Intracranial Solitary Fibrous Tumors: a heterogeneous entity with an uncertain clinical behavior.

Intracranial Solitary Fibrous Tumors: a heterogeneous entity with an uncertain clinical behavior.

World Neurosurg. 2019 Feb 01;:

Authors: Gubian A, Ganau M, Cebula H, Todeschi J, Scibilia N, Noel G, Spatola G, Chaussemy D, Nannavecchia B, P G, Coca A, Pop R, Signorelli F, Proust F, Lhermitte B, Chibbaro S

Abstract
Intracranial solitary fibrous tumors (ISFT) are rare mesenchymal neoplasms, originating in the meninges, characterized by very different biological and clinical behaviors. Benign histotypes such as hemangiopericytomas are now considered a cellular phenotypic variant of this heterogeneous group of rare spindle-cell tumors. Due to their rarity and resemblance to other more common brain tumors, ISFTs are often poorly recognized and remain a diagnostic challenge: in fact, ISFT might either have a benign/indolent clinical behavior or show biological aggressivity with local and distant recurrences after surgery. We describe herein a surgical series of 29 patients treated for ISFTs confirmed histologically and through immunohistochemistry. We attempt to provide a focus on the natural history of these pathologies and the need for a tailored management.

PMID: 30716501 [PubMed - as supplied by publisher]

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