Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding

Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding

Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding, Published online: 09 January 2019; doi:10.1038/s41586-018-0840-5

Cryo-electron microscopy structures of bacterial RNAP–promoter DNA complexes, including structures of partially melted intermediates, suggest a universally conserved common mechanism for promoter DNA opening prior to gene expression.

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