Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents.

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Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents.

Chem Commun (Camb). 2019 Jan 22;55(8):1096-1099

Authors: Zhao H, Tao L, Zhang F, Zhang Y, Liu Y, Xu H, Diao G, Ni L

Abstract
Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2}6- (M = NiII (1), CoII (2), imi = imidazole) containing a strong M-Cimi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)4]22- {Sb8W36} precursor. Compound 1 was highly cytotoxic against gastric cancer cells by arresting the cell cycle in the S-phase and inducing cell apoptosis.

PMID: 30620027 [PubMed - indexed for MEDLINE]

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