Visible Light‐driven Copper Photoredox‐catalyzed Multicomponent Coupling of Arylamines, Terminal Alkynes, and Alcohols via HAT Process

The first successful example of 3‐component coupling of N‐alkylanilines, terminal alkynes, and alcohols was achieved at R.T. via a visible light‐mediated copper‐catalyzed photoredox‐hydrogen atom transfer (HAT) process. This method allows preparation of propargylamines via unique selective α‐C‐H bond activation of unactivated alkylalcohols. Preliminary studies indicate that a formation of α‐oxy radical is operative. 53 examples were presented. This approach allows facilitates rapid access to biologically important propargylamines from abundant methanol feedstock.

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