E47 modulates hepatic glucocorticoid action

E47 modulates hepatic glucocorticoid action

E47 modulates hepatic glucocorticoid action, Published online: 18 January 2019; doi:10.1038/s41467-018-08196-5

Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs.

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