Solitary fibrous tumor/hemangiopericytoma of spinal cord: a retrospective single-center study of 16 cases.

Solitary fibrous tumor/hemangiopericytoma of spinal cord: a retrospective single-center study of 16 cases.

World Neurosurg. 2018 Dec 13;:

Authors: Wang J, Zhao K, Han L, Jiao L, Liu W, Xu Y, Niu H, Ke C, Shu K, Lei T

Abstract
OBJECTIVE: In this study, we retrospectively reviewed our experience in the surgical management of solitary fibrous tumor/hemangiopericytomas (SFT/HPCs) of the spinal cord.
METHODS: 16 cases with SFT/HPCs of the spinal cord were enrolled in this study. Data on clinical presentation, radiological findings, histopathological features, surgical treatment, adjuvant therapy, and prognosis were retrospectively reviewed. Kaplan-Meier curves and log-rank tests were employed to identify the prognostic factors for recurrence and overall survival (OS).
RESULTS: Our series included 6 men and 10 women with a male/female ratio of 1:1.7. Magnetic resonance imaging (MRI) revealed slightly hyperintense lesions on T2-weighted images for all 16 patients. All tumors showed positive immunohistochemical staining for STAT6. Statistical analysis of clinical data demonstrated that age, gender, tumor location, tumor size, medullary compartment location and KI-67 index were not associated with recurrence and overall survival (OS) (p>0.05). However, WHO III grade was significantly associated with recurrence (p<0.01). Gross total resection (GTR) and postoperative radiotherapy significantly reduced recurrence (p<0.01 and p<0.05), but only GTR showed remarkable benefits to improve OS (p<0.05).
CONCLUSIONS: SFT/HPCs of spinal cord are extremely rare neoplasms with a propensity to recur. Hyperintensity on T2-weighted MRI imaging combined with positive immunohistochemical staining for STAT6 are important clues for classification and differentiation of these tumors. The extent of resection, WHO grade and postoperative radiotherapy might be predictive factors for recurrence. Complete tumor resection should be strived whenever possible, and adjuvant radiotherapy is recommended after surgical resection. Moreover, a regular and long-term follow up is mandatory to monitor recurrence.

PMID: 30554000 [PubMed - as supplied by publisher]

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