Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion, Published online: 11 January 2019; doi:10.1038/s41467-018-08193-8

Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.

from A via a.sfakia on Inoreader https://go.nature.com/2RJFjv4