Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics

Lipidomics is a rapidly growing field with numerous examples showing the importance of lipid molecules throughout biology. It has also shed light onto the vast and complex functions performed by many lipids that possess an immense diversity in molecular structures. Mass spectrometry is the tool of choice for analysing lipids and has been the key catalyst driving the field forward. However MS does not yet permit true molecular lipidomics where the identification and quantification of lipids having defined molecular structures can be routinely achieved. Here we describe recent advances in MS‐based lipidomics that allow access to higher levels of molecular information in lipidomics experiments. These advances will form a key piece of a puzzle as the field moves towards systems characterisation of lipids at the molecular level.

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