Paradoxical Relations between Basilar Artery Reconfiguration and Superior Cervical Ganglia Ischemia Following Bilateral Common Carotid Artery Ligation.

Paradoxical Relations between Basilar Artery Reconfiguration and Superior Cervical Ganglia Ischemia Following Bilateral Common Carotid Artery Ligation.

World Neurosurg. 2019 Feb 01;:

Authors: Kilic M, Kilic B, Aydin MD, Kanat A, Yilmaz I, Eseoglu M, Gundogdu B

Abstract
ACKGROUND: The relationship between superior cervical ganglia (SCG) ischemia due to bilateral common carotid artery ligation (BCCAL) and basilar artery (BA) reconfiguration was investigated.
METHOD: Twenty-three rabbits were randomly divided into three groups: GIII rabbits underwent BCCAL (n = 13), GII rabbits were sham-operated controls (n = 5), and GI rabbits did not undergo surgery (n = 5). Degenerated neuron densities (DND) within SCG were correlated with the BA vasodilatation index (VDI).
RESULTS: Mean live and DND in SCG of GI rabbits were 11.235 ± 982/μm3 and 11 ± 3/μm3, respectively, with a mean heart rate of 294 ± 21 beats/min. Mean SCG DND and heart rates were 213 ± 42/μm3 and 242 ± 17 beats/min for sham group (Group II) rabbits and 1743 ± 285/μm3 and 199 ± 19 beats/min for study group (Group III) rabbits, respectively. BA VDI values in sham group (Group II) (1.32 ± 0.10) and study group (Group III) rabbits, (0.976 ± 0.112) rabbits significantly differed from those in control group (Group I) (1.65 ± 0.12; P< 0.005 vs sham group (Group II); P< 0.0001 vs BCCAL applied group (Group III) and between Group II and Group III rabbits (P< 0.005).
CONCLUSION: A meaningful and paradoxical correlation was detected between the BA VDI values and degenerated neuron density of SCG following BCCAL. Although a low degenerated neuron density within SCG may provoke excessive sympathetic activity and prevent excessive BA dilatation with steno-occlusive carotid artery diseases, a high degenerated neuron density may cause dangerous vasodilatation of BA.

PMID: 30716499 [PubMed - as supplied by publisher]

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