pubmed br j cancer [jour],

Direct Ras G12C inhibitors: crossing the rubicon.

Related ArticlesDirect Ras G12C inhibitors: crossing the rubicon. Br J Cancer. 2019 Jun 26;: Authors: Lindsay CR, Blackhall FH Abstract Despite its status as the most commonly mutated oncogene in cancer, Ras has long been considered 'undruggable'. In 2019, we will see the first clinical trial results for direct mutant Ras inhibitors, a result of persistent cross-disciplinary research that has been informed by a number of previous clinical and biological...

pubmed br j cancer [jour]

Thu Jun 27, 2019 15:00

Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry.

Related ArticlesNotch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry. Br J Cancer. 2019 Jun 26;: Authors: Capulli M, Hristova D, Valbret Z, Carys K, Arjan R, Maurizi A, Masedu F, Cappariello A, Rucci N, Teti A Abstract BACKGROUND: Recurrence after >5-year disease-free survival affects one-fifth of breast cancer patients and is the clinical manifestation of cancer cell...

pubmed br j cancer [jour]

Thu Jun 27, 2019 15:00

Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy.

Related ArticlesCorrection: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy. Br J Cancer. 2019 Jun 24;: Authors: Fumet JD, Richard C, Ledys F, Klopfenstein Q, Joubert P, Routy B, Truntzer C, Gagné A, Hamel MA, Guimaraes CF, Coudert B, Arnould L, Favier L, Lagrange A, Ladoire S, Saintigny P, Ortiz-Cuaran S, Perol M, Foucher P, Hofman P, Ilie M, Chevrier S, Boidot R, Derangere V, Ghiringhelli F ...

pubmed br j cancer [jour]

Thu Jun 27, 2019 15:00

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression.

Related ArticlesAnti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression. Br J Cancer. 2019 Jun 25;: Authors: Berndsen RH, Castrogiovanni C, Weiss A, Rausch M, Dallinga MG, Miljkovic-Licina M, Klaassen I, Meraldi P, van Beijnum JR, Nowak-Sliwinska P Abstract BACKGROUND: Crenolanib is a tyrosine kinase inhibitor targeting PDGFR-α, PDGFR-β and Fms related tyrosine kinase-3 (FLT3) that is currently evaluated...

pubmed br j cancer [jour]

Thu Jun 27, 2019 15:00

Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases.

Related ArticlesClaudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. Br J Cancer. 2019 Jun 25;: Authors: Coati I, Lotz G, Fanelli GN, Brignola S, Lanza C, Cappellesso R, Pellino A, Pucciarelli S, Spolverato G, Guzzardo V, Munari G, Zaninotto G, Scarpa M, Mastracci L, Farinati F, Realdon S, Pilati P, Lonardi S, Valeri N, Rugge M, Kiss A, Loupakis F, Fassan M Abstract BACKGROUND: Claudin-18...

pubmed br j cancer [jour]

Thu Jun 27, 2019 15:00