NanomaterialsNanomaterials, Vol. 10, Pages 138: Addendum: Zurob, E., et al. Inhibition of Wild Enterobacter cloacae Biofilm Formation by Nanostructured Graphene- and Hexagonal Boron Nitride-Coated Surfaces. Nanomaterials 2019, 9, 49Nanomaterials, Vol. 10, Pages 138: Addendum: Zurob, E., et al. Inhibition of Wild Enterobacter cloacae Biofilm Formation by Nanostructured Graphene- and Hexagonal Boron Nitride-Coated Surfaces. Nanomaterials 2019, 9, 49 Nanomaterials doi: 10.3390/nano10010138 Authors:...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 457: DM1 Phenotype Variability and Triplet Repeat Instability: Challenges in the Development of New TherapiesIJMS, Vol. 21, Pages 457: DM1 Phenotype Variability and Triplet Repeat Instability: Challenges in the Development of New Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21020457 Authors: Tomé Gourdon Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disease caused by an unstable cardiotocography...
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CellsCells, Vol. 9, Pages 177: SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES CellsCells, Vol. 9, Pages 177: SSEA3 and Sialyl Lewis a Glycan Expression Is Controlled by B3GALT5 LTR through Lamin A-NFYA and SIRT1-STAT3 Signaling in Human ES Cells Cells doi: 10.3390/cells9010177 Authors: Bi-He Cai Hsueh-Yi Lee Chi-Kan Chou Po-Han Wu Hsiang-Chi Huang Chia-Chun Chao Hsiao-Yu Chung Reiji Kannagi B3GALT5 is involved in...
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AntioxidantsAntioxidants, Vol. 9, Pages 69: Contribution of Individual Polyphenols to Antioxidant Activity of Cotoneaster bullatus and Cotoneaster zabelii Leaves—Structural Relationships, Synergy Effects and Application for Quality ControlAntioxidants, Vol. 9, Pages 69: Contribution of Individual Polyphenols to Antioxidant Activity of Cotoneaster bullatus and Cotoneaster zabelii Leaves—Structural Relationships, Synergy Effects and Application for Quality Control Antioxidants doi: 10.3390/antiox9010069...
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1azsmt-33lw7.htmlAbdominal Radiology, Vol. 45, Issue 1 - New Issue Alert.eml 2aj4ri-b7qkh.htmlAccepted Articles Alert_ Contact Dermatitis.eml 3a8n4e-3s3rd.htmlAccepted Articles Alert_ Photochemistry and Photobiology.eml 4aulbh-ozx2v.htmlAccepted Articles Alert_ Pigment Cell & Melanoma Research.eml 5ap0iz-c2zsy.htmlActa Biochimica et Biophysica Sinica Advance articles (2).eml 6ahw9e-xbeta.htmlActa Biochimica et Biophysica Sinica Advance articles.eml 7a44vv-6vzdf.htmlActa Biochimica et Biophysica...
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PAX2 promotes epithelial ovarian cancer progression involving fatty acid metabolic reprogramming.: This study investigated the expression of PAX2 in ovarian cancer. The expression of PAX2 in a murine allograft model of ovarian cancer, the RM model, led to a more rapidly growing cell line both in vitro and in vivo. This finding was in accordance with the shorter progression‑free survival observed in patients with a higher PAX2 expression, as determined in this study cohort by immunohistochemistry....
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Iodine ‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.: Iodine‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma. Int J Oncol. 2020 Jan 10;: Authors: Brito AF, Abrantes AM, Teixo R, Pires AS, Ribeiro AC, Ferreira RF, Fernandes A, Puga T, Laranjo M, Caramelo F, Boin I, Jefferson DM, Gonçalves AC, Martins R, Rodrigues J, Ribeiro IP, Barbosa De...
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Type of response to conversion chemotherapy strongly impacts survival after hepatectomy for initially unresectable colorectal liver metastases: Patients undergoing hepatectomy for initially unresectable colorectal liver metastases after conversion chemotherapy are at risk of (i) post‐operative complications related to prolonged preoperative chemotherapy and to more complex surgical procedures and (ii) short survival due to early disease recurrence. In this study, we compare short‐ and long‐term results...
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Equity of access to post‐mastectomy breast reconstruction at a regional plastic surgery centre: Access to post‐mastectomy breast reconstruction is not always equitable. We aim to assess the equity of access to breast reconstruction in the northern region of New Zealand. There is inequity in the rates of tertiary referral for reconstruction across ethnicities and health services termed District Health Boards in the northern region of New Zealand, which is likely multifactorial. AbstractBackgroundThe...
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Adverse Effects of Anticholinergic Drugs on Cognition and Mobility: Cutoff for Impairment in a Cross-Sectional Study in Young–Old and Old–Old Adults: AbstractBackgroundDrugs with anticholinergic properties are commonly prescribed in older adults despite growing evidence of their adverse outcomes. Several issues regarding these detrimental effects remain unresolved, such as the putative existence of a threshold above which anticholinergic drug consumption impairs cognitive or mobility performance.ObjectivesWe...
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Atypical hemolytic uremic syndrome: a case report: AbstractBackgroundThrombotic microangiopathy is a pathological condition comprised of microvascular thrombosis involving any organ of the body leading to thrombocytopenia, Coombs-negative hemolytic anemia, and end-organ damage. The most common forms of thrombotic microangiopathies are Shiga toxin-producing Escherichia coli-mediated hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome. The atypical...
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Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation: Background. Alzheimer's disease (AD) is the most common cause of dementia in elderly patients. Recently, several studies have shown that inflammation and oxidative stress precede the cardinal neuropathological manifestations of AD. In view of the proven antioxidant effects of probiotics, we proposed that continuous dietary supplementation with milk fermented with kefir grains might improve cognitive and metabolic...
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Mapping the ischemic penumbra and predicting stroke progression in acute ischemic stroke: the overlooked role of susceptibility weighted imaging: AbstractObjectivesAsymmetrically prominent veins (APVs) detected on susceptibility weighted imaging (SWI) in acute stroke patients are assumed to signify compromised cerebral perfusion. We aimed to explore the role of APVs in identifying the ischemic penumbra and predicting stroke progression in acute stroke patientsMethodsTwenty patients with a middle...
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Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson's Disease Model: Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration. This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in the physiopathological mechanisms of Parkinson's disease. Two different...
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Osteoarthritis and Aging: Young Adults with Osteoarthritis: AbstractPurpose of ReviewDespite perceptions that osteoarthritis only affects older adults, many people develop osteoarthritis before 65 years of age and live decades with pain and disability. It is critical to understand why some adults develop osteoarthritis early in life and the consequences of aging with osteoarthritis.Recent FindingsOver half of people diagnosed with symptomatic knee osteoarthritis are under 65 years of age. Key risk...
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Comparison of Utilization Trends between Biosimilars and Generics: Lessons from the Nationwide Claims Data in South Korea: AbstractBackgroundSouth Korea is unique in that it leads global markets in R&D as well as production of biosimilar products and was the first market into which some biosimilar products were introduced. We analyzed the time trend of market penetration and simulated saved spending by biosimilars in South Korea.MethodsWe pulled Korean National Health Insurance claims data from...
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Patients' perspectives of outcomes after total knee and total hip arthroplasty: a nominal group study: AbstractBackgroundWhile total joint replacements (TJR) are frequently performed, there is little qualitative research to define the outcomes most important to patients.MethodsPatients who had received total hip (THR) or total knee replacements (TKR) participated in 8 nominal groups to answer the question "What result/results matter the most to a patient undergoing/having a knee or hip replacement?"...
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Minimally invasive technique for gastrostomy tube insertion: A novel laparoscopic approach: AbstractIntroductionPercutaneous endoscopic gastrostomy (PEG) is the most common way of inserting a gastrostomy tube. If PEG is not appropriate for a patient, then the laparoscopic or open technique should be used. Here, we introduce a new laparoscopic technique for inserting a gastrostomy tube.Material and Surgical TechniqueWe used this new laparoscopic approach in 21 patients for whom PEG was not suitable....
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Porcine models for studying complications and organ crosstalk in diabetes mellitus: AbstractThe worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in adults but also in children and adolescents. Diabetes is associated with macrovascular complications increasing the risk for cardiovascular disease and stroke, as well as microvascular complications leading to diabetic nephropathy, retinopathy and neuropathy. Animal models are essential for studying disease mechanisms...
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Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice: AbstractThe LIM homeodomain transcription factor Lmx1a shows a dynamic expression in the developing mouse ear that stabilizes in the non-sensory epithelium. Previous work showed that Lmx1a functional null mutants have an additional sensory hair cell patch in the posterior wall of a cochlear duct and have a mix of vestibular and cochlear hair cells in the basal cochlear...
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Assessing success in transitioning of young adults from pediatric to adult kidney practice: AbstractBackgroundTransfer from a pediatric to an adult medical setting is associated with many barriers. Additionally, there are little data on patients' assessment of the transition process itself. 3 years ago at Lurie Children's Hospital of Chicago, we established a kidney transition program with the help of an adult nephrologist, physician assistant (PA) and social worker (LCSW). After 18 months, we evaluated...
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Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation: Background. Alzheimer's disease (AD) is the most common cause of dementia in elderly patients. Recently, several studies have shown that inflammation and oxidative stress precede the cardinal neuropathological manifestations of AD. In view of the proven antioxidant effects of probiotics, we proposed that continuous dietary supplementation with milk fermented with kefir grains might improve cognitive and metabolic...
08:43
Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson's Disease Model: Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration. This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in the physiopathological mechanisms of Parkinson's disease. Two different...
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Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth: AbstractBackgroundCircular RNAs (circRNAs) have recently emerged as a new family of noncoding RNAs that are involved in the causation and progression of various cancers. However, the roles of circRNAs in the tumorigenesis of gastric cancer (GC) are still largely unknown.MethodsThe expression profiles of circRNAs in GC were identified in open GEO database and were evaluated at the mRNA level in clinical GC samples...
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Thirty-Day Outcomes after Surgery for Primary Sarcomas of the Extremities: An Analysis of the NSQIP Database: Background. Primary bone and soft tissue sarcomas are rare tumors requiring wide surgical resection and reconstruction to achieve local control. Postoperative complications can lead to delays in adjuvant therapy, potentially affecting long-term oncologic outcomes. Understanding postoperative complication risks is essential; however, past studies are limited by small sample sizes. Purpose....
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Orthognathic Surgery after Mandibular Large-Volume Osteoma Treatment: Osteoma is a benign asymptomatic osseous tumor. Characterization of osteoma is the proliferation of cancellous or compact bone that increases in size by continuous formation of bone. It can be seen in any craniofacial structures, usually in paranasal sinuses and jaws. In this study, we present a 17-year-old male patient with a giant osteoma in the mandibular condyle. Posttreatment post-op follow-up, post-ortho, and orthognathic...
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Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds: A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119...
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Urinary tract infections in children < 2 years of age hospitalized in a tertiary medical center in Southern Israel: epidemiologic, imaging, and microbiologic characteristics of first episode in life: AbstractThe objectives of the study were to describe the epidemiologic, microbiologic, and imaging characteristics of first 44 UTI episode in hospitalized infants and children < 2 years of age. A UTI episode was diagnosed based on suprapubic aspiration or urinary catheterization and report of a...
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Efficacy of Panobinostat for the Treatment of Multiple Myeloma: Panobinostat represents a potent oral nonselective pan-histone deacetylase inhibitor (HDAC) with activity in myeloma patients. It has been approved by the FDA and EMA in combination with bortezomib and dexamethasone for the treatment of multiple myeloma, in patients who have received at least two prior regimens, including bortezomib and an immunomodulatory agent. In order to further explore its clinical potential, it is evaluated in...
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Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats: Some lactic acid bacteria (LAB) are observed to be potential probiotics with functional properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia management. This study investigated the ability and mechanism of Lactobacillus rhamnosus BSL and Lactobacillus rhamnosus R23 on lowering FBG in diabetic rats induced by streptozotocin...
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Chronic Pancreatitis—Update on Pathophysiology and Therapeutic Approaches: AbstractChronic pancreatitis is an inflammatory condition characterized by structural change within the pancreas, that leads to progressive and irreversible loss of functioning pancreatic parenchyma, exocrine/endocrine dysfunction and an increased risk of pancreatic ductal adenocarcinoma. Whilst hallmarks of advanced disease are readily identifiable on routine clinical imaging, concordance between structural changes within...
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Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection: AbstractTight junction proteins are pivotal to prevent bacterial invasion of the epithelial barrier. We here report that supplementation with vitamin D can strengthen the urinary bladder lining. Vitamin D deficient and sufficient mice were infected with Escherichia coli (E. coli) transurethrally to cause urinary tract infection. In addition, bladder biopsies were obtained...
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Slipping rib syndrome in an adolescent wrestler: Slipping rib syndrome is a commonly missed diagnosis of upper abdominal pain. It results from hypermobility of the anterior rib due to the disruption of the interchondral ligaments, most likely secondary to repetitive motions or some inciting event. The hypermobility leads to impingement of the intercostal nerves resulting in significant pain.A 10-year-old adolescent male child was evaluated for 4 months of intermittent, left-sided, upper abdominal...
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Hereditary transthyretin amyloidosis caused by the rare Phe33Leu mutation: Hereditary transthyretin amyloidosis is a rare progressive systemic disease. We describe a physically active 46-year-old man who presented with dyspnoea on exertion. An echocardiogram showed increased left ventricular wall thickness and diastolic dysfunction, but normal systolic function. The QRS voltage on ECG was normal. The patient was diagnosed with hypertrophic cardiomyopathy, and several years passed before establishment...
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Infant with status epilepticus secondary to systemic lidocaine toxicity from topical application: A previously healthy 11-month-old infant presented to the emergency department in status epilepticus. There was no clear trigger of her seizure activity which resolved with benzodiazepines and fosphenytoin. On further review, her parents disclosed that she had been prescribed topical 4% lidocaine cream for a groin rash and was ultimately diagnosed with lidocaine toxicity in the emergency department....
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Case series of adenomatoid odontogenic tumour of jaws with variations in presentation: Adenomatoid odontogenic tumour (AOT) is a rare tumour of odontogenic origin with distinct clinicopathological appearance but is often clinically misdiagnosed as a cyst. The most common site is the anterior maxilla in the canine region. We present here two cases, one at its commonest location in the maxillary canine while the other is at the uncommon location of the anterior mandible. Its clinical features of painless...
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Atypical tear of the long head of the biceps tendon in a young male adult: A 34-year-old man, with previous anabolic steroid abuse, presented with right shoulder pain following an underhand bowling swing. Examination indicated a Popeye sign of the right biceps, and positive Speeds, Yergason and O'Brian's tests. MRI indicated a complete tear of the intra-articular portion of the long head of biceps tendon (LHBT). Interestingly, the tear occurred within the glenohumeral joint allowing the proximal...
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Computer-aided diagnosis for World Health Organization-defined chest radiograph primary-endpoint pneumonia in children: AbstractBackgroundThe chest radiograph is the most common imaging modality to assess childhood pneumonia. It has been used in epidemiological and vaccine efficacy/effectiveness studies on childhood pneumonia.ObjectiveTo develop computer-aided diagnosis (CAD4Kids) for chest radiography in children and to evaluate its accuracy in identifying World Health Organization (WHO)-defined...
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Effectiveness of non-pharmacological strategies in the management of type 2 diabetes in primary care: a protocol for a systematic review and network meta-analysis: IntroductionDespite the increasing number of drugs and various guidelines on the management of type 2 diabetes mellitus (T2DM), several patients continue with the disease uncontrolled. There are several non-pharmacological treatments available for managing T2DM, but various of them have never been compared directly to determine the best...
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Protocol for a prospective, controlled, cross-sectional, diagnostic accuracy study to evaluate the specificity and sensitivity of ambulatory monitoring systems in the prompt detection of hypoxia and during movement: IntroductionAutomated continuous ambulatory monitoring may provide an alternative to intermittent manual vital signs monitoring. This has the potential to improve frequency of measurements, timely escalation of care and patient safety. However, a major barrier to the implementation of...
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Quantitative analysis of medical students and physicians knowledge of degenerative cervical myelopathy: ObjectivesWe have previously identified a delay in general practitioner (GP) referrals for patients with degenerative cervical myelopathy (DCM). The aim of this study was to evaluate whether an education gap existed for DCM along the GP training pathway by quantitatively assessing training in, and knowledge of, this condition.DesignGap analysis: comparison of DCM to other conditions. Comparators...
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Evaluation of iLead, a generic implementation leadership intervention: mixed-method preintervention-postintervention design: ObjectivesThe present study aimed to evaluate the iLead intervention and to investigate whether or not transfer of training can be supported by contextualising the intervention (recruiting all managers from one branch of the organisation while focusing on one implementation case, as well as training senior management).DesignA pre-evaluation–postevaluation design was applied...
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Bluebelle pilot randomised controlled trial of three wound dressing strategies to reduce surgical site infection in primary surgical wounds: ObjectiveSurgical site infection (SSI) affects up to 25% of primary surgical wounds. Dressing strategies may influence SSI risk. The Bluebelle study assessed the feasibility of a multicentre randomised controlled trial (RCT) to evaluate the effectiveness and cost-effectiveness of different dressing strategies to reduce SSI in primary surgical wounds.DesignA...
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Yoga practice in the UK: a cross-sectional survey of motivation, health benefits and behaviours: ObjectivesDespite the popularity of yoga and evidence of its positive effects on physical and mental health, little is known about yoga practice in the UK. This study investigated the characteristics of people who practise yoga, reasons for initiating and maintaining practice, and perceived impact of yoga on health and well-being.Design, setting and participantsA cross-sectional online anonymous survey...
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Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study: ObjectiveThe aims of this study were to describe distributions of the prevalence of osteopenia and osteoporosis and identify the potential risk factors by gender in a Chinese rural population.DesignA cross-sectional survey.Setting and participantsA total of 8475 participants (18–79 years) were obtained from the Henan Rural Cohort Study. Bone mineral density...
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Efficacy of a topical herbal and mineral formulation (Dynamiclear) for the treatment of herpes simplex labialis in the community setting: study protocol for a randomised, double-blind placebo-controlled trial: IntroductionHerpes simplex labialis (HSL) is a common infection that can cause painful lesions on the oral mucosa, commonly referred to as cold sores. Current biomedical treatments include topical aciclovir, which reduces the episode duration by an average of 0.5 days. This study will examine...
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Comparisons of body mass index, waist circumference, waist-to-height ratio and a body shape index (ABSI) in predicting high blood pressure among Malaysian adolescents: a cross-sectional study: ObjectiveTo compare the performance of different anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and a body shape index to predict high blood pressure (BP) in adolescents using the 90th and 95th percentiles as two different thresholds.DesignCross-sectional...
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Does adiposity mediate the relationship between physical activity and biological risk factors in youth? – A cross-sectional study from the International Children's Accelerometry Database (ICAD)International journal of obesity (2005)Latest additions to Europe PMC1hGenomic Polymorphism at the Interferon-Induced Helicase (IFIH1) Locus Contributes to Graves' Disease SusceptibilityThe Journal of clinical endocrinology and metabolismLatest additions to Europe PMC1hPrimary microRNA transcripts are processed...
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Open retromuscular versus laparoscopic ventral hernia repair for medium-sized defects: where is the value?: AbstractPurposeThere is increasing emphasis on value in health care, defined as quality over cost required to deliver care. We analyzed outcomes and costs of repairing medium-sized ventral hernias to identify whether an open retromuscular or laparoscopic intraperitoneal onlay approach would provide superior value to the patient and healthcare system.MethodsA retrospective analysis of prospectively...
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Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression: AbstractBackgroundLocalized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related oncoprogression for GC.MethodsFrom August to December 2013, 106 GC patients were prospectively included. The regional expression...
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Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R: AbstractThis paper focuses on the production of a high-affinity monoclonal antibody (mAb) that can efficiently detect and block purinergic ligand-gated ion channel 7 receptor (P2X7R). To achieve this goal, the extracellular domain of human P2X7R, P2X7R-ECD, was used as an immunogen for BALB/c mice, inducing them to produce spleen lymphocytes that were subsequently fused with...
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The location of premalignant colorectal polyps under age 50: a further rationale for screening sigmoidoscopy: AbstractPurposeThe incidence of colorectal cancer (CRC) among young adults has been dramatically rising, with guidelines for screening recently adjusted to start at age 45. However, knowledge of the precursor lesions is limited. We recently reported that 83% of CRC diagnosed under age 50 are left sided. Our aim was to analyze the location and histology of benign colorectal lesions found in...
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Use of intravenous iron therapy in colorectal cancer patient with iron deficiency anemia: a propensity-score matched study: AbstractPurposeIron deficiency anemia is common in colorectal cancer patients and is related to poor surgical outcome. Increasing evidence supports preoperative use of intravenous iron (IVI) to correct anemia. Our study investigates effect of preoperative IVI on hemoglobin level.MethodsFrom August 2017 to March 2019, colorectal cancer patients with iron deficiency anemia received...
08:28
Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection: AbstractTight junction proteins are pivotal to prevent bacterial invasion of the epithelial barrier. We here report that supplementation with vitamin D can strengthen the urinary bladder lining. Vitamin D deficient and sufficient mice were infected with Escherichia coli (E. coli) transurethrally to cause urinary tract infection. In addition, bladder biopsies were obtained...
08:28
The efficacy of statins in the treatment of Alzheimer's disease: a meta-analysis of randomized controlled trial: AbstractObjectiveAlzheimer's disease (AD) is a common type of dementia, which has caused heavy global economic and health burden, and the using of statins to treat AD has caused widely debated. The purpose of this meta-analysis is to explore the effect of statins in the treatment of Alzheimer's disease.MethodsStudies were retrieved by searching PubMed, Embase, Cochrane library, OvisdSP,...
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Mobile Stroke Units—the Changing Face of Emergency Medicine Stroke Management: AbstractPurpose of ReviewTo provide a summary of mobile stroke unit (MSU) utilization within Emergency Medicine stroke systems.Recent FindingsMSUs have been deployed around the world into prehospital stroke systems demonstrating the ability to differentiate stroke subtypes and to initiate thrombolysis in eligible patients with shorter symptom onset to treatment times than conventional systems. MSU technology may enable...
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Pharmaceutics, Vol. 12, Pages 62: Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?: Pharmaceutics, Vol. 12, Pages 62: Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?Pharmaceutics doi: 10.3390/pharmaceutics12010062Authors: Marco Cavaco Diana Gaspar Miguel ARB Castanho Vera Neves The incidence of brain metastases (BM) in cancer patients is increasing. After diagnosis, overall survival (OS) is poor, elicited by the lack of an effective treatment....
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Smartphone coupled with paper-based chemical sensor for on-site determination of iron(III) in environmental and biological samples: AbstractWe report a smartphone–paper-based sensor impregnated with cetyltrimethylammonium bromide modified silver nanoparticles (AgNPs/CTAB) for determination of Fe3+ in water and blood plasma samples. The methodology for determination of Fe3+ is based on the change in signal intensity of AgNPs/CTAB fabricated on a paper substrate after the deposition of analyte, using...
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GSE143490 Real time quantitative PCR analysis of serum circulating miRNAs from patients with head and neck tumors. [exp2]Contributor : Bartłomiej TomasikSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensThe samples were drawn from patients with diagnosed oropharyngeal cancer. We used blood samples (10ml) collected from patients after diagnosis, before treatment. Blood was centrifuged for 10 min, after which serum was aspirated, aliquoted in RNAse-free tubes, stored at −80°C until...
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Fluorescent recognition and selective detection of nitrite ions with carbon quantum dots: AbstractThe nitrite ion (NO2−) is a vital inorganic species that occurs both in natural ecological systems and human bodies. The high concentration of NO2− can be harmful for animal and human health. It is important to develop a simple, sensitive, reliable, and economic methodology to precisely monitor NO2− in various environmental and biological fields. Thus, a novel nitrite biosensor based on carbon quantum...
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Microscopic structure of the tongue in the lesser hedgehog tenrec ( Echinops telfairi , Afrosoricida) and its relation to phylogenesis: AbstractThe tongue of the lesser hedgehog tenrec (Echinops telfairi) was evaluated by light and scanning electron microscopy. Dorsal and lateral surfaces of the tongue were densely covered with various types of lingual papillae. Two types of mechanical papillae (filiform and conical) and two types of sensory papillae (fungiform and vallate) were observed. Rostrocaudally,...
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Computer-aided diagnosis for World Health Organization-defined chest radiograph primary-endpoint pneumonia in children: AbstractBackgroundThe chest radiograph is the most common imaging modality to assess childhood pneumonia. It has been used in epidemiological and vaccine efficacy/effectiveness studies on childhood pneumonia.ObjectiveTo develop computer-aided diagnosis (CAD4Kids) for chest radiography in children and to evaluate its accuracy in identifying World Health Organization (WHO)-defined...
08:24
GSE116930 Recapitulating the Human Segmentation Clock with Pluripotent Stem Cells - RNAseq analysis of healthy control (WT) and knock-out reporter lines of segmentation clock genes HES7, DLL3, LFNG and MESP2.Contributors : Yoshihiro Yamanaka ; Maya Uemura ; Satoko Sakurai ; Takuya Yamamoto ; Cantas AlevSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPluripotent stem cells (PSCs) have increasingly been used to model different aspects of embryogenesis and organ...
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Incidental lymphopenia and mortality: a prospective cohort study [Research]: BACKGROUND:It is unknown if incidental lymphopenia detected in the general population is associated with higher all-cause and cause-specific mortality. We aimed to identify the associations between lymphopenia and all-cause and cause specific mortality.METHODS:In a prospective cohort study, we examined and followed participants enrolled in the Copenhagen General Population Study between November 2003 and April 2015. In our...
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Pharmaceuticals, Vol. 13, Pages 12: Current Status of PSMA-Radiotracers for Prostate Cancer: Data Analysis of Prospective Trials Listed on ClinicalTrials.gov: Pharmaceuticals, Vol. 13, Pages 12: Current Status of PSMA-Radiotracers for Prostate Cancer: Data Analysis of Prospective Trials Listed on ClinicalTrials.govPharmaceuticals doi: 10.3390/ph13010012Authors: Claus Zippel Sarah C. Ronski Sabine Bohnet-Joschko Frederik L. Giesel Klaus Kopka The recent development of dedicated prostate-specific...
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The impact of acute remote ischaemic preconditioning on cerebrovascular function: AbstractPurposeRemote ischaemic preconditioning (RIPC) refers to the protection conferred to tissues and organs via brief periods of ischaemia in a remote vascular territory, including the brain. Recent studies in humans report that RIPC provides neuroprotection against recurrent (ischaemic) stroke. To better understand the ability of RIPC to improve brain health, the present study explored the potential for RIPC to...
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Preoperative frailty predicts adverse short‐term postoperative outcomes in patients treated with radical nephroureterectomy: AbstractBackgroundTo investigate the effect of frailty on short‐term postoperative outcomes and total hospital charges (THCs) in patients with non‐metastatic upper urinary tract carcinoma, treated with radical nephroureterectomy (RNU).MethodsWithin the National Inpatient Sample (NIS) database we identified 11 258 RNU patients (2000‐2015). We used the Johns Hopkins frailty‐indicator...
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Clinical pathway for enhanced recovery after surgery for gastric cancer: A prospective single‐center phase II clinical trial for safety and efficacy: AbstractBackgroundWe aimed to evaluate the safety and efficacy of a clinical pathway (CP) for enhanced recovery after surgery (ERAS) in gastric cancer patients, including early oral feeding and discharge on postoperative day 4.MethodsWe performed a prospective, single‐center, phase II clinical trial. Based on proposed indications for an ERAS CP in our...
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The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery: AbstractBackgroundThe proposed underlying mechanisms of anxiety and depression, and of postoperative neurocognitive disorder (NCD), each include immune system involvement. Therefore, the aims of this study were to investigate the incidence of postoperative NCD 3 months after surgery among oncological patients undergoing surgery and to evaluate the role of preoperative anxiety and depression.MethodA...
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Probiotics, Nutrition, and the Small Intestine: AbstractPurpose of ReviewProbiotics are promising remedial treatments for symptoms of small intestine (SI) diseases and promoters of overall good health. Probiotics play an important role in supporting a healthy SI microbiome (eubiosis), and in preventing establishment of unhealthy microbiota. SI eubiosis promotes optimal nutrient uptake, and optimal nutritional status maintains a healthy SI, reducing the likelihood of SI diseases. It is important to...
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The Many Faces of Meckel's Diverticulum: Update on Management in Incidental and Symptomatic Patients
The Many Faces of Meckel's Diverticulum: Update on Management in Incidental and Symptomatic Patients: AbstractPurpose of ReviewMeckel's diverticulum may be detected incidentally or present with symptoms from infancy and to old age. The presentation may be acute, with several complications associated with the condition. We aim to review the many faces with which a Meckel's diverticulum may present, either symptomatically or as an incidental finding.Recent FindingsDue to its rarity, recent studies...
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Apremilast: A Review in Oral Ulcers of Behçet's Disease: AbstractThe oral phosphodiesterase 4 inhibitor apremilast (Otezla®) is indicated for the treatment of oral ulcers associated with Behçet's disease in some countries, including the USA (where it is the first agent approved for the disease) and Japan. In phase 2 and 3 trials in adults with this chronic and debilitating disorder, 12 weeks of treatment with apremilast 30 mg twice daily reduced the number and pain of oral ulcers and disease activity...
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Zanubrutinib: First Approval: AbstractZanubrutinib (Brukinsa®), an orally-administered Bruton tyrosine kinase (BTK) inhibitor, is being developed by BeiGene for the treatment of B-cell malignancies. Zanubrutinib received accelerated approval in the USA on 14 November 2019 for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy, based on overall response rate (ORR) seen in phase II and I/II clinical trials. This article summarizes the milestones...
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Cancers, Vol. 12, Pages 191: Multiple Myeloma and Thrombosis: Prophylaxis and Risk Prediction Tools: Cancers, Vol. 12, Pages 191: Multiple Myeloma and Thrombosis: Prophylaxis and Risk Prediction ToolsCancers doi: 10.3390/cancers12010191Authors: Despina Fotiou Maria Gavriatopoulou Evangelos Terpos Thromboembolism in multiple myeloma (MM) patients remains a common complication that renders the optimization of our thromboprophylaxis practice necessary. This review aims to make clear the need for...
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Cancers, Vol. 12, Pages 190: In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate: Cancers, Vol. 12, Pages 190: In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence RateCancers doi: 10.3390/cancers12010190Authors: Wei Peng Henriette S. de Bruijn Timo L. M. ten Hagen Kristian Berg Jan L. N. Roodenburg Go M. van Dam Max J. H....
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