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Κυριακή 15 Οκτωβρίου 2017

Aetiological Heterogeneity of Head and Neck Squamous Cell Carcinomas: The Role of Human Papillomavirus Infections, Smoking, and Alcohol.

Aetiological Heterogeneity of Head and Neck Squamous Cell Carcinomas: The Role of Human Papillomavirus Infections, Smoking, and Alcohol.

Carcinogenesis. 2017 Sep 28;:

Authors: Farsi NJ, Rousseau MC, Schlecht N, Castonguay G, Allison P, Nguyen-Tan PF, Soulieres D, Coutlée F, Hier M, Madathil S, Franco EL, Nicolau B

Abstract
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors. We tested exfoliated oral cells for HPV-DNA by polymerase chain reaction. We included only OPC cases (n=188) and controls (n=427) without missing values for HPV, smoking, or alcohol. We examined associations by estimating odds ratios (OR) and corresponding 95% confidence intervals (CI) using unconditional logistic regression. Smoking (OR=1.90, 95%CI: 1.04-3.45) and alcohol (OR=2.74, 95%CI: 1.45-5.15) were associated with an increased risk of OPC independent of HPV status. Positivity for HPV16 among heavy smokers and heavy alcohol users was associated with a 30.4-fold (95%CI: 8.94-103.26) and 18.6-fold (95%CI: 5.75-60.13) elevation in risk of OPC relative to participants who were HPV negative, respectively. Moreover, the combined effect of heavy smoking and alcohol comsumption with HPV16 infection substantially increased OPC risk (OR=48.76, 95%CI: 15.83-150.17) and (OR=50.60, 95%CI: 15.96-160.40), respectively. Our results support the independent roles of smoking, alcohol and HPV infection in OPC risk, and a possible combined effect. Efforts should be made to tackle these major risk factors simultaneously.

PMID: 29029021 [PubMed - as supplied by publisher]



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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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