Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma, Published online: 18 January 2019; doi:10.1038/s41467-018-08269-5

Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.

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