MITF phosphorylation; Cross talk between GSK3 and MAPK signaling

Abstract

Microphthalmia‐associated transcription factor (MITF) is one of the most heavily studied lineage factors, important for both melanocyte development and melanoma survival (Lin and Fisher, 2007). Its expression is tightly regulated via multiple mechanisms and cellular signals, operating in various contexts. For example, MITF expression is strongly upregulated transcriptionally downstream of MC1R‐cAMP signals that control the pigmentation (tanning) response to UV radiation. In other contexts, MITF has been shown to be targeted by a multitude of post‐translational modifications that confer variably well understood effects on MITF's transcriptional activity.

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