De novo design of potent and selective mimics of IL-2 and IL-15

De novo design of potent and selective mimics of IL-2 and IL-15

De novo design of potent and selective mimics of IL-2 and IL-15, Published online: 09 January 2019; doi:10.1038/s41586-018-0830-7

A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.

from A via a.sfakia on Inoreader https://go.nature.com/2ss3vnL