Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche, Published online: 17 December 2018; doi:10.1038/s41467-018-07740-7

Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque seminiferous tubules, which matures these into late PGCs and spermatogonia-like cells.

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