World Neurosurgery,

Surgical Outcome in an Iniencephaly Survivor: Case Report and Review of the Literature

Publication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Deepak Khatri, Jaskaran S. Gosal, Jeena Joseph, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Raj KumarBackgroundIniencephaly is an extremely rare congenital neural tube defect (NTD) involving the occipital region with rachischisis of the cervicothoracic spine and fixed retroflexion deformity of the head. It affects an estimated 0.1–10 out of 10,000 pregnancies and carries a dismal prognosis. Most affected children are either...

World Neurosurgery

Thu Jun 27, 2019 13:43

Surgical Management of Idiopathic Thoracic Spinal Cord Herniation

Publication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Natalie Neale, Ashwin Ramayya, William WelchBackgroundIdiopathic spinal cord herniation is a rare condition that involves spinal cord herniation through a defect in the ventral dura.Case DescriptionWe present a case of a 61-year-old woman who initially presented in 2016 with an approximately 1-year history of burning right lower extremity pain and gait instability. Her neurologic examination was consistent with thoracic...

World Neurosurgery

Thu Jun 27, 2019 13:43

Current Approaches and Challenges in the Molecular Therapeutic Targeting of Glioblastoma

Publication date: September 2019Source: World Neurosurgery, Volume 129Author(s): James Mooney, Joshua D. Bernstock, Adeel Ilyas, Ahmed Ibrahim, Daisuke Yamashita, James M. Markert, Ichiro NakanoSurgical resection continues to predominate as the primary treatment modality in glioblastoma (GBM). Effective chemotherapeutic/biologic agents capable of targeting GBM have yet to be developed in part because of the exceptionally heterogeneous nature and unique microenvironmental conditions associated with...

World Neurosurgery

Thu Jun 27, 2019 13:43