Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion‐Pair Photocatalysis

A bioinspired radical Stetter reaction of α‐keto acids and aldehydes has been designed that is contingent on a formal "radical umpolung" concept. In their Communication (DOI: 10.1002/anie.201809601), R. Gilmour and co‐workers synergise organo‐ and photocatalysis activation principles to expand the mechanistic and synthetic scope of the classic Stetter reaction to include α,β‐unsaturated aldehyde acceptors, and thus solve a longstanding chemoselectivity problem.

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