Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry, Published online: 03 January 2019; doi:10.1038/s41467-018-07851-1

Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights into improved inhibition between small molecules and Env.

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