Digging into the Sequential Space of Thiolactone Precision Polymers: A Combinatorial Strategy to Identify Functional Domains

Sequence coins function: Sequences that bind m‐THPC are selected from a library of thiolactone (Tla)/Michael oligomers by single‐bead readout with MALDI‐TOF MS/MS. The corresponding Tla/Michael‐PEG conjugates make m‐THPC available in solution and allow drug payload as well as drug release kinetics to be fine‐tuned by sequence variation in the precision segment.

Abstract

Functional sequences of precision polymers based on thiolactone/Michael chemistry are identified from a large one‐bead one‐compound library. Single‐bead readout by MALDI‐TOF MS/MS identifies sequences that host m‐THPC that is a second generation photo‐sensitizer drug. The corresponding Tla/Michael‐PEG conjugates make m‐THPC available in solution and drug payload as well as drug release kinetics can be fine‐tuned by the precision segment.

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