Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway, Published online: 09 January 2019; doi:10.1038/s41467-018-07859-7

Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.

from A via a.sfakia on Inoreader https://go.nature.com/2RmOmmA