Various etiologies could cause focal 131I accumulation. Hepatic cyst is one of these etiologies. Here we present a 59-year-old man with a history of papillary thyroid cancer resection who received radioiodine therapy for three times. The images after the 131I therapy of the second and third time showed variable activity uptake in the same hepatic cysts. Received for publication November 13, 2018; revision accepted November 15, 2018. Conflicts of interest and sources of funding: This work was supported by the Key Project of Hubei Province Technical Innovation Special Funding (No. 2017ACA182), and the Clinical Research Physician Program of Tongji Medical College, Huazhong University of Science and Technology (No. 5001530008). None declared to all authors. Correspondence to: Xiaoli Lan, MD, PhD, Department of Nuclear Medicine, Wuhan Union Hospital, No. 1277 Jiefang Ave, Wuhan, 430022, China. E-mail: LXL730724@hotmail.com. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
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