Αρχειοθήκη ιστολογίου

Κυριακή 5 Νοεμβρίου 2017

Comparing Sirona Dental Systems (SIRO) and Its Competitors

Sirona Dental Systems is one of 87 publicly-traded companies in the "Advanced Medical Equipment & Technology" industry, but how does it contrast to its peers? We will compare Sirona Dental Systems to similar businesses based on the strength of its dividends, earnings, valuation, profitability, analyst recommendations, risk and institutional ownership. Sirona Dental Systems has a beta of 1.33, suggesting that its share price is 33% more volatile than the S&P 500.



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Bioactive treatments in bone grafts for implant-based rehabilitation: Systematic review and meta-analysis

Abstract

Background

The use of bioactive proteins, such as rhBMP-2, may improve bone regeneration in oral and maxillofacial surgery.

Purpose

Analyze the effect of using bioactive proteins for bone regeneration in implant-based rehabilitation.

Materials and Methods

Seven databases were screened. Only clinical trials that evaluated the use of heterologous sources of bioactive proteins for bone formation prior to implant-based rehabilitation were included. Statistical analyses were carried out using a random-effects model by comparing the standardized mean difference between groups for bone formation, and risk ratio for implant survival (P ≤ .05).

Results

Seventeen studies were included in the qualitative analysis, and 16 in the meta-analysis. For sinus floor augmentation, bone grafts showed higher amounts of residual bone graft particles than bioactive treatments (P ≤ .05). While for alveolar ridge augmentation bioactive treatments showed a higher level of bone formation than control groups (P ≤ .05). At 3 years of follow-up, no statistically significant differences were observed for implant survival (P > .05).

Conclusions

Bioactive proteins may improve bone formation in alveolar ridge augmentation, and reduce residual bone grafts in sinus floor augmentation. Further studies are needed to evaluate the long-term effect of using bioactive treatments for implant-based rehabilitation.



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Dementia and oral health status

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28 observational studies were included in this review of the oral health status of people with dementia. The findings suggest that compared with people without dementia those with dementia have poorer oral health.

The post Dementia and oral health status appeared first on National Elf Service.



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Pediatric acute mastoiditis in the era of pneumococcal vaccination

Objectives/Hypothesis

The objective was to describe trends in the annual prevalence of hospitalization for pediatric acute mastoiditis since introduction of the 7-valent pneumococcal vaccine in 2000 and the 13-valent vaccine in 2010.

Study Design

Cross-sectional retrospective data analysis.

Methods

The Kids' Inpatient Database from years 2000 to 2012 was analyzed. To determine the annual prevalence of hospitalization for acute mastoiditis, nationally weighted frequencies of hospitalization for children <21 years with acute mastoiditis diagnoses were collected. Trend analysis of hospitalization rates from 2000 to -2012 was performed.

Results

From 2000 to 2012, there was no significant trend in hospitalization rates for acute mastoiditis overall (1.38 and 1.43 per 100,000 persons in 2000 and 2012, respectively; P = .86) or by age group. When comparing hospitalization rates at time points 2000 and 2012, children <1 year (4.65 and 3.27 per 100,000 persons, P = .0023) and 1 to 2 years of age (3.95 and 3.18 per 100,000 persons, respectively; P = .0107) demonstrated declines in hospitalization over time. Between 2009 and 2012, hospitalization rates also significantly declined for children aged <1 year (4.50 to 3.27 per 100,000 persons, P = .0056) and 1 to 2 years (4.30 to 3.18 per 100,000 persons, P = .0002) but increased for children 5 to 9 years (1.10 to 1.81 per 100,000 persons, P < .0001) and 10 to 20 years of age (0.41 to 0.72 per 100,000 persons, P < .0001).

Conclusions

Despite introduction of two pneumococcal vaccines, rates of hospitalization for pediatric acute mastoiditis did not decline between 2000 and 2012. Between 2009 and 2012, however, children 0 to 2 years of age showed declining hospitalization rates, possibly reflecting the protective benefit of the 13-valent pneumococcal vaccine.

Level of Evidence

4 Laryngoscope, 2017



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Current practices for voice rest recommendations after phonomicrosurgery

Objectives/Hypothesis

The aim of this study was to understand current protocols for voice rest implemented by laryngologists immediately after phonomicrosurgery for benign vocal fold lesions.

Study Design

Cross-sectional survey.

Methods

A 24-item survey was sent via electronic mail to laryngologists across the country to gather data on their recommendations of type and dosage of voice rest, factors involved in this decision, and recommendations for other behavioral modifications.

Results

A majority of the laryngologists implement 7 days of complete voice rest for nodules, cysts, polyps, and Reinke's edema, 1 to 4 days for leukoplakia and papilloma, and over 8 days of relative voice rest for most lesions. A majority of the laryngologists also employ a combination of complete and relative voice rest.

Conclusions

The more common recommendation for complete voice rest is 7 days for nodules, cysts, polyps, and Reinke's edema, and 1 to 4 days for leukoplakia and papilloma. Relative voice rest when recommended is typically recommended for over 8 days. Voice rest recommendations were not affected by surgery type alone, but were determined by either lesion type alone or lesion type combined with surgery type.

Levels of Evidence

4. Laryngoscope, 2017



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Prediction of mortality and morbidity in head and neck cancer patients 80 years of age and older undergoing surgery

Objectives

To determine postoperative complications and mortality rates in octogenarian and older head and neck cancer patients undergoing ablative surgical resections and to identify factors associated with postoperative morbidity and mortality.

Methods

Retrospective cohort study investigating risk factors for 30-day serious complication risk and 90-day mortality risk for patients aged 80 years and older who underwent ablative head and neck oncologic surgical procedures at an academic tertiary care center between 2005 and 2015.

Results

Of the 219 patients who underwent 241 surgeries, 74 patients experienced serious complications within 30 days and 25 died within 90 days of surgery. American Society of Anesthesiologists (ASA) score of 4 or greater, and operating room (OR) time ≥6 hours were independently associated with serious complications, whereas age ≥90 years, overall severe comorbidity score, presence of preoperative dysphagia, and large extent of resection were associated with increased risk of death in 90 days. Models to predict risk of 30-day serious complications and 90-day mortality were then developed.

Conclusion

Patient and surgical treatment factors predict risk of serious complications and mortality in patients aged 80 years and older undergoing ablative head and neck surgery. Predictive models may guide preoperative discussion with patients.

Level of Evidence

2b. Laryngoscope, 2017



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Vibratory function and healing outcomes after small intestinal submucosa biomaterial implantation for chronic vocal fold scar

Objectives/Hypothesis

Vocal fold scar is a major cause of dysphonia, and optimal treatments do not currently exist. Small intestinal submucosa (SIS) is a biomaterial developed for the treatment of a variety of pathologies. The purpose of this study was to investigate the effects of SIS implantation on tissue remodeling in scarred vocal folds using routine staining, immunohistochemistry, and high-speed videoendoscopy (HSV).

Study Design

Prospective, blinded group analysis.

Methods

Thirteen New Zealand White rabbits underwent a vocal fold scarring procedure followed by microflap elevation with or without SIS implantation. Seven months later, they underwent a phonation procedure with HSV and laryngeal harvest. Alcian blue and elastica van Gieson staining and immunohistochemistry for collagen types I and III were used to evaluate histological healing outcomes. Dynamic functional remodeling of the scarred vocal fold in the presence of SIS implants was evaluated using HSV imaging to capture restoration of vibratory amplitude, amplitude ratio, and left-right phase symmetry.

Results

Density of collagen I was significantly decreased in SIS versus microflap-treated vocal folds. No differences were found between groups for hyaluronic acid, elastin, or collagen type III. Organization of elastin in the subepithelial region appeared to affect amplitude of vibration and the shape of the vocal fold edge.

Conclusions

SIS implantation into chronic scar reduced the density of collagen I deposits. There was no evidence of a negative impact or complication from SIS implantation. Regardless of treatment type, organization of elastin in the subepithelial region may be important to vibratory outcomes.

Level of Evidence

NA Laryngoscope, 2017



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Is multidisciplinary team care for head and neck cancer worth it?



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Clinical trials in rhinosinusitis: Identifying areas for improvement

Objectives/Hypothesis

To characterize trends in rhinosinusitis clinical trials to provide recommendations for therapeutic directions, highlight possible redundancy, and provide a framework for prioritization of future clinical trials.

Study Design

Database analysis.

Methods

Data were collected from ClinicalTrials.gov including all clinical trials that focused on rhinosinusitis with the exclusion of trials withdrawn prior to enrollment. Variables recorded included study design, study population, pharmaceutical involvement, publication, and whether a trial was a medical or surgical intervention. Associated publications were identified using the PubMed, Embase, and Cochrane databases.

Results

There were 269 rhinosinusitis clinical trials, dating from 1993 to 2017, that met inclusion reauirements. Of the studies included in this analysis, 51.7% had at least one scientific publication, and of those with publications, 80.6% had positive results and 19.3% had negative results. Twenty-three clinical trials (8.5%) studied drugs already approved for rhinosinusitis, 113 (42.0%) trials studied drugs that were approved for other uses, 42 (15.6%) trials studied experimental drugs, and 102 (39.4%) studied surgical intervention. Of the trials studying drugs, the data showed many clinical trials that studied the same drug. The data demonstrate a steady decline in clinical trials with medical intervention and a rise in clinical trials with surgical intervention.

Conclusions

This analysis is the first to characterize rhinosinusitis clinical trials, highlighting the over-representation of certain drugs and demonstrating an increased focus on clinical trials employing surgical intervention. We provide a framework to discuss prioritization of future studies to guide clinical and research practice.

Level of Evidence

4. Laryngoscope, 2017



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The relationship between endolymphatic hydrops in the vestibule and low-frequency air-bone gaps

Objectives/Hypothesis

To investigate the relationship between endolymphatic hydrops and hearing level, focusing on significant vestibular endolymphatic hydrops adjacent to the stapes footplate and low-frequency air-bone gaps.

Study Design

Retrospective study.

Methods

The study included 1,548 ears from 775 patients who underwent magnetic resonance imaging examination in our university hospital to investigate possible endolymphatic hydrops between January 2012 and December 2015. Ears were evaluated by magnetic resonance imaging performed 4 hours after intravenous injection of a standard dose of gadodiamide hydrate and/or 24 hours after intratympanic injection of gadopentetate dimeglumine diluted eightfold. Comparison of hearing thresholds on pure-tone audiometry was performed between ears having endolymphatic hydrops adjacent to the stapes footplate and those having nonadjacent endolymphatic hydrops.

Results

Forty-one ears (22 men and 19 women, mean age 48.4 years) showed significant cochlear and vestibular endolymphatic hydrops adjacent to the stapes footplate, and 79 ears (30 men and 49 women, mean age 45.0 years) showed significant nonadjacent cochlear and vestibular endolymphatic hydrops. The average air-bone gap at 250 Hz was significantly higher in the group of ears with adjacent hydrops than in those with nonadjacent hydrops.

Conclusions

The appearance of low-frequency air-bone gaps suggests deterioration of endolymphatic hydrops, particularly in ears with Ménière's disease, and could be a useful indicator for evaluating and treating patients with endolymphatic hydrops.

Level of Evidence

4. Laryngoscope, 2017



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Motor and sensory morbidity associated with the anterolateral thigh perforator free flap

Objective

To quantify changes in motor function, sensation, and lower extremity quality of life following anterior lateral thigh free flap (ALT) resection.

Methods

This mixed methods study contained both a prospective cohort arm (n = 20) and retrospective cross-sectional arm (n = 20). In both arms, patients underwent formal motor and sensation testing of the ipsilateral and contralateral thigh by sphygmomanometry and monofilament testing. In the prospective arm, data was collected preoperatively and at the 6-month and 1-year follow-up visits. In the retrospective arm, consecutive patients with a minimum of 6-month postoperative follow-up were enrolled.

Results

Postoperatively, 82% of participants endorsed some degree of numbness and tingling at the donor site. On monofilament testing, patients from the prospective arm showed decreased sensibility of the midthigh at both the 6- and 12-month assessment (P < 0.01). Two-point discrimination scores were moderately correlated with the cross-sectional surface area of the flap. Donor thighs demonstrated a similar peak isometric quadriceps contraction (retrospective [retro]: 47 ± 24 mmHg, prospective [pro]: 90 ± 36 mmHg) to the unoperated thighs (retro: 43 mmHg ± 22, pro: 69 ± 35.3 mmHg, P = 0.49). When stratified by perforator anatomy, no significant differences were noted. Subjective donor site morbidity measured with the lower extremity function scale demonstrated no statistically significant difference between the preoperative and 12-month postoperative assessment.

Conclusion

The ALT flap offers minimal donor site morbidity. Reduced sensibility of the ALT flap is a common complaint among patients. Quadriceps strength is not significantly affected by an ALT free flap harvest.

Level of Evidence

4. Laryngoscope, 2017



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Pediatric tinnitus: A clinical perspective

Objectives/Hypothesis

To define the clinical features and natural history of pediatric tinnitus from a practicing otolaryngologist's perspective and formulate hypotheses therein.

Study Design

Retrospective chart review.

Methods

A retrospective chart review of the electronic medical record was undertaken. Only relevant records with a prior otolaryngology clinic visit and audiologic testing were included. Patients seen during the last 2 years of the study period were contacted and completed a questionnaire to assess change in tinnitus and quantify potential alterations in quality of life, associated symptoms, and natural history.

Results

One hundred eighty subjects with mean/median age of 11.5/11.5 years were identified. Hearing loss was identified in 40 subjects (22.2%). Etiology of tinnitus was identified in 95 subjects (52.8 %). Tinnitus-specific and/or nonspecific therapies were given to 80 subjects (44.4%). Of the 54 available subjects, 28 (51.9%) participated in the telephone questionnaire. Tinnitus complaints shifted favorably to the improvement or resolution categories (P = .001) between the initial clinic visit and the telephone interview. Shorter duration of tinnitus was associated with a higher probability of having improved tinnitus (P = .046).

Conclusions

This study distinguishes pediatric tinnitus from adult tinnitus in terms of lower association with underlying hearing loss, lower likelihood of reported anxiety, and higher likelihood of improvement and resolution. There are opportunities for tinnitus prevention in the areas of reducing head injury and noise-induced hearing loss.

Level of Evidence

4 Laryngoscope, 2017



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Penetrating injuries to the duodenum: An analysis of 879 patients from the National Trauma Data Bank, 2010 to 2014

imageBACKGROUND: Despite wide belief that the duodenal Organ Injury Scale has been validated, this has not been reported in the published literature. Based on clinical experience, we hypothesize that the American Association for Surgery of Trauma Organ Injury Scale (AAST-OIS) for duodenal injuries can independently predict mortality. Our objectives were threefold: (1) describe the national profile of penetrating duodenal injuries, (2) identify predictors of morbidity and mortality, and (3) validate the duodenum AAST-OIS as a statistically significant predictor of mortality. METHODS: Using the Abbreviated Injury Scale 2005 and International Classification of Diseases—9th Rev.—Clinical Modification (ICD-9-CM) E-codes, we identified 879 penetrating duodenal trauma patients from the National Trauma Data Bank between 2010 and 2014. We controlled patient-level covariates of age, biological sex, systolic blood pressure (SBP), Glasgow Coma Scale (GCS) score, pulse, Injury Severity Score (ISS), and Organ Injury Scale (OIS) grade. We estimated multivariable generalized linear mixed models to account for the nesting of patients within trauma centers. RESULTS: Our results indicated an overall mortality rate of 14.4%. Approximately 10% of patients died within 24 hours of admission, of whom 76% died in the first 6 hours. Patients averaged approximately five associated injuries, 45% of which involved the liver and colon. Statistically significant independent predictors of mortality were firearm mechanism, SBP, GCS, pulse, ISS, and AAST-OIS grade. Specifically, odds of death were decreased with 10 mm Hg higher admission SBP (13% decreased odds), one point higher GCS (14.4%), 10-beat lower pulse (8.2%), and 10-point lower ISS (51.0%). CONCLUSION: This study is the first to report the national profile of penetrating duodenal injuries. Using the National Trauma Data Bank, we identified patterns of injury, predictors of outcome, and validated the AAST-OIS for duodenal injuries as a statistically significant predictor of morbidity and mortality. LEVEL OF EVIDENCE: Epidemiologic/Prognostic, level IV.

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The "Mortality Ascent": Hourly Risk of Death for Hemodynamically Unstable Trauma Patients at Level II versus Level I Trauma Centers.

Background: Severely injured trauma patients have higher in-hospital mortality at Level II versus Level I Trauma Centers (TCs). In order to better understand these differences, we sought to determine if there were any time-periods during which hemodynamically unstable trauma patients are at higher risk of death at Level II versus Level I TCs within the first 24 hours post-admission. Study design: Trauma patients aged 18-64 years, with Injury Severity Score >=15, SBP

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Reflections on the Future of Epidemiology: How Students Can Inform Our Vision



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Dentist supports Mouth Cancer Action Month

A Luton dental surgery is urging people to make an appointment for NHS dental treatment this month, which is Mouth Cancer Action Month. Mouth cancer is one of the UK's fastest increasing cancers, with cases up by almost 40 per cent in the last decade and 70 per cent of cases diagnosed in men.



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Dietary copper restriction in Wilson’s disease

Dietary copper restriction in Wilson's disease

Dietary copper restriction in Wilson's disease, Published online: 06 November 2017; doi:10.1038/s41430-017-0002-0



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Timing, duration, and severity of iron deficiency in early development and motor outcomes at 9 months

Timing, duration, and severity of iron deficiency in early development and motor outcomes at 9 months

Timing, duration, and severity of iron deficiency in early development and motor outcomes at 9 months, Published online: 06 November 2017; doi:10.1038/s41430-017-0015-8



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How empathic are vegan medical professionals compared to others? Leads from a paper–pencil-survey

How empathic are vegan medical professionals compared to others? Leads from a paper–pencil-survey

How empathic are vegan medical professionals compared to others? Leads from a paper–pencil-survey, Published online: 06 November 2017; doi:10.1038/s41430-017-0007-8



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Mortality due to refeeding syndrome? You only find what you look for, and you only look for what you know

Mortality due to refeeding syndrome? You only find what you look for, and you only look for what you know

Mortality due to refeeding syndrome? You only find what you look for, and you only look for what you know, Published online: 06 November 2017; doi:10.1038/s41430-017-0018-5



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Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women, Published online: 06 November 2017; doi:10.1038/s41430-017-0010-0



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The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study, Published online: 06 November 2017; doi:10.1038/s41430-017-0009-6



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Marine oxygen production and open water supported an active nitrogen cycle during the Marinoan Snowball Earth

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Depth dependent stress revealed by aftershocks



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Niki Bezzant: Lose weight and save money

On the go and no time to finish that story right now? Your News is the place for you to save content to read later from any device. Register with us and content you save will appear here so you can access them to read later.



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Dietary copper restriction in Wilson’s disease



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Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women



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Timing, duration, and severity of iron deficiency in early development and motor outcomes at 9 months



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The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study



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Mortality due to refeeding syndrome? You only find what you look for, and you only look for what you know



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How empathic are vegan medical professionals compared to others? Leads from a paper–pencil-survey



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Seek First To Understand

In his highly acclaimed, widely read, book The Seven Habits of Highly Effective People, Steven Covey tells us to try to listen and understand what the other person is trying to tell us. If we do this, we gain different perspective on their point of view.

Too often, we make our minds up about what a person is saying within seconds. If they look angry, we begin to feel defensive. If they are smiling, we relax and assume it's going to be a pleasant experience. It's all just superficial information that we're receiving, and not enough to go on. I'm sure body language experts might disagree, but I've found body language doesn't always tell the story. Digging deeper gives us more information and hopefully, helps us understand the other person a little more.

The other day an elderly gentleman came into our practice with a stack of papers in his hand, a Yankee accent (we're in the South, but I'm from Brooklyn, NY, so I can say that) and a very pissed off, somewhat condescending attitude. I was at lunch so the front desk assistant tried to help him. She then asked the financial coordinator to speak to him, who then asked the insurance coordinator to take a crack at it. When I walked in from lunch, the front desk coordinator had gotten the dentist involved, the dentist had about had it with him and I was getting a very excited version of what had transpired. I headed up to the front desk with a lot of stuff going through my head before I even set eyes on the patient.

Here's what I saw. A very aggravated, 81 year old man, Joe, with a stack of statements in his hand and a hole in his "temporary anterior splint". Through the ensuing conversation, he repeatedly alternated between sticking the tip of his tongue in the hole and shaking the broken piece that he had in a Baggie, at me and demanding I stick it back in. The whole time I kept thinking, "Why is he so mad?"  Our excellent front desk coordinator sat at her computer right next to me and kept pulling up info she thought would help. Thank goodness for that great proactive thinking. Our financial coordinator was busy pulling up any facts she had, and our insurance coordinator was close at hand, too. There's was no making this patient happy. I explained that the splint was a temporary measure that wasn't meant to be a permanent answer. He was confused about the difference between the splint, a crown and a bridge and was sure he had a bridge. The more I tried to explain at that point, the angrier he became. I finally said, "I know you're mad, I want to help you, but I can't help you understand if you won't let me talk." He left, swearing he'd find another dentist. 

After he left, I couldn't stop thinking about the look on his face the whole time he was ranting. I looked way back in his chart notes and noticed that his wife had died 12 years ago and he now lived with his youngest daughter. (A few days later I found out she had just been diagnosed with MS) So, at 69 he lost his wife. I'm sure he'd only retired shortly before her death and was now looking at the rest of his life without his wife. I doubt that's what he had planned for them. Maybe that's not an excuse to be so angry with others, but it helped me understand a little of why he might be the way he is. I also noticed that the temporary dentist who did the splint, referred to it as splinted crowns, since she had splinted the extracted crowns of the teeth onto the splint. That's what made him think he had crowns. It nagged at me that I didn't know any of this before I talked to him.

I decided to create a patient complaint sheet that gave a little more order and information to addressing unhappy patients. First, I didn't want to come into the picture after 3 people had already talked to an angry patient. If you've ever watched them make a fire on Naked and Afraid, one person starts the flame, another one adds kindling to get it to catch, and then they add the big logs to really get it going.  I don't want to be the big log again. On the sheet I created, the first person to talk to the patient logs the patient's complaint and asks them to take a seat so they can get me. If it's a financial issue, the sheet then goes to the finance coordinator to fill out her info, possibly the insurance coordinator for her input, the front desk coordinator for background info, and then I get the sheet. I can go talk to the doctor first if needed, and then approach the patient with the information I wish I'd had with Joe. I know it sounds like that sheet really travels, but all of those people know somethings going on and are doing their part so they only have the sheet for a minute or two before I get it. 

To my happy surprise, Joe showed up again one morning, again with a pile of paper in his hand. The entire front desk group turned to me with a look of "Here we go again" on their faces. I greeted the patient and asked what I could help him with. He said, "If you'll have me back, I've decided to go ahead and have the damned bridge." I told him to give me a minute and went and talked to the doctor. She agreed to do the bridge, but that he must agree not to come in the office angry, rather to talk things out if there was something he needed help with. I asked Joe to come into my office and let him know we'd do it, but he needed to take a different approach to his concerns from now on. He agreed. We talked for quite a while and I discovered that Joe was quite funny and interesting. His wife had indeed died, he was her 4th husband and, as he put it, "The best of the bunch!". He was taking his daughter to the Cleveland Clinic the next week to see about her MS. He'd served in the army and went back to school at night for 3 years to get a degree, in the days before the government started paying for it. (screwed again) He'd worked at IBM for 35 years and never got rich, but he got by. He did editing, so he expected the info he was given to be written out and perfect. I'm starting to understand Joe a little better, are you?  At 81 years old, he believed "I have to stand up for myself, because there's nobody else who will." 

So, don't you have to give a bit of admiration to an 81 year old who still has the gumption to stand up for himself? He's been through a lot of life, and he's still standing up for himself. That's the world looking out through Joe's eyes. Does that mean we have to stand there and absorb his anger? No. We can try first to understand where it's coming from. We can stop taking it personally. He's angry at the situation as he perceives it. Are we so sensitive that we can't put our own feelings aside for a moment to try to understand a patient, or can we realize if we work with patients, they will sometimes be angry, that's a fact of the job. We may not always be able to give them what they are demanding, but we can sure make them feel like we are trying. Just by aligning yourself with them, rather than against them, you are getting somewhere. They feel it if you are truly trying to help, just as they feel it when your back goes up and you stop trying to understand what they want, or how they feel.

It's not always easy, but if it was, would we even need you? If you can't handle the heat, should you be in our kitchen? The real test of an employee is how they respond when the going gets tough. So, first try to understand the patient, then the way will seem much clearer.

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Gilbert, Arizona Oral Surgeon Selected to the "America's Best Dentists" 2017 Directory

GILBERT , ARIZONA, UNITED STATES, October 30, 2017 / EINPresswire.com / -- Gilbert, Arizona dentist, Dr. Peter Spanganberg has been selected to the "America's Best Dentists" registry for 2017. Selections were made by the National Consumer Advisory Board, an organization that identifies top professionals in their fields.



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Employee Request Off Form-Feel Free to Download

I get asked to share my Employee Request Off Form a lot, so I thought I'd write a quick blog about it and share it here.

Just like every other system in my office, this form was born out of necessity. With a team of 10, it was difficult to honor, keep track, and cover request off days. There were a few times when multiple people had requested off, and because I was too busy to check the schedule properly, we [more…]

The post Employee Request Off Form-Feel Free to Download appeared first on Next Step Dental Resource.



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Us Two: Journalist Sarah Lang and author/cartoonist Sarah Laing

Sarah Laing, 44, is a cartoonist, fiction writer, illustrator, and graphic designer. Sarah Lang, 37, is the books and culture writer for Capital magazine, and a freelance journalist.



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Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury.

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Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury.

Neurotherapeutics. 2017 Nov 03;:

Authors: Kigerl KA, Mostacada K, Popovich PG

Abstract
Spinal cord injury (SCI) disrupts the autonomic nervous system (ANS), impairing its ability to coordinate organ function throughout the body. Emerging data indicate that the systemic pathology that manifests from ANS dysfunction exacerbates intraspinal pathology and neurological impairment. Precisely how this happens is unknown, although new data, in both humans and in rodent models, implicate changes in the composition of bacteria in the gut (i.e., the gut microbiota) as disease-modifying factors that are capable of affecting systemic physiology and pathophysiology. Recent data from rodents indicate that SCI causes gut dysbiosis, which exacerbates intraspinal inflammation and lesion pathology leading to impaired recovery of motor function. Postinjury delivery of probiotics containing various types of "good" bacteria can partially overcome the pathophysiologal effects of gut dysbiosis; immune function, locomotor recovery, and spinal cord integrity are partially restored by a sustained regimen of oral probiotics. More research is needed to determine whether gut dysbiosis varies across a range of clinically relevant variables, including sex, injury level, and injury severity, and whether changes in the gut microbiota can predict the onset or severity of common postinjury comorbidities, including infection, anemia, metabolic syndrome, and, perhaps, secondary neurological deterioration. Those microbial populations that dominate the gut could become "druggable" targets that could be manipulated via dietary interventions. For example, personalized nutraceuticals (e.g., pre- or probiotics) could be developed to treat the above comorbidities and improve health and quality of life after SCI.

PMID: 29101668 [PubMed - as supplied by publisher]



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A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole.

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A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole.

Eur J Drug Metab Pharmacokinet. 2017 Nov 04;:

Authors: Wilby KJ

Abstract
Invasive fungal infections are a major cause of morbidity and mortality, especially for immunocompromised patients. Treatment options are few and most are limited by safety and formulation concerns. Isavuconazole is a new triazole antifungal agent with official indications for the treatment of invasive fungal infections caused by Aspergillus and Mucormycosis. Its clinical efficacy has been proven in two landmark trials, SECURE and VITAL. This review aims to summarize and evaluate the published literature reporting clinical pharmacokinetic and pharmacodynamic outcome data of isavuconazole in humans. Data from healthy volunteers demonstrated high oral bioavailability, high hepatic metabolism, and an extended elimination half-life. Data from diseased patients confirmed these findings and also consistently demonstrated that regular dosing of isavuconazole results in achievement of concentrations and exposures that meet pharmacodynamic targets for therapeutic efficacy. Additionally, it was found that renal dysfunction, and mucositis do not majorly affect pharmacokinetic or pharmacodynamic outcomes yet further study is required for severe hepatic and gastric impairment. Future studies should further attempt to understand dose and concentration response relationships, investigate the role (if any) of therapeutic drug monitoring, and strive to optimize dosing in special populations.

PMID: 29101732 [PubMed - as supplied by publisher]



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High performance dental resin composites with hydrolytically stable monomers

Publication date: Available online 4 November 2017
Source:Dental Materials
Author(s): Xiaohong Wang, George Huyang, Sri Vikram Palagummi, Xiaohui Liu, Drago Skrtic, Carlos Beauchamp, Rafael Bowen, Jirun Sun
ObjectiveThe objectives of this project were to: 1) develop strong and durable dental resin composites by employing new monomers that are hydrolytically stable, and 2) demonstrate that resin composites based on these monomers perform superiorly to the traditional bisphenol A glycidyl dimethacrylate/triethylene glycol dimethacrylate (Bis-GMA/TEGDMA) composites under testing conditions relevant to clinical applications.MethodsNew resins comprising hydrolytically stable, ether-based monomer, i.e., triethylene glycol divinylbenzyl ether (TEG-DVBE), and urethane dimethacrylate (UDMA) were produced via composition-controlled photo-polymerization. Their composites contained 67.5wt% of micro and 7.5wt% of nano-sized filler. The performances of both copolymers and composites were evaluated by a battery of clinically-relevant assessments: degree of vinyl conversion (DC: FTIR and NIR spectroscopy); refractive index (n: optical microscopy); elastic modulus (E), flexural strength (F) and fracture toughness (KIC) (universal mechanical testing); Knoop hardness (HK; indentation); water sorption (Wsp) and solubility (Wsu) (gravimetry); polymerization shrinkage (Sv; mercury dilatometry) and polymerization stress (tensometer). The experimental UDMA/TEG-DVBE composites were compared with the Bis-GMA/TEGDMA composites containing the identical filler contents, and with the commercial micro hybrid flowable composite.ResultsUDMA/TEG-DBVE composites exhibited n, E, Wsp, Wsu and Sv equivalent to the controls. They outperformed the controls with respect to F (up to 26.8% increase), KIC (up to 27.7% increase), modulus recovery upon water sorption (full recovery vs. 91.9% recovery), and stress formation (up to 52.7% reduction). In addition, new composites showed up to 27.7% increase in attainable DC compared to the traditional composites. Bis-GMA/TEGDMA controls exceeded the experimental composites with respect to only one property, the composite hardness. Significantly, up to 18.1% lower HK values in the experimental series (0.458GPa) were still above the clinically required threshold of approx. 0.4GPa.SignificanceHydrolytic stability, composition-controlled polymerization and the overall enhancement in clinically-relevant properties of the new resin composites make them viable candidates to replace traditional resin composites as a new generation of strong and durable dental restoratives.

Graphical abstract

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Delta touts affordability amid criticism from dentists

Dentists complained to the Legislature on Monday that they felt coerced into joining Delta Dental's new, lower-cost insurance plan, called Total Choice, and they asked lawmakers to impose more government control over the dental benefits giant. Last year, Delta told dentists it was offering a new plan through a for-profit subsidiary of the non-profit parent and initially gave them about a month to sign onto the new network or face a "one-year lockout," Massachusetts Dental Society President David Lustbader told lawmakers.



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Nursing students' perceptions of teachers' uncivil behaviors: a qualitative research

One of the main issues in nursing education that teachers and students frequently encounter is uncivil behaviors. This type of behavior is destructive for the teaching and learning environment. As teachers play an important role in nursing students' education and are ultimately their role models, the identification of these behaviors in nursing teachers appears to be essential. This study was conducted to determine nursing students' perceptions of their teachers' uncivil behaviors.

The present study was conducted using a qualitative approach and content analysis. A total of 13 nursing students were selected through purposive sampling, and deep and semi-structured interviews were conducted with them. Content analysis was performed using an inductive approach.

Three main categories were obtained through data analysis; disruptive behaviors affecting communication climate (subthemes: humiliation, the lack of supportiveness, and distrust), disruptive behaviors affecting ethical climate (subthemes: self-centeredness, coercion and aggression, and harassment), and disruptive behaviors affecting learning climate (subthemes: poor teaching skills, poor time management, and indiscipline). Given that human dignity takes precedence over education, any action causing humiliation and embarrassment can have inverse effects on the students and may harm them. These behaviors taint the educational role. Since students select their teachers as their role models, the impact of teachers' uncivil behaviors on students cannot be neglected. Neglecting these behaviors might lead to their persistence in the clinical setting and irreparable damage to patients, who are the ultimate recipients of care.

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