Enantioselective Aluminum‐Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold

SPO rules: A chiral Ni/SPO regime enabled outstanding levels of enantio‐control in asymmetric C−H alkylations with unactivated alkenes.

Abstract

Highly enantioselective nickel‐catalyzed alkene endo‐hydroarylations were accomplished with full selectivity by organometallic C−H activation. The asymmetric assembly of chiral six‐membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.

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