aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability, Published online: 17 December 2018; doi:10.1038/s41467-018-07739-0

The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both angiogenesis and angiosarcomas.

from A via a.sfakia on Inoreader https://ift.tt/2SRM0s8