Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis, Published online: 17 December 2018; doi:10.1038/s41467-018-07785-8

It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and lesion sizes in MS lesions.

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