Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells, Published online: 21 January 2019; doi:10.1038/s41467-018-08172-z

Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.

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