Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma

xlomafota13 shared this article with you from Inoreader Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma Via Head & Neck Abstract Background We attempted to identify the most reliable immune-related index for predicting nasopharyngeal carcinoma (NPC) prognosis and to reveal its precise and integrated relationship with NPC progression. Method One thousand seven hundred and six patients with newly diagnosed NPC (1320 from the primary cohort and 386 from the validated cohort) from January 2010 to March 2014 were enrolled. Clinical features and 12 immune-related variables were analyzed. Results A high absolute lymphocyte count (ALC; >3.2 × 109/L) correlated with a poor prognosis of patients with NPC. Significant OS differences were discovered between patients with high ALC and no ALC elevation (p < 0.05, in primary cohort), showing similar prognostic risk to patients with advanced NPC (p > 0.05, in validated cohort). ALC improved the predictive performance of the basic tumor-node-metastasis prognostic model (p = 0.025), which was reliably validated in the external independent cohort. Conclusion High ALC is a surrogate marker for improved prognostic risk stratification in NPC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Successful outcomes with flaps for recurrent cerebrospinal fluid leaks: A systematic review of the literature

xlomafota13 shared this article with you from Inoreader Successful outcomes with flaps for recurrent cerebrospinal fluid leaks: A systematic review of the literature Via leak of cerebrospinal fluid J Plast Reconstr Aesthet Surg. 2022 Jan 22:S1748-6815(22)00036-5. doi: 10.1016/j.bjps.2022.01.022. Online ahead of print. ABSTRACT Complex back wounds with cerebrospinal fluid (CSF) leak constitute a challenge for surgeons in clinical practice. While repair of complex back wounds with various flaps is well described in the literature, there is a paucity of reviews and articles regarding optimal treatment for refractory CSF leaks. The aim of this systematic review was to present the different flap techniques proposed in the literature for CSF leaks fistulas and pseudo-meningoceles. A systematic review of the literature was conducted using the PubMed, Medline, Embase, and Cochrane databases. Studies tackling different flap techniques used for spinal or skull base CSF leak were included in the studies. The main outcomes were complications and recurrences after previous failed treatments. Fifteen studies were included in the study, constituting a cohort of 42 patients (mean age 45 years; F/M ratio 1.15:1). A previous unsuccessful non-flap procedure was proposed in 88.1% of patients for their CSF leak. Only 16.7% had a recurrence of their CSF leak after the flap procedure. Free radial forearm flap and regional muscle flaps were more frequently used in the skull base region. Pedicled omental flaps and reverse turnover latissimus dorsi were the most commonly used flaps in the thoracolumbar region. No statistically significant differences were found between these flaps regarding rates of complications and recurrence. Flaps should be considered as a safe and effective treatment option for complex back wounds with CSF leaks. All proposed flaps in the literature seem to provide an equivalent cure rate for recurrent and refractory leaks. PMID:35168923 | DOI:10.1016/j.bjps.2022.01.022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Successful outcomes with flaps for recurrent cerebrospinal fluid leaks: A systematic review of the literature

xlomafota13 shared this article with you from Inoreader Successful outcomes with flaps for recurrent cerebrospinal fluid leaks: A systematic review of the literature Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Jan 22:S1748-6815(22)00036-5. doi: 10.1016/j.bjps.2022.01.022. Online ahead of print. ABSTRACT Complex back wounds with cerebrospinal fluid (CSF) leak constitute a challenge for surgeons in clinical practice. While repair of complex back wounds with various flaps is well described in the literature, there is a paucity of reviews and articles regarding optimal treatment for refractory CSF leaks. The aim of this systematic review was to present the different flap techniques proposed in the literature for CSF leaks fistulas and pseudo-meningoceles. A systematic review of the literature was conducted using the PubMed, Medline, Embase, and Cochrane databases. Studies tackling different flap techniques used for spinal or skull base CSF leak were included in the studies. The main outcomes were complications and recurrences after previous failed treatments. Fifteen studies were included in the study, constit uting a cohort of 42 patients (mean age 45 years; F/M ratio 1.15:1). A previous unsuccessful non-flap procedure was proposed in 88.1% of patients for their CSF leak. Only 16.7% had a recurrence of their CSF leak after the flap procedure. Free radial forearm flap and regional muscle flaps were more frequently used in the skull base region. Pedicled omental flaps and reverse turnover latissimus dorsi were the most commonly used flaps in the thoracolumbar region. No statistically significant differences were found between these flaps regarding rates of complications and recurrence. Flaps should be considered as a safe and effective treatment option for complex back wounds with CSF leaks. All proposed flaps in the literature seem to provide an equivalent cure rate for recurrent and refractory leaks. PMID:35168923 | DOI:10.1016/j.bjps.2022.01.022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nasopharyngeal Radiation-Induced Sarcoma: A Case Report

xlomafota13 shared this article with you from Inoreader Nasopharyngeal Radiation-Induced Sarcoma: A Case Report Via ear nose throat Ear Nose Throat J. 2022 Feb 16:1455613221079499. doi: 10.1177/01455613221079499. Online ahead of print. ABSTRACT The primary treatment for nasopharyngeal carcinoma (NPC) is radiotherapy. In rare cases, patients with NPC treated with radiotherapy may develop radiation-induced sarcoma (RIS), a malignant tumor, in the field of previous radiation. The prognosis is poor, and complete surgical resection is the only potentially curative treatment. We report a case of radiation-indu ced nasopharyngeal sarcoma after radiotherapy for NPC with suspected lung and liver metastases in a 69-year-old woman. PMID:35170364 | DOI:10.1177/01455613221079499 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Rosai-Dorfman disease originating from nasal septal mucosa and presenting with nasal dorsum collapse: A case report with literature review

xlomafota13 shared this article with you from Inoreader Rosai-Dorfman disease originating from nasal septal mucosa and presenting with nasal dorsum collapse: A case report with literature review Via ear nose throat Ear Nose Throat J. 2022 Feb 16:1455613221079500. doi: 10.1177/01455613221079500. Online ahead of print. ABSTRACT Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon histiocytic disease with idiopathic etiology and unique pathology. Extra-nodal RDD that occurs in the nasal cavity is extremely unusual and the characteristic clinical features are unknown. Herein, we report a case of nasal septum RDD, with intermittent epistax is from the left nasal cavity, which led to collapse of the nasal bridge. The patient underwent surgical biopsy, and a diagnosis of nasal septum RDD was established. No further treatment was performed. An enlarged mass was found in the second postoperative year which was treated by surgical excision in the third postoperative year. To improve the current diagnostic and therapeutic approach of extra-nodal RDD, we incorporate previous reports from the literature to discuss the pathological characteristics, pathogenesis, clinical manifestations, diagnosis, and therapy for this rare disease. PMID:35171732 | DOI:10.1177/01 455613221079500 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early death in supraglottic laryngeal squamous cell carcinoma: A population-based study

xlomafota13 shared this article with you from Inoreader Early death in supraglottic laryngeal squamous cell carcinoma: A population-based study Via ear nose throat Ear Nose Throat J. 2022 Feb 16:1455613221078184. doi: 10.1177/01455613221078184. Online ahead of print. ABSTRACT BACKGROUND: Supraglottic laryngeal squamous cell carcinoma (LSCC) is the second most common type of laryngeal cancer with a poor prognosis. Current population-based estimates of the early death rate and associated factors for early death of supraglottic LSCC are lacking. The purpose of this study was to assess the early death rate and related factors for early dea th in patients with supraglottic LSCC. METHODS: We identified 3733 adult patients diagnosed with supraglottic LSCC between 2010 and 2017 for whom the vital status at 3 months was known from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were staged according to the seventh edition of the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system. The early death (survival time ≤ 3 months) rate was calculated. Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the early death rate. RESULTS: 313 (8.38%) of the 3733 patients died within 3 months of diagnosis of supraglottic LSCC. Of these, 225 patients died from cancer-specific causes. Multivariate logistic regression analyses confirmed that advanced age, male sex, advanced T stage, advanced N stage, advanced M stage, and not undergoing treatment (surgery, radiotherapy, and chemotherapy) had significant c orrelations with all-cause early death in supraglottic LSCC. In addition, advanced age, advanced T stage, advanced N stage, advanced M stage, and not undergoing treatment (surgery, radiotherapy, and chemotherapy) were significantly correlated with cancer specificity in supraglottic LSCC. CONCLUSION: When a tumor is newly diagnosed, we should pay close attention to sex, age, unmarried status and AJCC TNM staging to quickly detect supraglottic LSCC patients with a tendency toward early death. These findings have implications for precise prognosis prediction and individualized and personalized patient counseling and therapy. PMID:35171058 | DOI:10.1177/01455613221078184 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bilateral Pulsatile Tinnitus Caused by Bilateral Dilated Mastoid Emissary Vein

xlomafota13 shared this article with you from Inoreader Bilateral Pulsatile Tinnitus Caused by Bilateral Dilated Mastoid Emissary Vein Via ear nose throat Ear Nose Throat J. 2022 Feb 16:1455613221077597. doi: 10.1177/01455613221077597. Online ahead of print. ABSTRACT Pulsatile tinnitus is a rhythmic type of tinnitus. Most cases are caused by vascular disorders and present as synchronous with the patient's heartbeat. A dilated mastoid emissary vein may cause pulsatile tinnitus. Here, we report the first case of bilateral pulsatile tinnitus caused by dilated bilateral mastoid emissary vein. The patient suffered from bilateral pu lsatile tinnitus for 2 years. His bilateral tinnitus disappeared temporarily when the bilateral mastoid processes were compressed. Temporal bone computed tomographic (CT) showed the bilateral dilated mastoid emissary canals. Cranial Magnetic resonance venograms (MRV) showed the bilateral dilated mastoid emissary veins. We explained the risk of surgery to the patient. Because the patient could tolerate his tinnitus and did not have a hemangioma or tumor, he did not choose to undergo surgery. PMID:35171065 | DOI:10.1177/01455613221077597 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.