Effect of monocarboxylate transporter-1 on the biological behavior of iodine-refractory thyroid carcinoma

xlomafota13 shared this article with you from Inoreader Effect of monocarboxylate transporter-1 on the biological behavior of iodine-refractory thyroid carcinoma Via radioactive iodine Transl Cancer Res. 2021 Nov;10(11):4914-4928. doi: 10.21037/tcr-21-2417. ABSTRACT BACKGROUND: Differentiated thyroid cancer (DTC) is the most common thyroid tumor, and the cells of DTC patients can lose the ability to differentiate in their natural state or during treatment and develop radioiodine-refractory DTC (RAI-R DTC), resulting in increased malignancy. Monocarboxylate transporter-1 (MCT1 ) is positively correlated with the level of malignant of various tumo rs, and its expression in RAI-R DTC cells is correlated with their biological cell traits. METHODS: Data from 14 iodine-refractory thyroid carcinoma patients were collected, and the effective radioiodine treatment group was used as the control group. The expression of MCT1 in iodine-refractory thyroid carcinoma and its effect on biological behaviors was observed and the molecular mechanism underlying RAI-R DTC was investigated to determine the cause of the loss of sensitivity of DTC to radioactive iodine using Immunohistochemical staining, Western blot, transwell assay, wound healing assay, flow cytogram assay. RESULTS: Compared to radioiodine-sensitive DTC (RAI-DTC), which was responded to iodine treatment, MCT1 was highly expressed in RAI-R DTC cells. The overexpression or inhibition of MCT1 altered the biological characteristics of papillary thyroid carcinoma (TPC-1) cells. The overexpression of MCT1< /i> in TPC-1 cells increased the invasive, proliferative, and migratory abilities of the cells. Conversely, the downregulation of MCT1 decreased the invasive, proliferative and migratory abilities of the cells. CONCLUSIONS: The expression of MCT1 was enhanced in RAI-R DTC cells. MCT1 appears to be closely related to the invasive metastasis of RAI-R DTC cells, and it may be the cause of the loss of the iodine uptake ability of RAI-R DTC. PMID:35116343 | PMC:PMC8797869 | DOI:10.21037/tcr-21-2417 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New approaches for patients with advanced radioiodine-refractory thyroid cancer

xlomafota13 shared this article with you from Inoreader New approaches for patients with advanced radioiodine-refractory thyroid cancer Via radioactive iodine World J Clin Oncol. 2022 Jan 24;13(1):9-27. doi: 10.5306/wjco.v13.i1.9. ABSTRACT The cumulative evidence over the past decades has shown that the incidence of differentiated thyroid carcinoma (DTC) has exponentially increased. Approximately 10% of patients with DTC exhibit recurrent or metastatic disease, and about two-thirds of the latter will be defined as refractory to radioactive iodine (RAIR) treatment. Since this condition implies 10-year survival rates less than 10% after de tection, using available treatments, such as systemic and targeted therapies, have become increasingly relevant. The initiation of these treatments aims to reach stabilization, tumor volume reduction, and/or symptom improvement and it should be decided by highly specialized endocrinologists/oncologists on the basis of patient's features. Considering that despite enlarged progression-free survival was proven, multikinase inhibitors remain non-curative, their benefits last for a limited time and the side effects potentially cause harm and quality of life reduction. In this context, molecular testing of cancer cells provides a promising spectrum of targeted therapies that offer increased compatibility with individual patient needs by improving efficacy, progression free survival, overall survival and adverse events profile. This review article aims to provide a summary of the current therapeutic strategies in advanced RAIR-DTC, including approved target therapies as well as those for < i>off-label use, RAI resensitization agents, and immunotherapy. PMID:35116229 | PMC:PMC8790300 | DOI:10.5306/wjco.v13.i1.9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Updates in hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in 2021

xlomafota13 shared this article with you from Inoreader Updates in hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in 2021 Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 31:S0007-4551(22)00001-7. doi: 10.1016/j.bulcan.2021.12.009. Online ahead of print. ABSTRACT Overall, 2021 was marked by the confirmation of the major interest of cell cycle inhibitors for hormone receptor (HR) positive/human epidermal growth factor receptor 2 (HER2) negative advanced breast cancers with very high overall survival data exceeding five years for hormone-sensitive disease. Studies have also confirmed the efficacy and safety of this therapeutic class in the elderly population. New cell cycle inhibitors are under development (SHR6390). New combinations are also being evaluated, notably palbociclib with SAR439859 (a new selective estrogen receptor degrader: SERD). Targeting of the Phosphoinositide 3-kinases (PI3K) pathway by taselisib, in hormone-resistant disease with a Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) mutation, modestly improves progression-free survival but with a non-negligible toxicity of the treatment. PMID:35115114 | DOI:10.1016/j.bulcan.2021.12.009 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bilateral persistent primitive olfactory arteries associated with an accessory anterior cerebral artery

xlomafota13 shared this article with you from Inoreader Bilateral persistent primitive olfactory arteries associated with an accessory anterior cerebral artery Via radiol anat Surg Radiol Anat. 2022 Feb 4. doi: 10.1007/s00276-022-02893-z. Online ahead of print. ABSTRACT Persistent primitive olfactory artery (PPOA) is a relatively rare variation of the proximal anterior cerebral artery (ACA) that generally follows an extreme anteroinferior course and takes a hairpin turn before continuing to the A2 segment of the ACA. This variation is usually seen unilaterally, and the anterior communicating artery (ACoA) is usually long or absent. We herein repor t a case of bilateral persistent PPOAs associated with an accessory ACA. The length of the bilateral A1 segments was normal and the length of the ACoA was normally short. Thus, hypoplasia of the distal A1 segment is important but not necessary for the formation of the PPOA. To our knowledge, no similar cases have been reported in the relevant English language literature. PMID:35122111 | DOI:10.1007/s00276-022-02893-z View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A comprehensive analysis of intratumor microbiome in head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader A comprehensive analysis of intratumor microbiome in head and neck squamous cell carcinoma Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Feb 5. doi: 10.1007/s00405-022-07284-z. Online ahead of print. ABSTRACT PURPOSE: Human microbiome has been considered as the second genome of our body. The intratissue/intratumor microbiome analysis is a relatively new field and deserves more attention. In this study, we conducted a comprehensive analysis of microbiome signatures of head and neck squamous cell carcinoma (HNSC). METHODS: The intratumor microbiome profiling and clinicopathological information about a total of 177 HNSC samples, including 155 tumors and 22 adjacent normal tissues, were obtained from The Cancer Microbiome Atlas (TCMA) and The Cancer Genome Atlas (TCGA) databases. We identified the microbes that differed between tumors and normal tissues, and assessed their utility values as diagnostic biomarkers. The microbiome signatures under different conditions of clinicopathological parameters were also analyzed. RESULTS: The intratissue microbiome profiles differed between tumor and normal samples of HNSC. The composition of four, six, and six microbes changed in tumors compared to normal tissues at the phylum, order, and genus levels, respectively (P < 0.05). Eight of the differential microbes performed well in distinguishing tumors from normal tissues (AUC > 0.7, P ≤ 0.001). The microbiome signature was found to be associated with tumor clinicopathological characteristics such as host-gender, host-age, tumor stage, and neoplasm histologic grade. CONCLUSION: Overall, our results revealed an intratissue microbiome signature of HNSC. We concluded that the intratumor microbiome signature may also reflect human biology in both healthy and disease status, and provide novel perspective for microbiota research about their roles in tumors. PMID:35122129 | DOI:10.1007/s00405-022-07284-z View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of endoscopic and microscopic tympanoplasty in patients with chronic otitis media

xlomafota13 shared this article with you from Inoreader Comparison of endoscopic and microscopic tympanoplasty in patients with chronic otitis media Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Feb 5. doi: 10.1007/s00405-022-07273-2. Online ahead of print. ABSTRACT BACKGROUND: To compare the results between type I tympanoplasty performed with transcanal endoscopic ear surgery (TEES) and microscopic ear surgery (MES) for treatment of chronic otitis media in a homogenous group of patients. METHODS: A retrospective study was performed in our department between January 2011 and January 2016 to review primary type I tympanoplasty cases with a subtotal perforation, an intact ossicular chain, a dry ear for at least 1 month, normal middle ear mucosa, and a follow-up period of at least 6 months post surgery. The adoption of TEES or MES was divided temporally (before and since 2013). TEES was undertaken in 224 patients (224 ears) and MES in 121 patients (121 ears). RESULTS: The successful graft take rate was 94.64% (212/224) in the TEES group and 90.91% (110/121) in the MES group (P = 0.239). The improvements in the air conduction levels between the 2 groups were not statistically different at 1, 3, or 6 (> 6) months (P > 0.05) after surgery. The improvements in the air-bone gaps were not significantly different between the 2 groups (P > 0.05). The average hearing gains in the TEES group 6 (and > 6) months post surgery were 11.85 ± 5.47 dB, which was better than 10.48 ± 5.18 dB in the MES group (P = 0.031). The use of medical resources was lower in the TEES group than in the MES group regarding the average operating time (49.22 ± 8.24 min vs 81.22 ± 14.73 min, respectively; P < 0.0001). Patients receiving MES had a significant higher incidence of the wound problems (ear pain, numbness around the ears, and wet ear; P < 0.05). CONCLUSION: TEES for type I tympanoplasty seems to achieve a shorter operative time and ideal tympanic membrane healing rate and hearing results in patients with chronic otitis media. PMID:35122510 | DOI:10.1007/s00405-022-07273-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigation of Added Value of Imaging Performed in a Prone Position to Standard 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer

xlomafota13 shared this article with you from Inoreader Investigation of Added Value of Imaging Performed in a Prone Position to Standard <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):23-32. doi: 10.4274/mirt.galenos.2021.48343. ABSTRACT OBJECTIVES: To investigate whether additional imaging in a prone position has any value to the supine whole-body 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) images by comparing the visual and quantitative data about a local disease in the breast and axilla for the initial staging of breast cancer (BC). METHODS: In this study, a total of 91 female patients with the BC were studied. Both the supine and prone images were examined based on the axial diameter, number and location of the primary tumor, local invasion signs of the tumor, the number of axillary lymph nodes with a suspected metastasis, metabolic parameters of the primary tumor and axillary lymph nodes, and registration artifacts of the PET and CT images were evaluated individually. These findings were compared with the h istopathological data obtained after a surgery. RESULTS: In the evaluation of a supine and prone imaging, tumor diameter and metabolic tumor volume (MTV) values of the breast lesions were greater in the supine position than in the prone position. However, there was no significant difference found between the other metabolic parameters of a primary tumor and axilla in both positions. In the supine and prone images, accuracy for skin involvement was 84% and 91.3%, respectively. CONCLUSION: In our study, we observed that, obtaining additional images in the prone position does not significantly benefit the evaluation of a local disease. The average values of the primary tumor diameter and MTV in the prone position appear to be smaller than the one in the supine position. However, the prone imaging in the patients with a newly diagnosed BC may be beneficial in selected patients and may contribute to preventing the false-positive results especially in patients with a suspected skin involvement. PMID:35114748 | DOI:10.4274/mirt.galenos.2021.48343 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Myocardial Ischemia on MPI SPECT in a Patient with Acute Myeloid Leukemia Without Significant Coronary Artery Disease

xlomafota13 shared this article with you from Inoreader Myocardial Ischemia on MPI SPECT in a Patient with Acute Myeloid Leukemia Without Significant Coronary Artery Disease Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):63-65. doi: 10.4274/mirt.galenos.2020.36035. ABSTRACT Herein, we report the case of a 56-year-old male patient with acute myeloid leukemia (AML) in remission who had asymptomatic myocardial ischemia on myocardial perfusion imaging and transthoracic echocardiography. Angiography did not reveal any significant coronary artery disease. Although the etiology is not entirely clear, this case suggested that myocardial perfusion imaging should be considered in patients with AML who received idarubicin to screen for possible myocardial dysfunction. PMID:35114755 | DOI:10.4274/mirt.galenos.2020.36035 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The raft cytoskeleton binding protein complexes personate functional regulators in cell behaviors

xlomafota13 shared this article with you from Inoreader The raft cytoskeleton binding protein complexes personate functional regulators in cell behaviors Via histochem Acta Histochem. 2022 Feb 2;124(2):151859. doi: 10.1016/j.acthis.2022.151859. Online ahead of print. ABSTRACT Several cytoskeleton proteins interact with raft proteins to form raft-cytoskeleton binding protein complexes (RCPCs) that control cell migration and adhesion. The purpose of this paper is to review the latest research on the modes and mechanisms by which a RCPC controls different cellular functions. This paper discusses RCPC composition and its role in cytoskeleton r eorganization, as well as the latest developments in molecular mechanisms that regulate cell adhesion and migration under normal conditions. In addition, the role of some external stimuli (such as stress and chemical signals) in this process is further debated, and meanwhile potential mechanisms for RCPC to regulate lipid raft fluidity is proposed. Thus, this review mainly contributes to the understanding of RCPC signal transduction in cells. Additionally, the targeted signal transduction of RCPC and its mechanism connection with cell behaviors will provide a logical basis for the development of unified interventions to combat metastasis related dysfunction and diseases. PMID:35123353 | DOI:10.1016/j.acthis.2022.151859 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Role of Histogram-Based Textural Analysis of 18F-FDG PET/CT in Evaluating Tumor Heterogeneity and Predicting the Prognosis of Invasive Lung Adenocarcinoma

xlomafota13 shared this article with you from Inoreader The Role of Histogram-Based Textural Analysis of <sup>18</sup>F-FDG PET/CT in Evaluating Tumor Heterogeneity and Predicting the Prognosis of Invasive Lung Adenocarcinoma Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):33-41. doi: 10.4274/mirt.galenos.2021.79037. ABSTRACT OBJECTIVES: This study aimed to investigate the contributory role of histogram-based textural features (HBTFs) extracted from 18fluorinefluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in tumoral heterogeneity (TH) evaluation and invasive lung adenocarcinoma (ILA) prognosis prediction. METHODS: This retrospective study analyzed the data of 72 patients with ILA who underwent 18F-FDG PET/CT followed by surgical resection. The maximum standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis values were calculated for each tumor. Additionally, HBTFs were extracted from 18F-FDG PET/CT images using the software program. ILA was classified into the following five histopathological subtypes according to the predominant pattern: Lepidic adenocarcinoma (LA), acinar adenocarcinoma, papillary adenocarcinoma, solid adenocarcinoma (SA), and micropapillary adenocarcinoma (MA). Differences between 18F-FDG PET/CT parameters and histopathological subtypes were evaluated using non-parametric tests. The study endpoints include overall survival (OS) and progression-free survival (PFS). The prognostic values of clinicopathological factors and 18F-FDG PET/CT parameters were evaluated using the Cox regression analyses. RESULTS: The median SUVmax and entropy values were significantly higher in SA-MA, whereas lower in LA. The median energy-uniformity value of the LA was significantly higher than the others. Among all parameters, only skewness and kurtosis were significantly associated with lymph node involvement status. The median values for follow-up time, PFS, and OS were 31.26, 16.07, and 20.87 months, respectively. The univariate Cox regression analysis showed that lymph node involvement was the only significant predictor for PFS. The multivariate Cox regression analysis revealed that higher SUVmax (≥11.69) and advanced stage (IIB-IIIA) were significantly associated with poorer OS [hazard ratio (HR): 3.580, p=0.024 and HR: 7.608, p=0.007, respectively]. CONCLUSION: HBTFs were tightly associated with clinicopathological factors causing TH. Among the 18F-FDG PET/CT parameters, only skewness and kurtosis were associated with lymph node involvement, whereas SUVmax was the only independent predictor of OS. TH measurement with HBTFs may contribute to conventional metabolic parameters in guiding precision medicine for ILA. PMID:35114750 | DOI:10.4274/mirt.galenos.2021.79037 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hybrid Renal Cortical Imaging with Single Photon Emission Computerized Tomography/Computed Tomography in a Pediatric Patient with Severe Caudal Regression Syndrome

xlomafota13 shared this article with you from Inoreader Hybrid Renal Cortical Imaging with Single Photon Emission Computerized Tomography/Computed Tomography in a Pediatric Patient with Severe Caudal Regression Syndrome Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):69-71. doi: 10.4274/mirt.galenos.2020.84755. ABSTRACT Caudal regression syndrome (CRS) or sacral agenesis is a rarely seen malformation with a varying degree of structural abnormalities, including multiorgan system dysfunctions, reported with higher incidence among children of mothers with diabetes, as in this case. Spinal anomalies can range from coccyx hemiagenesis to the total absence of lower lumbar vertebrae and sacrum in most severe cases. Herein, we have presented a 9-year-old patient with CRS who had renal failure. Technetium-99m dimercaptosuccinic acid renal scintigraphy revealed bilaterally non-functioning kidneys with no renal cortical uptake. Renal anomalies in CRS with vertebral, anorectal, cardiac, trachea-esophageal, renal, and limb anomalies association include one-sided renal agenesis, multicystic dysplastic kidneys, and ureter duplications. PMID:35114757 | DOI:10.4274/mirt.galenos.2020.84755 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.