(Institute of Cancer Research) Guiding chemotherapy to a tumor by attaching it to the antibody-based target drug Herceptin (trastuzumab) is effective at treating women with breast cancer who have no other treatment options, a new clinical trial shows.The two-in-one treatment kept breast cancer at bay in women with a type of the disease called HER2-positive breast cancer who had stopped responding to existing drugs. (Source: EurekAlert! - Social and Behavioral Science)
Thu Jun 27, 2019 06:00
Contributors : Francesco Cianflone ; Dejan Lazarevic ; Marco J Morelli ; Giulia M Scotti ; Giovanni Tonon ; Umberto CapitanioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIntroduction: The aim of this pilot study is to establish a radiogenomic characterisation of a clear-cell renal cell carcinoma (ccRCC) subpopulation, focusing on the transcriptomic underpinnings of radiomic features.Materials& Methods: To establish the viability of conducting a combined...
06:46
CONCLUSIONS Age does not affect counts and percentages of rare T lymphocyte subpopulations in the blood of healthy Cuban adults. Sex differences found for some phenotypes suggest the need for different reference values for women and men. PMID: 31242168 [PubMed - in process] (Source: MEDICC Review)
06:31
Empowering Cuban Women: Marta Núñez MS PhD, Sociologist & Consulting Professor, University of Havana. MEDICC Rev. 2018 Jul;20(3):6-9 Authors: Gorry C Abstract After nearly 60 years of universal education and health, coupled with national policies supporting women's rights and advancement, the results are in: according to recent data, more than half of Cuban scientists and almost 60% of all professionals in Cuba are women. Moreover, women's representation in government...
06:31
Authors: Blanco-García E, Ledón N, Lage-Dávila A Abstract Public health systems face the contradiction of skyrocketing cancer incidence and cancer drug prices, thus limiting patient access to more effective treatments. The situation is particularly dire in low- and middle-income countries. We urgently need consensus on the main determinants of this problem, as well as specific, effective and feasible solutions. Analysis of available data reveals that the problem has reached its current...
06:31
Authors: Vougioukalou S, Boaz A, Gager M, Locock L Abstract Ethnography is increasingly being used in the evaluation of quality improvement and change initiatives in healthcare settings, particularly in the form of 'focused' and 'rapid' ethnographies. This new ethnographic genre is tailored to suit narrower enquiries within clinical pathways. However, the application of ethnography to the evaluation of quality improvement is not straightforward or free from reductionist bias, particularly...
06:28
In conclusion, intra-tumoral blood feeding of the locally advanced lung cancer did not predict the effects of induction therapy, whereas smaller sized tumors tended to show a better response. PMID: 31239597 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
06:27
In conclusion, the visibility of early gastric cancer from the surrounding mucosa using ultrathin endoscopy with FICE was better than that using white light conventional endoscopy, especially for reddish lesions. PMID: 31239593 [PubMed - in process] (Source: Nagoya Journal of Medical Science)
06:27
Authors: Kajiyama H, Suzuki S, Utsumi F, Nishino K, Niimi K, Mizuno M, Yoshikawa N, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Shibata K, Nagasaka T, Kikkawa F Abstract Malignant ovarian neoplasm is one of the most lethal malignancies among cancers of the female reproductive system. Occasionally, these tumors originate from non-ovarian organs as metastatic lesions since the ovary is a frequent metastatic target of many cancers. However, there limited clinical information on metastatic ovarian...
06:27
Exploration of coping styles in male patients with head and neck cancer: a prospective cohort study.
Authors: Sato N, Kimura H, Adachi Y, Nishio N, Ando M, Tokura T, Nagashima W, Kishi S, Yamauchi A, Yoshida K, Hiramatsu M, Fujimoto Y, Ozaki N Abstract Majority of head and neck cancer (HNC) patients are male, and more than 85% of patients with HNC have the habit of smoking and drinking. Due to the specific demographic characteristics, HNC patients are anticipated to have specific coping styles, affecting psychological distress, survival, and quality of life. We explored the subscales of...
06:27
Authors: Tochigi K, Funahashi Y, Mori A, Matsukawa Y, Kato M, Gotoh M Abstract A 55-year-old man with a solitary kidney was diagnosed with an 8.5 cm renal cell carcinoma in the right kidney without metastasis. Twenty five months of sunitinib treatment reduced the tumor from 8.5 to 5.5 cm and enabled nephron-sparing surgery. He has no evidence of recurrence 58 months after the surgery. PMID: 31239602 [PubMed - in process] (Source: Nagoya Journal of Medical Science)MedWorm Message: Have...
06:27
Authors: Iwata Y, Kinoshita T, Kimura K, Komori K, Hayashi D, Akazawa T, Shigeyoshi I, Tsutsuyama M, Kawakami J, Ouchi A, Natsume S, Uemura N, Ito Y, Misawa K, Senda Y, Abe T, Ito S, Tajika M, Yatabe Y, Yoshida K, Shimizu Y Abstract Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph's nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old...
06:27
This study provides a comprehensive description of breast cancer among AN women, providing new and updated information on clinical and demographic factors, cancer incidence trends, regional variations and breast cancer survival. Abbreviations: AIAN: American Indian/Alaska Native; AN: Alaska Native; ANMC: Alaska Native Medical Center; ANTR: Alaska Native Tumor Registry; CI: Confidence Interval; HR: Hazard Ratio; ICD-O-3: International Classification of Diseases for Oncology - Third Edition; NHW -...
06:24
CONCLUSIONS: Disease burden associated with chronic HCV infection is projected to peak in the Czech Republic in 30-40 years. Assuming that the current portion of DAAs used remains constant, a significant reduction in HCV disease burden is possible through increased diagnosis and treatment through 2030. This analysis provides evidence in order to facilitate the development of national strategies for HCV care and management in the Czech Republic. PMID: 31241282 [PubMed - in process] (Source: Central...
06:21
CONCLUSION: The study confirmed previous results that smoking and low education are significantly associated with HNC. Additionally, results pointed to significant HNC and breast cancer risk in HNC patient's families that may have originated from passive smoking or a smoking habit stemming from social environments that support it. Better dissemination programmes regarding smoking risks for children and adults are needed, targeting not only individuals but also families. PMID: 31241284 [PubMed...
06:21
CONCLUSIONS: A thorough epidemiological investigation of the two first generations of this family, the study of their spouses and children, and the twenty years of follow up provided a strong presumption that the infection with HCV had occurred within this family through the promiscuous use of the same inadequately sterilized glass syringe for intramuscular therapies, as was a common practice during the fifties and sixties worldwide and still is in some part of the world. PMID: 31241295 [PubMed...
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Conclusion: Our data confirm the association of primiparity over 30 years of age and low level of schooling with GBC. (Source: Ciencia e Saude Coletiva)
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Conclusion: Our data confirm the association of primiparity over 30 years of age and low level of schooling with GBC. (Source: Ciencia e Saude Coletiva)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
06:08
Contributors : Eman Abu-Gharbieh ; Bipin ChandSeries Type : Expression profiling by arrayOrganism : Homo sapiensInvestigate the mechanistic pathway for the antitumour activity of M. fruticosa on different cancer cell lines (Source: GEO: Gene Expression Omnibus)
06:00
Contributors : Kathleen Clark ; Barbara GravesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensOur in vitro binding studies support a model whereby MED25 exhibits multivalent interactions with a subset of related ETS factors, ETV1/4/5. We hypothesize that the interaction would allow for coregulation of genes by ETV1/4/5 and MED25, acting perhaps to link the ETVs to the Mediator complex. To explore this possibility, we compared the genome occupancy...
06:00
Contributors : Kathleen Clark ; Barbara GravesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur in vitro binding studies support a model whereby MED25 exhibits multivalent interactions with a subset of related ETS factors, ETV1/4/5. We hypothesize that the interaction would allow for coregulation of genes by ETV1/4/5 and MED25, acting perhaps to link the ETVs to the Mediator complex. To explore this possibility, we compared the genome occupancy for FLAG-tagged...
06:00
CONCLUSION: This study shows that 1.2% of patients would have been incorrectly diagnosed as Stage II if extended D3 mesenterectomy had not been performed. Similarly, lymph node metastases would have been left behind in 4.1% of patients if extended D3 mesenterectomy had not been performed. PMID: 31237343 [PubMed - as supplied by publisher] (Source: Surgical Technology International)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social...
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Study Design: This is a retrospective cohort. Objective: Determine the relationship of body morphometry to postoperative survival in patients with vertebral metastases. Summary of Background Data: Most operations for vertebral metastases aim for palliation not cure, yet expected patient survival heavily influences treatment plans. We seek to demonstrate that preoperative fat and muscle volumes on standard-of-care computed tomography (CT) are independent predictors of survival after surgery...
05:35
Authors: Cole LM, Clench MR, Francese S Abstract Since the birth of proteomics science in the 1990, the number of applications and of sample preparation methods has grown exponentially, making a huge contribution to the knowledge in life science disciplines. Continuous improvements in the sample treatment strategies unlock and reveal the fine details of disease mechanisms, drug potency, and toxicity as well as enable new disciplines to be investigated such as forensic science.This chapter...
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In conclusion, eudesmin exhibited antitumor activity via downregulating EZH2 expression through the inhibition of Akt signaling pathway. Eudesmin could be developed as a new pharmacologic approach for NPC treatment. PMID: 31026422 [PubMed - indexed for MEDLINE] (Source: Chemico-Biological Interactions)
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Authors: Kumari R, Sunil D, Ningthoujam RS, Kumar NA Abstract Tumor hypoxia is the low tissue oxygen levels seen characteristically in rapidly proliferating and expanding neoplasms. It affects both malignant tumor cells and its microenvironment, resulting in dysfunctional neovascularization. This leads to epithelial-to-mesenchymal transition phenotype, facilitating tumor progression through cell mobility, invasion, and metastasis. The hypoxic condition in solid tumors is thus an indicator...
04:56
Authors: Giménez-Dejoz J, Weber S, Fernández-Pardo Á, Möller G, Adamski J, Porté S, Parés X, Farrés J Abstract The aldo-keto reductase (AKR) superfamily comprises NAD(P)H-dependent enzymes that catalyze the reduction of a variety of carbonyl compounds. AKRs are classified in families and subfamilies. Humans exhibit three members of the AKR1B subfamily: AKR1B1 (aldose reductase, participates in diabetes complications), AKR1B10 (overexpressed in several cancer types), and the recently described...
04:56
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,