoud Seif-Elnasr, Mohamed F. Fathalla View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Adolescent Presentation of Nasal Chondromesenchymal Hamartoma

xlomafota13 shared this article with you from Inoreader Adolescent Presentation of Nasal Chondromesenchymal Hamartoma Via JAMA Otolaryngology–Head & Neck Surgery Online First This case report describes an adolescent male who presented with a right-sided nasal mass after sustaining a concussion and was subsequantly diagnosed with a nasal chondromesenchymal hamartoma. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Expression of cell divisioncycle-associated genes and their prognostic significance in hepatocellular carcinoma.

xlomafota13 shared this article with you from Inoreader Expression of cell divisioncycle-associated genes and their prognostic significance in hepatocellular carcinoma. Via International Journal of Clinical and Experimental Pathology Related Articles Expression of cell divisioncycle-associated genes and their prognostic significance in hepatocellular carcinoma. Int J Clin Exp Pathol. 2021;14(2):151-169 Authors: Wang Z, Xu J, Zhang S, Chang L Abstract The cell division cycle-associated (CDCA) protein family plays an essential role in tumor progression by cell division. However, the function of each CDCA family member in hepatocellular carcinoma (HCC) is not well known. This study is to find the roles of CDCAs in the prognosis of HCC patients by using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, and cBioPortal databases. Overexpression of CDCA mRNA and protein were found to be significantly associated with individual cancer stages and tumor grades in HCC patients. Higher mRNA expressions of 6 CDCA family members were found to be significantly associated with shorter overall survival (OS) in HCC patients. Multivariate analysis showed that overexpressions of CDCA mRNA were independent prognostic factors for shorter OS in HCC patients. Moreover, a high mutation rate of CDCAs (27%) was also detected in HCC patients, and genetic alteration in CDCAs was associated with shorter overall survival (OS) and disease-fre e survival (DFS) in HCC patients. Finally, a functional analysis showed that CDCAs were mainly enriched in the cell cycle (hsa04110) and oocyte meiosis. Overall, these results indicated that CDCA2/3/4/5/8 could be prognostic biomarkers of survival in HCC patients. PMID: 33564348 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.