Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives. Semin Cancer Biol. 2020 May 22;: Authors: Patra S, Mishra SR, Behera BP, Mahapatra KK, Panigrahi DP, Bhol CS, Praharaj PP, Sethi G, Patra SK, Bhutia SK Abstract Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to maintain cyto-homeostasis....
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. Autophagy. 2020 May 25;:1-19 Authors: Hossain MI, Marcus JM, Lee JH, Garcia PL, Singh V, Shacka JJ, Zhang J, Gropen TI, Falany CN, Andrabi SA Abstract Stroke is a leading cause of death and disability. The pathophysiological mechanisms associated with stroke are very complex and not fully understood. Lysosomal function has a vital physiological function in the...
Fucoxanthin treatment inhibits nasopharyngeal carcinoma cell proliferation through induction of autophagy mechanism. Environ Toxicol. 2020 May 25;: Authors: Long Y, Cao X, Zhao R, Gong S, Jin L, Feng C Abstract Nasopharyngeal carcinoma (NPC) arises from the epithelium of the nasopharyngeal mucosa. Elderly people above the age of 65 years are more susceptible to NPC. Nasopharyngectomy is the renowned treatment procedure to NPC; however, it is too...
Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small cell lung cancer cells by regulating autophagy. Cell Biol Int. 2020 May 25;: Authors: Kong R Abstract Non-small cell lung carcinoma (NSCLC) continues to top the list of cancer mortalities worldwide. The role of circular RNAs (circRNAs) in tumorigenesis has been increasingly appreciated, although it is relatively unexplored in NSCLC. Herein, we reported on the role of hsa_circ_0085131...
A review of the chemopreventative and chemotherapeutic properties of the phytochemicals berberine, resveratrol and curcumin, and their influence on cell death via the pathways of apoptosis and autophagy. Cell Biol Int. 2020 May 25;: Authors: Sean D'Arcy M Abstract Phytochemicals are a diverse group of compounds found in a variety of fruits, vegetables and herbs, and have been reported to possess a number of health benefits. Marketed as supplements...
High-Throughput Image-Based Aggresome Quantification. SLAS Discov. 2020 May 25;:2472555220919708 Authors: Lesire L, Chaput L, Cruz De Casas P, Rousseau F, Piveteau C, Dumont J, Pointu D, Déprez B, Leroux F Abstract Aggresomes are subcellular perinuclear structures where misfolded proteins accumulate by retrograde transport on microtubules. Different methods are available to monitor aggresome formation, but they are often laborious, time-consuming,...
Epibrassinolide-induced autophagy occurs in an Atg5-independent manner due to endoplasmic stress induction in MEF cells. Amino Acids. 2020 May 24;: Authors: Adacan K, Obakan-Yerlikaya P, Arisan ED, Coker-Gurkan A, Kaya RI, Palavan-Unsal N Abstract Epibrassinolide (EBR), a polyhydroxysteroid belongs to plant growth regulator family, brassinosteroids and has been shown to have a similar chemical structure to mammalian steroid hormones. Our findings...
Cross talk between alcohol-induced oxidative stress and HCV replication. Arch Microbiol. 2020 May 24;: Authors: Sobhanimonfared F, Bamdad T, Roohvand F Abstract Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV) infection and aggravates disease consequences in alcohol-abusing patients. Although the exact reasons by which alcohol consumption affects several cellular pathways in liver cells are not clear, they might be partially...
CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum. Br J Cancer. 2020 May 25;: Authors: Hsin IL, Chiu LY, Ou CC, Wu WJ, Sheu GT, Ko JL Abstract BACKGROUND: Adaptive drug resistance is an unfavourable prognostic factor in cancer therapy. Pemetrexed-resistant lung cancer cells possess high-metastatic ability via ERK-ZEB1 pathway-activated epithelial-mesenchymal...
Long non-coding RNA HOTAIR in cervical cancer: Molecular marker, mechanistic insight, and therapeutic target. Adv Clin Chem. 2020;97:117-140 Authors: Zhou YH, Cui YH, Wang T, Luo Y Abstract Cervical cancer is a common gynecologic malignant tumor with high mortality. HOX transcript antisense RNA (HOTAIR), a trans-acting long non-coding RNA (lncRNA) containing six exons in humans, is transcribed from the antisense strand of homeobox gene C cluster....
Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study. Crit Care. 2020 May 24;24(1):249 Authors: Van Dyck L, Vanhorebeek I, Wilmer A, Schrijvers A, Derese I, Mebis L, Wouters PJ, Van den Berghe G, Gunst J, Casaer MP Abstract BACKGROUND: In two recent randomized controlled trials, withholding parenteral nutrition early in critical illness improved outcome as compared to early up-to-calculated-target...
Related ArticlesDoxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy. FASEB J. 2019 10;33(10):11096-11108 Authors: Catanzaro MP, Weiner A, Kaminaris A, Li C, Cai F, Zhao F, Kobayashi S, Kobayashi T, Huang Y, Sesaki H, Liang Q Abstract Doxorubicin (Dox) is a widely used antineoplastic agent that can cause heart failure. Dox cardiotoxicity is closely associated with mitochondrial damage. Mitochondrial fission...
Related ArticlesOxidative Inhibition of Pbp1 Phase Separation. Biochemistry. 2019 07 16;58(28):3057-3059 Authors: Chong PA, Forman-Kay JD PMID: 31282150 [PubMed - indexed for MEDLINE]
Related ArticlesCyclosporine A as a Cardioprotective Agent During Donor Heart Retrieval, Storage, or Transportation: Benefits and Limitations. Transplantation. 2019 06;103(6):1140-1151 Authors: Gao L, Hicks M, Villanueva JE, Doyle A, Chew HC, Qui MR, Jabbour A, Dhital KK, Macdonald PS Abstract BACKGROUND: Storage of donor hearts in cardioplegic solutions supplemented with conditioning agents activating endogenous mitochondrial protective signaling enhanced...
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Related ArticlesFine tuning of p53 functions between normal and leukemic cells: a new strategy for the treatment of chronic lymphocytic leukemia. Haematologica. 2019 12;104(12):2332-2334 Authors: Stankovic T PMID: 31787615 [PubMed - indexed for MEDLINE]
Related ArticlesResponse to Comment by Jonathan Weiss et al. Haematologica. 2019 11;104(11):e542 Authors: Tausch E, Stilgenbauer S PMID: 31666347 [PubMed - indexed for MEDLINE]
Related ArticlesResponse to Comment by Amato T. et al. Haematologica. 2019 11;104(11):e541 Authors: Giudice ID, Foà R PMID: 31666346 [PubMed - indexed for MEDLINE]
Related ArticlesAcquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia (Comment to Tausch et al.). Haematologica. 2019 11;104(11):e540 Authors: Weiss J, Peifer M, Herling CD, Frenzel LP, Hallek M PMID: 31666345 [PubMed - indexed for MEDLINE]
Related ArticlesMitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Cancer Cell. 2019 10 14;36(4):369-384.e13 Authors: Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND,...
Related ArticlesTREM1/Dap12-based CAR-T cells show potent antitumor activity. Immunotherapy. 2019 08;11(12):1043-1055 Authors: Chen B, Zhou M, Zhang H, Wang C, Hu X, Wang B, Wang E Abstract Aim: Chimeric antigen receptor-engineered T (CAR-T) cells have gained huge success in treating hematological malignancies, yet the CD3ζ-based CAR-T therapies have not shown comparable clinical benefits in solid tumors. We designed an alternative chimeric immunoreceptor...
Related ArticlesEighty-nine-year-old woman with fatigue and reduced appetite. Heart. 2019 06;105(11):880-892 Authors: Thayaparan AS, Haikerwal D PMID: 31092679 [PubMed - indexed for MEDLINE]
Related ArticlesThe t(11;14)(q13;q32)/CCND1-IGH translocation in chronic lymphocytic leukaemia/small lymphocytic lymphoma: an unusual genetic aberration during the natural clinical course. Histopathology. 2019 08;75(2):291-294 Authors: Liu Y, Roshal M, Xiao W, Zhang Y, Aypar U, Yu W, Nafa K, Arcila M, Moung C, Dogan A, Park J, Ho C PMID: 31021442 [PubMed - indexed for MEDLINE]
Related ArticlesTimes Not to Forget Radiotherapy When Treating Patients With Lymphoma. J Oncol Pract. 2019 04;15(4):167-172 Authors: Enke CA Abstract Radiation therapy remains an important component of lymphoma treatment. It has evolved with improvements in technology and a better understanding of how to successfully integrate it into lymphoma treatment. There are specific clinical presentations where omission of radiation therapy could adversely affect...
Related ArticlesFlorid T follicular helper cell hyperplasia associated with extranodal marginal zone lymphoma: a diagnostic pitfall which may mimic T cell lymphoma. Histopathology. 2019 08;75(2):287-290 Authors: Vroobel KM, O'Connor S, Cunningham D, Wren D, Sharma B, Wotherspoon A, Attygalle AD PMID: 30860612 [PubMed - indexed for MEDLINE]
Related ArticlesAssociation of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study. Lancet HIV. 2019 04;6(4):e240-e249 Authors: Hernández-Ramírez RU, Qin L, Lin H, Leyden W, Neugebauer RS, Althoff KN, Achenbach CJ, Hessol NA, D'Souza G, Gebo KA, Gill MJ, Grover S, Horberg MA, Li J, Mathews WC, Mayor AM, Park LS, Rabkin CS, Salters K, Justice AC, Moore RD,...
Related ArticlesInfusion-related reactions to rituximab: frequency, mechanisms and predictors. Expert Rev Clin Immunol. 2019 04;15(4):383-389 Authors: Paul F, Cartron G Abstract INTRODUCTION: Rituximab, an anti-CD20 monoclonal antibody (mAb), is indicated in the treatment of B-cell non-Hodgkin lymphomas, chronic lymphoid leukemia, and rheumatoid arthritis. The occurrence of infusion-related reactions (IRR), especially during the first infusion, is one...
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Cerebrovascular pathology and misdiagnosis of multiple system atrophy: An autopsy study. Parkinsonism Relat Disord. 2020 May 16;75:34-40 Authors: Koga S, Roemer SF, Tipton PW, Low PA, Josephs KA, Dickson DW Abstract BACKGROUND: Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by a combination of dysautonomia, parkinsonism, and cerebellar ataxia. Other disorders can mimic MSA, but it is unknown whether cerebrovascular...
Inappropriate antidiuretic hormone secretion in amyotrophic lateral sclerosis. Clin Neuropathol. 2020 May 25;: Authors: Douglas A, Baborie A Abstract Only a few cases of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the setting of amyotrophic lateral sclerosis (ALS) have been described in the literature. We present the case of an 81-year-old male who developed severe hyponatremia following elective total hip replacement. His past...
Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology. Acta Neuropathol. 2020 May 24;: Authors: Reichard RR, Kashani KB, Boire NA, Constantopoulos E, Guo Y, Lucchinetti CF Abstract We report the neuropathological findings of a patient who died from complications of COVID-19. The decedent was initially hospitalized for surgical management of underlying coronary artery disease. He developed post-operative...
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Coping strategies of family caregivers in spinal cord injury: a qualitative study. Disabil Rehabil. 2020 May 23;:1-10 Authors: Zanini C, Fiordelli M, Amann J, Brach M, Gemperli A, Rubinelli S Abstract Purpose: To identify the coping strategies used by family caregivers of persons with spinal cord injury (SCI) in Switzerland in order to develop tailored support programs.Materials and methods: Purposive sample of >18 years participants, speaking an...
How is right hemisphere communication disorder disabling? Evidence from response mobilizing actions in conversation. Disabil Rehabil. 2020 May 23;:1-14 Authors: Barnes S, Beeke S, Bloch S Abstract Aim: Assessment and intervention strategies for communication disorders caused by right hemisphere stroke are at an early stage of development. There is also little evidence on how right hemisphere communication disorder is disabling for everyday life. This...
Evaluation of the MCAST, a multidisciplinary toolkit to improve mental capacity assessment. Disabil Rehabil. 2020 May 23;:1-8 Authors: Jayes M, Palmer R, Enderby P Abstract Purpose: To evaluate the usability and acceptability of the Mental Capacity Assessment Support Toolkit (MCAST) in healthcare settings and whether its use was associated with increased legal compliance and assessor confidence.Materials and methods: A mixed methods convergence triangulation...
The effects of an intradialytic resistance training on lower extremity muscle functions. Disabil Rehabil. 2020 May 24;:1-7 Authors: Zelko A, Rosenberger J, Skoumalova I, Kolarcik P, Madarasova Geckova A, van Dijk JP, Reijneveld SA Abstract Purpose: The loss of muscle functions is a significant health issue among dialysis patients. Poor muscle strength negatively affects a patient's mobility, independence and quality of life. The aim of the study was...
Effects of the model of human occupation-based home modifications on the time use, occupational participation and activity limitation in people with disabilities: a pilot randomized controlled trial. Disabil Rehabil Assist Technol. 2020 May 23;:1-7 Authors: Jo YJ, Kim H Abstract Purpose: To compare the effect of intervention providing home modifications and assistive devices based on MOHO theory with home exercise on people with disability in time use,...
Virtual reality interventions to enhance upper limb motor improvement after a stroke: commonly used types of platform and outcomes. Disabil Rehabil Assist Technol. 2020 May 23;:1-9 Authors: Subramanian SK, Cross MK, Hirschhauser CS Abstract Introduction: Virtual Reality (VR) based platforms are useful in enhancing post-stroke sub-optimal upper limb (UL) motor improvement. A variety of options are available from expensive highly customizable platforms...
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Highly pathogenic H7N9 avian influenza virus infection associated with up-regulation of PD-1/PD-Ls pathway-related molecules. Int Immunopharmacol. 2020 May 22;85:106558 Authors: Li YH, Hu CY, Cheng LF, Wu XX, Weng TH, Wu NP, Yao HP, Li LJ Abstract To investigate the main transcriptional and biological changes of human host during low and highly pathogenic avian H7N9 influenza virus infection and to analyze the possible causes of escalated virulence and...
Mysterious Virus: A Review on Behavior and Treatment Approaches of the Novel Coronavirus, 2019-nCoV.
Mysterious Virus: A Review on Behavior and Treatment Approaches of the Novel Coronavirus, 2019-nCoV. Arch Med Res. 2020 May 06;: Authors: Hemmati F, Saedi S, Hemmati-Dinarvand M, Zarei M, Seghatoleslam A Abstract At the end of the year 2019, the novel coronavirus (2019-nCoV) was spreading in Wuhan, China, and the outbreak process has a high speed. It was recognized as a pandemic by the World Health Organization (WHO) on 11 March 2020. Coronaviruses are...
Stem cell therapy: a potential approach for treatment of influenza virus and coronavirus-induced acute lung injury. Stem Cell Res Ther. 2020 May 24;11(1):192 Authors: Du J, Li H, Lian J, Zhu X, Qiao L, Lin J Abstract Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity and mortality in ALI and acute...
Related ArticlesThe cost of influenza-associated hospitalizations and outpatient visits in Kenya. BMC Public Health. 2019 May 10;19(Suppl 3):471 Authors: Emukule GO, Ndegwa LK, Washington ML, Paget JW, Duque J, Chaves SS, Otieno NA, Wamburu K, Ndigirigi IW, Muthoka PM, van der Velden K, Mott JA Abstract BACKGROUND: We estimated the cost-per-episode and the annual economic burden associated with influenza in Kenya. METHODS: From July 2013-August...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,