Regio‐ and Stereoselective Synthesis of Functionalized Dihydropyridines, Pyridines and 2H‐Pyrans Triggered by Heck Coupling of Monocyclopropanated Heterocycles

The palladium‐catalyzed coupling between aryl halides and monocyclopropanated pyrroles or furans has been developed leading to valuable six‐membered N‐ and O‐heterocycles. As the key step, a selective cleavage of the non‐activated endocyclic C‐C bond of the 2‐heterobicyclo‐[2.1.0]hexane framework is achieved. The developed method offers an access to highly functionalized piperidines, pyridines and pyrans that are challenging to access by traditional methods.

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