Peptide‐Coated Platinum Nanoparticles with Selective Toxicity against Liver Cancer Cells

Selective toxicity: Peptide‐stabilized, monodisperse platinum nanoparticles were developed that selectively kill liver cancer cells over other cancer and non‐cancerous cells. The peptide was identified in a combinatorial screening; it renders the PtNPs highly stable and enables their cellular uptake as well as the release of toxic Pt^II ions in an oxidative environment.

Abstract

Peptide‐stabilized platinum nanoparticles (PtNPs) were developed that have significantly greater toxicity against hepatic cancer cells (HepG2) than against other cancer cells and non‐cancerous liver cells. The peptide H‐Lys‐Pro‐Gly‐dLys‐NH₂ was identified by a combinatorial screening and further optimized to enable the formation of water‐soluble, monodisperse PtNPs with average diameters of 2.5 nm that are stable for years. In comparison to cisplatin, the peptide‐coated PtNPs are not only more toxic against hepatic cancer cells but have a significantly higher tumor cell selectivity. Cell viability and uptake studies revealed that high cellular uptake and an oxidative environment are key for the selective cytotoxicity of the peptide‐coated PtNPs.

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