PRMT5 is essential for B cell development and germinal center dynamics

PRMT5 is essential for B cell development and germinal center dynamics

PRMT5 is essential for B cell development and germinal center dynamics, Published online: 03 January 2019; doi:10.1038/s41467-018-07884-6

Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells, yet modulates, in p53-independent manners, the survival and differentiation of mature B cells.

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