Svår reaktion av antiepileptikum hos kvinna med ursprung från Asien - Karbamazepininducerat Stevens–Johnsons syndrom/toxisk epidermal nekrolys vanligare hos personer med viss asiatisk härkomst.

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Svår reaktion av antiepileptikum hos kvinna med ursprung från Asien - Karbamazepininducerat Stevens–Johnsons syndrom/toxisk epidermal nekrolys vanligare hos personer med viss asiatisk härkomst.

Lakartidningen. 2017 Feb 21;114:

Authors: Anastasopoulou S, Komuda M, Presman B, Karlsson M, Tomson T

Abstract
Stevens-Johnson syndrome/toxic epidermal necrolysis after initiation of carbamazepine in a HLA-B*15:02 gene carrier - screening in risk patients is recommended A 32-year-old woman, adopted from Indonesia, developed Stevens-Johnsons syndrome (SJS)/toxic epidermal necrolysis (TEN) after initiating carbamazepine treatment for epilepsy. SJS and TEN are rare but life-threatening adverse effects of carbamazepine, with a 72-100% risk of occurrence in patients carrying the HLA-B*15:02 allele. The HLA-B*15:02 allele is common in several Asian groups but less prevalent in European populations. Screening for HLA-B*15:02, or choice of medication other than aromatic anticonvulsants in patients with Asian ancestry, is recommended when treatment with carbamazepine is considered.

PMID: 28221394 [PubMed - indexed for MEDLINE]

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