Imprinted genes influencing the quality of maternal care.

Related Articles

Imprinted genes influencing the quality of maternal care.

Front Neuroendocrinol. 2018 Dec 13;:

Authors: Creeth H, McNamara GI, Isles AR, John RM

Abstract
In mammals successful rearing imposes a cost on later reproductive fitness specifically on the mother creating the potential for parental conflict. Loss of function of three imprinted genes in the dam result in deficits in maternal care suggesting that, like maternal nutrients, maternal care is a resource over which the parental genomes are in conflict. However, the induction of maternal care is a complex and highly regulated process. Unsurprisingly many gene disruptions, as well as adverse environmental exposures in pregnancy, result in maternal care deficits. Recent compelling evidence for a more purposeful imprinting phenomenon comes from studying the impact of two imprinted genes, Phlda2 and Peg3, expressed in the placenta on the mother's behaviour. The explicit demonstration that imprinted genes expressed in the offspring influence maternal behaviour lends significant weight to the hypothesis that maternal care is a resource that has been manipulated by the paternal genome.

PMID: 30553874 [PubMed - as supplied by publisher]

from A via a.sfakia on Inoreader https://ift.tt/2PJ3BAp