Bracco Imaging is set to acquire Blue Earth Diagnostics for about $450 million. Upon closing of the transaction, Burlington, the MA-based company will be a subsidiary of Bracco Imaging, led by its current leadership team. Milan, Italy-based Bracco Imaging said Blue Earth Diagnostics will retain the well-established brand name. âBlue Earth Diagnosticsâ innovative products and pipeline will significantly enhance Bracco Imagingâs portfolio in precision medicine and personalized diagnostics, while...
Thu Jun 27, 2019 15:47
(The Lancet) The new study is the first to show pooled estimates of population-level impact of HPV vaccination on CIN2+ from several countries, the benefit of vaccinating more than one age group, along with substantial herd effects in countries achieving high vaccination coverage. Published in The Lancet, the results provide strong evidence of HPV vaccination working to prevent cervical cancer in real-world settings as both the cause (HPV infection) and precancerous cervical lesions are declining....
Wed Jun 26, 2019 06:00
CONCLUSION: Thyroid disorders and eye diseases are interrelated through several mechanisms thus, awareness of this relation is of a great impact on early diagnosis and treatment. PMID: 31237221 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
02:38
(Source: BMJ News)
02:36
ConclusionCollectively, the present study suggests an inhibitory role of MBNL1-AS1 in colon cancer by upregulating miR-412-3p-targeted MYL9. Thus, this study provides an enhanced understanding of MBNL1-AS1 along with miR-412-3p and MYL9 as therapeutic targets for colon cancer. (Source: Clinics and Research in Hepatology and Gastroenterology)
02:03
Colorectal cancer (CRC) is the 2nd most common cancer among men and women in the United States and can be prevented through adequate screening and surveillance by physicians. Gastroenterologists encounter numerous patients in the outpatient setting with a variety of conditions; however, CRC screening and surveillance are not always addressed, especially at new patient visits. The aim of this quality improvement (QI) project was to optimize outpatient CRC screening and surveillance for new outpatients...
02:02
(Source: Clinical Gastroenterology and Hepatology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
02:02
We read the article by Kim et al,1 “Disparate Trends in Mortality of Etiology-Specific Chronic Liver Disease Among Hispanic Sub-populations”, with great interest. Liver cancer, and hepatocellular carcinoma (HCC) in particular, has historically disproportionately impacted Hispanics in the United States. Although considerabl e and important differences have been documented by disaggregated Hispanic subgroups,2–4 this variation has largely been overlooked in liver cancer prevention and control efforts....
02:02
In this study, we develop adherent gold nanoparticles (GNPs) and paclitaxel (PTX)-loaded PLGA microspheres for the treatment of PC. Polydopamine (pD) was used as a linker to adhere GNPs to the surface of PLGA-Ms and characterized using TEM. Short-term cytotoxicity of GNPs-pD-PTX-PLGA-Ms with or without NIR treatment was evaluated using CCK-8 assays. ROS and western blot assay were performed to determine the intensity of ROS following the treatment of GNPs-pD-PTX-PLGA-Ms with or without NIR in Panc-1...
01:56
Authors: Vr R, Muddegowda U, Rai V R Abstract Nanomaterial-based anticancer treatment is promising nowadays because of their small size that can penetrate and interact both inside and outside the cell surface. In the present study, a simple protocol was followed for the conjugation of the biologically synthesised Selenium nanoparticles (SeNPs) and short chain synthetic peptide. SeNPs was synthesised by using the culture supernatant of Streptomyces griseoruber, Actinomycetes isolated from...
01:53
(Source: Clinical and Experimental Gastroenterology)
00:59
Bone metastases from a 1p/19q codeleted and IDH1 -mutant anaplastic oligodendroglioma: a case report
ConclusionThis case joins less than 20 other reported cases of oligodendroglioma bone marrow metastasis, and is one of only a handful of cases of diffuse bone metastases beyond the axial skeleton. To the best of our knowledge, the early relapse of 1p/19q codeleted anaplastic oligodendroglioma with this distribution of metastases has never been described in the literature. (Source: Journal of Medical Case Reports)MedWorm Message: Have you tried our new medical search engine? More powerful than before....
00:00
A large study, published in theBMJ, reports an association between women who are early risers and a reduced risk of breast cancer.CNN (Source: Society for Endocrinology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Jun 27, 2019 14:00
In conclusion, these are the first patients with myeloid malignancies associated with acquired severe platelet dysfunction and overproduction of cAMP. PMID: 31240986 [PubMed - as supplied by publisher] (Source: Platelets)
01:44
ConclusionsThe clinical implications of HPV in NPC are further elucidated but require more investigation.Level of evidenceIV. (Source: American Journal of Otolaryngology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
01:38
Publication date: Available online 26 June 2019Source: Pharmacological ResearchAuthor(s): Surya Kant Tripathi, Kamal Pandey, Munmun Panda, Michael J. Spinella, Kannan RR Rengasamy, Bijesh K BiswalAbstractLung cancer is the most common cancer-related death worldwide. Natural compounds have shown high biological and pharmaceutical relevance as anticancer agents. Retinoids are natural derivatives of vitamin A having many regulatory functions in the human body, including vision, cellular proliferation...
01:15
Publication date: Available online 27 June 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Michael K. Pugsley, Tessa de Korte, Venkatesha Udupa, Simon Authier, Michael J. CurtisAbstractThis editorial previews and summarizes the content of the current themed issue of J Pharm Tox Methods derived from the recent 2018 Annual Safety Pharmacology Society (SPS) meeting held in Washington, DC. The papers highlight improvements in methods and study endpoints used in non-clinical...
01:15
ConclusionWe demonstrate for the first time that NKT can sensitize ADR-resistant A549/ADR cells to ADR in vitro and in vivo. Metformin, on the other hand, failed to show any synergistic effect with ADR in A549/ADR cells.Graphical abstract (Source: Phytomedicine)
01:15
ConclusionTherefore, studies on the interaction between artemisinin derivatives and P-gp provide important information for the development of novel anti-cancer artemisinin derivatives to reverse P-gp mediated MDR and for the design of rational artemisinin-based combination therapies against cancer.Graphical abstract (Source: Phytomedicine)
01:15
No abstract available (Source: Dermatologic Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
01:11
CONCLUSION Intralesional MTX may be considered as the initial treatment for solitary KA, multiple KA, or in poor surgical candidates. (Source: Dermatologic Surgery)
01:11
CONCLUSION Physicians and patients were concordant regarding skin cancer treatment on multiple spheres. Areas of discordance include patient fear of unknown future risk, recurrence, or empowering patients to make treatment choices, and may be areas of continued improvement for delivery of patient-centered care. (Source: Dermatologic Surgery)
01:11
No abstract available (Source: Dermatologic Surgery)
01:11
Retraction notice to "miR-1271 promotes non-small-cell lung cancer cell proliferation and invasion via targeting HOXA5" [Biochem. Biophys. Res. Commun. 458/3 (2015) 714-719]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):729 Authors: Wang Y, Xu L, Jiang L PMID: 31239034 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
01:07
Retraction notice to "miR-613 inhibits proliferation and invasion of breast cancer cell via VEGFA" [Biochem. Biophys. Res. Commun. 478/1 (2016) 274-278]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):734 Authors: Wu J, Yuan P, Mao Q, Lu P, Xie T, Yang H, Wang C PMID: 31239039 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)
01:07
Retraction notice to "miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A" [Biochem. Biophys. Res. Commun. 464/4 (2015) 1309-1313]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):728 Authors: Shao M, Geng Y, Lu P, Xi Y, Wei S, Wang L, Fan Q, Ma W PMID: 31239033 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
01:07
Retraction notice to "miR-361-5p inhibits hepatocellular carcinoma cell proliferation and invasion by targeting VEGFA" [Biochem. Biophys. Res. Commun. 479/4 (2016) 901-906]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):732 Authors: Cui W, Li Y, Xu K, Chen G, Lu X, Duan Q, Kang Z PMID: 31239037 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)
01:07
Retraction notice to "miR-367 promotes proliferation and invasion of hepatocellular carcinoma cells by negatively regulating PTEN" [Biochem. Biophys. Res. Commun. 470/1 (2016) 187-191]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):727 Authors: Meng X, Lu P, Fan Q PMID: 31239032 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)
01:07
Retraction notice to "The miR-599 promotes non-small cell lung cancer cell invasion via SATB2" [Biochem. Biophys. Res. Commun. 485/1 (2017) 35-40]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):733 Authors: Tian W, Wang G, Liu Y, Huang Z, Zhang C, Ning K, Yu C, Shen Y, Wang M, Li Y, Wang Y, Zhang BC, Zhao Y PMID: 31239038 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)
01:07
Retraction notice to "miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog" [Biochem. Biophys. Res. Commun. 480/3 (2016) 369-374]. Biochem Biophys Res Commun. 2019 Aug 06;515(4):735 Authors: Bi M, Chen W, Yu H, Wang J, Ding F, Tang DJ, Tang C PMID: 31239040 [PubMed - in process] (Source: Biochemical and Biophysical Research communications)
01:07
This study aimed at analyzing the safety, efficacy and feasibility of transcatheter arterial embolization (TAE) in the treatment of hepatic tumor hemorrhage. Methods: This retrospective study included all patients undergoing embolization attempt for hepatic tumor hemorrhage in the Helsinki University Hospital during 2004-2017. Electronic medical records provided the study data. Outcomes included the 30-day rebleeding, complication and mortality rates, need for blood transfusions, durations of intensive...
00:52
Publication date: Available online 27 June 2019Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Wa Cai, Ai-Wen Chen, Lei Ding, Wei-Dong ShenAbstractPrevious studies have confirmed the efficacy of acupuncture treatment for tinnitus. However, no relevant studies of the exact mechanism of acupuncture efficacy on tinnitus have been published. Enrolled participants with left-sided tinnitus received acupuncture treatment at TE3 and TE5. The acupuncture session lasted for 30 minutes. Infrared...
00:41
The recall comes amid renewed concerns after a recent expanded recall and the discovery of a fourth potential carcinogen in another commonly used hypertension and heart failure medication.Medscape Medical News (Source: Medscape Cardiology Headlines)
00:35
Communication skills are different from doctoring skills, but they can be learned, and proper evidence-based training with role play can be'game changing. 'Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Thu Jun 27, 2019 21:24
(Source: Karmanos Cancer Institute)
Thu Jun 27, 2019 19:00
(University of Cambridge) Researchers at the University of Cambridge have criticized a recent study calling into question guidelines on genetic testing for hereditary breast cancer. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
A new study reinforces the need for universal mismatch repair protein immunohistochemistry screening of tumors from endometrial cancer patients, as well as germline genetic testing in accordance with guidelines. (Source: CancerNetwork)
Thu Jun 27, 2019 06:00
(JAMA Network) An observational study suggests the US Preventive Services Task Force (USPSTF) lung cancer screening guidelines may be too conservative for African-American smokers and that some eligibility criteria changes could result in more screenings of African-American smokers at high risk for lung cancer. The study looked at new lung cancer cases in a predominantly low-income and African-American population group to assess their eligibility for lung cancer screening using the USPSTF criteria....
Thu Jun 27, 2019 06:00
(Sanford Burnham Prebys Medical Discovery Institute) Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging 'fuel' through an alternative supply route, called macropinocytosis. Blocking this process, often described as 'cellular drinking,' could lead to tumor-starving drugs. Now, scientists from Sanford Burnham Prebys have identified a signaling pathway that regulates macropinocytosis, the nutritional cue that triggers the process and key metabolic differences between tumors...
Thu Jun 27, 2019 06:00
(European Society for Medical Oncology) Please find below the most important news that will be announced in connection with the 2019 ESMO World Congress on Gastrointestinal Cancer. Press releases will be made available and press conferences organised on a daily basis, before and during the Congress. Media representatives are kindly requested to respect embargoes as indicated. (Source: EurekAlert! - Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log...
Thu Jun 27, 2019 06:00
(Massachusetts General Hospital) A study by investigators from the Massachusetts General Hospital Cancer Center has found that, contrary to common assumptions, the fact that a specific genetic mutation frequently arises in particular tumors may not signify that the mutation drives cancer development and progression. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
(University of Pennsylvania School of Medicine) Most 'nudges' seek to increase a behavior, but this is one of the few employed to reduce it. (Source: EurekAlert! - Cancer)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Jun 27, 2019 06:00
(Karolinska Institutet) Lung cancer cells use antioxidants, endogenous or dietary, to spread in the body by activating a protein called BACH1 and increasing the uptake and use of sugar, Swedish and American researchers report in two independent studies. The studies, which are published in the eminent scientific journal Cell, pave the way for new therapeutic strategies for lung cancer. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
(Vanderbilt University Medical Center) Guidelines that determine which smokers qualify for CT scans are excluding a significant number of African Americans who develop lung cancer, according to a study released today in JAMA Oncology. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
(NYU Langone Health / NYU School of Medicine) A new study explains why lung cancer spreads faster in patients with certain genetic changes, and suggests that taking vitamin E, long thought of as preventive, may cause the same spread. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
(University of California - Irvine) Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression. A new University of California, Irvine-led study indicates this is not always true. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer's disease. The report appeared online today in the journal Cell. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
Healthy eating, exercise, and avoiding smoking can save lives. So why aren't more doctors talking to patients about lifestyle changes? (Source: CancerNetwork)
Thu Jun 27, 2019 06:00
After more than 7 years of follow-up, the phase III PHARE trial failed to show that 6 months of adjuvant trastuzumab therapy was noninferior to 12 months in patients with HER2+ early breast cancer. (Source: CancerNetwork)
Thu Jun 27, 2019 06:00
(McGill University) A new collaborative study, led by researchers at McGill University's Goodman Cancer Research Centre (GCRC), and published in the journal Molecular Cell, uncovers novel functions for polycistronic microRNAs and showing how cancers such as lymphoma twist these functions to reorganize the information networks that control gene expression. (Source: EurekAlert! - Cancer)
Thu Jun 27, 2019 06:00
(Children's Hospital of Philadelphia) Researchers who analyzed data in the electronic health records of children seen by hematology/oncology specialists at three large medical centers have developed an algorithm to accurately identify appropriate pediatric oncology patients for future clinical studies. By expediting and refining the selection of patients for research, the researchers aim to ultimately improve outcomes for a variety of pediatric cancers (Source: EurekAlert! - Cancer)
Wed Jun 26, 2019 06:00
ConclusionsAC may be an effective method for improving the condition of breast cancer-related lymphoedema. However, due to the high risk of bias and the low quality of the available studies, further high-quality RCTs are needed to confirm the efficacy of AC for breast cancer-related lymphoedema patients. (Source: EXPLORE: The Journal of Science and Healing)
00:41
ConclusionThis study revealed that C. curetum has potential α-amylase, α-glucosidase, porcine pancreatic lipase enzyme inhibitory activity and cytotoxic activity against the HeLa and Colo-205 cancer cell lines, which indicates the presence of biologically active and cytotoxic compounds in this plant species. This may be considered a challenge for developing bioactive compounds in diabetes, obesity and cancer management. (Source: European Journal of Integrative Medicine)
00:41
Authors: McClymont E, Lee M, Elwood C, Mitchell-Foster S, van Schalkwyk J, Ogilvie G, Money D PMID: 31235371 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
00:23
Publication date: Available online 26 June 2019Source: Seminars in Cancer BiologyAuthor(s): Charbel K. Moussalem, Elie Massaad, Wassim Baassiri, M. Akhtar Anwar, Firas Kobeissy, Ali Eid, Nadine Darwiche, Ibrahim OmeisAbstractSarcomas, especially spine sarcomas, are rare yet debilitating and are underestimated types of cancer. Treatment options for spine sarcomas are limited to chemotherapy, radiotherapy and surgical intervention. Accumulating evidence suggests a complex course associated with the...
00:18
ConclusionsChondroblastoma is a rare benign to intermediate grade bone tumour with a potential to metastasise. Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in femoral head. occur in patients with open growth plates. (Source: Journal of Bone Oncology)
00:17
We report lack of significant benefit in long-term outcomes for younger Hispanic MM patients over time. This could be due to multifactorial causes which need to be addressed to mitigate outcome disparities. (Source: Clinical Lymphoma Myeloma and Leukemia)
00:17
ConclusionIf Ld is to be considered a treatment choice, at least a partial response should be obtained after the first therapy cycle to maintain double-agent therapy safely. (Source: Clinical Lymphoma Myeloma and Leukemia)
00:17
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Elie Rassy, Nicholas PavlidisAbstractCancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers for which a primary tumor cannot be identified after a standardized work-up. The biology of CUP has not been fully elucidated and epidemiologic data may be helpful in this regard. The variations in the incidence-rate over time and between countries reflect changes in the risk factors for CUP, incidence trends...
00:17
ConclusionsTobacco smoking and a high intake of spirits were indicated as risk factors for thymoma. (Source: Cancer Epidemiology)
00:17
ConclusionsExamining Asian Americans as a single group results in missed ethnic-specific disparities in ovarian cancer, hence disaggregating this heterogeneous population in future research is warranted. (Source: Cancer Epidemiology)
00:17
Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Publication date: Available online 26 June 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Rong Guo, Yang Long, Zhengze Lu, Miao Deng, Penghui He, Man Li, Qin HeAbstractChemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised. Since some prodrugs are still with poor solubility or stability, a synergy strategy is needed to enhance their efficacy. Gemcitabine (GEM) is a prescribed...
00:17
No abstract available (Source: Melanoma Research)
00:17
No abstract available (Source: Melanoma Research)
00:17
This retrospective cohort study assessed the prognostic significance of distant metastasis-free interval (DMFI) in patients with relapsed BRAF-mutant melanoma treated with BRAF with or without MEK inhibitors (BRAFi ± MEKi). Patients with a DMFI of up to 24 months were compared with those with DMFI of more than 24 months, with regard to their postrelapse progression-free survival (PR-PFS) and overall survival (PR-OS). In total, 109 patients were included in the study. Median DMFI was 25.3 (range:...
00:17
No abstract available (Source: Melanoma Research)
00:17
Targeting immune cells instead of cancer cells is a new and successful therapeutic approach in patients with a variety of advanced cancers. Blocking antibodies bind to specific immune-checkpoint molecules namely cytotoxic T-lymphocyte-associated antigen 4, programmed cell death protein-1, and programmed cell death-ligand 1. However, their mechanism of action can lead to immune-related adverse events. In particular, neurological immune-related adverse events present, currently, a problem, as they...
00:17
We report two cases of cobimetinib-induced and vemurafenib-induced reversible interstitial pneumonitis. Two patients presenting a BRAF-mutated metastatic melanoma were treated with cobimetinib and vemurafenib. After 3 months, they developed severe feverish dyspnea. Thoracic imaging showed a pattern of organizing pneumonia in one case and a pattern of hypersensitivity pneumonitis in the other case. Infectious and cardiogenic causes were eliminated. An improvement was noted after discontinuation of...
00:17
No abstract available (Source: Melanoma Research)
00:17
A vaccine that could expand melanoma-specific T cells might reduce the risk of recurrence of resected melanoma and could provide an alternative or adjunct to standard immunotherapy options. We tested the safety and immunogenicity of a vaccine coupling a melanoma-associated peptide with a xenogenic peptide (to promote epitope spreading) and/or resiquimod (to activate antigen-presenting cells). HLA-A2-positive patients with resected stage II, III, and IV melanoma were assigned to treatment on one of...
00:17
No abstract available (Source: Melanoma Research)
00:17
The objective was to determine if the absence of FasL signaling would affect melanoma liver metastases by influencing the antimelanoma properties of liver natural killer (NK) cells. Melanoma liver metastases were induced in wild-type C57BL/6 mice and the gld/gld mutant C57BL/6 mouse strain that expresses a defective form of FasL (CD95L) that fails to engage and signal via the Fas receptor (CD95). Liver metastases were produced by intrasplenic injection of B16LS9 melanoma cells. Liver NK cell activity...
00:17
Selective inhibition of the mutant BRAF protein is a highly promising therapeutic approach for melanoma patients carrying the BRAFV600E mutation. Despite the remarkable clinical response, most patients develop resistance and experience tumour regrowth. To clarify the molecular background of BRAF inhibitor resistance, we generated four drug-resistant melanoma cell lines from paired primary/metastatic cell lines using a vemurafenib analogue PLX4720. Three of the resistant cell lines showed decreased...
00:17
Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 patients with localized DM were included for analysis. 2082 were treated with wide local excision (WLE) and 308 were treated with wide local excision and adjuvant radiation therapy (WLE...
00:17
The cancer/testis antigen (CTA) family is a group of antigens whose expression is restricted to male germline cells of the testis and various malignancies. This expression pattern makes this group of antigens potential targets for immunotherapy. The aim of this study was to create an overview of CTA expressed by melanoma cells at mRNA and protein level. A systematic literature search was performed in Medline (PubMed) and Embase from inception up to and including February 2018. Studies were screened...
00:17
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface proteoglycan that enhances malignant potential in melanoma and several other tumor types. CSPG4 functions as a transmembrane scaffold in melanoma cells to activate oncogenic signaling pathways such as focal adhesion kinase (FAK) and extracellular signal regulated kinases 1,2, that control motility, invasion and anchorage independent growth. Here, we demonstrate that CSPG4 promotes directional motility and anchorage independent growth of...
00:17
In resected high-risk melanoma (stage IIB/C-III) the risk of locoregional and/or distant recurrence is substantial and so far adjuvant therapies have been fairly unsuccessful. Interferon showed slight improvements in recurrence-free survival (RFS) but failed to convincingly improve overall survival (OS). In these patients, adjuvant therapy with treatments that show promising results in stage IV disease is arising. Studies using immune checkpoint blockade with anti-CTLA-4 and anti-PD-1 agents reveal...
00:17
This study aimed to investigate whether NLK expression in melanoma correlates with VEGFR2-related angiogenesis and melanoma metastasis. Immunohistochemistry analysis using 175 biopsied tissues of melanoma patients showed that NLK is expressed in 73.7% of melanoma tissues, whereas 26.3% of the samples showed absent expression of NLK. In metastatic melanoma, the expression of NLK was significantly lower than that in primary melanoma (P = 0.002). Furthermore, tissues with a lower expression of NLK showed...
00:17
The development of immunotherapy has improved the treatment of melanoma; however, resistance and frequent recurrence persist and remain a major problem. N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark on mRNA and is essential for various physiological processes; however, its role in melanoma is unknown. Utilizing human normal melanocyte and melanoma cell lines, we analyzed the expression of METTL3 by quantitative RT-PCR. We inhibited the METTL3 expression by shRNA and analyzed...
00:17
ConclusionThe reflexology intervention delivered by lay caregivers reduced hospital visits and increased workplace productivity in a short-term period, which has potential for cost saving for health care systems and employers.Trial registrationNCT01582971 (Source: Supportive Care in Cancer)
00:14
ConclusionsVirtually all cancer pain syndromes can present mixed pathophysiology. Certain syndromes can include neuropathic components that are frequently overlooked. (Source: Supportive Care in Cancer)
00:14
(Source: Supportive Care in Cancer)
00:14
ConclusionsOur observations that hyperglycemia and increased glycemic variability were associated with lower remission rates and increased mortality in older patients suggest glycemic control may be a potentially modifiable factor to improve AML outcomes. (Source: Supportive Care in Cancer)
00:14
ConclusionsThe dynamic assessments of pain demand the simplest, and the most complete possible procedure, to avoid feasibility problems or self-/hetero-assessment excesses that might lead to less precise and less reliable results. Multimodal and interdisciplinary approaches are being developed, making it possible to optimize cancer pain management. (Source: Supportive Care in Cancer)
00:14
ConclusionsGiven the difficulties still present in the management of pain in cancer, and whilst cancer is often considered as a chronic condition, the concept of multimorphic pain proposes a practical, optimised and innovative approach for clinicians and, ultimately, for patients experiencing pain. (Source: Supportive Care in Cancer)
00:14
ConclusionsThe results indicate that many adult survivors have concerns about physical, emotional, and practical issues but are not receiving help to reduce their suffering. It is imperative we take action to correct this current reality. (Source: Supportive Care in Cancer)
00:14
ConclusionsThe home-based exercise program may improve the QOL and psychological health in colorectal cancer survivors. We have demonstrated that the home-based exercise program was effective in increasing the level of PA in colorectal cancer survivors. (Source: Supportive Care in Cancer)
00:14
ConclusionCompetence, honesty, respect, and patience are important characteristics which should be focused on in communication training of medical students and physicians. In spite of compassion being rated as less important, training on compassion/empathy might help doctors to improve coping with the continuous confrontation with complications, progress, suffering, and death of their patients. (Source: Supportive Care in Cancer)
00:14
ConclusionsAwareness of the clinical factors associated with adherence to analgesic drugs may help clinicians to identify cancer patients at a greater risk of non-adherence, reinforce optimal pain management, and improve the QoL by enhancing adherence to pain medications. (Source: Supportive Care in Cancer)
00:14
ConclusionsThese findings suggest that telephone-based reminiscence therapy can reduce depression symptoms in colorectal cancer patients undergoing postoperative chemotherapy. Telephone-based reminiscence therapy may also improve anxiety, but no better than telephone support. Alternatively, telephone-based reminiscence therapy did not improve subjective well-being or social support. We suggest that clinicians provide appropriate telephone-based reminiscence therapy in long-term care institutions...
00:14
ConclusionsFatigue needs to be taken seriously in the aftercare of melanoma survivors as it is associated with multiple functional and quality of life impairments and heightened distress. Reduction of fatigue in melanoma patients should address younger survivors (under 40 years) and older survivors (over 60 years) with additional chronic illness and focus on illness coping and social support. (Source: Supportive Care in Cancer)
00:14
ConclusionsUltimately, the use of the interventional therapies can be limited by the requirement of specific trained healthcare teams and technical support, or the lack of health policies. However, these interventional strategies need to be proposed as soon as possible to each patient requiring them, as they can greatly improve quality of life. (Source: Supportive Care in Cancer)
00:14
AbstractThis commentary deals with the need of an early integration between hematologist and palliative care specialists as well as pain therapists as a routine basis in order to ensure the best management of patients affected by acute leukemia from the onset of the disease and in the stages of causal therapy. This strategy could limit the burden of painful symptoms and, in addition, avoid unnecessary suffering to patients, ensuring the best conditions for optimal outcome of these patients with extremely...
00:14
ConclusionsDemographic, health and lifestyle variables are associated with changes in meeting PA guidelines from pre-diagnosis to post-diagnosis in prostate cancer survivors. Programming should be aimed at offering interventions to help inactive survivors adopt PA and active survivors to maintain PA. (Source: Supportive Care in Cancer)
00:14
ConclusionThis concept could also be of interest to survivors of other cancer entities. (Source: Supportive Care in Cancer)
00:14
ConclusionsAccording to our results, HCPs should systematically include FCs into OACs ’ care plan through the use of concrete actions such as the “family systems approach” suggested by Duhamel, and integrate a systematic FC’s needs assessment. (Source: Supportive Care in Cancer)
00:14
British Journal of Cancer, Published online: 28 June 2019; doi:10.1038/s41416-019-0506-6Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma (Source: British Journal of Cancer)
00:00
Authors: Nguyen M, Sandhu SS, Sivamani RK Abstract Actinic keratosis (AK) is an early in situ squamous cell carcinoma that results from UV light exposure and has the potential to evolve into invasive tumor. Therefore, it is crucial that AKs are monitored and treated appropriately. Photodynamic therapy (PDT) is a treatment option that is minimally invasive and leaves patients with cosmetically superior results. However, disadvantages of PDT include pain and lengthy clinic visits. Accordingly,...
Thu Jun 27, 2019 23:59
Priced RightWe provide, to our customers, the sameFetal Bovine Serum (FBS) we use in ourdefined media. This FBS enriched media is used in culturing all our human 2 and 3-D based Assays. Our FBS is of the highest quality and priced right at $379/500 ml.Here're some recent publications referencing its use.Gabriela Fernandes, Stephen T Vanyo, Shahad Bakheet Alsharif, Sebastiano Andreana, Michelle B Visser, Rosemary Dziak, Ph.D.Strontium Effects on Human Gingival Fibroblasts. https://doi.org/10.1563/aaid-joi-D-18-00253Douglas...
Thu Jun 27, 2019 16:14
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,